Panx1 (pannexin 1) - Rat Genome Database

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Gene: Panx1 (pannexin 1) Mus musculus
Analyze
Symbol: Panx1
Name: pannexin 1
RGD ID: 1552235
MGI Page MGI
Description: Exhibits actin filament binding activity and channel activity. Involved in several processes, including positive regulation of interleukin-1 production; response to ATP; and response to ischemia. Localizes to plasma membrane. Is expressed in male reproductive gland or organ; nervous system; sensory organ; and submandibular gland primordium. Orthologous to human PANX1 (pannexin 1); PARTICIPATES IN neuron-to-neuron signaling pathway via the electrical synapse; INTERACTS WITH 1,2-dimethylhydrazine; 3'-O-(4-Benzoyl)benzoyl ATP; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI847747; pannexin-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39914,917,081 - 14,956,774 (-)NCBIGRCm39mm39
GRCm39 Ensembl914,913,424 - 14,956,774 (-)Ensembl
GRCm38915,005,785 - 15,045,478 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl915,002,128 - 15,045,478 (-)EnsemblGRCm38mm10GRCm38
MGSCv37914,810,229 - 14,849,922 (-)NCBIGRCm37mm9NCBIm37
MGSCv36914,756,178 - 14,795,871 (-)NCBImm8
Celera912,286,408 - 12,326,356 (-)NCBICelera
Cytogenetic Map9A2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10898987   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14597722   PMID:15028292   PMID:15661370   PMID:15782199   PMID:16026466  
PMID:16141072   PMID:16141073   PMID:16143426   PMID:16616526   PMID:17009242   PMID:17149368   PMID:17379420   PMID:17389364   PMID:17433728   PMID:17925379   PMID:18322214   PMID:18490713  
PMID:18596211   PMID:18649185   PMID:18695503   PMID:18945939   PMID:19009624   PMID:19047635   PMID:19056988   PMID:19130485   PMID:19213873   PMID:19416975   PMID:19474335   PMID:19692571  
PMID:19780818   PMID:20086016   PMID:20332104   PMID:20664064   PMID:20829356   PMID:21267068   PMID:21505260   PMID:21508259   PMID:21546608   PMID:21606493   PMID:21677750   PMID:21865551  
PMID:21873635   PMID:21949881   PMID:21983290   PMID:22002608   PMID:22147915   PMID:22235111   PMID:22267745   PMID:22311983   PMID:22384122   PMID:22426419   PMID:22458943   PMID:22499153  
PMID:22753409   PMID:22768083   PMID:22785119   PMID:22797941   PMID:22915101   PMID:22945868   PMID:22952282   PMID:22956545   PMID:22956847   PMID:22965528   PMID:22982782   PMID:23033481  
PMID:23111424   PMID:23284764   PMID:23390418   PMID:23449592   PMID:23549611   PMID:23583931   PMID:23659289   PMID:23675350   PMID:23742824   PMID:23827947   PMID:23885286   PMID:23964896  
PMID:24194600   PMID:24522432   PMID:24531690   PMID:24590064   PMID:24646995   PMID:24668173   PMID:24694658   PMID:24751934   PMID:24839011   PMID:24860098   PMID:24885326   PMID:25056878  
PMID:25070895   PMID:25080488   PMID:25100586   PMID:25170954   PMID:25309319   PMID:25360084   PMID:25605289   PMID:25637780   PMID:25690012   PMID:25796110   PMID:25819435   PMID:25947940  
PMID:25987548   PMID:26002464   PMID:26035172   PMID:26109673   PMID:26126730   PMID:26136251   PMID:26163370   PMID:26195825   PMID:26242575   PMID:26386583   PMID:26453396   PMID:26553756  
PMID:26572062   PMID:26573818   PMID:26596404   PMID:26792207   PMID:26818508   PMID:26828725   PMID:26839965   PMID:27076682   PMID:27099931   PMID:27159053   PMID:27255725   PMID:27548819  
PMID:27626380   PMID:27769744   PMID:27784763   PMID:27797339   PMID:27910899   PMID:28134928   PMID:28158679   PMID:28195232   PMID:28445139   PMID:28705898   PMID:28751666   PMID:28780469  
PMID:28855161   PMID:29057961   PMID:29087614   PMID:29098296   PMID:29221793   PMID:29234270   PMID:29246445   PMID:29563335   PMID:29643381   PMID:29710868   PMID:29744875   PMID:29745255  
PMID:29848662   PMID:29866797   PMID:29952014   PMID:29987408   PMID:30077007   PMID:30377218   PMID:30385873   PMID:30655582   PMID:30745457   PMID:30814251   PMID:30862176   PMID:30902848  
PMID:30918989   PMID:30952430   PMID:31033038   PMID:31118206   PMID:31202174   PMID:31202927   PMID:31411729   PMID:31554905   PMID:31818976   PMID:31849935   PMID:32070042   PMID:32132172  
PMID:32238926   PMID:32241676   PMID:32260308   PMID:32819386   PMID:33449849  


Genomics

Comparative Map Data
Panx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39914,917,081 - 14,956,774 (-)NCBIGRCm39mm39
GRCm39 Ensembl914,913,424 - 14,956,774 (-)Ensembl
GRCm38915,005,785 - 15,045,478 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl915,002,128 - 15,045,478 (-)EnsemblGRCm38mm10GRCm38
MGSCv37914,810,229 - 14,849,922 (-)NCBIGRCm37mm9NCBIm37
MGSCv36914,756,178 - 14,795,871 (-)NCBImm8
Celera912,286,408 - 12,326,356 (-)NCBICelera
Cytogenetic Map9A2NCBI
PANX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1194,128,841 - 94,181,968 (+)EnsemblGRCh38hg38GRCh38
GRCh381194,128,841 - 94,185,596 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371193,862,007 - 93,915,134 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361193,501,742 - 93,554,786 (+)NCBINCBI36hg18NCBI36
Build 341193,501,741 - 93,554,783NCBI
Celera1191,149,894 - 91,202,958 (+)NCBI
Cytogenetic Map11q21NCBI
HuRef1189,937,250 - 89,990,295 (+)NCBIHuRef
CHM1_11193,745,100 - 93,798,158 (+)NCBICHM1_1
Panx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2811,851,176 - 11,889,774 (-)NCBI
Rnor_6.0 Ensembl813,566,739 - 13,606,040 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0813,567,185 - 13,606,040 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0813,508,401 - 13,547,151 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4811,809,752 - 11,849,392 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1811,809,751 - 11,849,392 (-)NCBI
Celera813,320,676 - 13,358,794 (-)NCBICelera
Cytogenetic Map8q12NCBI
Panx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955414401,188 - 448,470 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955414405,483 - 448,470 (-)NCBIChiLan1.0ChiLan1.0
PANX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11192,628,760 - 92,685,118 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1192,628,760 - 92,685,109 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01189,142,686 - 89,295,972 (+)NCBIMhudiblu_PPA_v0panPan3
PANX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1216,665,730 - 6,715,272 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl216,668,269 - 6,715,858 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha216,675,643 - 6,724,808 (-)NCBI
ROS_Cfam_1.0216,846,046 - 6,895,302 (-)NCBI
UMICH_Zoey_3.1216,626,593 - 6,676,016 (-)NCBI
UNSW_CanFamBas_1.0216,695,903 - 6,745,264 (-)NCBI
UU_Cfam_GSD_1.0216,746,177 - 6,795,582 (-)NCBI
Panx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494779,118,039 - 79,154,514 (+)NCBI
SpeTri2.0NW_004936674736,911 - 773,406 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PANX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl926,443,815 - 26,491,002 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1926,443,425 - 26,491,010 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2930,047,789 - 30,182,476 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PANX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1185,356,507 - 85,413,146 (+)NCBI
ChlSab1.1 Ensembl185,356,610 - 85,409,275 (+)Ensembl
Vero_WHO_p1.0NW_02366604340,394,937 - 40,454,501 (-)NCBI
Panx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473538,766,973 - 38,823,284 (+)NCBI

Position Markers
AI847747  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A2UniSTS
Whitehead/MRC_RH9195.11UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142326Tgq19_mtriglyceride QTL 19 (mouse)Not determined121060750Mouse
1300899Chol6_mcholesterol 6 (mouse)Not determined9129902908Mouse
13434920Dcollq1_mdifferential colonization level QTL 1 (mouse)9130430544Mouse
35673312Ari7_mantibody response to influenza 7, day 45, IgG3 (mouse)9780000022300000Mouse
1300849Sles4_msystemic lupus erythmatosus suppressor 4 (mouse)Not determined9910756137395074Mouse
13504833Bglu19_mblood glucose level 19 (mouse)9999947243999472Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91245867446458818Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91347987947479879Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:993
Count of miRNA genes:499
Interacting mature miRNAs:598
Transcripts:ENSMUST00000056755, ENSMUST00000164273, ENSMUST00000166933, ENSMUST00000169288
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000056755   ⟹   ENSMUSP00000053557
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl915,005,785 - 15,045,478 (-)Ensembl
RefSeq Acc Id: ENSMUST00000164273   ⟹   ENSMUSP00000126405
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl915,002,128 - 15,045,478 (-)Ensembl
RefSeq Acc Id: ENSMUST00000166933
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl915,007,918 - 15,010,508 (-)Ensembl
RefSeq Acc Id: ENSMUST00000169288   ⟹   ENSMUSP00000132764
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl915,010,086 - 15,043,797 (-)Ensembl
RefSeq Acc Id: NM_019482   ⟹   NP_062355
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39914,917,081 - 14,956,774 (-)NCBI
GRCm38915,005,785 - 15,045,478 (-)NCBI
MGSCv37914,810,229 - 14,849,922 (-)RGD
Celera912,286,408 - 12,326,356 (-)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062355   ⟸   NM_019482
- UniProtKB: Q9JIP4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000126405   ⟸   ENSMUST00000164273
RefSeq Acc Id: ENSMUSP00000132764   ⟸   ENSMUST00000169288
RefSeq Acc Id: ENSMUSP00000053557   ⟸   ENSMUST00000056755

Promoters
RGD ID:6844902
Promoter ID:MM_KWN:56409
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Lung,   MEF_B4,   Spleen
Transcripts:NM_019482
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36914,849,574 - 14,850,074 (-)MPROMDB
RGD ID:8668832
Promoter ID:EPDNEW_M12447
Type:initiation region
Name:Panx1_1
Description:Mus musculus pannexin 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38915,045,454 - 15,045,514EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1860055 AgrOrtholog
Ensembl Genes ENSMUSG00000031934 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000053557 UniProtKB/TrEMBL
  ENSMUSP00000126405 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000132764 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000056755 UniProtKB/TrEMBL
  ENSMUST00000164273 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000169288 UniProtKB/TrEMBL
InterPro Innexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pannexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:55991 UniProtKB/Swiss-Prot
MGD MGI:1860055 ENTREZGENE
NCBI Gene 55991 ENTREZGENE
PANTHER PTHR15759 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Innexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Panx1 PhenoGen
PROSITE PANNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B1PL19_MOUSE UniProtKB/TrEMBL
  E9PY07_MOUSE UniProtKB/TrEMBL
  PANX1_MOUSE UniProtKB/Swiss-Prot
  Q3U181_MOUSE UniProtKB/TrEMBL
  Q9JIP4 ENTREZGENE
UniProt Secondary Q5RL18 UniProtKB/Swiss-Prot
  Q9CXS7 UniProtKB/Swiss-Prot