Tlr6 (toll-like receptor 6) - Rat Genome Database

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Gene: Tlr6 (toll-like receptor 6) Mus musculus
Analyze
Symbol: Tlr6
Name: toll-like receptor 6
RGD ID: 1552386
MGI Page MGI
Description: Enables diacyl lipopeptide binding activity. Involved in several processes, including cellular response to oxidised low-density lipoprotein particle stimulus; positive regulation of biosynthetic process; and positive regulation of defense response. Part of Toll-like receptor 2-Toll-like receptor 6 protein complex. Is expressed in brain; cerebral cortex; embryo; and telencephalon. Human ortholog(s) of this gene implicated in aspergillosis; asthma; infective endocarditis; rhinitis; and tuberculosis. Orthologous to human TLR6 (toll like receptor 6).
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39565,109,373 - 65,128,387 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl565,109,374 - 65,117,440 (-)EnsemblGRCm39 Ensembl
GRCm38564,953,092 - 64,970,942 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl564,952,031 - 64,960,097 (-)EnsemblGRCm38mm10GRCm38
MGSCv37565,344,334 - 65,351,273 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36565,232,241 - 65,239,169 (-)NCBIMGSCv36mm8
Celera562,225,900 - 62,232,840 (-)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map533.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
buta-1,3-diene  (EXP)
butyric acid  (ISO)
cadmium selenide  (ISO)
carbon nanotube  (EXP)
ceric oxide  (ISO)
choline  (EXP)
cisplatin  (EXP)
Cuprizon  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
ethylparaben  (ISO)
flutamide  (ISO)
folic acid  (EXP)
gentamycin  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
levamisole  (EXP)
manganese(II) chloride  (ISO)
mangiferin  (EXP)
metformin  (ISO)
methamphetamine  (EXP)
Muraglitazar  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
o-anisidine  (ISO)
O-methyleugenol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
parthenolide  (ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
urethane  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amyloid-beta  (ISO)
cellular response to diacyl bacterial lipopeptide  (IBA,ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (IGI,ISO)
detection of diacyl bacterial lipopeptide  (ISO)
immune response  (IEA)
immune system process  (IEA)
inflammatory response  (IBA)
innate immune response  (IEA)
microglial cell activation  (ISO)
MyD88-dependent toll-like receptor signaling pathway  (IGI,ISO)
negative regulation of interleukin-8 production  (ISO)
negative regulation of toll-like receptor 2 signaling pathway  (ISO)
negative regulation of tumor necrosis factor production  (IGI)
nitric oxide metabolic process  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cytokine production involved in inflammatory response  (IGI)
positive regulation of extrinsic apoptotic signaling pathway  (IGI)
positive regulation of gene expression  (IGI,IMP)
positive regulation of inflammatory response  (IGI)
positive regulation of interleukin-1 beta production  (IDA)
positive regulation of interleukin-12 production  (NAS)
positive regulation of interleukin-6 production  (ISS)
positive regulation of macrophage activation  (IGI)
positive regulation of nitric oxide biosynthetic process  (IGI)
positive regulation of NLRP3 inflammasome complex assembly  (IDA)
positive regulation of reactive oxygen species biosynthetic process  (IMP)
response to bacterial lipoprotein  (ISO)
signal transduction  (IEA)
toll-like receptor signaling pathway  (IBA,ISO)
toll-like receptor TLR6:TLR2 signaling pathway  (ISO)
TRIF-dependent toll-like receptor signaling pathway  (IGI)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. TLR4 links podocytes with the innate immune system to mediate glomerular injury. Banas MC, etal., J Am Soc Nephrol. 2008 Apr;19(4):704-13. doi: 10.1681/ASN.2007040395. Epub 2008 Feb 6.
2. Toll-like receptor 6 drives interleukin-17A expression during experimental hypersensitivity pneumonitis. Fong DJ, etal., Immunology. 2010 May;130(1):125-36. Epub 2010 Jan 11.
3. A Toll-like receptor 2/6 agonist reduces allergic airway inflammation in chronic respiratory sensitisation to Timothy grass pollen antigens. Fuchs B, etal., Int Arch Allergy Immunol. 2010;152(2):131-9. Epub 2009 Dec 16.
4. An association between single nucleotide polymorphisms within TLR and TREM-1 genes and infective endocarditis. Golovkin AS, etal., Cytokine. 2015 Jan;71(1):16-21. doi: 10.1016/j.cyto.2014.08.001. Epub 2014 Sep 16.
5. Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression. Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1.
6. Pyrexia, anorexia, adipsia, and depressed motor activity in rats during systemic inflammation induced by the Toll-like receptors-2 and -6 agonists MALP-2 and FSL-1. Hubschle T, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R180-7. Epub 2005 Sep 8.
7. Beneficial effects of TLR-2/6 ligation in pulmonary bacterial infection and immunization with Pseudomonas aeruginosa. Kerber-Momot T, etal., Inflammation. 2010 Feb;33(1):58-64.
8. TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. Kesh S, etal., Ann N Y Acad Sci. 2005 Dec;1062:95-103.
9. Macrophage-activating lipopeptide-2 (MALP-2) induces a localized inflammatory response in rats resulting in activation of brain sites implicated in fever. Knorr C, etal., Brain Res. 2008 Apr 18;1205:36-46. Epub 2008 Feb 21.
10. Toll-like receptor heterodimer variants protect from childhood asthma. Kormann MS, etal., J Allergy Clin Immunol. 2008 Jul;122(1):86-92, 92.e1-8. Epub 2008 Jun 10.
11. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
12. Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. Liu Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G442-50. Epub 2009 Jul 16.
13. Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease. Ma X, etal., PLoS One. 2007 Dec 19;2(12):e1318.
14. MGDs mouse GO annotations MGD data from the GO Consortium
15. MGD IEA MGD IEA
16. Respiratory syncytial virus activates innate immunity through Toll-like receptor 2. Murawski MR, etal., J Virol. 2009 Feb;83(3):1492-500. Epub 2008 Nov 19.
17. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Polymorphisms in the toll-like receptor 2 subfamily and risk of asthma: a case-control analysis in a Chinese population. Qian FH, etal., J Investig Allergol Clin Immunol. 2010;20(4):340-6.
20. Mouse MP Annotation Import Pipeline RGD automated import pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma. Tantisira K, etal., Genes Immun. 2004 Aug;5(5):343-6.
24. MicroRNA-494-3p alleviates inflammatory response in sepsis by targeting TLR6. Wang HF, etal., Eur Rev Med Pharmacol Sci. 2019 Apr;23(7):2971-2977. doi: 10.26355/eurrev_201904_17578.
Additional References at PubMed
PMID:9682022   PMID:10231569   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11095740   PMID:11217851   PMID:11431423   PMID:11686851   PMID:11698470   PMID:11739528   PMID:12077222  
PMID:12432564   PMID:12477932   PMID:12825186   PMID:12825894   PMID:12935356   PMID:14739339   PMID:14966134   PMID:15034058   PMID:15128825   PMID:15482852   PMID:15557622   PMID:15580661  
PMID:15606799   PMID:15731092   PMID:15905587   PMID:16141072   PMID:16141073   PMID:16455646   PMID:16602821   PMID:16622218   PMID:16832055   PMID:16886064   PMID:16889948   PMID:17004992  
PMID:17082629   PMID:17339472   PMID:17456769   PMID:17572686   PMID:17595379   PMID:18036178   PMID:18180310   PMID:18195069   PMID:18203139   PMID:18394314   PMID:18424724   PMID:18559428  
PMID:18854239   PMID:19122641   PMID:19211042   PMID:19362712   PMID:19382893   PMID:19458089   PMID:19657352   PMID:19847289   PMID:19931471   PMID:19936231   PMID:19952355   PMID:20037584  
PMID:20056792   PMID:20351187   PMID:20456021   PMID:20478617   PMID:20495560   PMID:21057502   PMID:21098227   PMID:21239713   PMID:21308778   PMID:21482737   PMID:21685327   PMID:21846723  
PMID:21873635   PMID:21998742   PMID:22005301   PMID:22198949   PMID:22214850   PMID:22315281   PMID:22523066   PMID:22666391   PMID:22778390   PMID:22822027   PMID:23071157   PMID:23077245  
PMID:23460520   PMID:23477738   PMID:23677476   PMID:23716075   PMID:23812099   PMID:23843525   PMID:23853597   PMID:23868938   PMID:24091496   PMID:24593842   PMID:24621922   PMID:24669857  
PMID:24683188   PMID:24860120   PMID:25056943   PMID:25246533   PMID:25431887   PMID:25681338   PMID:26226614   PMID:26578650   PMID:26831104   PMID:26940740   PMID:27015965   PMID:28220810  
PMID:28317806   PMID:28655763   PMID:28775078   PMID:28808328   PMID:31084431   PMID:31729371   PMID:31771941   PMID:32652111   PMID:33011801   PMID:34206257   PMID:34395439  


Genomics

Comparative Map Data
Tlr6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39565,109,373 - 65,128,387 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl565,109,374 - 65,117,440 (-)EnsemblGRCm39 Ensembl
GRCm38564,953,092 - 64,970,942 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl564,952,031 - 64,960,097 (-)EnsemblGRCm38mm10GRCm38
MGSCv37565,344,334 - 65,351,273 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36565,232,241 - 65,239,169 (-)NCBIMGSCv36mm8
Celera562,225,900 - 62,232,840 (-)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map533.54NCBI
TLR6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38438,822,897 - 38,868,390 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl438,822,897 - 38,856,817 (-)EnsemblGRCh38hg38GRCh38
GRCh37438,824,518 - 38,859,376 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36438,504,803 - 38,507,555 (-)NCBINCBI36Build 36hg18NCBI36
Build 34438,650,973 - 38,653,726NCBI
Celera439,263,872 - 39,296,634 (-)NCBICelera
Cytogenetic Map4p14NCBI
HuRef438,149,688 - 38,182,937 (-)NCBIHuRef
CHM1_1438,824,910 - 38,858,032 (-)NCBICHM1_1
T2T-CHM13v2.0438,793,030 - 38,827,904 (-)NCBIT2T-CHM13v2.0
Tlr6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81443,715,809 - 43,727,019 (+)NCBIGRCr8
mRatBN7.21443,362,164 - 43,374,500 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1443,362,164 - 43,375,685 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1443,721,986 - 43,733,208 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01445,021,938 - 45,033,160 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01443,502,105 - 43,513,327 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01445,024,351 - 45,041,188 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1445,024,351 - 45,046,446 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01444,835,326 - 44,850,999 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41446,089,365 - 46,100,687 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11446,091,755 - 46,103,077 (+)NCBI
Celera1442,506,234 - 42,517,444 (+)NCBICelera
Cytogenetic Map14p11NCBI
Tlr6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554438,422,534 - 8,424,942 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554438,401,461 - 8,427,175 (+)NCBIChiLan1.0ChiLan1.0
TLR6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2339,012,720 - 39,034,220 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1439,201,456 - 39,226,747 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0433,153,151 - 33,174,053 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1439,007,970 - 39,038,717 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl439,009,103 - 39,011,490 (-)Ensemblpanpan1.1panPan2
TLR6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1373,504,357 - 73,523,964 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl373,520,706 - 73,523,099 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha376,051,457 - 76,071,053 (+)NCBIDog10K_Boxer_Tasha
Tlr6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528539,677,687 - 39,695,258 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364826,607,753 - 6,610,143 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364826,607,723 - 6,610,161 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl830,159,754 - 30,180,650 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1830,159,744 - 30,180,650 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2831,642,296 - 31,644,684 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLR6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12711,439,288 - 11,461,580 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2711,459,181 - 11,461,571 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604757,852,558 - 57,878,018 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlr6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248407,323,022 - 7,349,334 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tlr6
623 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:72
Interacting mature miRNAs:75
Transcripts:ENSMUST00000062315
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
11353827Hplq1_mhot plate latency 1 (mouse)53157045865570458Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
10043995Hbnr9_mHeligmosomoides bakeri nematode resistance 9 (mouse)Not determined53348866767488876Mouse
1301845Lxw4_mlupus BXSB x NZW 4 (mouse)Not determined53569446269694594Mouse
11049561Lmr24e_mleishmaniasis resistance 24e (mouse)53569446269694594Mouse
11049559Lmr24c_mleishmaniasis resistance 24c (mouse)53569446269694594Mouse
11049558Lmr24b_mleishmaniasis resistance 24b (mouse)53569446269694594Mouse
1301223Hdlq7_mHDL QTL 7 (mouse)Not determined53585456869854714Mouse
13464252Ahl10_mage related hearing loss, early onset 10 (mouse)53585456869854714Mouse
4141647Hrvhf1_mheart rate variability, high frequency 1 (mouse)Not determined3643342370433423Mouse
1301170Lith13_mlithogenic gene 13 (mouse)Not determined53649448670494598Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
13464246Ahl11_mage related hearing loss, early onset 11 (mouse)53764377771643896Mouse
1300951Gbvq1_mgallstone bladder volume QTL 1 (mouse)Not determined53811168172111798Mouse
13464245Ahl12_mage related hearing loss, early onset 12 (mouse)53811168172111798Mouse
1301698Pcfm4_mperiosteal circumference and femur length 4 (mouse)Not determined54458584378585965Mouse
13207584Mwmlpt4_mMorris water maze latency to platform, training, 4 (mouse)54632260680322606Mouse
13207588Mwmlpa4_mMorris water maze latency to platform, all, 4 (mouse)54632260680322606Mouse
14746981Manh57_mmandible shape 57 (mouse)54716974281169742Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
13464248Ahl13_mage related hearing loss, early onset 13 (mouse)55564587489645995Mouse
10043962Obq27_mobesity QTL 27 (mouse)Not determined55628565590285655Mouse
10044005Ahl7_mage related hearing loss 7 (mouse)Not determined55833050292330641Mouse
11040591Lmr3c_mleishmaniasis resistance 3c (mouse)55960280193602980Mouse
11040592Lmr3d_mleishmaniasis resistance 3d (mouse)55960280193602980Mouse
11040589Lmr3a_mleishmaniasis resistance 3a (mouse)55960280193602980Mouse
11040590Lmr3b_mleishmaniasis resistance 3b (mouse)55960280193602980Mouse
1301843Listr1_mlisteriosis resistance 1 (mouse)Not determined56024608194246203Mouse
13464247Ahl14_mage related hearing loss, early onset 14 (mouse)56040306294403160Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56265056896650688Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6265056896650688Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56265056896650688Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
11049560Lmr24d_mleishmaniasis resistance 24d (mouse)56437487798374996Mouse

Markers in Region
AB020808  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38564,953,032 - 64,953,120UniSTSGRCm38
MGSCv37565,344,271 - 65,344,359UniSTSGRCm37
Celera562,225,837 - 62,225,925UniSTS
Cytogenetic Map5C3.1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000062315   ⟹   ENSMUSP00000062096
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl565,109,374 - 65,117,390 (-)Ensembl
GRCm38.p6 Ensembl564,952,031 - 64,960,047 (-)Ensembl
RefSeq Acc Id: ENSMUST00000201307   ⟹   ENSMUSP00000143865
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl565,112,566 - 65,117,440 (-)Ensembl
GRCm38.p6 Ensembl564,955,223 - 64,960,097 (-)Ensembl
RefSeq Acc Id: ENSMUST00000239485   ⟹   ENSMUSP00000159286
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl565,110,449 - 65,117,391 (-)Ensembl
GRCm38.p6 Ensembl564,953,106 - 64,960,048 (-)Ensembl
RefSeq Acc Id: NM_001359180   ⟹   NP_001346109
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39565,109,373 - 65,117,391 (-)NCBI
GRCm38564,953,106 - 64,960,048 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001384171   ⟹   NP_001371100
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39565,109,373 - 65,117,391 (-)NCBI
GRCm38564,953,095 - 64,959,166 (-)NCBI
Sequence:
RefSeq Acc Id: NM_011604   ⟹   NP_035734
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39565,109,373 - 65,117,391 (-)NCBI
GRCm38564,953,106 - 64,960,048 (-)NCBI
MGSCv37565,344,334 - 65,351,273 (-)RGD
Celera562,225,900 - 62,232,840 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030254364   ⟹   XP_030110224
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39565,109,379 - 65,128,387 (-)NCBI
GRCm38564,953,092 - 64,970,942 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036164995   ⟹   XP_036020888
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39565,109,379 - 65,127,221 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_035734   ⟸   NM_011604
- Peptide Label: precursor
- UniProtKB: Q9EPW9 (UniProtKB/Swiss-Prot),   Q9WTQ4 (UniProtKB/Swiss-Prot),   Q7TPC5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030110224   ⟸   XM_030254364
- Peptide Label: isoform X1
- UniProtKB: Q3UV88 (UniProtKB/TrEMBL),   Q7TPC5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001346109   ⟸   NM_001359180
- Peptide Label: precursor
- UniProtKB: Q9EPW9 (UniProtKB/Swiss-Prot),   Q9WTQ4 (UniProtKB/Swiss-Prot),   Q7TPC5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001371100   ⟸   NM_001384171
- Peptide Label: precursor
- UniProtKB: Q9EPW9 (UniProtKB/Swiss-Prot),   Q9WTQ4 (UniProtKB/Swiss-Prot),   Q7TPC5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000159286   ⟸   ENSMUST00000239485
RefSeq Acc Id: ENSMUSP00000062096   ⟸   ENSMUST00000062315
RefSeq Acc Id: ENSMUSP00000143865   ⟸   ENSMUST00000201307
RefSeq Acc Id: XP_036020888   ⟸   XM_036164995
- Peptide Label: isoform X1
- UniProtKB: Q3UV88 (UniProtKB/TrEMBL),   Q7TPC5 (UniProtKB/TrEMBL)
Protein Domains
LRRCT   TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EPW9-F1-model_v2 AlphaFold Q9EPW9 1-795 view protein structure

Promoters
RGD ID:6886752
Promoter ID:EPDNEW_M6827
Type:initiation region
Name:Tlr6_1
Description:Mus musculus toll-like receptor 6 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38564,960,048 - 64,960,108EPDNEW
RGD ID:6838494
Promoter ID:MM_KWN:42365
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:ENSMUST00000062315,   UC008XMY.2
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36565,350,641 - 65,351,141 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1341296 AgrOrtholog
Ensembl Genes ENSMUSG00000051498 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000062315 UniProtKB/TrEMBL
  ENSMUST00000062315.7 UniProtKB/Swiss-Prot
  ENSMUST00000201307.3 UniProtKB/TrEMBL
  ENSMUST00000239485 ENTREZGENE
  ENSMUST00000239485.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toll-like_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1341296 ENTREZGENE
NCBI Gene 21899 ENTREZGENE
PANTHER PTHR24365 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24365:SF422 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tlr6 PhenoGen
PIRSF Toll-like_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS INTRLKN1R1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0J9YTV4_MOUSE UniProtKB/TrEMBL
  Q0PM14_MOUSE UniProtKB/TrEMBL
  Q3UV88 ENTREZGENE, UniProtKB/TrEMBL
  Q7TPC5 ENTREZGENE, UniProtKB/TrEMBL
  Q9EPW9 ENTREZGENE
  Q9WTQ4 ENTREZGENE
  TLR6_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q9WTQ4 UniProtKB/Swiss-Prot