Pla2g3 (phospholipase A2, group III) - Rat Genome Database

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Gene: Pla2g3 (phospholipase A2, group III) Mus musculus
Analyze
Symbol: Pla2g3
Name: phospholipase A2, group III
RGD ID: 1552182
MGI Page MGI
Description: Exhibits calcium-dependent phospholipase A2 activity. Involved in several processes, including positive regulation of secretion by cell; regulation of gene expression; and spermatid development. Predicted to localize to centriole and recycling endosome. Is expressed in several structures, including alimentary system; cranium; genitourinary system; integumental system; and nervous system. Orthologous to human PLA2G3 (phospholipase A2 group III); PARTICIPATES IN arachidonic acid metabolic pathway; glutamate signaling pathway; glycerophospholipid metabolic pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9130003P18Rik; GIII sPLA2; group 3 secretory phospholipase A2; group III secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 3; sPLA2-III
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,438,158 - 3,449,346 (+)NCBIGRCm39mm39
GRCm39 Ensembl113,438,284 - 3,449,350 (+)Ensembl
GRCm38113,488,158 - 3,499,346 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,488,284 - 3,499,350 (+)EnsemblGRCm38mm10GRCm38
MGSCv37113,388,230 - 3,394,169 (+)NCBIGRCm37mm9NCBIm37
MGSCv36113,388,302 - 3,399,353 (+)NCBImm8
Celera113,979,003 - 3,985,078 (+)NCBICelera
Cytogenetic Map11A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14681479   PMID:15863501   PMID:16141072   PMID:16141073   PMID:17868035   PMID:19371233   PMID:20424323  
PMID:21267068   PMID:23624557   PMID:26637123   PMID:26828067   PMID:28947740   PMID:30635555   PMID:32482892  


Genomics

Comparative Map Data
Pla2g3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,438,158 - 3,449,346 (+)NCBIGRCm39mm39
GRCm39 Ensembl113,438,284 - 3,449,350 (+)Ensembl
GRCm38113,488,158 - 3,499,346 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,488,284 - 3,499,350 (+)EnsemblGRCm38mm10GRCm38
MGSCv37113,388,230 - 3,394,169 (+)NCBIGRCm37mm9NCBIm37
MGSCv36113,388,302 - 3,399,353 (+)NCBImm8
Celera113,979,003 - 3,985,078 (+)NCBICelera
Cytogenetic Map11A1NCBI
PLA2G3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2231,134,807 - 31,140,508 (-)EnsemblGRCh38hg38GRCh38
GRCh382231,134,807 - 31,140,508 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372231,530,793 - 31,536,494 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,860,793 - 29,866,469 (-)NCBINCBI36hg18NCBI36
Build 342229,855,346 - 29,861,023NCBI
Celera2215,330,868 - 15,336,544 (-)NCBI
Cytogenetic Map22q12.2NCBI
HuRef2214,492,451 - 14,498,127 (-)NCBIHuRef
CHM1_12231,490,658 - 31,496,458 (-)NCBICHM1_1
Pla2g3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21478,367,625 - 78,373,913 (+)NCBI
Rnor_6.0 Ensembl1483,724,933 - 83,730,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01483,724,828 - 83,730,614 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01484,412,999 - 84,418,680 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,119,872 - 84,125,552 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11484,130,645 - 84,143,800 (+)NCBI
Celera1477,281,569 - 77,287,249 (+)NCBICelera
Cytogenetic Map14q21NCBI
Pla2g3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554555,315,450 - 5,320,053 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554555,314,520 - 5,320,151 (-)NCBIChiLan1.0ChiLan1.0
PLA2G3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12229,995,364 - 30,001,160 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2229,995,364 - 30,001,160 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02212,158,589 - 12,164,441 (-)NCBIMhudiblu_PPA_v0panPan3
PLA2G3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12624,127,074 - 24,132,508 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2624,128,005 - 24,132,508 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,994,204 - 24,002,589 (-)NCBI
ROS_Cfam_1.02624,506,855 - 24,515,226 (-)NCBI
UMICH_Zoey_3.12624,210,260 - 24,218,645 (-)NCBI
UNSW_CanFamBas_1.02624,472,253 - 24,480,619 (-)NCBI
UU_Cfam_GSD_1.02624,533,532 - 24,541,902 (-)NCBI
Pla2g3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118117,049,648 - 117,058,557 (-)NCBI
SpeTri2.0NW_004936755307,166 - 312,683 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLA2G3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,923,787 - 47,928,810 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,923,005 - 47,928,762 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21451,034,721 - 51,040,254 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLA2G3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11914,025,373 - 14,033,214 (-)NCBI
ChlSab1.1 Ensembl1914,025,742 - 14,030,643 (-)Ensembl
Pla2g3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247477,602,848 - 7,607,872 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301765Skull15_mskull morphology 15 (mouse)Not determined11126026374Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11126026374Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11272035536721472Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11126026374Mouse
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123930487Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1127705234277232Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11330000034600000Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11330000018500000Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11330000060800000Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11330000019800000Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11330000018200000Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11330000044200000Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11330000063000000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:846
Count of miRNA genes:525
Interacting mature miRNAs:643
Transcripts:ENSMUST00000044682, ENSMUST00000064265, ENSMUST00000151860
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_172791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006514689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006514690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006514691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003949433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_872206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK033572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL713875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000044682   ⟹   ENSMUSP00000041571
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl113,488,299 - 3,499,350 (+)Ensembl
RefSeq Acc Id: ENSMUST00000064265   ⟹   ENSMUSP00000068699
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl113,488,284 - 3,494,166 (+)Ensembl
RefSeq Acc Id: ENSMUST00000151860
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl113,488,990 - 3,494,163 (+)Ensembl
RefSeq Acc Id: NM_172791   ⟹   NP_766379
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,438,227 - 3,444,166 (+)NCBI
GRCm38113,488,227 - 3,494,166 (+)NCBI
MGSCv37113,388,230 - 3,394,169 (+)RGD
Celera113,979,003 - 3,985,078 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006514689   ⟹   XP_006514752
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,438,158 - 3,449,346 (+)NCBI
GRCm38113,488,158 - 3,499,346 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006514690   ⟹   XP_006514753
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,438,158 - 3,444,168 (+)NCBI
GRCm38113,488,158 - 3,494,168 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006514691   ⟹   XP_006514754
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,438,158 - 3,444,168 (+)NCBI
GRCm38113,488,158 - 3,494,168 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030245957   ⟹   XP_030101817
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,438,860 - 3,444,168 (+)NCBI
GRCm38113,489,589 - 3,494,168 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036156649   ⟹   XP_036012542
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,438,158 - 3,444,168 (+)NCBI
RefSeq Acc Id: XM_036156650   ⟹   XP_036012543
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,438,762 - 3,444,168 (+)NCBI
RefSeq Acc Id: XM_036156651   ⟹   XP_036012544
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,438,158 - 3,444,168 (+)NCBI
RefSeq Acc Id: XM_036156652   ⟹   XP_036012545
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,438,158 - 3,444,168 (+)NCBI
RefSeq Acc Id: XR_003949433
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,438,158 - 3,449,346 (+)NCBI
GRCm38113,488,158 - 3,499,346 (+)NCBI
Sequence:
RefSeq Acc Id: XR_872206
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,438,158 - 3,449,346 (+)NCBI
GRCm38113,488,158 - 3,499,346 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_766379   ⟸   NM_172791
- Peptide Label: precursor
- UniProtKB: Q6AXH0 (UniProtKB/TrEMBL),   Q8BZT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006514752   ⟸   XM_006514689
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006514754   ⟸   XM_006514691
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006514753   ⟸   XM_006514690
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_030101817   ⟸   XM_030245957
- Peptide Label: isoform X7
RefSeq Acc Id: ENSMUSP00000068699   ⟸   ENSMUST00000064265
RefSeq Acc Id: ENSMUSP00000041571   ⟸   ENSMUST00000044682
RefSeq Acc Id: XP_036012542   ⟸   XM_036156649
- Peptide Label: isoform X4
RefSeq Acc Id: XP_036012544   ⟸   XM_036156651
- Peptide Label: isoform X6
RefSeq Acc Id: XP_036012545   ⟸   XM_036156652
- Peptide Label: isoform X8
RefSeq Acc Id: XP_036012543   ⟸   XM_036156650
- Peptide Label: isoform X5
Protein Domains
PA2c

Promoters
RGD ID:8673732
Promoter ID:EPDNEW_M14897
Type:initiation region
Name:Pla2g3_1
Description:Mus musculus phospholipase A2, group III , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38113,488,299 - 3,488,359EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2444945 AgrOrtholog
Ensembl Genes ENSMUSG00000034579 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000041571 UniProtKB/TrEMBL
  ENSMUSP00000068699 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000044682 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000064265 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000151860 ENTREZGENE
Gene3D-CATH 1.20.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PLipase_A2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_His_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:237625 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2444945 ENTREZGENE
NCBI Gene 237625 ENTREZGENE
Pfam Phospholip_A2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pla2g3 PhenoGen
PROSITE PA2_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48619 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt PA2G3_MOUSE UniProtKB/Swiss-Prot
  Q6AXH0 ENTREZGENE, UniProtKB/TrEMBL
  Q8BL71_MOUSE UniProtKB/TrEMBL
  Q8BV23_MOUSE UniProtKB/TrEMBL
  Q8BZT7 ENTREZGENE