Nek8 (NIMA (never in mitosis gene a)-related expressed kinase 8) - Rat Genome Database

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Gene: Nek8 (NIMA (never in mitosis gene a)-related expressed kinase 8) Mus musculus
Analyze
Symbol: Nek8
Name: NIMA (never in mitosis gene a)-related expressed kinase 8
RGD ID: 1552572
MGI Page MGI
Description: Predicted to enable ATP binding activity; metal ion binding activity; and protein serine/threonine kinase activity. Acts upstream of or within determination of left/right symmetry and heart development. Located in ciliary base and ciliary inversin compartment. Is expressed in collecting duct; cortical renal tubule; node; and renal tubule. Used to study autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in nephronophthisis 9 and renal-hepatic-pancreatic dysplasia. Orthologous to human NEK8 (NIMA related kinase 8).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 4632401F23Rik; b2b1449C; b2b1449Clo; jck; juvenile cystic kidney; never in mitosis A-related kinase 8; NIMA-related expressed kinase 8; nimA-related protein kinase 8; serine/threonine-protein kinase Nek8
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,056,932 - 78,067,501 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,056,932 - 78,067,501 (-)EnsemblGRCm39 Ensembl
GRCm381178,166,106 - 78,176,695 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,166,106 - 78,176,675 (-)EnsemblGRCm38mm10GRCm38
MGSCv371177,979,608 - 77,990,168 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361177,982,715 - 77,992,861 (-)NCBIMGSCv36mm8
Celera1185,665,979 - 85,676,539 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8. McCooke JK, etal., BMC Genomics. 2012 Aug 16;13:393. doi: 10.1186/1471-2164-13-393.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7782068   PMID:8510385   PMID:9351583   PMID:10349636   PMID:10645949   PMID:10725249   PMID:10922068   PMID:11015567   PMID:11042159   PMID:11076861   PMID:12405636   PMID:12421721  
PMID:12477932   PMID:14600027   PMID:15371535   PMID:15489334   PMID:15761153   PMID:16141072   PMID:16141073   PMID:16267153   PMID:16774131   PMID:16928806   PMID:17928412   PMID:18189147  
PMID:18199800   PMID:18235101   PMID:18799693   PMID:20169535   PMID:20554900   PMID:20562878   PMID:20921623   PMID:20937855   PMID:21267068   PMID:21565611   PMID:21873635   PMID:22687244  
PMID:23274954   PMID:23793029   PMID:23973373   PMID:24166835   PMID:24319055   PMID:24700869   PMID:25599650   PMID:25671767   PMID:25807483   PMID:25934702   PMID:26967905   PMID:27053712  
PMID:27076647   PMID:27114383   PMID:27892797   PMID:28826940   PMID:29357413   PMID:29395339   PMID:31915367   PMID:36523654   PMID:37598857  


Genomics

Comparative Map Data
Nek8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,056,932 - 78,067,501 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,056,932 - 78,067,501 (-)EnsemblGRCm39 Ensembl
GRCm381178,166,106 - 78,176,695 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,166,106 - 78,176,675 (-)EnsemblGRCm38mm10GRCm38
MGSCv371177,979,608 - 77,990,168 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361177,982,715 - 77,992,861 (-)NCBIMGSCv36mm8
Celera1185,665,979 - 85,676,539 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
NEK8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381728,728,788 - 28,743,455 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1728,725,897 - 28,743,455 (+)EnsemblGRCh38hg38GRCh38
GRCh371727,055,806 - 27,070,473 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361724,079,959 - 24,093,911 (+)NCBINCBI36Build 36hg18NCBI36
Build 341724,079,958 - 24,093,911NCBI
Celera1723,914,995 - 23,928,979 (+)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1723,264,730 - 23,278,592 (+)NCBIHuRef
CHM1_11727,118,302 - 27,132,262 (+)NCBICHM1_1
T2T-CHM13v2.01729,671,595 - 29,686,240 (+)NCBIT2T-CHM13v2.0
Nek8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81063,558,940 - 63,570,954 (-)NCBIGRCr8
mRatBN7.21063,060,868 - 63,073,546 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,061,253 - 63,072,416 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1067,693,525 - 67,704,703 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,198,879 - 67,210,057 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01062,669,900 - 62,681,011 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01065,404,489 - 65,439,059 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,425,771 - 65,437,143 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01066,196,993 - 66,230,588 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,458,886 - 64,470,044 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11064,472,568 - 64,483,018 (+)NCBI
Celera1062,038,910 - 62,050,078 (-)NCBICelera
Cytogenetic Map10q25NCBI
Nek8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554814,417,773 - 4,427,885 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554814,417,773 - 4,427,885 (-)NCBIChiLan1.0ChiLan1.0
NEK8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21935,716,348 - 35,732,975 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11737,596,329 - 37,613,488 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01728,033,001 - 28,048,157 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11728,539,621 - 28,553,282 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1728,539,621 - 28,550,860 (-)Ensemblpanpan1.1panPan2
NEK8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,923,208 - 42,933,083 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,923,288 - 42,932,352 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha942,078,973 - 42,088,848 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0943,741,379 - 43,751,253 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl943,741,425 - 43,751,220 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1942,524,530 - 42,534,168 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,816,751 - 42,826,387 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0942,895,059 - 42,904,934 (+)NCBIUU_Cfam_GSD_1.0
Nek8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560242,060,781 - 42,074,138 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365384,938,708 - 4,952,194 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365384,938,739 - 4,952,083 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEK8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1244,965,116 - 44,975,083 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11244,963,095 - 44,975,092 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21246,948,058 - 46,960,030 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEK8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11622,495,745 - 22,506,782 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660757,613,680 - 7,627,632 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nek8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247861,303,308 - 1,314,188 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247861,303,283 - 1,314,188 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nek8
271 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1596
Count of miRNA genes:619
Interacting mature miRNAs:760
Transcripts:ENSMUST00000017549, ENSMUST00000125528, ENSMUST00000131015, ENSMUST00000141444, ENSMUST00000142812, ENSMUST00000147798, ENSMUST00000148154, ENSMUST00000152611
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301078Alcp2_malcohol preference locus 2 (mouse)Not determined117220979684731462Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
12903994Opfaq3_mopen field activity QTL 3 (mouse)117373754182069425Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
4141365Ltxs3_mlethal factor toxin susceptibility 3 (mouse)Not determined117757387380746358Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse

Markers in Region
UniSTS:236650  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381178,166,203 - 78,166,440UniSTSGRCm38
MGSCv371177,979,705 - 77,979,942UniSTSGRCm37
Celera1185,666,076 - 85,666,313UniSTS
Cytogenetic Map11B5-CUniSTS
Cytogenetic Map11B5UniSTS
cM Map1144.0UniSTS
Nek8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B5UniSTS
cM Map1144.0UniSTS
D11Seg6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381178,171,232 - 78,171,409UniSTSGRCm38
MGSCv371177,984,734 - 77,984,911UniSTSGRCm37
Celera1185,671,105 - 85,671,282UniSTS
Cytogenetic Map11B5UniSTS
cM Map1144.89UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000017549   ⟹   ENSMUSP00000017549
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1178,056,932 - 78,067,501 (-)Ensembl
GRCm38.p6 Ensembl1178,166,106 - 78,176,675 (-)Ensembl
RefSeq Acc Id: ENSMUST00000125528
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1178,056,936 - 78,058,213 (-)Ensembl
GRCm38.p6 Ensembl1178,166,110 - 78,167,387 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131015
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1178,057,347 - 78,067,453 (-)Ensembl
GRCm38.p6 Ensembl1178,166,521 - 78,176,627 (-)Ensembl
RefSeq Acc Id: ENSMUST00000141444
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1178,058,080 - 78,058,859 (-)Ensembl
GRCm38.p6 Ensembl1178,167,254 - 78,168,033 (-)Ensembl
RefSeq Acc Id: ENSMUST00000142812
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1178,060,817 - 78,067,440 (-)Ensembl
GRCm38.p6 Ensembl1178,169,991 - 78,176,614 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147798
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1178,059,798 - 78,060,654 (-)Ensembl
GRCm38.p6 Ensembl1178,168,972 - 78,169,828 (-)Ensembl
RefSeq Acc Id: ENSMUST00000148154   ⟹   ENSMUSP00000127554
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1178,062,013 - 78,067,460 (-)Ensembl
GRCm38.p6 Ensembl1178,171,187 - 78,176,634 (-)Ensembl
RefSeq Acc Id: ENSMUST00000152611
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1178,056,932 - 78,067,437 (-)Ensembl
GRCm38.p6 Ensembl1178,166,106 - 78,176,611 (-)Ensembl
RefSeq Acc Id: NM_080849   ⟹   NP_543125
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391178,056,932 - 78,067,492 (-)NCBI
GRCm381178,166,106 - 78,176,666 (-)NCBI
MGSCv371177,979,608 - 77,990,168 (-)RGD
Celera1185,665,979 - 85,676,539 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006532183   ⟹   XP_006532246
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391178,057,612 - 78,067,501 (-)NCBI
GRCm381178,166,786 - 78,176,695 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006532184   ⟹   XP_006532247
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391178,056,932 - 78,067,501 (-)NCBI
GRCm381178,166,106 - 78,176,695 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006532185   ⟹   XP_006532248
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391178,057,611 - 78,067,501 (-)NCBI
GRCm381178,166,785 - 78,176,695 (-)NCBI
Sequence:
RefSeq Acc Id: NP_543125   ⟸   NM_080849
- UniProtKB: Q3U498 (UniProtKB/Swiss-Prot),   Q9D685 (UniProtKB/Swiss-Prot),   Q91ZR4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006532247   ⟸   XM_006532184
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006532246   ⟸   XM_006532183
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006532248   ⟸   XM_006532185
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSMUSP00000017549   ⟸   ENSMUST00000017549
RefSeq Acc Id: ENSMUSP00000127554   ⟸   ENSMUST00000148154
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91ZR4-F1-model_v2 AlphaFold Q91ZR4 1-698 view protein structure

Promoters
RGD ID:6821409
Promoter ID:MM_KWN:8669
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:OTTMUST00000000375,   OTTMUST00000000376
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361177,980,731 - 77,981,231 (-)MPROMDB
RGD ID:6822327
Promoter ID:MM_KWN:8671
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000108338,   OTTMUST00000000314,   OTTMUST00000000315,   OTTMUST00000000317,   OTTMUST00000000318,   OTTMUST00000000320,   OTTMUST00000000369,   OTTMUST00000000370,   OTTMUST00000000371,   OTTMUST00000000372,   OTTMUST00000000373,   UC007KII.1,   UC007KIJ.1,   UC007KIK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361177,990,101 - 77,993,382 (+)MPROMDB
RGD ID:8675678
Promoter ID:EPDNEW_M15870
Type:multiple initiation site
Name:Nek8_1
Description:Mus musculus NIMA -related expressed kinase 8 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381178,176,628 - 78,176,688EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1890646 AgrOrtholog
Ensembl Genes ENSMUSG00000017405 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000017549 ENTREZGENE
  ENSMUST00000017549.13 UniProtKB/Swiss-Prot
  ENSMUST00000148154.3 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.30 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RCC1/BLIP-II UniProtKB/Swiss-Prot
  Reg_chr_condens UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  STKc_Nek8 UniProtKB/Swiss-Prot
KEGG Report mmu:140859 UniProtKB/Swiss-Prot
MGD MGI:1890646 ENTREZGENE
NCBI Gene 140859 ENTREZGENE
PANTHER PROTEIN CBG16200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE NEK8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RCC1 UniProtKB/Swiss-Prot
PhenoGen Nek8 PhenoGen
PRINTS RCCNDNSATION UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  RCC1_3 UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50985 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9Q258_MOUSE UniProtKB/TrEMBL
  NEK8_MOUSE UniProtKB/Swiss-Prot
  Q3U498 ENTREZGENE
  Q91ZR4 ENTREZGENE
  Q9D685 ENTREZGENE
UniProt Secondary Q3U498 UniProtKB/Swiss-Prot
  Q9D685 UniProtKB/Swiss-Prot