Pno1 (partner of NOB1 homolog) - Rat Genome Database

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Gene: Pno1 (partner of NOB1 homolog) Mus musculus
Analyze
Symbol: Pno1
Name: partner of NOB1 homolog
RGD ID: 1553017
MGI Page MGI
Description: Predicted to enable RNA binding activity. Predicted to be involved in ribosomal small subunit biogenesis. Predicted to be located in nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; heart; and immune system. Orthologous to human PNO1 (partner of NOB1 homolog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1810003N24Rik; AA407421; AU015468; AU019495; AU042323; Emi; Emi3; expressed during mesenchymal induction 3; Im; Imi3; induced during mesenchymal induction 3; RNA-binding protein PNO1; RP23-32H19.2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391117,153,198 - 17,161,589 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1117,153,198 - 17,161,568 (-)EnsemblGRCm39 Ensembl
GRCm381117,203,198 - 17,211,589 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1117,203,198 - 17,211,568 (-)EnsemblGRCm38mm10GRCm38
MGSCv371117,103,201 - 17,111,592 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361117,103,205 - 17,111,556 (-)NCBIMGSCv36mm8
Celera1117,576,862 - 17,586,116 (-)NCBICelera
Cytogenetic Map11A2NCBI
cM Map119.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. CK1delta and CK1epsilon are components of human 40S subunit precursors required for cytoplasmic 40S maturation. Zemp I, etal., J Cell Sci. 2014 Mar 15;127(Pt 6):1242-53. doi: 10.1242/jcs.138719. Epub 2014 Jan 14.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10844592   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15489334   PMID:15497447   PMID:15782199   PMID:16033648  
PMID:16141072   PMID:16141073   PMID:19521500   PMID:21267068   PMID:21677750   PMID:21873635   PMID:23029399   PMID:24457600  


Genomics

Comparative Map Data
Pno1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391117,153,198 - 17,161,589 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1117,153,198 - 17,161,568 (-)EnsemblGRCm39 Ensembl
GRCm381117,203,198 - 17,211,589 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1117,203,198 - 17,211,568 (-)EnsemblGRCm38mm10GRCm38
MGSCv371117,103,201 - 17,111,592 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361117,103,205 - 17,111,556 (-)NCBIMGSCv36mm8
Celera1117,576,862 - 17,586,116 (-)NCBICelera
Cytogenetic Map11A2NCBI
cM Map119.79NCBI
PNO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38268,157,888 - 68,176,238 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl268,157,888 - 68,176,238 (+)EnsemblGRCh38hg38GRCh38
GRCh37268,385,020 - 68,403,370 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36268,238,509 - 68,256,595 (+)NCBINCBI36Build 36hg18NCBI36
Celera268,234,624 - 68,252,699 (+)NCBICelera
Cytogenetic Map2p14NCBI
HuRef268,122,490 - 68,140,549 (+)NCBIHuRef
CHM1_1268,315,807 - 68,333,894 (+)NCBICHM1_1
T2T-CHM13v2.0268,168,438 - 68,186,793 (+)NCBIT2T-CHM13v2.0
Pno1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81495,811,335 - 95,819,903 (-)NCBIGRCr8
mRatBN7.21491,609,711 - 91,618,280 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1491,609,233 - 91,618,324 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1495,916,949 - 95,925,440 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01497,161,286 - 97,169,776 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01493,626,351 - 93,634,842 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014100,364,192 - 100,372,760 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14100,364,190 - 100,372,760 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014100,166,648 - 100,175,216 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41498,102,423 - 98,110,989 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11498,121,567 - 98,130,134 (-)NCBI
Celera1490,655,865 - 90,664,433 (-)NCBICelera
Cytogenetic Map14q22NCBI
Pno1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542416,697,109 - 16,705,993 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542416,697,109 - 16,705,963 (-)NCBIChiLan1.0ChiLan1.0
PNO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21258,232,032 - 58,246,847 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A58,236,264 - 58,250,795 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A68,209,911 - 68,224,772 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1 Ensembl2A69,334,447 - 69,347,707 (+)Ensemblpanpan1.1panPan2
PNO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11067,231,087 - 67,241,800 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1067,231,101 - 67,241,441 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1067,122,166 - 67,132,859 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01068,250,301 - 68,260,998 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1068,250,289 - 68,260,894 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11067,934,891 - 67,945,572 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01068,232,471 - 68,243,164 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01068,528,209 - 68,538,938 (+)NCBIUU_Cfam_GSD_1.0
Pno1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629215,951,369 - 15,960,817 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649112,610,497 - 12,620,985 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649112,610,463 - 12,620,828 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl374,068,828 - 74,084,789 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1374,071,621 - 74,084,896 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2377,603,531 - 77,616,769 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PNO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11438,910,265 - 38,927,213 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1438,911,410 - 38,927,172 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604573,048,811 - 73,066,021 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pno1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247625,159,936 - 5,170,588 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247625,161,418 - 5,170,583 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pno1
270 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:300
Count of miRNA genes:250
Interacting mature miRNAs:266
Transcripts:ENSMUST00000020317, ENSMUST00000123754
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11325000018150000Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11325000018450000Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11325000019750000Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
10053676Eae44a_mexperimental allergic encephalomyelitis susceptibility 44a (mouse)Not determined11450789621379532Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse
1357518Tgyl1_mtriglyceride level 1 (mouse)Not determined11688027733916219Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
1300990Bits3_mbitterness sensitivity 3 (mouse)Not determined11837212142372260Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
1302171Pgia28_mproteoglycan induced arthritis 28 (mouse)Not determined11890609742906218Mouse
4141047Nilac1_mnicotine induced locomotor activity 1 (mouse)Not determined11901178043011942Mouse
13524844Ppiq9_mprepulse inhibition QTL 9 (mouse)11904999735077325Mouse
13463472Mcvq15_mmean corpuscular volume QTL 15 (mouse)111095123244951464Mouse
13463479Mchq19_mmean corpuscular hemoglobin QTL 19 (mouse)111095123244951464Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
10412216Eae44_mexperimental allergic encephalomyelitis susceptibility 44 (mouse)Not determined111226863739950840Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse

Markers in Region
AU015468  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381117,203,274 - 17,203,508UniSTSGRCm38
MGSCv371117,103,277 - 17,103,511UniSTSGRCm37
Celera1117,576,938 - 17,577,172UniSTS
Cytogenetic Map11A2UniSTS
Whitehead/MRC_RH11149.09UniSTS
RH136409  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381117,203,540 - 17,203,726UniSTSGRCm38
MGSCv371117,103,543 - 17,103,729UniSTSGRCm37
Celera1117,577,204 - 17,577,390UniSTS
Cytogenetic Map11A2UniSTS
AU042323  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381117,203,474 - 17,203,560UniSTSGRCm38
MGSCv371117,103,477 - 17,103,563UniSTSGRCm37
Celera1117,577,138 - 17,577,224UniSTS
Cytogenetic Map11A2UniSTS
Whitehead/MRC_RH11135.96UniSTS
Pno1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A2UniSTS
cM Map11 UniSTS
RH125687  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381117,203,208 - 17,203,429UniSTSGRCm38
MGSCv371117,103,211 - 17,103,432UniSTSGRCm37
Celera1117,576,872 - 17,577,093UniSTS
Cytogenetic Map11A2UniSTS
Whitehead/MRC_RH11155.08UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000020317   ⟹   ENSMUSP00000020317
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1117,153,198 - 17,161,568 (-)Ensembl
GRCm38.p6 Ensembl1117,203,198 - 17,211,568 (-)Ensembl
RefSeq Acc Id: ENSMUST00000123754
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1117,158,789 - 17,161,054 (-)Ensembl
GRCm38.p6 Ensembl1117,208,789 - 17,211,054 (-)Ensembl
RefSeq Acc Id: NM_025443   ⟹   NP_079719
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391117,153,198 - 17,161,589 (-)NCBI
GRCm381117,203,198 - 17,211,589 (-)NCBI
MGSCv371117,103,201 - 17,111,592 (-)RGD
Celera1117,576,862 - 17,586,116 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_079719   ⟸   NM_025443
- UniProtKB: Q9CPS7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000020317   ⟸   ENSMUST00000020317
Protein Domains
KH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CPS7-F1-model_v2 AlphaFold Q9CPS7 1-248 view protein structure

Promoters
RGD ID:6821579
Promoter ID:MM_KWN:6518
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_178909,   OTTMUST00000011607,   OTTMUST00000011608
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361117,111,491 - 17,112,267 (-)MPROMDB
RGD ID:8674024
Promoter ID:EPDNEW_M15043
Type:initiation region
Name:Pno1_1
Description:Mus musculus partner of NOB1 homolog , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381117,211,535 - 17,211,595EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913499 AgrOrtholog
Ensembl Genes ENSMUSG00000020116 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000020317 ENTREZGENE
  ENSMUST00000020317.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1370.10 UniProtKB/Swiss-Prot
InterPro KH_dom UniProtKB/Swiss-Prot
  KH_dom_type_1_sf UniProtKB/Swiss-Prot
KEGG Report mmu:66249 UniProtKB/Swiss-Prot
MGD MGI:1913499 ENTREZGENE
NCBI Gene 66249 ENTREZGENE
PANTHER PTHR12826:SF13 UniProtKB/Swiss-Prot
  RIBONUCLEASE Y UniProtKB/Swiss-Prot
PhenoGen Pno1 PhenoGen
SMART SM00322 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54791 UniProtKB/Swiss-Prot
UniProt PNO1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 Pno1  partner of NOB1 homolog    partner of NOB1 homolog (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED