Prss46 (protease, serine 46) - Rat Genome Database
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Gene: Prss46 (protease, serine 46) Mus musculus
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Symbol: Prss46
Name: protease, serine 46
RGD ID: 1552176
MGI Page MGI
Description: Predicted to have serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to extracellular space. Orthologous to human PRSS46P (serine protease 46, pseudogene); INTERACTS WITH carbon nanotube; dexamethasone; silicon dioxide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1700112C13Rik; 79H19B; MGC107146; protease, serine, 46; serine protease 46; Tessp6; testis serine protease 6
RGD Orthologs
Human
Rat
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,673,574 - 110,685,590 (+)NCBIGRCm39mm39
GRCm389110,844,506 - 110,856,522 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,844,506 - 110,856,522 (+)EnsemblGRCm38mm10GRCm38
MGSCv379110,747,010 - 110,759,026 (+)NCBIGRCm37mm9NCBIm37
MGSCv369110,689,322 - 110,701,338 (+)NCBImm8
Celera9110,575,237 - 110,582,022 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IBA)

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12140191   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:17219777   PMID:18799693   PMID:21677750   PMID:21873635  
PMID:31403672  


Genomics

Comparative Map Data
Prss46
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,673,574 - 110,685,590 (+)NCBIGRCm39mm39
GRCm389110,844,506 - 110,856,522 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,844,506 - 110,856,522 (+)EnsemblGRCm38mm10GRCm38
MGSCv379110,747,010 - 110,759,026 (+)NCBIGRCm37mm9NCBIm37
MGSCv369110,689,322 - 110,701,338 (+)NCBImm8
Celera9110,575,237 - 110,582,022 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
PRSS46P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl346,719,583 - 46,736,429 (-)EnsemblGRCh38hg38GRCh38
GRCh38346,719,583 - 46,736,427 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37346,761,073 - 46,777,921 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map3p21.31NCBI
HuRef346,803,923 - 46,820,771 (-)NCBIHuRef
CHM1_1346,711,189 - 46,728,057 (-)NCBICHM1_1
Prss46
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08119,121,671 - 119,133,455 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,121,669 - 119,133,546 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,460,084 - 118,471,867 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,238,452 - 115,245,337 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18115,257,906 - 115,264,792 (+)NCBI
Celera8110,116,548 - 110,123,433 (+)NCBICelera
Cytogenetic Map8q32NCBI
PRSS46P
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1347,721,393 - 47,737,885 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0346,618,007 - 46,635,153 (-)NCBIMhudiblu_PPA_v0panPan3
Prss46
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936596548,354 - 563,883 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRSS46
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11329,640,448 - 29,665,549 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,911,542 - 32,916,508 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103227550
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1228,142,559 - 8,170,057 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13515058Adip20d_madiposity 20d (mouse)9108915010118915010Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:292
Count of miRNA genes:133
Interacting mature miRNAs:141
Transcripts:ENSMUST00000119427, ENSMUST00000176403
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000119427
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9110,849,538 - 110,856,516 (+)Ensembl
RefSeq Acc Id: ENSMUST00000176403   ⟹   ENSMUSP00000135787
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9110,844,506 - 110,856,522 (+)Ensembl
RefSeq Acc Id: NM_183103   ⟹   NP_898926
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,673,574 - 110,685,590 (+)NCBI
GRCm389110,844,506 - 110,856,522 (+)ENTREZGENE
MGSCv379110,747,010 - 110,759,026 (+)RGD
Celera9110,575,237 - 110,582,022 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_898926 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH87878 (Get FASTA)   NCBI Sequence Viewer  
  BAC25167 (Get FASTA)   NCBI Sequence Viewer  
  EDL08993 (Get FASTA)   NCBI Sequence Viewer  
  Q5M8S2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_898926   ⟸   NM_183103
- UniProtKB: Q5M8S2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000135787   ⟸   ENSMUST00000176403
Protein Domains
Peptidase S1

Promoters
RGD ID:8671028
Promoter ID:EPDNEW_M13545
Type:initiation region
Name:Prss46_2
Description:Mus musculus protease, serine 46 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13546  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389110,844,506 - 110,844,566EPDNEW
RGD ID:8671030
Promoter ID:EPDNEW_M13546
Type:initiation region
Name:Prss46_1
Description:Mus musculus protease, serine 46 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13545  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389110,849,521 - 110,849,581EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921556 AgrOrtholog
Ensembl Genes ENSMUSG00000049719 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000135787 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000176403 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
KEGG Report mmu:74306 UniProtKB/Swiss-Prot
MGD MGI:1921556 ENTREZGENE
NCBI Gene 74306 ENTREZGENE
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Prss46 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniGene Mm.87419 ENTREZGENE
UniProt PRS46_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8C1Q8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-26 Prss46  protease, serine 46    protease, serine, 46  Symbol and/or name change 5135510 APPROVED