Rcor2 (REST corepressor 2) - Rat Genome Database

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Gene: Rcor2 (REST corepressor 2) Mus musculus
Analyze
Symbol: Rcor2
Name: REST corepressor 2
RGD ID: 1552246
MGI Page MGI
Description: Enables enzyme binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; retina; and skeleton. Orthologous to human RCOR2 (REST corepressor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1A1; 1A13; AW122124; co-repressor of Rest; CoR; CoREST; M-CoREST; Rcor; Rcor1; RE1-silencing transcription factor (REST) co-repressor 1; REST co-repressor 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39197,244,759 - 7,252,590 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl197,244,690 - 7,252,590 (+)EnsemblGRCm39 Ensembl
GRCm38197,267,394 - 7,275,225 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl197,267,325 - 7,275,225 (+)EnsemblGRCm38mm10GRCm38
MGSCv37197,344,255 - 7,349,715 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36197,327,144 - 7,342,269 (+)NCBIMGSCv36mm8
Celera197,041,658 - 7,047,118 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Ballas N, etal., Cell 2005 May 20;121(4):645-57.
2. The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex. Grimes JA, etal., J Biol Chem 2000 Mar 31;275(13):9461-7.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Identification and localization of M-CoREST (1A13), a mouse homologue of the human transcriptional co-repressor CoREST, in the developing mouse CNS. Tontsch S, etal., Mech Dev 2001 Oct;108(1-2):165-9.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12904583   PMID:14610273   PMID:15226823   PMID:15489334   PMID:15618518   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:16602821   PMID:17392792   PMID:17707228   PMID:18287559   PMID:18799693   PMID:19345177   PMID:19424149   PMID:19497860   PMID:19888342   PMID:19997604  
PMID:20059953   PMID:20362541   PMID:20362542   PMID:20412781   PMID:20713442   PMID:20823235   PMID:21267068   PMID:21433225   PMID:21536733   PMID:21677750   PMID:21731673   PMID:21873635  
PMID:21878487   PMID:22083510   PMID:22570500   PMID:23576758   PMID:23592795   PMID:23595969   PMID:23892456   PMID:24105743   PMID:24496614   PMID:24652990   PMID:24794437   PMID:24843136  
PMID:24952961   PMID:25051986   PMID:25074806   PMID:25575549   PMID:25793264   PMID:26206133   PMID:26365490   PMID:26795843   PMID:27112428   PMID:28049845   PMID:28671696   PMID:28744012  
PMID:29256041   PMID:30186101   PMID:30442713   PMID:30973865   PMID:31202927   PMID:32325033   PMID:34321999   PMID:34709266   PMID:35345626   PMID:35762573  


Genomics

Comparative Map Data
Rcor2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39197,244,759 - 7,252,590 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl197,244,690 - 7,252,590 (+)EnsemblGRCm39 Ensembl
GRCm38197,267,394 - 7,275,225 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl197,267,325 - 7,275,225 (+)EnsemblGRCm38mm10GRCm38
MGSCv37197,344,255 - 7,349,715 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36197,327,144 - 7,342,269 (+)NCBIMGSCv36mm8
Celera197,041,658 - 7,047,118 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.32NCBI
RCOR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381163,911,230 - 63,927,762 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1163,911,230 - 63,917,164 (-)EnsemblGRCh38hg38GRCh38
GRCh371163,678,702 - 63,684,636 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,435,278 - 63,440,892 (-)NCBINCBI36Build 36hg18NCBI36
Build 341163,435,279 - 63,440,892NCBI
Celera1161,004,887 - 61,010,510 (-)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1160,007,723 - 60,013,347 (-)NCBIHuRef
CHM1_11163,561,706 - 63,567,330 (-)NCBICHM1_1
T2T-CHM13v2.01163,900,584 - 63,917,122 (-)NCBIT2T-CHM13v2.0
Rcor2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,882,585 - 213,890,022 (+)NCBIGRCr8
mRatBN7.21204,453,403 - 204,461,403 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1204,454,360 - 204,460,838 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,804,250 - 212,810,716 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01219,899,612 - 219,906,074 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01212,590,658 - 212,597,120 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,513,970 - 222,525,356 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,519,615 - 222,524,779 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01523,568,509 - 23,574,620 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,951,234 - 209,957,329 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11210,109,663 - 210,115,758 (+)NCBI
Celera1201,987,882 - 201,993,898 (+)NCBICelera
Cytogenetic Map1q43NCBI
Rcor2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542221,102,022 - 21,111,974 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542221,102,185 - 21,111,974 (+)NCBIChiLan1.0ChiLan1.0
RCOR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2965,138,240 - 65,144,162 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11166,183,441 - 66,189,363 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01159,268,592 - 59,274,534 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11162,618,972 - 62,624,732 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1162,618,975 - 62,624,732 (-)Ensemblpanpan1.1panPan2
RCOR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11853,096,599 - 53,101,427 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1853,096,592 - 53,100,808 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1851,702,388 - 51,707,358 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01854,140,672 - 54,145,644 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1854,140,293 - 54,145,660 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11853,243,316 - 53,248,285 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01852,819,199 - 52,823,656 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01853,603,241 - 53,608,208 (+)NCBIUU_Cfam_GSD_1.0
Rcor2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049478,778,031 - 8,784,051 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365995,220,350 - 5,226,402 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365995,220,380 - 5,226,397 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RCOR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl28,148,526 - 8,153,677 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.128,146,680 - 8,153,680 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.227,350,360 - 7,352,881 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RCOR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1110,330,137 - 10,336,485 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl110,330,387 - 10,336,469 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038107,669,947 - 107,675,920 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rcor2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476722,341,078 - 22,346,408 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476722,341,172 - 22,346,289 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rcor2
299 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:687
Count of miRNA genes:373
Interacting mature miRNAs:419
Transcripts:ENSMUST00000066646, ENSMUST00000113369, ENSMUST00000134167, ENSMUST00000140442
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300776Lfp3_mlong free running period 3 (mouse)Not determined19120328703Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse
25394536Skmw86_mskeletal muscle weight 86, TA (mouse)1950648178957825Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse

Markers in Region
AU024026  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38197,275,567 - 7,275,685UniSTSGRCm38
MGSCv37197,350,057 - 7,350,175UniSTSGRCm37
Celera197,047,460 - 7,047,578UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map19BUniSTS
cM Map193.0UniSTS
Whitehead/MRC_RH1934.54UniSTS
AW122124  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38197,274,985 - 7,275,132UniSTSGRCm38
MGSCv37197,349,475 - 7,349,622UniSTSGRCm37
Celera197,046,878 - 7,047,025UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map19BUniSTS
cM Map193.0UniSTS
Whitehead/MRC_RH1929.63UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000066646   ⟹   ENSMUSP00000063335
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl197,245,644 - 7,252,590 (+)Ensembl
GRCm38.p6 Ensembl197,268,279 - 7,275,225 (+)Ensembl
RefSeq Acc Id: ENSMUST00000113369   ⟹   ENSMUSP00000108996
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl197,247,129 - 7,252,589 (+)Ensembl
GRCm38.p6 Ensembl197,269,764 - 7,275,224 (+)Ensembl
RefSeq Acc Id: ENSMUST00000134167
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl197,248,317 - 7,249,134 (+)Ensembl
GRCm38.p6 Ensembl197,270,952 - 7,271,769 (+)Ensembl
RefSeq Acc Id: ENSMUST00000140442   ⟹   ENSMUSP00000114858
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl197,244,690 - 7,247,509 (+)Ensembl
GRCm38.p6 Ensembl197,267,325 - 7,270,144 (+)Ensembl
RefSeq Acc Id: NM_001320554   ⟹   NP_001307483
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39197,245,644 - 7,252,590 (+)NCBI
GRCm38197,268,279 - 7,275,225 (+)NCBI
Sequence:
RefSeq Acc Id: NM_054048   ⟹   NP_473389
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39197,244,759 - 7,252,590 (+)NCBI
GRCm38197,267,394 - 7,275,225 (+)NCBI
MGSCv37197,344,255 - 7,349,715 (+)RGD
Celera197,041,658 - 7,047,118 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006526551   ⟹   XP_006526614
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39197,245,626 - 7,252,590 (+)NCBI
GRCm38197,268,261 - 7,275,225 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030250677   ⟹   XP_030106537
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39197,245,650 - 7,252,590 (+)NCBI
GRCm38197,268,285 - 7,275,225 (+)NCBI
Sequence:
RefSeq Acc Id: NP_473389   ⟸   NM_054048
- UniProtKB: Q9JMK4 (UniProtKB/Swiss-Prot),   Q8C796 (UniProtKB/Swiss-Prot),   A0A0R4J1I0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006526614   ⟸   XM_006526551
- Peptide Label: isoform X1
- UniProtKB: A0A0R4J1I0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001307483   ⟸   NM_001320554
- UniProtKB: Q9JMK4 (UniProtKB/Swiss-Prot),   Q8C796 (UniProtKB/Swiss-Prot),   A0A0R4J1I0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030106537   ⟸   XM_030250677
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000063335   ⟸   ENSMUST00000066646
RefSeq Acc Id: ENSMUSP00000108996   ⟸   ENSMUST00000113369
RefSeq Acc Id: ENSMUSP00000114858   ⟸   ENSMUST00000140442
Protein Domains
ELM2   SANT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8C796-F1-model_v2 AlphaFold Q8C796 1-523 view protein structure

Promoters
RGD ID:13678740
Promoter ID:EPDNEW_M23519
Type:initiation region
Name:Rcor2_1
Description:Mus musculus REST corepressor 2 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38197,268,279 - 7,268,339EPDNEW
RGD ID:6830368
Promoter ID:MM_KWN:26247
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   ES_Cell,   Lung
Transcripts:OTTMUST00000041974,   UC008GKN.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36197,341,271 - 7,341,902 (+)MPROMDB
RGD ID:6830364
Promoter ID:MM_KWN:26248
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   ES_Cell,   Lung
Transcripts:OTTMUST00000041945
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36197,341,931 - 7,343,282 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1859854 AgrOrtholog
Ensembl Genes ENSMUSG00000024968 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000066646 ENTREZGENE
  ENSMUST00000066646.12 UniProtKB/Swiss-Prot
  ENSMUST00000113369 ENTREZGENE
  ENSMUST00000113369.3 UniProtKB/TrEMBL
  ENSMUST00000140442.8 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.1880 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.1240.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ELM2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REST_helical UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SANT/Myb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SANT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:104383 UniProtKB/Swiss-Prot
MGD MGI:1859854 ENTREZGENE
NCBI Gene 104383 ENTREZGENE
PANTHER REST COREPRESSOR 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REST COREPRESSOR COREST PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ELM2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myb_DNA-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REST_helical UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rcor2 PhenoGen
PROSITE ELM2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SANT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ELM2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SANT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J1I0 ENTREZGENE, UniProtKB/TrEMBL
  D3YUX3_MOUSE UniProtKB/TrEMBL
  Q8C796 ENTREZGENE
  Q9JMK4 ENTREZGENE
  RCOR2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q9JMK4 UniProtKB/Swiss-Prot