Mlh3 (mutL homolog 3) - Rat Genome Database

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Gene: Mlh3 (mutL homolog 3) Mus musculus
Analyze
Symbol: Mlh3
Name: mutL homolog 3
RGD ID: 1553165
MGI Page MGI
Description: Enables centromeric DNA binding activity and chromatin binding activity. Acts upstream of or within meiotic nuclear division; mismatch repair; and protein localization. Located in chiasma; male germ cell nucleus; and synaptonemal complex. Part of mismatch repair complex. Is expressed in brain; early conceptus; ileum; reproductive system; and trigeminal nerve. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal cancer; endometrial cancer; and hereditary nonpolyposis colorectal cancer type 7. Orthologous to human MLH3 (mutL homolog 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AV125803; BB126472; DNA mismatch repair protein Mlh3; MGC100285; mutL (E. coli) homolog 3; mutL 3; mutL homolog 3 (E coli)
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391285,281,240 - 85,317,421 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1285,281,294 - 85,317,373 (-)EnsemblGRCm39 Ensembl
GRCm381285,234,466 - 85,270,647 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1285,234,520 - 85,270,599 (-)EnsemblGRCm38mm10GRCm38
MGSCv371286,575,470 - 86,611,514 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361286,123,567 - 86,159,702 (-)NCBIMGSCv36mm8
Celera1286,692,170 - 86,728,214 (-)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1239.61NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mechanisms and functions of DNA mismatch repair. Li GM Cell Res. 2008 Jan;18(1):85-98.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. A role for MLH3 in hereditary nonpolyposis colorectal cancer. Wu Y, etal., Nat Genet. 2001 Oct;29(2):137-8.
11. The polymorphisms of miRNA-binding site in MLH3 and ERCC1 were linked to the risk of colorectal cancer in a case-control study. Zhang Q, etal., Cancer Med. 2018 Apr;7(4):1264-1274. doi: 10.1002/cam4.1319. Epub 2018 Mar 8.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10615123   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12091911   PMID:12095912   PMID:12477932   PMID:14610273   PMID:15282163  
PMID:15467367   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16204034   PMID:16260499   PMID:16564751   PMID:16622010   PMID:17696610   PMID:18057311   PMID:18430927   PMID:18551179  
PMID:18787696   PMID:18799693   PMID:19014927   PMID:21267068   PMID:21655083   PMID:21873635   PMID:22164254   PMID:22628407   PMID:23396135   PMID:24194600   PMID:24204315   PMID:24204323  
PMID:24390283   PMID:24891606   PMID:26753533   PMID:28942922   PMID:31170160   PMID:31237565   PMID:32555348   PMID:32619224   PMID:34408140   PMID:34469738   PMID:36440627   PMID:38355793  


Genomics

Comparative Map Data
Mlh3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391285,281,240 - 85,317,421 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1285,281,294 - 85,317,373 (-)EnsemblGRCm39 Ensembl
GRCm381285,234,466 - 85,270,647 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1285,234,520 - 85,270,599 (-)EnsemblGRCm38mm10GRCm38
MGSCv371286,575,470 - 86,611,514 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361286,123,567 - 86,159,702 (-)NCBIMGSCv36mm8
Celera1286,692,170 - 86,728,214 (-)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1239.61NCBI
MLH3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381475,013,775 - 75,051,467 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1475,013,769 - 75,051,532 (-)EnsemblGRCh38hg38GRCh38
GRCh371475,480,478 - 75,518,170 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,550,220 - 74,587,988 (-)NCBINCBI36Build 36hg18NCBI36
Build 341474,553,052 - 74,587,886NCBI
Celera1455,518,160 - 55,555,906 (-)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,648,309 - 55,686,423 (-)NCBIHuRef
CHM1_11475,419,018 - 75,456,769 (-)NCBICHM1_1
T2T-CHM13v2.01469,222,838 - 69,260,934 (-)NCBIT2T-CHM13v2.0
Mlh3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,612,535 - 110,649,408 (-)NCBIGRCr8
mRatBN7.26104,881,483 - 104,917,686 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,881,483 - 104,917,728 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6105,051,106 - 105,087,218 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,349,977 - 105,386,089 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,719,639 - 104,755,751 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06109,059,386 - 109,095,876 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,059,341 - 109,095,557 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,461,410 - 116,497,654 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,280,910 - 109,318,893 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16109,285,219 - 109,322,303 (-)NCBI
Celera6102,704,430 - 102,740,558 (-)NCBICelera
Cytogenetic Map6q31NCBI
Mlh3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955523518,565 - 546,410 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955523515,409 - 547,257 (+)NCBIChiLan1.0ChiLan1.0
MLH3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21576,099,113 - 76,133,996 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11475,315,617 - 75,351,233 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,568,033 - 55,603,672 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11474,413,023 - 74,447,543 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1474,413,319 - 74,445,749 (-)Ensemblpanpan1.1panPan2
MLH3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1848,123,263 - 48,153,989 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl848,124,105 - 48,154,102 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha847,806,221 - 47,838,110 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0848,349,721 - 48,381,613 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl848,351,734 - 48,381,134 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1848,020,522 - 48,052,403 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0848,042,010 - 48,073,886 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0848,440,485 - 48,472,367 (-)NCBIUU_Cfam_GSD_1.0
Mlh3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864027,873,503 - 27,906,386 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364884,164,918 - 4,195,517 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364884,164,322 - 4,195,408 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MLH3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12452,231,468 - 52,266,179 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605340,458,381 - 40,497,060 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mlh3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473426,642,946 - 26,674,315 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473426,642,800 - 26,677,187 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mlh3
811 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:764
Count of miRNA genes:293
Interacting mature miRNAs:322
Transcripts:ENSMUST00000019378, ENSMUST00000166821
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
14746976Manh73_mmandible shape 73 (mouse)126585713199857131Mouse
27226776Tibl6_mtibia length 6, 5 week (mouse)126064678692666774Mouse
1300633Cdcs7_mcytokine deficiency colitis susceptibility 7 (mouse)Not determined126468908398689229Mouse
1301337Cdcs8_mcytokine deficiency colitis susceptibility 8 (mouse)Not determined126468908398689229Mouse
25823169Hrsq8_mhost response to SARS QTL 8, log titer (mouse)1281696245108495368Mouse
27226771Tibl14_mtibia length 14, 10 week (mouse)126834677498766259Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
1357749Vtbt13_mvertebral trabecular bone trait 13 (mouse)Not determined125313200287132145Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277512220111512220Mouse
1301046Par3_mpulmonary adenoma resistance 3 (mouse)Not determined126395670897956883Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
1357757Lnopy2_mlens opacity 2 (mouse)Not determined125284662686846796Mouse
1301689Skull18_mskull morphology 18 (mouse)Not determined1273887422107887526Mouse
10043895Bw20_mbody weight QTL 20 (mouse)Not determined126230825296308252Mouse
27226797Scvln19_msacral vertebrae length 2, 16 week (mouse)126214678699466259Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124169317590887526Mouse
1301926Adip6_madiposity 6 (mouse)Not determined1273887422107887526Mouse
10043948Pbft6_mpercent body fat 6 (mouse)Not determined126120542795205427Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
1301476Pbwg12_mpostnatal body weight growth 12 (mouse)Not determined126204016496040364Mouse
27226728Tibl20_mtibia length 20, 16 week (mouse)125914678693866774Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse

Markers in Region
BB126472  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381285,268,125 - 85,268,250UniSTSGRCm38
MGSCv371286,609,075 - 86,609,200UniSTSGRCm37
Celera1286,725,775 - 86,725,900UniSTS
Cytogenetic Map12D2UniSTS
Whitehead/MRC_RH12792.56UniSTS
Mlh3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12D2UniSTS
cM Map12 UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001304475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_175337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006515703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006515704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006515706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC159237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK029786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK035887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY090776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE993968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000019378   ⟹   ENSMUSP00000019378
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1285,281,294 - 85,317,373 (-)Ensembl
GRCm38.p6 Ensembl1285,234,520 - 85,270,599 (-)Ensembl
Ensembl Acc Id: ENSMUST00000166821   ⟹   ENSMUSP00000129900
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1285,281,303 - 85,317,365 (-)Ensembl
GRCm38.p6 Ensembl1285,234,529 - 85,270,591 (-)Ensembl
Ensembl Acc Id: ENSMUST00000220854   ⟹   ENSMUSP00000152840
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1285,282,154 - 85,317,373 (-)Ensembl
GRCm38.p6 Ensembl1285,235,380 - 85,270,599 (-)Ensembl
Ensembl Acc Id: ENSMUST00000223005
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1285,281,304 - 85,289,752 (-)Ensembl
GRCm38.p6 Ensembl1285,234,530 - 85,242,978 (-)Ensembl
Ensembl Acc Id: ENSMUST00000223230   ⟹   ENSMUSP00000152686
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1285,281,294 - 85,313,058 (-)Ensembl
GRCm38.p6 Ensembl1285,234,520 - 85,266,284 (-)Ensembl
RefSeq Acc Id: NM_001304475   ⟹   NP_001291404
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391285,281,240 - 85,317,365 (-)NCBI
GRCm381285,234,466 - 85,270,591 (-)NCBI
Sequence:
RefSeq Acc Id: NM_175337   ⟹   NP_780546
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391285,281,240 - 85,317,373 (-)NCBI
GRCm381285,234,466 - 85,270,599 (-)NCBI
MGSCv371286,575,470 - 86,611,514 (-)RGD
Celera1286,692,170 - 86,728,214 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006515703   ⟹   XP_006515766
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391285,281,240 - 85,317,421 (-)NCBI
GRCm381285,234,466 - 85,270,647 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006515704   ⟹   XP_006515767
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391285,281,240 - 85,317,418 (-)NCBI
GRCm381285,234,520 - 85,270,646 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006515706   ⟹   XP_006515769
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391285,281,240 - 85,317,418 (-)NCBI
GRCm381285,234,520 - 85,270,502 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036157329   ⟹   XP_036013222
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391285,281,240 - 85,317,418 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036157330   ⟹   XP_036013223
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391285,281,240 - 85,317,412 (-)NCBI
Sequence:
RefSeq Acc Id: NP_780546   ⟸   NM_175337
- UniProtKB: Q3V1X3 (UniProtKB/TrEMBL),   Q68FG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006515766   ⟸   XM_006515703
- Peptide Label: isoform X1
- UniProtKB: A0A1Y7VMP7 (UniProtKB/TrEMBL),   Q3V1X3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006515767   ⟸   XM_006515704
- Peptide Label: isoform X1
- UniProtKB: A0A1Y7VMP7 (UniProtKB/TrEMBL),   Q3V1X3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006515769   ⟸   XM_006515706
- Peptide Label: isoform X1
- UniProtKB: A0A1Y7VMP7 (UniProtKB/TrEMBL),   Q3V1X3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001291404   ⟸   NM_001304475
- UniProtKB: Q3V1X3 (UniProtKB/TrEMBL),   Q68FG1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000152686   ⟸   ENSMUST00000223230
Ensembl Acc Id: ENSMUSP00000129900   ⟸   ENSMUST00000166821
Ensembl Acc Id: ENSMUSP00000019378   ⟸   ENSMUST00000019378
Ensembl Acc Id: ENSMUSP00000152840   ⟸   ENSMUST00000220854
RefSeq Acc Id: XP_036013222   ⟸   XM_036157329
- Peptide Label: isoform X2
- UniProtKB: Q3V1X3 (UniProtKB/TrEMBL),   Q68FG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036013223   ⟸   XM_036157330
- Peptide Label: isoform X2
- UniProtKB: Q3V1X3 (UniProtKB/TrEMBL),   Q68FG1 (UniProtKB/TrEMBL)
Protein Domains
DNA mismatch repair protein S5   MutL C-terminal dimerisation

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A1Y7VMP7-F1-model_v2 AlphaFold A0A1Y7VMP7 1-1443 view protein structure

Promoters
RGD ID:8678836
Promoter ID:EPDNEW_M17443
Type:initiation region
Name:Mlh3_1
Description:Mus musculus mutL homolog 3 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381285,270,599 - 85,270,659EPDNEW
RGD ID:6823200
Promoter ID:MM_KWN:12198
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:UC007OGS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361286,607,076 - 86,607,576 (-)MPROMDB
RGD ID:6823199
Promoter ID:MM_KWN:12199
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000019378
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361286,611,294 - 86,611,794 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1353455 AgrOrtholog
Ensembl Genes ENSMUSG00000021245 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000019378 ENTREZGENE
  ENSMUST00000019378.8 UniProtKB/TrEMBL
  ENSMUST00000166821 ENTREZGENE
  ENSMUST00000166821.8 UniProtKB/TrEMBL
  ENSMUST00000220854 ENTREZGENE
  ENSMUST00000220854.2 UniProtKB/TrEMBL
  ENSMUST00000223230.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1370.100 UniProtKB/TrEMBL
  3.30.1540.20 UniProtKB/TrEMBL
  3.30.230.10 UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/TrEMBL
InterPro DNA_mismatch_repair_C UniProtKB/TrEMBL
  DNA_mismatch_repair_CS UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/TrEMBL
  MutL/Mlh/Pms UniProtKB/TrEMBL
  MutL/Mlh/PMS UniProtKB/TrEMBL
  MutL_C UniProtKB/TrEMBL
  MutL_C_dimsub UniProtKB/TrEMBL
  MutL_C_regsub UniProtKB/TrEMBL
  MutL_C_sf UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/TrEMBL
KEGG Report mmu:217716 UniProtKB/TrEMBL
MGD MGI:1353455 ENTREZGENE
NCBI Gene Mlh3 ENTREZGENE
PANTHER PTHR10073 UniProtKB/TrEMBL
  PTHR10073:SF47 UniProtKB/TrEMBL
Pfam DNA_mis_repair UniProtKB/TrEMBL
  HATPase_c_3 UniProtKB/TrEMBL
  MutL_C UniProtKB/TrEMBL
PhenoGen Mlh3 PhenoGen
PROSITE DNA_MISMATCH_REPAIR_1 UniProtKB/TrEMBL
SMART DNA_mis_repair UniProtKB/TrEMBL
  MutL_C UniProtKB/TrEMBL
Superfamily-SCOP ATP_bd_ATPase UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  SSF118116 UniProtKB/TrEMBL
UniProt A0A1Y7VJX4_MOUSE UniProtKB/TrEMBL
  A0A1Y7VMP7 ENTREZGENE, UniProtKB/TrEMBL
  Q3TRU3_MOUSE UniProtKB/TrEMBL
  Q3V1X3 ENTREZGENE, UniProtKB/TrEMBL
  Q68FG1 ENTREZGENE, UniProtKB/TrEMBL
  Q8BZC3_MOUSE UniProtKB/TrEMBL
  Q8C0U7_MOUSE UniProtKB/TrEMBL
  Q8R407_MOUSE UniProtKB/TrEMBL
  Q99L38_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-09-25 Mlh3  mutL homolog 3  Mlh3  mutL homolog 3 (E coli)  Symbol and/or name change 5135510 APPROVED
2024-08-21 Mlh3  mutL homolog 3 (E coli)  Mlh3  mutL homolog 3  Symbol and/or name change 5135510 APPROVED
2024-08-21 Mlh3  mutL homolog 3  Mlh3  mutL homolog 3 (E coli)  Symbol and/or name change 5135510 APPROVED
2024-08-21 Mlh3  mutL homolog 3 (E coli)  Mlh3  mutL homolog 3  Symbol and/or name change 5135510 APPROVED
2016-02-29 Mlh3  mutL homolog 3    mutL homolog 3 (E coli)  Symbol and/or name change 5135510 APPROVED