Myrip (myosin VIIA and Rab interacting protein) - Rat Genome Database
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Gene: Myrip (myosin VIIA and Rab interacting protein) Mus musculus
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Symbol: Myrip
Name: myosin VIIA and Rab interacting protein
RGD ID: 1552941
MGI Page MGI
Description: Exhibits Rab GTPase binding activity; cytoskeletal protein binding activity; and protein kinase A binding activity. Predicted to be involved in positive regulation of insulin secretion. Localizes to several cellular components, including exocyst; melanosome; and photoreceptor outer segment. Is expressed in brain; genitourinary system; heart; lung; and skeletal muscle. Orthologous to human MYRIP (myosin VIIA and Rab interacting protein); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: A230081N12Rik; exophilin 8; exophilin-8; myosin-VIIa- and Rab-interacting protein; rab effector MyRIP; Slac; Slac2-c; Slac2c; slp homolog lacking C2 domains c; synaptotagmin-like protein lacking C2 domains C
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399120,132,996 - 120,305,167 (+)NCBIGRCm39mm39
GRCm389120,303,520 - 120,476,101 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9120,301,513 - 120,474,841 (+)EnsemblGRCm38mm10GRCm38
MGSCv379120,213,191 - 120,383,952 (+)NCBIGRCm37mm9NCBIm37
MGSCv369120,152,771 - 120,323,532 (+)NCBImm8
Celera9120,765,412 - 120,944,453 (+)NCBICelera
Cytogenetic Map9F4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12062444   PMID:12221080   PMID:12477932   PMID:12590134   PMID:15927964   PMID:16141072   PMID:16141073  
PMID:17352418   PMID:17451552   PMID:17827149   PMID:18799693   PMID:19317802   PMID:21267068   PMID:21441305   PMID:21873635   PMID:22993210   PMID:28673385  


Genomics

Comparative Map Data
Myrip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399120,132,996 - 120,305,167 (+)NCBIGRCm39mm39
GRCm389120,303,520 - 120,476,101 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9120,301,513 - 120,474,841 (+)EnsemblGRCm38mm10GRCm38
MGSCv379120,213,191 - 120,383,952 (+)NCBIGRCm37mm9NCBIm37
MGSCv369120,152,771 - 120,323,532 (+)NCBImm8
Celera9120,765,412 - 120,944,453 (+)NCBICelera
Cytogenetic Map9F4NCBI
MYRIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl339,808,914 - 40,260,321 (+)EnsemblGRCh38hg38GRCh38
GRCh38339,808,914 - 40,260,321 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37339,850,405 - 40,301,812 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36339,826,307 - 40,276,816 (+)NCBINCBI36hg18NCBI36
Build 34339,826,306 - 40,276,808NCBI
Celera339,793,218 - 40,244,467 (+)NCBI
Cytogenetic Map3p22.1NCBI
HuRef339,894,694 - 40,345,886 (+)NCBIHuRef
CHM1_1339,801,261 - 40,251,713 (+)NCBICHM1_1
Myrip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08128,972,307 - 129,139,257 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,972,311 - 129,139,251 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08128,171,783 - 128,337,841 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48125,317,671 - 125,478,667 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18125,337,407 - 125,492,971 (+)NCBI
Celera8119,163,194 - 119,324,938 (+)NCBICelera
Cytogenetic Map8q32NCBI
Myrip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542029,540,027 - 29,696,504 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542029,542,479 - 29,697,646 (-)NCBIChiLan1.0ChiLan1.0
MYRIP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1339,991,586 - 40,435,763 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl340,079,777 - 40,433,613 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0339,715,890 - 40,163,826 (+)NCBIMhudiblu_PPA_v0panPan3
MYRIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl239,448,559 - 9,763,182 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1239,448,564 - 9,765,328 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Myrip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647328,921,837 - 29,252,737 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYRIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1324,347,660 - 24,556,735 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11324,347,574 - 24,556,743 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21326,806,466 - 26,855,152 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103227432
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1221,369,820 - 1,765,121 (+)NCBI
ChlSab1.1 Ensembl221,370,001 - 1,765,311 (+)Ensembl
Myrip
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473078,388,192 - 78,582,051 (-)NCBI

Position Markers
20.MMHAP29FRG8.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389120,365,600 - 120,365,794UniSTSGRCm38
GRCm389120,365,600 - 120,366,166UniSTSGRCm38
MGSCv379120,274,718 - 120,274,912UniSTSGRCm37
MGSCv379120,274,718 - 120,275,284UniSTSGRCm37
Celera9120,830,185 - 120,830,397UniSTS
Celera9120,830,185 - 120,830,754UniSTS
Cytogenetic Map9F4UniSTS
Whitehead_YAC9 UniSTS
D9Mit19  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389120,362,769 - 120,362,868UniSTSGRCm38
MGSCv379120,271,887 - 120,271,986UniSTSGRCm37
Celera9120,827,333 - 120,827,422UniSTS
Cytogenetic Map9F4UniSTS
cM Map971.0UniSTS
Whitehead Genetic968.9UniSTS
Whitehead/MRC_RH91182.94UniSTS
Whitehead_YAC9 UniSTS
Myrip  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9F4UniSTS
cM Map9 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1295
Count of miRNA genes:651
Interacting mature miRNAs:809
Transcripts:ENSMUST00000048121, ENSMUST00000129168, ENSMUST00000133173, ENSMUST00000139665
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000048121   ⟹   ENSMUSP00000046891
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9120,303,936 - 120,474,841 (+)Ensembl
RefSeq Acc Id: ENSMUST00000129168
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9120,427,406 - 120,432,483 (+)Ensembl
RefSeq Acc Id: ENSMUST00000133173   ⟹   ENSMUSP00000122046
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9120,301,513 - 120,422,262 (+)Ensembl
RefSeq Acc Id: ENSMUST00000139665
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9120,409,883 - 120,417,204 (+)Ensembl
RefSeq Acc Id: ENSMUST00000214784   ⟹   ENSMUSP00000149149
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9120,386,309 - 120,432,951 (+)Ensembl
RefSeq Acc Id: NM_144557   ⟹   NP_653140
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399120,133,139 - 120,303,900 (+)NCBI
GRCm389120,304,073 - 120,474,834 (+)NCBI
MGSCv379120,213,191 - 120,383,952 (+)RGD
Celera9120,765,412 - 120,944,453 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006512125   ⟹   XP_006512188
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399120,133,076 - 120,303,907 (+)NCBI
GRCm389120,303,581 - 120,476,101 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006512127   ⟹   XP_006512190
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399120,238,202 - 120,305,167 (+)NCBI
GRCm389120,409,128 - 120,476,101 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006512128   ⟹   XP_006512191
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399120,132,996 - 120,282,716 (+)NCBI
GRCm389120,303,520 - 120,453,650 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_653140   ⟸   NM_144557
- UniProtKB: Q8K3I4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006512191   ⟸   XM_006512128
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006512188   ⟸   XM_006512125
- Peptide Label: isoform X1
- UniProtKB: Q8K3I4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006512190   ⟸   XM_006512127
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000122046   ⟸   ENSMUST00000133173
RefSeq Acc Id: ENSMUSP00000046891   ⟸   ENSMUST00000048121
RefSeq Acc Id: ENSMUSP00000149149   ⟸   ENSMUST00000214784
Protein Domains
FYVE_2   Rab_eff_C   RabBD

Promoters
RGD ID:6844854
Promoter ID:MM_KWN:59167
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000058053
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369120,212,661 - 120,213,312 (+)MPROMDB
RGD ID:8671226
Promoter ID:EPDNEW_M13644
Type:initiation region
Name:Myrip_1
Description:Mus musculus myosin VIIA and Rab interacting protein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13645  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389120,303,974 - 120,304,034EPDNEW
RGD ID:8671228
Promoter ID:EPDNEW_M13645
Type:multiple initiation site
Name:Myrip_2
Description:Mus musculus myosin VIIA and Rab interacting protein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13644  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389120,304,463 - 120,304,523EPDNEW
RGD ID:6844855
Promoter ID:MM_KWN:59172
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000058056
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369120,335,476 - 120,335,976 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2384407 AgrOrtholog
Ensembl Genes ENSMUSG00000041794 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000046891 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000122046 UniProtKB/TrEMBL
  ENSMUSP00000149149 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000048121 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000133173 UniProtKB/TrEMBL
  ENSMUST00000214784 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FYVE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myrip/Melanophilin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rab_BD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:245049 UniProtKB/Swiss-Prot
MGD MGI:2384407 ENTREZGENE
NCBI Gene 245049 ENTREZGENE
Pfam FYVE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rab_eff_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Myrip PhenoGen
PROSITE RABBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57903 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.100936 ENTREZGENE
UniProt A0A1L1SQQ9_MOUSE UniProtKB/TrEMBL
  F7CFT8_MOUSE UniProtKB/TrEMBL
  MYRIP_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A1L320 UniProtKB/Swiss-Prot
  A1L321 UniProtKB/Swiss-Prot
  Q8CFC0 UniProtKB/Swiss-Prot
  Q8K4H5 UniProtKB/Swiss-Prot