Has1 (hyaluronan synthase 1) - Rat Genome Database

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Gene: Has1 (hyaluronan synthase 1) Mus musculus
Analyze
Symbol: Has1
Name: hyaluronan synthase 1
RGD ID: 1552209
MGI Page MGI
Description: Exhibits hyaluronan synthase activity. Involved in extracellular matrix assembly; extracellular polysaccharide biosynthetic process; and hyaluronan biosynthetic process. Localizes to cytoplasm and membrane. Is expressed in several structures, including alimentary system; embryo mesenchyme; gonad; heart; and skin. Orthologous to human HAS1 (hyaluronan synthase 1); INTERACTS WITH 17beta-estradiol; 4-hydroxyphenyl retinamide; 5-aza-2'-deoxycytidine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: HA synthase 1; HAS; hyaluronan synthase1; hyaluronate synthase 1; hyaluronic acid synthase 1; MGC159127; MGC159129
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391718,063,588 - 18,075,450 (-)NCBIGRCm39mm39
GRCm39 Ensembl1718,063,585 - 18,075,467 (-)Ensembl
GRCm381717,833,691 - 17,855,589 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1717,843,323 - 17,855,205 (-)EnsemblGRCm38mm10GRCm38
MGSCv371717,980,290 - 17,992,152 (-)NCBIGRCm37mm9NCBIm37
MGSCv361717,547,941 - 17,559,804 (-)NCBImm8
Celera1718,784,007 - 18,795,939 (-)NCBICelera
Cytogenetic Map17A3.2NCBI
cM Map1710.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:13782   PMID:8626618   PMID:8798544   PMID:8889548   PMID:9016821   PMID:9169154   PMID:9206724   PMID:9442026   PMID:9457904   PMID:9494089   PMID:10093717   PMID:10349636  
PMID:10455188   PMID:10617644   PMID:11006212   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11431361   PMID:12477932   PMID:14681479   PMID:14724275   PMID:15765504   PMID:15854028  
PMID:16110480   PMID:16141072   PMID:16141073   PMID:19320776   PMID:20823158   PMID:21267068   PMID:21677750   PMID:21850020   PMID:21873635   PMID:22529214   PMID:22654110   PMID:22785117  
PMID:23382716   PMID:24057227   PMID:24194600   PMID:24790187   PMID:25384213   PMID:27289075   PMID:27626380   PMID:28863216   PMID:29672913   PMID:29966020   PMID:30897620   PMID:32623025  


Genomics

Comparative Map Data
Has1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391718,063,588 - 18,075,450 (-)NCBIGRCm39mm39
GRCm39 Ensembl1718,063,585 - 18,075,467 (-)Ensembl
GRCm381717,833,691 - 17,855,589 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1717,843,323 - 17,855,205 (-)EnsemblGRCm38mm10GRCm38
MGSCv371717,980,290 - 17,992,152 (-)NCBIGRCm37mm9NCBIm37
MGSCv361717,547,941 - 17,559,804 (-)NCBImm8
Celera1718,784,007 - 18,795,939 (-)NCBICelera
Cytogenetic Map17A3.2NCBI
cM Map1710.53NCBI
HAS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1951,713,112 - 51,723,991 (-)EnsemblGRCh38hg38GRCh38
GRCh381951,713,112 - 51,723,991 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371952,216,365 - 52,227,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,908,177 - 56,919,033 (-)NCBINCBI36hg18NCBI36
Build 341956,908,176 - 56,919,033NCBI
Celera1949,265,901 - 49,276,762 (-)NCBI
Cytogenetic Map19q13.41NCBI
HuRef1948,547,305 - 48,558,022 (-)NCBIHuRef
CHM1_11952,218,163 - 52,229,071 (-)NCBICHM1_1
Has1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2158,693,411 - 58,705,653 (-)NCBI
Rnor_6.0 Ensembl159,720,612 - 59,732,409 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0159,720,612 - 59,732,409 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0160,640,270 - 60,652,067 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4156,503,365 - 56,516,133 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1156,506,309 - 56,519,078 (-)NCBI
Celera154,874,356 - 54,879,329 (-)NCBICelera
Cytogenetic Map1q12NCBI
Has1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955558826,853 - 836,809 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955558826,853 - 836,809 (+)NCBIChiLan1.0ChiLan1.0
HAS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11957,537,049 - 57,547,804 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1957,537,049 - 57,547,804 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01948,657,165 - 48,668,130 (-)NCBIMhudiblu_PPA_v0panPan3
HAS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11105,376,091 - 105,386,043 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1105,376,536 - 105,385,134 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1104,949,702 - 104,959,564 (+)NCBI
ROS_Cfam_1.01105,886,101 - 105,895,963 (+)NCBI
UMICH_Zoey_3.11105,558,334 - 105,568,196 (+)NCBI
UNSW_CanFamBas_1.01105,199,396 - 105,209,300 (+)NCBI
UU_Cfam_GSD_1.01105,994,224 - 106,004,086 (+)NCBI
Has1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093494,768,242 - 4,775,106 (+)NCBI
SpeTri2.0NW_004937026125,622 - 132,141 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl658,307,029 - 58,313,486 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1658,303,274 - 58,313,486 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2651,877,028 - 51,888,298 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HAS1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1644,540,036 - 44,552,396 (-)NCBI
ChlSab1.1 Ensembl644,540,363 - 44,547,711 (-)Ensembl
Vero_WHO_p1.0NW_02366607324,594,280 - 24,606,885 (-)NCBI
Has1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248323,327,626 - 3,341,928 (+)NCBI

Position Markers
AW488161  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381717,843,598 - 17,843,685UniSTSGRCm38
MGSCv371717,980,562 - 17,980,649UniSTSGRCm37
Celera1718,784,279 - 18,784,366UniSTS
Cytogenetic Map17A3.2UniSTS
Whitehead/MRC_RH17235.56UniSTS
D82964  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381717,843,386 - 17,843,470UniSTSGRCm38
MGSCv371717,980,350 - 17,980,434UniSTSGRCm37
Celera1718,784,067 - 18,784,151UniSTS
Cytogenetic Map17A3.2UniSTS
Whitehead/MRC_RH17236.06UniSTS
Whitehead/MRC_RH17238.46UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357452Vtbt18_mvertebral trabecular bone trait 18 (mouse)Not determined17120924747Mouse
1302196Myaa1_mmodifier of Yaa 1 (mouse)Not determined17120924747Mouse
1357902Obq19_mobesity QTL 19 (mouse)Not determined17125443244Mouse
12910982Pifs2_mpeptide-induced fatal syndrome 2 (mouse)17125970523Mouse
1357743Lith3_mlithogenic gene 3 (mouse)Not determined17125975624Mouse
1300613Pcyts4_mplasmacytoma susceptibility 4 (mouse)Not determined17126862710Mouse
1301615Cfld3_mcystic fibrosis lung disease 3 (mouse)Not determined17126862710Mouse
1302100Circp2_mcircadian photosensitivity 2 (mouse)Not determined17128979566Mouse
12910527Nrq1a_mnoise-induced hearing loss resistant QTL 1a (mouse)17128979566Mouse
12910528Nrq1_mnoise-induced hearing loss resistant QTL 1 (mouse)17128979566Mouse
13524851Asrq8_macoustic startle response 8 (mouse)17130809908Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17312791337128037Mouse
1357680Idd23_minsulin dependent diabetes susceptibility 23 (mouse)Not determined17392461526182159Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17392461548559063Mouse
1301327Lmr7_mleishmaniasis resistance 7 (mouse)Not determined17480447727496965Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined480447745359340Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17480447746158776Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17480447747574740Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined480447765330362Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17667496240674962Mouse
4141608Phl1_mprogressive hearing loss 1 (mouse)Not determined17765701129268449Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17836594042366175Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17836594042366175Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171065914544659245Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1098759739053168Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1166699745667145Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171177921045779210Mouse
4142507Obrq13_mobesity resistance QTL 13 (mouse)Not determined1197944224857795Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171223281346232813Mouse
1558807Ceat1_mchronic experimental autoimmune thyroiditis 1 (mouse)Not determined171241779526182159Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171242798746427987Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171390439847904522Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171484267848842786Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171484267848842786Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171484267848842786Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171484267848842786Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171660074750600869Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171660074750600869Mouse
1301505Tir1_mtrypanosome infection response 1 (mouse)Not determined171660074750600869Mouse
1302038Radpf1_mradiation pulmonary fibrosis 1 (mouse)Not determined171661519333600869Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171681096950811104Mouse
1302042Acsns3_mAngiostrongylus costaricensis nematode susceptibility 3 (mouse)Not determined171724323451243371Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171724323451243371Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171724323451243371Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171724323451243371Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171724323451243371Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:107
Count of miRNA genes:97
Interacting mature miRNAs:106
Transcripts:ENSMUST00000003762
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000003762   ⟹   ENSMUSP00000003762
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1717,843,323 - 17,855,188 (-)Ensembl
RefSeq Acc Id: ENSMUST00000232410
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1717,847,176 - 17,855,205 (-)Ensembl
RefSeq Acc Id: NM_008215   ⟹   NP_032241
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391718,063,588 - 18,075,450 (-)NCBI
GRCm381717,843,326 - 17,855,188 (-)NCBI
MGSCv371717,980,290 - 17,992,152 (-)RGD
Celera1718,784,007 - 18,795,939 (-)RGD
cM Map17 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032241   ⟸   NM_008215
- UniProtKB: Q61647 (UniProtKB/Swiss-Prot),   Q3UUP6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000003762   ⟸   ENSMUST00000003762

Promoters
RGD ID:13674862
Promoter ID:EPDNEW_M21580
Type:single initiation site
Name:Has1_1
Description:Mus musculus hyaluronan synthase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381717,855,201 - 17,855,261EPDNEW
RGD ID:6849066
Promoter ID:MM_XEF:3008
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Lung,   Spleen
Transcripts:NM_001112611,   NM_001127118,   NM_001136212,   NM_001164030,   NM_001523
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361717,987,039 - 17,987,539 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:106590 AgrOrtholog
Ensembl Genes ENSMUSG00000003665 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000003762 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000003762 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.550.10 UniProtKB/TrEMBL
InterPro HAS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-diphossugar_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15116 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:106590 ENTREZGENE
NCBI Gene 15116 ENTREZGENE
PANTHER PTHR22913:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Has1 PhenoGen
Superfamily-SCOP SSF53448 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HYAS1_MOUSE UniProtKB/Swiss-Prot
  Q05A37_MOUSE UniProtKB/TrEMBL
  Q3UUP6 ENTREZGENE, UniProtKB/TrEMBL
  Q61647 ENTREZGENE
  Q8BPN0_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-14 Has1  hyaluronan synthase 1    hyaluronan synthase1  Symbol and/or name change 5135510 APPROVED