Ces2a (carboxylesterase 2A) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ces2a (carboxylesterase 2A) Mus musculus
Analyze
No known orthologs.
Symbol: Ces2a
Name: carboxylesterase 2A
RGD ID: 1552829
MGI Page MGI
Description: Enables carboxylesterase activity. Acts upstream of or within protein glycosylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in liver. Orthologous to human CES2 (carboxylesterase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9130231C15Rik; AI266984; carboxylesterase 6; carboxylic ester hydrolase 2A; Ces; Ces6; pyrethroid hydrolase Ces2a
RGD Orthologs
Alliance Genes
More Info homologs ...
Related Pseudogenes: Gm7208  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398105,460,635 - 105,468,266 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8105,460,635 - 105,468,266 (+)EnsemblGRCm39 Ensembl
GRCm388104,734,003 - 104,741,634 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8104,734,003 - 104,741,634 (+)EnsemblGRCm38mm10GRCm38
MGSCv378107,257,903 - 107,265,534 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368107,623,137 - 107,630,761 (+)NCBIMGSCv36mm8
Celera8108,964,463 - 108,972,010 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:15123619   PMID:15208658   PMID:16141072   PMID:16141073   PMID:20931200   PMID:21677750   PMID:21873635  
PMID:30733279   PMID:37059417  


Genomics

Variants

.
Variants in Ces2a
217 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:507
Count of miRNA genes:341
Interacting mature miRNAs:378
Transcripts:ENSMUST00000034346, ENSMUST00000159303, ENSMUST00000161824, ENSMUST00000164182
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871829531105829637Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined872122809106123021Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873929123107929226Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined876402145110402251Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined876411976110412125Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined879245241113245331Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879808806113809031Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881819296115819296Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)882345783116345783Mouse
1301766Desp1_mdespair 1 (mouse)Not determined885486208119486373Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined886443553120443701Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined886443553120443701Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined886443553120443701Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined896245241129745061Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)897626632130127694Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)898390634130127694Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined898563635130127694Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899828531130127694Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899828531130127694Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100965309130127694Mouse
1300560Tgl1_mtriglyceride level 1 (mouse)Not determined8102486208111650036Mouse
1300681Pgia22_mproteoglycan induced arthritis 22 (mouse)Not determined8102486208116025457Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8103443553127781786Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8105033977130127694Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8105033977130127694Mouse

Markers in Region
AI266984  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388104,740,172 - 104,740,272UniSTSGRCm38
MGSCv378107,264,072 - 107,264,172UniSTSGRCm37
Celera8108,970,548 - 108,970,648UniSTS
Cytogenetic Map8D3UniSTS
Whitehead/MRC_RH81214.53UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000034346   ⟹   ENSMUSP00000034346
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8105,460,635 - 105,468,262 (+)Ensembl
GRCm38.p6 Ensembl8104,734,003 - 104,741,630 (+)Ensembl
RefSeq Acc Id: ENSMUST00000159303   ⟹   ENSMUSP00000148459
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8105,466,240 - 105,467,909 (+)Ensembl
GRCm38.p6 Ensembl8104,739,608 - 104,741,277 (+)Ensembl
RefSeq Acc Id: ENSMUST00000161824   ⟹   ENSMUSP00000148699
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8105,460,660 - 105,464,156 (+)Ensembl
GRCm38.p6 Ensembl8104,734,028 - 104,737,524 (+)Ensembl
RefSeq Acc Id: ENSMUST00000164182   ⟹   ENSMUSP00000127346
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8105,460,650 - 105,468,266 (+)Ensembl
GRCm38.p6 Ensembl8104,734,018 - 104,741,634 (+)Ensembl
RefSeq Acc Id: NM_001190330   ⟹   NP_001177259
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398105,460,635 - 105,468,266 (+)NCBI
GRCm388104,734,003 - 104,741,634 (+)ENTREZGENE
MGSCv378107,257,903 - 107,265,534 (+)RGD
Celera8108,964,463 - 108,972,010 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_133960   ⟹   NP_598721
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398105,460,635 - 105,468,266 (+)NCBI
GRCm388104,734,003 - 104,741,634 (+)ENTREZGENE
MGSCv378107,257,903 - 107,265,534 (+)RGD
Celera8108,964,463 - 108,972,010 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_598721   ⟸   NM_133960
- Peptide Label: isoform 1 precursor
- UniProtKB: E9Q3D0 (UniProtKB/Swiss-Prot),   Q3TMR2 (UniProtKB/Swiss-Prot),   Q8QZR3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001177259   ⟸   NM_001190330
- Peptide Label: isoform 2 precursor
- UniProtKB: Q8QZR3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000148459   ⟸   ENSMUST00000159303
RefSeq Acc Id: ENSMUSP00000127346   ⟸   ENSMUST00000164182
RefSeq Acc Id: ENSMUSP00000034346   ⟸   ENSMUST00000034346
RefSeq Acc Id: ENSMUSP00000148699   ⟸   ENSMUST00000161824
Protein Domains
Carboxylesterase type B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8QZR3-F1-model_v2 AlphaFold Q8QZR3 1-558 view protein structure

Promoters
RGD ID:8668033
Promoter ID:EPDNEW_M12048
Type:multiple initiation site
Name:Ces2a_1
Description:Mus musculus carboxylesterase 2A , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388104,734,008 - 104,734,068EPDNEW
RGD ID:6842935
Promoter ID:MM_KWN:55503
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000067808,   OTTMUST00000067810
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368107,257,561 - 107,258,061 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2142491 AgrOrtholog
Ensembl Genes ENSMUSG00000055730 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034346 ENTREZGENE
  ENSMUST00000034346.15 UniProtKB/Swiss-Prot
  ENSMUST00000159303.3 UniProtKB/TrEMBL
  ENSMUST00000161824.2 UniProtKB/TrEMBL
  ENSMUST00000164182 ENTREZGENE
  ENSMUST00000164182.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_AS UniProtKB/Swiss-Prot
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot
KEGG Report mmu:102022 UniProtKB/Swiss-Prot
MGD MGI:2142491 ENTREZGENE
NCBI Gene 102022 ENTREZGENE
PANTHER CARBOXYLESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYRETHROID HYDROLASE CES2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam COesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ces2a PhenoGen
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/Swiss-Prot
  CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1D5RLQ1_MOUSE UniProtKB/TrEMBL
  A0A1D5RMA7_MOUSE UniProtKB/TrEMBL
  E9Q3D0 ENTREZGENE
  EST2A_MOUSE UniProtKB/Swiss-Prot
  Q3TMR2 ENTREZGENE
  Q8QZR3 ENTREZGENE
  Q8VC76_MOUSE UniProtKB/TrEMBL
UniProt Secondary E9Q3D0 UniProtKB/Swiss-Prot
  Q3TMR2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Ces2a  carboxylesterase 2A  Ces6  carboxylesterase 6  Symbol and/or name change 5135510 APPROVED