Iscu (iron-sulfur cluster assembly enzyme) - Rat Genome Database

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Gene: Iscu (iron-sulfur cluster assembly enzyme) Mus musculus
Analyze
Symbol: Iscu
Name: iron-sulfur cluster assembly enzyme
RGD ID: 1553245
MGI Page MGI
Description: Enables protein homodimerization activity. Involved in [4Fe-4S] cluster assembly. Located in mitochondrion. Part of mitochondrial [2Fe-2S] assembly complex. Orthologous to human ISCU (iron-sulfur cluster assembly enzyme).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2310020H20Rik; AA407971; iron-sulfur cluster assembly enzyme ISCU; iron-sulfur cluster assembly enzyme ISCU, mitochondrial; IscU iron-sulfur cluster scaffold homolog; ISCU2; Ni; Nifu; NifU-like N-terminal domain containing; nifU-like N-terminal domain-containing protein; nifU-like protein; Nifun; nitrogen fixation cluster-like
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm2594  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395113,910,479 - 113,916,349 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5113,910,809 - 113,916,349 (+)EnsemblGRCm39 Ensembl
GRCm385113,772,418 - 113,778,288 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5113,772,748 - 113,778,288 (+)EnsemblGRCm38mm10GRCm38
MGSCv375114,222,821 - 114,228,291 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365114,033,811 - 114,039,281 (+)NCBIMGSCv36mm8
Celera5110,873,936 - 110,879,406 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N and Rouault TA, Biochim Biophys Acta. 2015 Jun;1853(6):1493-512. doi: 10.1016/j.bbamcr.2014.09.009. Epub 2014 Sep 19.
3. miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis. McCormick RI, etal., Br J Cancer. 2013 Mar 19;108(5):1133-42. doi: 10.1038/bjc.2013.56. Epub 2013 Feb 28.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
6. MIR-210 modulates mitochondrial respiration in placenta with preeclampsia. Muralimanoharan S, etal., Placenta. 2012 Oct;33(10):816-23. doi: 10.1016/j.placenta.2012.07.002. Epub 2012 Jul 26.
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16286020   PMID:17597094  
PMID:17603005   PMID:18614015   PMID:19808020   PMID:21165651   PMID:21298097   PMID:21873635   PMID:23508953   PMID:24917298   PMID:25597503   PMID:26560363   PMID:27519411   PMID:29097656  
PMID:29610276   PMID:30550785   PMID:32325033  


Genomics

Comparative Map Data
Iscu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395113,910,479 - 113,916,349 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5113,910,809 - 113,916,349 (+)EnsemblGRCm39 Ensembl
GRCm385113,772,418 - 113,778,288 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5113,772,748 - 113,778,288 (+)EnsemblGRCm38mm10GRCm38
MGSCv375114,222,821 - 114,228,291 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365114,033,811 - 114,039,281 (+)NCBIMGSCv36mm8
Celera5110,873,936 - 110,879,406 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.55NCBI
ISCU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812108,561,463 - 108,569,384 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12108,562,582 - 108,569,368 (+)EnsemblGRCh38hg38GRCh38
GRCh3712108,955,239 - 108,963,160 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612107,480,512 - 107,487,273 (+)NCBINCBI36Build 36hg18NCBI36
Celera12108,625,685 - 108,632,553 (+)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12106,020,849 - 106,027,716 (+)NCBIHuRef
CHM1_112108,922,512 - 108,929,380 (+)NCBICHM1_1
T2T-CHM13v2.012108,530,831 - 108,538,753 (+)NCBIT2T-CHM13v2.0
Iscu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81248,512,852 - 48,518,696 (-)NCBIGRCr8
mRatBN7.21242,852,305 - 42,858,150 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,852,305 - 42,858,150 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1244,018,678 - 44,024,102 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01244,632,273 - 44,637,697 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,692,805 - 43,698,229 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,621,454 - 48,627,297 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,621,454 - 48,627,297 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01250,403,338 - 50,409,181 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,886,419 - 43,892,329 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11243,749,819 - 43,755,677 (-)NCBI
Celera1244,453,913 - 44,459,757 (-)NCBICelera
Cytogenetic Map12q16NCBI
Iscu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554559,833,924 - 9,841,619 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554559,833,924 - 9,840,547 (+)NCBIChiLan1.0ChiLan1.0
ISCU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210116,622,727 - 116,629,492 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112116,619,125 - 116,625,859 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012106,132,987 - 106,140,879 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112109,529,162 - 109,537,053 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12109,529,162 - 109,537,053 (+)Ensemblpanpan1.1panPan2
ISCU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12618,300,800 - 18,307,668 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2618,300,803 - 18,307,652 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2617,492,198 - 17,499,090 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02618,647,123 - 18,654,012 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2618,647,126 - 18,653,991 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12617,701,195 - 17,708,096 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02618,638,137 - 18,645,016 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02618,656,527 - 18,663,400 (-)NCBIUU_Cfam_GSD_1.0
Iscu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118144,977,307 - 144,983,670 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936769491,530 - 498,692 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936769492,024 - 498,587 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ISCU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1442,216,111 - 42,222,711 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11442,216,103 - 42,222,570 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21444,761,391 - 44,767,990 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ISCU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111103,753,175 - 103,760,168 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11103,753,189 - 103,760,364 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037141,335,350 - 141,342,158 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Iscu
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474711,808,640 - 11,816,400 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474711,808,789 - 11,815,269 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1358
Count of miRNA genes:528
Interacting mature miRNAs:625
Transcripts:ENSMUST00000026937, ENSMUST00000112311, ENSMUST00000112312, ENSMUST00000123616, ENSMUST00000134881, ENSMUST00000145592, ENSMUST00000145778
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10045978Tir10_mtrypanosome infection response 10 (mouse)Not determined598019649114021986Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
25314310Syncl4_msynaptonemal complex length 4 (mouse)5103047866115538059Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
25314317Sccor3_msynaptonemal complex length to mean MLH1 count ratio 3 (mouse)5104347866114738061Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined597021753131021986Mouse
1301042Elmaz1_melevated maze behavior 1 (mouse)Not determined598019649116876624Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595465549129465722Mouse
1357886Diht_mdopamine-induced hypothermia (mouse)Not determined5104498738115101540Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100665965134665965Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined581019649115019803Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100665965134665965Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595233214129233330Mouse
11528550Sluc33_msusceptibility to lung cancer 33 (mouse)5104386871120711986Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592830166126830285Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595434580129434786Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596320385130320533Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580849259114849259Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595465549129465722Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
4141652Mrdq2_mmodifier of retinal degeneration QTL 2 (mouse)Not determined110253106118093673Mouse
4141139Hmtb4_mhemostasis and thrombosis rebleeding time 4 (mouse)Not determined108762509126882944Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99949422126882944Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined597021753131021986Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595465549129465722Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse

Markers in Region
D9Mit34.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map2C1.3UniSTS
Cytogenetic Map19D1UniSTS
Cytogenetic Map9F1UniSTS
Cytogenetic Map1FUniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map3F2UniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map11B4UniSTS
Cytogenetic Map5G3UniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map6F2UniSTS
Cytogenetic Map1C1.3UniSTS
Cytogenetic Map16B1UniSTS
Cytogenetic Map12C1UniSTS
Cytogenetic Map7E2UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map2E2UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map15E1UniSTS
Cytogenetic Map3G2UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map1E4UniSTS
Cytogenetic Map1E3UniSTS
Cytogenetic Map5E1UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map16B3UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map19D3UniSTS
Cytogenetic Map1H5UniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map2BUniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map9DUniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map17DUniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map13A1UniSTS
Cytogenetic Map3F2.1UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map12A3UniSTS
Cytogenetic Map1H2.1UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map2E1UniSTS
Cytogenetic Map11B2UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map5G1UniSTS
Cytogenetic Map6A2UniSTS
Cytogenetic Map7B1UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map5C3.1UniSTS
Cytogenetic Map2C3UniSTS
Cytogenetic Map17A3.2-A3.3UniSTS
Cytogenetic Map6E3UniSTS
Cytogenetic Map11B1.1UniSTS
Cytogenetic Map1H6UniSTS
Cytogenetic Map2C2UniSTS
Cytogenetic Map19CUniSTS
Cytogenetic Map17E1.3UniSTS
Cytogenetic Map5A1UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map1A1UniSTS
Cytogenetic Map13A5UniSTS
Cytogenetic MapXA1.1UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map3A3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map8CUniSTS
Cytogenetic Map12EUniSTS
Cytogenetic Map10C2UniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map2H3UniSTS
Cytogenetic Map2A1UniSTS
Cytogenetic Map1H1UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map9E1UniSTS
Cytogenetic Map9CUniSTS
Cytogenetic Map1A2UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map11B1.3UniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXC-DUniSTS
Cytogenetic Map5G1.3UniSTS
Cytogenetic Map7D1-E2UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map1H2.2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic Map11DUniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map16C1.1UniSTS
Cytogenetic Map15F2UniSTS
Cytogenetic Map9A2UniSTS
Cytogenetic Map1H4-H6UniSTS
Cytogenetic Map12D2UniSTS
Cytogenetic Map1G3UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map1H3UniSTS
Cytogenetic Map19BUniSTS
cM Map950.0UniSTS
Whitehead Genetic943.7UniSTS
RH124652  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385113,778,031 - 113,778,187UniSTSGRCm38
MGSCv375114,228,040 - 114,228,196UniSTSGRCm37
Celera5110,879,155 - 110,879,311UniSTS
Cytogenetic Map5FUniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000026937   ⟹   ENSMUSP00000026937
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5113,910,809 - 113,916,349 (+)Ensembl
GRCm38.p6 Ensembl5113,772,748 - 113,778,288 (+)Ensembl
Ensembl Acc Id: ENSMUST00000112311   ⟹   ENSMUSP00000107930
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5113,910,864 - 113,915,859 (+)Ensembl
GRCm38.p6 Ensembl5113,772,803 - 113,777,798 (+)Ensembl
Ensembl Acc Id: ENSMUST00000112312   ⟹   ENSMUSP00000107931
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5113,910,864 - 113,916,334 (+)Ensembl
GRCm38.p6 Ensembl5113,772,803 - 113,778,273 (+)Ensembl
Ensembl Acc Id: ENSMUST00000123616   ⟹   ENSMUSP00000117973
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5113,910,879 - 113,915,100 (+)Ensembl
GRCm38.p6 Ensembl5113,772,818 - 113,777,039 (+)Ensembl
Ensembl Acc Id: ENSMUST00000134881   ⟹   ENSMUSP00000120553
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5113,911,086 - 113,916,006 (+)Ensembl
GRCm38.p6 Ensembl5113,773,025 - 113,777,945 (+)Ensembl
Ensembl Acc Id: ENSMUST00000145592   ⟹   ENSMUSP00000123237
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5113,911,908 - 113,915,902 (+)Ensembl
GRCm38.p6 Ensembl5113,773,847 - 113,777,841 (+)Ensembl
Ensembl Acc Id: ENSMUST00000145778   ⟹   ENSMUSP00000117053
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5113,911,066 - 113,916,075 (+)Ensembl
GRCm38.p6 Ensembl5113,773,005 - 113,778,014 (+)Ensembl
RefSeq Acc Id: NM_001363317   ⟹   NP_001350246
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395113,910,862 - 113,916,349 (+)NCBI
GRCm385113,772,801 - 113,778,288 (+)NCBI
Sequence:
RefSeq Acc Id: NM_025526   ⟹   NP_079802
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395113,910,862 - 113,916,349 (+)NCBI
GRCm385113,772,801 - 113,778,288 (+)NCBI
MGSCv375114,222,821 - 114,228,291 (+)RGD
Celera5110,873,936 - 110,879,406 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030254754   ⟹   XP_030110614
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395113,910,479 - 113,916,335 (+)NCBI
GRCm385113,772,418 - 113,778,274 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030254755   ⟹   XP_030110615
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395113,910,832 - 113,916,336 (+)NCBI
GRCm385113,772,771 - 113,778,275 (+)NCBI
Sequence:
RefSeq Acc Id: NP_079802   ⟸   NM_025526
- Peptide Label: isoform 1 precursor
- UniProtKB: Q4VBC7 (UniProtKB/Swiss-Prot),   Q8K344 (UniProtKB/Swiss-Prot),   Q9D7P6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030110614   ⟸   XM_030254754
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030110615   ⟸   XM_030254755
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001350246   ⟸   NM_001363317
- Peptide Label: isoform 2
Ensembl Acc Id: ENSMUSP00000123237   ⟸   ENSMUST00000145592
Ensembl Acc Id: ENSMUSP00000026937   ⟸   ENSMUST00000026937
Ensembl Acc Id: ENSMUSP00000107931   ⟸   ENSMUST00000112312
Ensembl Acc Id: ENSMUSP00000107930   ⟸   ENSMUST00000112311
Ensembl Acc Id: ENSMUSP00000117053   ⟸   ENSMUST00000145778
Ensembl Acc Id: ENSMUSP00000120553   ⟸   ENSMUST00000134881
Ensembl Acc Id: ENSMUSP00000117973   ⟸   ENSMUST00000123616
Protein Domains
NIF system FeS cluster assembly NifU N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D7P6-F1-model_v2 AlphaFold Q9D7P6 1-168 view protein structure

Promoters
RGD ID:6887644
Promoter ID:EPDNEW_M7273
Type:multiple initiation site
Name:Iscu_1
Description:Mus musculus iron-sulfur cluster assembly enzyme , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385113,772,801 - 113,772,861EPDNEW
RGD ID:6837746
Promoter ID:MM_KWN:43518
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000112311,   ENSMUST00000112312,   OTTMUST00000063602,   OTTMUST00000063608,   OTTMUST00000063609,   OTTMUST00000063610,   UC008YYO.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365114,222,021 - 114,222,937 (+)MPROMDB
RGD ID:6837750
Promoter ID:MM_KWN:43519
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   MEF_B6
Transcripts:OTTMUST00000063611
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365114,223,574 - 114,224,074 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913633 AgrOrtholog
Ensembl Genes ENSMUSG00000025825 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000026937 ENTREZGENE
  ENSMUST00000026937.12 UniProtKB/Swiss-Prot
  ENSMUST00000112311.8 UniProtKB/TrEMBL
  ENSMUST00000112312.8 UniProtKB/TrEMBL
  ENSMUST00000123616.8 UniProtKB/TrEMBL
  ENSMUST00000134881.2 UniProtKB/TrEMBL
  ENSMUST00000145592.2 UniProtKB/TrEMBL
  ENSMUST00000145778.8 UniProtKB/TrEMBL
Gene3D-CATH 3.90.1010.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ISC_FeS_clus_asmbl_IscU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NIF_FeS_clus_asmbl_NifU_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:66383 UniProtKB/Swiss-Prot
MGD MGI:1913633 ENTREZGENE
NCBI Gene 66383 ENTREZGENE
PANTHER IRON-SULFUR CLUSTER ASSEMBLY ENZYME ISCU, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10093 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NifU_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Iscu PhenoGen
Superfamily-SCOP SufE/NifU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3Z0K9_MOUSE UniProtKB/TrEMBL
  D3Z7W0_MOUSE UniProtKB/TrEMBL
  D6RE47_MOUSE UniProtKB/TrEMBL
  F6XUL3_MOUSE UniProtKB/TrEMBL
  F6ZBG7_MOUSE UniProtKB/TrEMBL
  ISCU_MOUSE UniProtKB/Swiss-Prot
  Q4VBC7 ENTREZGENE
  Q8K344 ENTREZGENE
  Q9D7P6 ENTREZGENE
UniProt Secondary Q4VBC7 UniProtKB/Swiss-Prot
  Q8K344 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-29 Iscu  iron-sulfur cluster assembly enzyme    IscU iron-sulfur cluster scaffold homolog (E. coli)  Symbol and/or name change 5135510 APPROVED