Aox4 (aldehyde oxidase 4) - Rat Genome Database

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Gene: Aox4 (aldehyde oxidase 4) Mus musculus
Analyze
No known orthologs.
Symbol: Aox4
Name: aldehyde oxidase 4
RGD ID: 1552786
MGI Page MGI
Description: Predicted to enable aldehyde oxidase activity; electron transfer activity; and molybdenum ion binding activity. Predicted to act upstream of or within electron transport chain. Predicted to be located in cytoplasm. Is expressed in anterior naris and external naris.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2310003G12Rik; aldehyde oxidase homolog 2; aldehyde oxidase structural homolog 2; AO; Aoh2; azaheterocycle hydroxylase 4; MGC144189; MGC144190; retinal oxidase
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39158,249,556 - 58,307,759 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl158,249,556 - 58,307,756 (+)EnsemblGRCm39 Ensembl
GRCm38158,210,397 - 58,268,600 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl158,210,397 - 58,268,597 (+)EnsemblGRCm38mm10GRCm38
MGSCv37158,267,241 - 58,325,441 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36158,155,016 - 58,213,143 (+)NCBIMGSCv36mm8
Celera158,724,329 - 58,782,603 (+)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map128.97NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa. Kurosaki M, etal., J Biol Chem 2004 Nov 26;279(48):50482-98. Epub 2004 Sep 20.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10893244   PMID:11042159   PMID:11076861   PMID:11562361   PMID:12477932   PMID:16141072   PMID:16141073   PMID:18981221   PMID:21267068   PMID:21873635   PMID:23263164  
PMID:25287365   PMID:27456060  


Genomics

Variants

.
Variants in Aox4
2375 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:561
Count of miRNA genes:422
Interacting mature miRNAs:475
Transcripts:ENSMUST00000040442, ENSMUST00000159240, ENSMUST00000161833, ENSMUST00000161926
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12310959173976915Mouse
4142433Hbnr1_mHeligmosomoides bakeri nematode resistance 1 (mouse)Not determined2555019158273271Mouse
11100001Col4a1m1_mcollagen, type IV, alpha 1 modifier 1 (mouse)12555019162946882Mouse
12880409V125Dq1_mvitamin D active form serum level QTL 1 (mouse)12603916060039160Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13476013873976915Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13476013873976915Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13476013873976915Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13476013873976915Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13476013873976915Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13476013873976915Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13913280874516365Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
12910780Pwgrq11_mpost-weaning growth rate QTL 11 (mouse)14086800867270256Mouse
12910786Pwgrq10_mpost-weaning growth rate QTL 10 (mouse)14086800867270256Mouse
12910788Pwgrq9_mpost-weaning growth rate QTL 9 (mouse)14086800867270256Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14127312475273271Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14127539975275399Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4225966776259667Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14293803176938167Mouse
12879917Shm3_msperm head morphology 3 (mouse)14418690462946882Mouse
1558855Eae30_mexperimental allergic encephalomyelitis susceptibility 30 (mouse)Not determined14541777372975057Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14594675579946882Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14685469080854839Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14685469080854839Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14734989481350013Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14888900682889210Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14888900682889210Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14889234582892485Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15089021684890216Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5142160585421605Mouse
4142307Shali1_msurvival time to hyperoxic acute lung injury 1 (mouse)Not determined5196402570406589Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15597494889975057Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15626621490266360Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15626621490266360Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15672692290727077Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15672692290727077Mouse
4141724Idd5.1_minsulin dependent diabetes susceptibility 5.1 (mouse)Not determined5772827662946882Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15794135191941351Mouse
14747009Manh49_mmandible shape 49 (mouse)15794135191941351Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15799197791992080Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15799197791992080Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15799197791992080Mouse

Markers in Region
D1Mit214  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38158,233,965 - 58,234,112UniSTSGRCm38
MGSCv37158,290,809 - 58,290,956UniSTSGRCm37
Celera158,747,887 - 58,748,030UniSTS
Cytogenetic Map1c1UniSTS
cM Map132.1UniSTS
Whitehead Genetic131.7UniSTS
Whitehead_YAC1 UniSTS
D1Mit5.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38158,257,371 - 58,257,546UniSTSGRCm38
MGSCv37158,314,215 - 58,314,390UniSTSGRCm37
Celera158,771,399 - 58,771,574UniSTS
Cytogenetic Map1c1UniSTS
cM Map132.8UniSTS
cM Map1 UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000040442   ⟹   ENSMUSP00000048929
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl158,249,556 - 58,307,756 (+)Ensembl
GRCm38.p6 Ensembl158,210,397 - 58,268,597 (+)Ensembl
RefSeq Acc Id: ENSMUST00000159240
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl158,249,610 - 58,254,569 (+)Ensembl
GRCm38.p6 Ensembl158,210,451 - 58,215,410 (+)Ensembl
RefSeq Acc Id: ENSMUST00000161833
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl158,249,591 - 58,299,541 (+)Ensembl
GRCm38.p6 Ensembl158,210,432 - 58,260,382 (+)Ensembl
RefSeq Acc Id: ENSMUST00000161926
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl158,279,765 - 58,284,320 (+)Ensembl
GRCm38.p6 Ensembl158,240,606 - 58,245,161 (+)Ensembl
RefSeq Acc Id: ENSMUST00000189059
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl158,250,377 - 58,252,521 (+)Ensembl
GRCm38.p6 Ensembl158,211,218 - 58,213,362 (+)Ensembl
RefSeq Acc Id: NM_023631   ⟹   NP_076120
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39158,249,556 - 58,307,756 (+)NCBI
GRCm38158,210,397 - 58,268,597 (+)NCBI
MGSCv37158,267,241 - 58,325,441 (+)RGD
Celera158,724,329 - 58,782,603 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006496287   ⟹   XP_006496350
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39158,270,001 - 58,307,759 (+)NCBI
GRCm38158,230,842 - 58,268,600 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036153692   ⟹   XP_036009585
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39158,263,340 - 58,307,759 (+)NCBI
Sequence:
RefSeq Acc Id: NP_076120   ⟸   NM_023631
- UniProtKB: Q8VI17 (UniProtKB/Swiss-Prot),   Q3TYQ9 (UniProtKB/Swiss-Prot),   Q148T8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006496350   ⟸   XM_006496287
- Peptide Label: isoform X2
- UniProtKB: Q148T8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000048929   ⟸   ENSMUST00000040442
RefSeq Acc Id: XP_036009585   ⟸   XM_036153692
- Peptide Label: isoform X1
- UniProtKB: Q148T8 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3TYQ9-F1-model_v2 AlphaFold Q3TYQ9 1-1336 view protein structure

Promoters
RGD ID:6873778
Promoter ID:EPDNEW_M340
Type:multiple initiation site
Name:Aox4_1
Description:Mus musculus aldehyde oxidase 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38158,210,451 - 58,210,511EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919122 AgrOrtholog
Ensembl Genes ENSMUSG00000038242 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000040442 ENTREZGENE
  ENSMUST00000040442.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.20.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.43.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.465.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  [2Fe-2S]-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO dehydrogenase flavoprotein, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 2Fe-2S-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe-2S-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe-2S_ferredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe-2S_ferredoxin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe2S_fd_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_Oxase/Xan_DH_a/b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_Oxase/Xan_DH_a/b_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_Oxase/xanthine_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AldOxase/xan_DH_MoCoBD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AldOxase/xan_DH_Mopterin-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AldOxase/xan_DH_Mopterin-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Beta-grasp_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO_DH_flav_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO_DH_flav_C_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH_sub1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mopterin_DH_FAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:71872 UniProtKB/Swiss-Prot
MGD MGI:1919122 ENTREZGENE
NCBI Gene 71872 ENTREZGENE
PANTHER ALDEHYDE OXIDASE 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XANTHINE DEHYDROGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ald_Xan_dh_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_Xan_dh_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO_deh_flav_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD_binding_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fer2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fer2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MoCoBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aox4 PhenoGen
PIRSF Xanthine_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE 2FE2S_FER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2FE2S_FER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD_PCMH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Ald_Xan_dh_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO_deh_flav_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47741 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54292 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54665 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55447 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56003 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56176 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt AOXD_MOUSE UniProtKB/Swiss-Prot
  Q148T8 ENTREZGENE, UniProtKB/TrEMBL
  Q3TYQ9 ENTREZGENE
  Q8VI17 ENTREZGENE
  Q9ES55_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q8VI17 UniProtKB/Swiss-Prot