Prlhr (prolactin releasing hormone receptor) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Prlhr (prolactin releasing hormone receptor) Mus musculus
Analyze
Symbol: Prlhr
Name: prolactin releasing hormone receptor
RGD ID: 1552398
MGI Page MGI
Description: Enables G protein-coupled receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway; feeding behavior; and hormone metabolic process. Predicted to be located in cilium. Predicted to be active in neuron projection and plasma membrane. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human PRLHR (prolactin releasing hormone receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G-protein coupled receptor 10; Gm339; Gpr; Gpr10; GR; Gr3; prolactin-releasing peptide receptor; PrRP receptor; Prrpr
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391960,454,079 - 60,457,907 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1960,455,170 - 60,456,742 (-)EnsemblGRCm39 Ensembl
GRCm381960,465,641 - 60,468,933 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1960,466,732 - 60,468,304 (-)EnsemblGRCm38mm10GRCm38
MGSCv371960,542,636 - 60,544,207 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361960,521,404 - 60,522,967 (-)NCBIMGSCv36mm8
Celera1962,669,595 - 62,671,166 (-)NCBICelera
Cytogenetic Map19D3NCBI
cM Map1956.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cilium  (IDA,ISO)
membrane  (IEA)
neuron projection  (IBA)
plasma membrane  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association between physical activity and blood pressure is modified by variants in the G-protein coupled receptor 10. Franks PW, etal., Hypertension. 2004 Feb;43(2):224-8. Epub 2003 Dec 22.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Mutated G-protein-coupled receptor GPR10 is responsible for the hyperphagia/dyslipidaemia/obesity locus of Dmo1 in the OLETF rat. Watanabe TK, etal., Clin Exp Pharmacol Physiol. 2005 May-Jun;32(5-6):355-66.
Additional References at PubMed
PMID:12477932   PMID:14742914   PMID:16299503   PMID:16602821   PMID:16794001   PMID:17904108   PMID:21267068   PMID:21873635   PMID:26053317   PMID:28154160   PMID:33450349   PMID:36922513  


Genomics

Comparative Map Data
Prlhr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391960,454,079 - 60,457,907 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1960,455,170 - 60,456,742 (-)EnsemblGRCm39 Ensembl
GRCm381960,465,641 - 60,468,933 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1960,466,732 - 60,468,304 (-)EnsemblGRCm38mm10GRCm38
MGSCv371960,542,636 - 60,544,207 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361960,521,404 - 60,522,967 (-)NCBIMGSCv36mm8
Celera1962,669,595 - 62,671,166 (-)NCBICelera
Cytogenetic Map19D3NCBI
cM Map1956.52NCBI
PRLHR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810118,589,997 - 118,595,648 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10118,589,997 - 118,595,648 (-)EnsemblGRCh38hg38GRCh38
GRCh3710120,349,509 - 120,355,160 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610120,342,906 - 120,345,150 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410120,343,633 - 120,344,746NCBI
Celera10114,083,566 - 114,085,810 (-)NCBICelera
Cytogenetic Map10q26.11NCBI
HuRef10113,981,999 - 113,984,243 (-)NCBIHuRef
CHM1_110120,637,272 - 120,639,516 (-)NCBICHM1_1
T2T-CHM13v2.010119,485,136 - 119,490,787 (-)NCBIT2T-CHM13v2.0
Prlhr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81269,592,735 - 269,594,422 (-)NCBIGRCr8
mRatBN7.21259,606,704 - 259,608,391 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1259,606,704 - 259,608,391 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1267,812,258 - 267,813,943 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01274,518,288 - 274,519,973 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01267,171,127 - 267,172,814 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01281,754,472 - 281,756,159 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1281,754,724 - 281,756,159 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01289,097,316 - 289,099,003 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41267,068,380 - 267,070,067 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11267,279,424 - 267,281,112 (-)NCBI
Celera1255,251,200 - 255,252,887 (-)NCBICelera
Cytogenetic Map1q55NCBI
Prlhr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543123,192,018 - 23,193,130 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543123,192,018 - 23,193,130 (-)NCBIChiLan1.0ChiLan1.0
PRLHR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28130,445,186 - 130,456,588 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110130,450,787 - 130,461,926 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010114,922,829 - 115,168,506 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110118,589,819 - 118,592,053 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10118,590,543 - 118,591,655 (-)Ensemblpanpan1.1panPan2
PRLHR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12828,950,300 - 28,956,140 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2828,954,469 - 28,955,581 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2829,097,625 - 29,099,209 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02829,484,495 - 29,486,071 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2829,484,543 - 29,485,655 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12829,042,666 - 29,044,242 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02829,056,498 - 29,061,577 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02829,255,022 - 29,256,598 (-)NCBIUU_Cfam_GSD_1.0
Prlhr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721317,378,820 - 17,384,205 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364868,180,436 - 8,181,548 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364868,177,111 - 8,181,663 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRLHR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14128,614,131 - 128,619,457 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114128,617,352 - 128,619,419 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214140,132,093 - 140,134,255 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRLHR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19111,399,821 - 111,402,946 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604872,660,323 - 72,667,180 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prlhr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473728,094,507 - 28,095,941 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473728,093,837 - 28,099,377 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prlhr
88 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:112
Interacting mature miRNAs:115
Transcripts:ENSMUST00000051277
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
4141650Chldq9_mcholesterol and HDL QTL 9 (mouse)Not determined193788298261420004Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193837605061420004Mouse
1302104Lfp1_mlong free running period 1 (mouse)Not determined193918406461420004Mouse
10043896Bw21_mbody weight QTL 21 (mouse)Not determined193959606661420004Mouse
1300585Pgia12_mproteoglycan induced arthritis 12 (mouse)Not determined194258685961420004Mouse

Markers in Region
UniSTS:487708  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381960,466,957 - 60,468,235UniSTSGRCm38
MGSCv371960,542,860 - 60,544,138UniSTSGRCm37
Celera1962,669,819 - 62,671,097UniSTS
Cytogenetic Map19D3UniSTS
UniSTS:495728  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381960,466,826 - 60,468,236UniSTSGRCm38
MGSCv371960,542,729 - 60,544,139UniSTSGRCm37
Celera1962,669,688 - 62,671,098UniSTS
Cytogenetic Map19D3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000051277   ⟹   ENSMUSP00000063114
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1960,455,170 - 60,456,742 (-)Ensembl
GRCm38.p6 Ensembl1960,466,732 - 60,468,304 (-)Ensembl
RefSeq Acc Id: NM_201615   ⟹   NP_963909
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391960,455,171 - 60,456,742 (-)NCBI
GRCm381960,466,733 - 60,468,304 (-)NCBI
MGSCv371960,542,636 - 60,544,207 (-)RGD
Celera1962,669,595 - 62,671,166 (-)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006527057   ⟹   XP_006527120
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391960,454,079 - 60,457,907 (-)NCBI
GRCm381960,465,641 - 60,468,933 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_963909 (Get FASTA)   NCBI Sequence Viewer  
  XP_006527120 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI25650 (Get FASTA)   NCBI Sequence Viewer  
  AAI25652 (Get FASTA)   NCBI Sequence Viewer  
  EDL01840 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000063114
  ENSMUSP00000063114.3
GenBank Protein Q6VMN6 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_963909   ⟸   NM_201615
- UniProtKB: E9QJU3 (UniProtKB/Swiss-Prot),   Q059H6 (UniProtKB/Swiss-Prot),   Q6VMN6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006527120   ⟸   XM_006527057
- Peptide Label: isoform X1
- UniProtKB: E9QJU3 (UniProtKB/Swiss-Prot),   Q059H6 (UniProtKB/Swiss-Prot),   Q6VMN6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000063114   ⟸   ENSMUST00000051277

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6VMN6-F1-model_v2 AlphaFold Q6VMN6 1-370 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2135956 AgrOrtholog
Ensembl Genes ENSMUSG00000045052 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000051277 ENTREZGENE
  ENSMUST00000051277.4 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Prolrel_pep_rcpt UniProtKB/Swiss-Prot
KEGG Report mmu:226278 UniProtKB/Swiss-Prot
MGD MGI:2135956 ENTREZGENE
NCBI Gene 226278 ENTREZGENE
PANTHER NEUROPEPTIDE Y RECEPTOR UniProtKB/Swiss-Prot
  PTHR24235:SF11 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Prlhr PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  PRPRECEPTOR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt E9QJU3 ENTREZGENE
  PRLHR_MOUSE UniProtKB/Swiss-Prot
  Q059H6 ENTREZGENE
  Q6VMN6 ENTREZGENE
UniProt Secondary E9QJU3 UniProtKB/Swiss-Prot
  Q059H6 UniProtKB/Swiss-Prot