Cnksr3 (Cnksr family member 3) - Rat Genome Database

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Gene: Cnksr3 (Cnksr family member 3) Mus musculus
Analyze
Symbol: Cnksr3
Name: Cnksr family member 3
RGD ID: 1552721
MGI Page MGI
Description: Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of peptidyl-serine phosphorylation; and positive regulation of sodium ion transport. Predicted to be located in cytoplasm and plasma membrane. Is expressed in dentate gyrus subgranular zone. Orthologous to human CNKSR3 (CNKSR family member 3).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 6820402C05; BC024086; CNK homolog protein 3; CNK3; connector enhancer of kinase suppressor of ras 3; connector enhancer of KSR 3; Mag; Magi1; maguin-like protein; membrane associated guanylate kinase interacting protein-like 1; membrane-associated guanylate kinase-interacting protein-like 1; MGC37681
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39107,069,061 - 7,162,237 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl107,069,063 - 7,162,237 (-)EnsemblGRCm39 Ensembl
GRCm38107,119,061 - 7,212,237 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl107,119,063 - 7,212,237 (-)EnsemblGRCm38mm10GRCm38
MGSCv37103,134,304 - 3,227,479 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36103,134,304 - 3,227,479 (+)NCBIMGSCv36mm8
Celera107,081,303 - 7,175,417 (-)NCBICelera
Cytogenetic Map10A1NCBI
cM Map101.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldrin  (EXP)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
DDT  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
folic acid  (EXP)
folpet  (EXP)
formaldehyde  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
hydrogen cyanide  (EXP)
hydrogen peroxide  (ISO)
isoprenaline  (EXP)
ketamine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
melphalan  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium cyanide  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (EXP)
temozolomide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
6. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:16141072   PMID:16141073   PMID:16602821   PMID:19567370   PMID:21267068   PMID:21677750   PMID:22851176  
PMID:24154525   PMID:28671696  


Genomics

Comparative Map Data
Cnksr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39107,069,061 - 7,162,237 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl107,069,063 - 7,162,237 (-)EnsemblGRCm39 Ensembl
GRCm38107,119,061 - 7,212,237 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl107,119,063 - 7,212,237 (-)EnsemblGRCm38mm10GRCm38
MGSCv37103,134,304 - 3,227,479 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36103,134,304 - 3,227,479 (+)NCBIMGSCv36mm8
Celera107,081,303 - 7,175,417 (-)NCBICelera
Cytogenetic Map10A1NCBI
cM Map101.85NCBI
CNKSR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386154,387,515 - 154,510,685 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6154,387,515 - 154,510,685 (-)EnsemblGRCh38hg38GRCh38
GRCh376154,708,649 - 154,831,819 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366154,768,125 - 154,873,445 (-)NCBINCBI36Build 36hg18NCBI36
Build 346154,818,546 - 154,923,906NCBI
Celera6155,460,772 - 155,566,082 (-)NCBICelera
Cytogenetic Map6q25.2NCBI
HuRef6152,289,215 - 152,394,549 (-)NCBIHuRef
CHM1_16154,989,508 - 155,094,800 (-)NCBICHM1_1
T2T-CHM13v2.06155,589,037 - 155,712,112 (-)NCBIT2T-CHM13v2.0
Cnksr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8145,904,581 - 45,996,921 (-)NCBIGRCr8
mRatBN7.2143,499,273 - 43,591,630 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl143,499,487 - 43,591,635 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx144,040,536 - 44,133,137 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0150,027,769 - 50,120,372 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0144,116,025 - 44,208,636 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0143,789,797 - 43,884,267 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl143,789,791 - 43,884,267 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0145,119,654 - 45,213,960 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4137,865,904 - 37,958,862 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1137,868,848 - 37,961,807 (-)NCBI
Celera139,135,338 - 39,227,832 (-)NCBICelera
Cytogenetic Map1q11NCBI
Cnksr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554397,524,333 - 7,616,447 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554397,524,401 - 7,616,447 (+)NCBIChiLan1.0ChiLan1.0
CNKSR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25174,428,046 - 174,534,938 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16172,319,737 - 172,425,198 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06152,221,458 - 152,326,885 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16156,666,986 - 158,292,640 (-)NCBIpanpan1.1PanPan1.1panPan2
CNKSR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1144,280,132 - 44,361,138 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl144,070,004 - 44,363,107 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha145,116,969 - 45,205,320 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0144,462,865 - 44,552,077 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl144,253,530 - 44,552,166 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1144,330,159 - 44,418,557 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0144,202,964 - 44,291,122 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0144,758,957 - 44,847,009 (-)NCBIUU_Cfam_GSD_1.0
Cnksr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946139,541,292 - 139,628,404 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364896,792,048 - 6,880,445 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364896,792,925 - 6,880,300 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNKSR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl112,297,676 - 12,396,688 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1112,297,740 - 12,396,946 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2114,301,232 - 14,451,489 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CNKSR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11381,945,080 - 82,050,304 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1381,943,423 - 82,050,175 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604054,347,357 - 54,454,077 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnksr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247853,805,389 - 3,902,216 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247853,805,829 - 3,905,554 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cnksr3
3083 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:784
Count of miRNA genes:309
Interacting mature miRNAs:341
Transcripts:ENSMUST00000015346, ENSMUST00000150282
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11532725Sluc44b_msusceptibility to lung cancer 44b (mouse)10126289265Mouse
11532724Sluc44c_msusceptibility to lung cancer 44c (mouse)10126289265Mouse
11532723Sluc44d_msusceptibility to lung cancer 44d (mouse)10126289265Mouse
11532722Sluc44e_msusceptibility to lung cancer 44e (mouse)10126289265Mouse
11532721Sluc44_msusceptibility to lung cancer 44 (mouse)10126289265Mouse
11532720Sluc44a_msusceptibility to lung cancer 44a (mouse)10126289265Mouse
11532718Sluc44f_msusceptibility to lung cancer 44f (mouse)10126289265Mouse
11532717Sluc44g_msusceptibility to lung cancer 44g (mouse)10126289265Mouse
11533917Mts2_mmammary tumor susceptibility 2 (mouse)10126289265Mouse
1300759Geot_mgeotaxia (mouse)Not determined10126289265Mouse
1300881Sluc29_msusceptibility to lung cancer 29 (mouse)Not determined10126289265Mouse
12879494Facq1_mfear acquisition QTL 1 (mouse)10131279130Mouse
15039341Nmrs28_mNAFLD-associated magnetic resonance shift 28 (mouse)1035100134351001Mouse
1357813Ath20_matherosclerosis 20 (mouse)Not determined10328318537283334Mouse
1300790Pgia6_mproteoglycan induced arthritis 6 (mouse)Not determined10381017137810295Mouse
1300997Eae15_msusceptibility to experimental allergic encephalomyelitis 15 (mouse)Not determined10440815438408276Mouse
13208561Wght8_mweight 8 (mouse)10495000043875996Mouse
1302092Ath11_matherosclerosis 11 (mouse)Not determined10615194558693521Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000015346   ⟹   ENSMUSP00000015346
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl107,069,063 - 7,162,237 (-)Ensembl
GRCm38.p6 Ensembl107,119,063 - 7,212,237 (-)Ensembl
RefSeq Acc Id: ENSMUST00000150282   ⟹   ENSMUSP00000115863
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl107,069,063 - 7,085,506 (-)Ensembl
GRCm38.p6 Ensembl107,119,063 - 7,135,506 (-)Ensembl
RefSeq Acc Id: NM_172546   ⟹   NP_766134
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39107,069,062 - 7,162,237 (-)NCBI
GRCm38107,119,062 - 7,212,237 (-)NCBI
MGSCv37103,134,304 - 3,227,479 (+)RGD
Celera107,081,303 - 7,175,417 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030244998   ⟹   XP_030100858
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39107,069,061 - 7,159,987 (-)NCBI
GRCm38107,119,061 - 7,210,001 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155726   ⟹   XP_036011619
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39107,069,061 - 7,162,231 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_766134   ⟸   NM_172546
- UniProtKB: Q3UDS2 (UniProtKB/Swiss-Prot),   Q8K2K0 (UniProtKB/Swiss-Prot),   Q8BMA3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030100858   ⟸   XM_030244998
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000115863   ⟸   ENSMUST00000150282
RefSeq Acc Id: ENSMUSP00000015346   ⟸   ENSMUST00000015346
RefSeq Acc Id: XP_036011619   ⟸   XM_036155726
- Peptide Label: isoform X1
Protein Domains
CRIC   DUF1170   PDZ   SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BMA3-F1-model_v2 AlphaFold Q8BMA3 1-555 view protein structure

Promoters
RGD ID:6819118
Promoter ID:MM_KWN:3390
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_172546
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36103,134,096 - 3,134,747 (+)MPROMDB
RGD ID:8671444
Promoter ID:EPDNEW_M13753
Type:initiation region
Name:Cnksr3_1
Description:Mus musculus Cnksr family member 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38107,212,204 - 7,212,264EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2674130 AgrOrtholog
Ensembl Genes ENSMUSG00000015202 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000015346 ENTREZGENE
  ENSMUST00000015346.12 UniProtKB/Swiss-Prot
  ENSMUST00000150282.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot
  2.30.42.10 UniProtKB/Swiss-Prot
InterPro CNK1-3_SAM UniProtKB/Swiss-Prot
  CNKSR2 UniProtKB/Swiss-Prot
  CRIC_domain UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
  SAM UniProtKB/Swiss-Prot
  SAM/pointed_sf UniProtKB/Swiss-Prot
KEGG Report mmu:215748 UniProtKB/Swiss-Prot
MGD MGI:2674130 ENTREZGENE
NCBI Gene 215748 ENTREZGENE
PANTHER CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS UniProtKB/Swiss-Prot
  CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 3 UniProtKB/Swiss-Prot
Pfam CRIC_ras_sig UniProtKB/Swiss-Prot
  DUF1170 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  SAM_1 UniProtKB/Swiss-Prot
PhenoGen Cnksr3 PhenoGen
PROSITE CRIC UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  SAM_DOMAIN UniProtKB/Swiss-Prot
SMART PDZ UniProtKB/Swiss-Prot
  SAM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47769 UniProtKB/Swiss-Prot
  SSF50156 UniProtKB/Swiss-Prot
UniProt CNKR3_MOUSE UniProtKB/Swiss-Prot
  Q3UDS2 ENTREZGENE
  Q8BMA3 ENTREZGENE
  Q8K2K0 ENTREZGENE
UniProt Secondary Q3UDS2 UniProtKB/Swiss-Prot
  Q8K2K0 UniProtKB/Swiss-Prot