Cnih2 (cornichon family AMPA receptor auxiliary protein 2) - Rat Genome Database

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Gene: Cnih2 (cornichon family AMPA receptor auxiliary protein 2) Mus musculus
Analyze
Symbol: Cnih2
Name: cornichon family AMPA receptor auxiliary protein 2
RGD ID: 1552794
MGI Page MGI
Description: Predicted to enable channel regulator activity. Predicted to be involved in negative regulation of anterograde synaptic vesicle transport and negative regulation of receptor localization to synapse. Predicted to act upstream of or within glutamatergic synaptic transmission; localization within membrane; and regulation of membrane potential. Located in dendritic spine and postsynaptic density. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human CNIH2 (cornichon family AMPA receptor auxiliary protein 2).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C; CNIH-2; Cnil; cornichon homolog 2; cornichon-like protein; MGC118475
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,142,896 - 5,148,549 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl195,142,896 - 5,148,549 (-)EnsemblGRCm39 Ensembl
GRCm38195,092,868 - 5,098,521 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,092,868 - 5,098,521 (-)EnsemblGRCm38mm10GRCm38
MGSCv37195,092,871 - 5,098,418 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,092,871 - 5,098,418 (-)NCBIMGSCv36mm8
Celera194,962,069 - 4,967,624 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:10022955   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14681479   PMID:15782199   PMID:16141072   PMID:16141073   PMID:20805473   PMID:21172611  
PMID:21343286   PMID:21543622   PMID:21677750   PMID:21873635   PMID:21993243   PMID:23522044   PMID:24194600   PMID:25218043   PMID:34079129   PMID:34321999   PMID:38355793  


Genomics

Comparative Map Data
Cnih2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,142,896 - 5,148,549 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl195,142,896 - 5,148,549 (-)EnsemblGRCm39 Ensembl
GRCm38195,092,868 - 5,098,521 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,092,868 - 5,098,521 (-)EnsemblGRCm38mm10GRCm38
MGSCv37195,092,871 - 5,098,418 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,092,871 - 5,098,418 (-)NCBIMGSCv36mm8
Celera194,962,069 - 4,967,624 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.24NCBI
CNIH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381166,278,175 - 66,284,206 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1166,278,175 - 66,285,301 (+)EnsemblGRCh38hg38GRCh38
GRCh371166,045,646 - 66,051,677 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,802,272 - 65,808,259 (+)NCBINCBI36Build 36hg18NCBI36
Build 341165,802,271 - 65,808,259NCBI
Celera1163,367,976 - 63,371,496 (+)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1162,361,871 - 62,376,861 (+)NCBIHuRef
CHM1_11165,929,773 - 65,935,793 (+)NCBICHM1_1
T2T-CHM13v2.01166,271,838 - 66,277,869 (+)NCBIT2T-CHM13v2.0
Cnih2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81211,828,791 - 211,834,474 (-)NCBIGRCr8
mRatBN7.21202,399,416 - 202,405,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1202,399,419 - 202,405,089 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1210,752,476 - 210,758,122 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01217,844,858 - 217,850,504 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01210,535,892 - 210,541,538 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01220,474,485 - 220,480,723 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1220,474,493 - 220,480,132 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,405,539 - 227,411,210 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41207,715,692 - 207,717,588 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11207,869,147 - 207,871,037 (-)NCBI
Celera1199,939,495 - 199,944,513 (-)NCBICelera
Cytogenetic Map1q43NCBI
Cnih2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542219,033,201 - 19,035,138 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542219,033,201 - 19,035,135 (-)NCBIChiLan1.0ChiLan1.0
CNIH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2967,511,975 - 67,517,994 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11168,554,850 - 68,560,863 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01161,643,633 - 61,649,646 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11164,969,447 - 64,975,156 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1164,969,447 - 64,975,156 (+)Ensemblpanpan1.1panPan2
CNIH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11851,020,263 - 51,026,280 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1851,021,116 - 51,026,273 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1849,628,921 - 49,634,836 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01852,058,624 - 52,064,534 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1852,059,259 - 52,064,720 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11851,158,624 - 51,164,533 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01850,732,786 - 50,738,700 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01851,522,930 - 51,528,840 (-)NCBIUU_Cfam_GSD_1.0
Cnih2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049476,868,527 - 6,874,251 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365993,310,872 - 3,316,573 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365993,310,873 - 3,316,575 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNIH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.126,102,347 - 6,109,424 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.225,178,633 - 5,184,482 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CNIH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.117,982,685 - 7,988,834 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl17,982,700 - 7,988,753 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038105,264,377 - 105,270,384 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnih2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476720,084,501 - 20,090,209 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476720,084,526 - 20,090,225 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cnih2
150 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:378
Count of miRNA genes:252
Interacting mature miRNAs:299
Transcripts:ENSMUST00000025805
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300776Lfp3_mlong free running period 3 (mouse)Not determined19120328703Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse
25394536Skmw86_mskeletal muscle weight 86, TA (mouse)1950648178957825Mouse

Markers in Region
Cnih2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38195,092,900 - 5,093,309UniSTSGRCm38
MGSCv37195,092,900 - 5,093,309UniSTSGRCm37
Celera194,962,098 - 4,962,507UniSTS
Cytogenetic Map19AUniSTS
cM Map19 UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000025805   ⟹   ENSMUSP00000025805
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl195,142,896 - 5,148,549 (-)Ensembl
GRCm38.p6 Ensembl195,092,868 - 5,098,521 (-)Ensembl
RefSeq Acc Id: ENSMUST00000235638   ⟹   ENSMUSP00000157729
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl195,143,155 - 5,148,410 (-)Ensembl
GRCm38.p6 Ensembl195,093,127 - 5,098,382 (-)Ensembl
RefSeq Acc Id: NM_001302333   ⟹   NP_001289262
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39195,142,896 - 5,148,549 (-)NCBI
GRCm38195,092,868 - 5,098,521 (-)NCBI
Celera194,962,066 - 4,967,727 (-)NCBI
Sequence:
RefSeq Acc Id: NM_009920   ⟹   NP_034050
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39195,142,896 - 5,148,549 (-)NCBI
GRCm38195,092,868 - 5,098,521 (-)NCBI
MGSCv37195,092,871 - 5,098,418 (-)RGD
Celera194,962,066 - 4,967,727 (-)NCBI
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034050   ⟸   NM_009920
- Peptide Label: isoform 1
- UniProtKB: O35089 (UniProtKB/Swiss-Prot),   Q3SYI8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289262   ⟸   NM_001302333
- Peptide Label: isoform 2
- UniProtKB: Q3SYI8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000025805   ⟸   ENSMUST00000025805
RefSeq Acc Id: ENSMUSP00000157729   ⟸   ENSMUST00000235638

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35089-F1-model_v2 AlphaFold O35089 1-160 view protein structure

Promoters
RGD ID:6829912
Promoter ID:MM_KWN:26054
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000025805
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36195,098,276 - 5,098,977 (-)MPROMDB
RGD ID:13678488
Promoter ID:EPDNEW_M23394
Type:initiation region
Name:Cnih2_1
Description:Mus musculus cornichon family AMPA receptor auxiliary protein2 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38195,098,494 - 5,098,554EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1277225 AgrOrtholog
Ensembl Genes ENSMUSG00000024873 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025805 ENTREZGENE
  ENSMUST00000025805.8 UniProtKB/Swiss-Prot
  ENSMUST00000235638.2 UniProtKB/TrEMBL
InterPro Cornichon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cornichon_conserved UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12794 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1277225 ENTREZGENE
NCBI Gene 12794 ENTREZGENE
PANTHER CORNICHON-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN CORNICHON HOMOLOG 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cornichon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cnih2 PhenoGen
PROSITE CORNICHON UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Cornichon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494B9S6_MOUSE UniProtKB/TrEMBL
  CNIH2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3SYI8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-22 Cnih2  cornichon family AMPA receptor auxiliary protein 2    cornichon homolog 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED