Sars2 (seryl-aminoacyl-tRNA synthetase 2) - Rat Genome Database

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Gene: Sars2 (seryl-aminoacyl-tRNA synthetase 2) Mus musculus
Analyze
Symbol: Sars2
Name: seryl-aminoacyl-tRNA synthetase 2
RGD ID: 1553226
MGI Page MGI
Description: Predicted to enable ATP binding activity; serine-tRNA ligase activity; and tRNA binding activity. Predicted to be involved in mitochondrial seryl-tRNA aminoacylation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; eye; integumental system; nervous system; and respiratory system. Orthologous to human SARS2 (seryl-tRNA synthetase 2, mitochondrial).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2410015F05Rik; D7Ertd353; D7Ertd353e; serine--tRNA ligase; serine--tRNA ligase, mitochondrial; SerRS; SerRSmt; seryl-tRNA synthetase, mitochondrial; seryl-tRNA(Ser/Sec) synthetase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,441,393 - 28,453,304 (+)NCBIGRCm39mm39
GRCm39 Ensembl728,441,417 - 28,453,296 (+)Ensembl
GRCm38728,741,957 - 28,753,879 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,741,992 - 28,753,871 (+)EnsemblGRCm38mm10GRCm38
MGSCv37729,527,010 - 29,538,874 (+)NCBIGRCm37mm9NCBIm37
MGSCv36728,450,756 - 28,462,615 (+)NCBImm8
Celera723,302,398 - 23,314,649 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (IBA,IDA,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mutations in the mitochondrial seryl-tRNA synthetase cause hyperuricemia, pulmonary hypertension, renal failure in infancy and alkalosis, HUPRA syndrome. Belostotsky R, etal., Am J Hum Genet. 2011 Feb 11;88(2):193-200. doi: 10.1016/j.ajhg.2010.12.010. Epub 2011 Jan 20.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10764807   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12904583   PMID:14681479   PMID:15081407   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:17179180   PMID:18614015   PMID:21267068   PMID:21873635   PMID:23375831   PMID:30196744   PMID:32325033  


Genomics

Comparative Map Data
Sars2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,441,393 - 28,453,304 (+)NCBIGRCm39mm39
GRCm39 Ensembl728,441,417 - 28,453,296 (+)Ensembl
GRCm38728,741,957 - 28,753,879 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,741,992 - 28,753,871 (+)EnsemblGRCm38mm10GRCm38
MGSCv37729,527,010 - 29,538,874 (+)NCBIGRCm37mm9NCBIm37
MGSCv36728,450,756 - 28,462,615 (+)NCBImm8
Celera723,302,398 - 23,314,649 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.91NCBI
SARS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,915,266 - 38,930,763 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1938,915,266 - 38,930,763 (-)EnsemblGRCh38hg38GRCh38
GRCh371939,405,906 - 39,421,403 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,097,746 - 44,113,376 (-)NCBINCBI36hg18NCBI36
Build 341944,097,746 - 44,113,376NCBI
Celera1936,208,338 - 36,223,965 (-)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1935,852,611 - 35,868,135 (-)NCBIHuRef
CHM1_11939,406,299 - 39,421,931 (-)NCBICHM1_1
T2T-CHM13v2.01941,719,237 - 41,734,732 (-)NCBI
Sars2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2184,028,972 - 84,040,725 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl184,028,986 - 84,040,725 (+)Ensembl
Rnor_6.0186,923,769 - 86,935,506 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,923,591 - 86,935,904 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,104,901 - 88,116,638 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,848,250 - 83,859,874 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1183,926,360 - 83,937,985 (+)NCBI
Celera178,421,419 - 78,432,891 (+)NCBICelera
Cytogenetic Map1q21NCBI
Sars2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468603,778 - 613,475 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955468603,778 - 613,475 (+)NCBIChiLan1.0ChiLan1.0
SARS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11944,571,434 - 44,586,472 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1944,565,214 - 44,568,594 (-)NCBIpanpan1.1panPan2
PanPan1.1 Ensembl1944,571,434 - 44,586,472 (-)Ensemblpanpan1.1panPan2
PanPan1.1 Ensembl1944,565,214 - 44,568,594 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01936,015,983 - 36,037,404 (-)NCBIMhudiblu_PPA_v0panPan3
SARS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,192,574 - 114,202,385 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,594,261 - 113,604,028 (+)NCBI
ROS_Cfam_1.01114,792,488 - 114,802,242 (+)NCBI
ROS_Cfam_1.0 Ensembl1114,792,518 - 114,802,238 (+)Ensembl
UMICH_Zoey_3.11114,350,232 - 114,360,002 (+)NCBI
UNSW_CanFamBas_1.01113,983,406 - 113,993,172 (+)NCBI
UU_Cfam_GSD_1.01114,979,139 - 114,988,912 (+)NCBI
Sars2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,433,577 - 13,443,664 (-)NCBI
SpeTri2.0NW_0049366611,861,646 - 1,871,707 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SARS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,716,679 - 47,728,310 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,717,363 - 47,728,394 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,266,872 - 43,276,311 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SARS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,536,160 - 33,552,160 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl633,536,498 - 33,552,000 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607311,558,681 - 11,574,652 (-)NCBIVero_WHO_p1.0
Sars2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,269,615 - 12,280,558 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462479412,269,773 - 12,280,537 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH127027  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38728,753,615 - 28,753,851UniSTSGRCm38
MGSCv37729,538,634 - 29,538,870UniSTSGRCm37
Celera723,314,409 - 23,314,645UniSTS
Cytogenetic Map7A3UniSTS
cM Map79.5UniSTS
Whitehead/MRC_RH7392.01UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
7394747asp3_maudiogenic seizure prone 3 (mouse)Not determined72730579836842367Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:165
Count of miRNA genes:151
Interacting mature miRNAs:157
Transcripts:ENSMUST00000094632
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000094632   ⟹   ENSMUSP00000092216
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,441,427 - 28,453,296 (+)Ensembl
GRCm38.p6 Ensembl728,742,002 - 28,753,871 (+)Ensembl
RefSeq Acc Id: ENSMUST00000207877   ⟹   ENSMUSP00000146884
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,441,417 - 28,446,454 (+)Ensembl
GRCm38.p6 Ensembl728,741,992 - 28,747,029 (+)Ensembl
RefSeq Acc Id: ENSMUST00000207897
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,441,433 - 28,445,181 (+)Ensembl
GRCm38.p6 Ensembl728,742,008 - 28,745,756 (+)Ensembl
RefSeq Acc Id: NM_023637   ⟹   NP_076126
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,441,393 - 28,453,304 (+)NCBI
GRCm38728,741,968 - 28,753,879 (+)NCBI
MGSCv37729,527,010 - 29,538,874 (+)RGD
Celera723,302,375 - 23,314,673 (+)ENTREZGENE
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006540375   ⟹   XP_006540438
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,441,393 - 28,448,427 (+)NCBI
GRCm38728,741,957 - 28,749,002 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006540376   ⟹   XP_006540439
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,446,982 - 28,453,297 (+)NCBI
GRCm38728,748,455 - 28,753,872 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003946566
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,441,393 - 28,453,290 (+)NCBI
GRCm38728,741,959 - 28,753,872 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_076126   ⟸   NM_023637
- Peptide Label: precursor
- UniProtKB: Q9JJL8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006540438   ⟸   XM_006540375
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006540439   ⟸   XM_006540376
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000146884   ⟸   ENSMUST00000207877
RefSeq Acc Id: ENSMUSP00000092216   ⟸   ENSMUST00000094632

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJL8-F1-model_v2 AlphaFold Q9JJL8 1-518 view protein structure

Promoters
RGD ID:6892482
Promoter ID:EPDNEW_M9692
Type:multiple initiation site
Name:Sars2_1
Description:Mus musculus seryl-aminoacyl-tRNA synthetase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38728,742,002 - 28,742,062EPDNEW
RGD ID:6842026
Promoter ID:MM_KWN:49661
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000056078,   UC009FZP.1,   UC009FZQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36729,526,756 - 29,527,457 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919234 AgrOrtholog
Ensembl Genes ENSMUSG00000070699 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000092216 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000146884.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000094632 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000207877.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.930.10 UniProtKB/Swiss-Prot
InterPro aa-tRNA-synt_IIb UniProtKB/Swiss-Prot
  aa-tRNA-synth_II UniProtKB/Swiss-Prot
  aa-tRNA-synth_II/BPL/LPL UniProtKB/Swiss-Prot
  Ser-tRNA-ligase_type_1 UniProtKB/Swiss-Prot
  Ser-tRNA-synth_1_N UniProtKB/Swiss-Prot
  SerRS_1_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SerRS_core UniProtKB/Swiss-Prot
  tRNA-bd_arm UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:71984 UniProtKB/Swiss-Prot
MGD MGI:1919234 ENTREZGENE
NCBI Gene 71984 ENTREZGENE
PANTHER PTHR11778 UniProtKB/Swiss-Prot
Pfam Seryl_tRNA_N UniProtKB/Swiss-Prot
  tRNA-synt_2b UniProtKB/Swiss-Prot
PhenoGen Sars2 PhenoGen
PRINTS TRNASYNTHSER UniProtKB/Swiss-Prot
PROSITE AA_TRNA_LIGASE_II UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46589 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55681 UniProtKB/Swiss-Prot
TIGRFAMs serS UniProtKB/Swiss-Prot
UniProt A0A140LIM8_MOUSE UniProtKB/TrEMBL
  Q9JJL8 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q68FL2 UniProtKB/Swiss-Prot
  Q9CWP1 UniProtKB/Swiss-Prot