Sh3rf1 (SH3 domain containing ring finger 1) - Rat Genome Database
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Gene: Sh3rf1 (SH3 domain containing ring finger 1) Mus musculus
Analyze
Symbol: Sh3rf1
Name: SH3 domain containing ring finger 1
RGD ID: 1551894
MGI Page MGI
Description: Exhibits MAP-kinase scaffold activity. Involved in neuron migration; positive regulation of JNK cascade; and regulation of alpha-beta T cell activation. Localizes to lamellipodium. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human SH3RF1 (SH3 domain containing ring finger 1); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2200003J05Rik; E3 ubiquitin-protein ligase SH3RF1; P; plenty of SH3 domains; plenty of SH3s; Posh; putative E3 ubiquitin-protein ligase SH3RF1; R75531; RING-type E3 ubiquitin transferase SH3RF1; SH3 domain-containing RING finger protein 1; SH3 multiple domains 2; SH3 multiple domains protein 2; Sh3md; Sh3md2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39861,677,117 - 61,918,327 (+)NCBIGRCm39mm39
GRCm38861,224,083 - 61,465,293 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl861,223,872 - 61,396,071 (+)EnsemblGRCm38mm10GRCm38
MGSCv37863,702,968 - 63,874,869 (+)NCBIGRCm37mm9NCBIm37
MGSCv36864,116,351 - 64,288,213 (+)NCBImm8
Celera863,790,185 - 63,958,432 (+)NCBICelera
Cytogenetic Map8B3.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12944902   PMID:14504284   PMID:14610273   PMID:15368895   PMID:16141072   PMID:16141073   PMID:16230351  
PMID:16571722   PMID:17095503   PMID:18287559   PMID:18829867   PMID:20926658   PMID:21267068   PMID:22959435   PMID:23963642   PMID:27026702   PMID:27084103   PMID:29432529   PMID:32325033  


Genomics

Comparative Map Data
Sh3rf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39861,677,117 - 61,918,327 (+)NCBIGRCm39mm39
GRCm38861,224,083 - 61,465,293 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl861,223,872 - 61,396,071 (+)EnsemblGRCm38mm10GRCm38
MGSCv37863,702,968 - 63,874,869 (+)NCBIGRCm37mm9NCBIm37
MGSCv36864,116,351 - 64,288,213 (+)NCBImm8
Celera863,790,185 - 63,958,432 (+)NCBICelera
Cytogenetic Map8B3.1NCBI
SH3RF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4169,094,259 - 169,270,956 (-)EnsemblGRCh38hg38GRCh38
GRCh384169,094,259 - 169,270,956 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374170,015,407 - 170,192,249 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364170,251,982 - 170,428,824 (-)NCBINCBI36hg18NCBI36
Build 344170,390,139 - 170,566,895NCBI
Celera4167,346,760 - 167,524,236 (-)NCBI
Cytogenetic Map4q32.3-q33NCBI
HuRef4165,769,030 - 165,945,877 (-)NCBIHuRef
CHM1_14169,991,853 - 170,168,646 (-)NCBICHM1_1
Sh3rf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01632,062,425 - 32,227,526 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1632,062,336 - 32,227,491 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01631,898,366 - 32,062,432 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41632,054,773 - 32,215,987 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11632,054,847 - 32,216,062 (-)NCBI
Celera1628,732,907 - 28,894,614 (-)NCBICelera
Cytogenetic Map16p12NCBI
Sh3rf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540336,988,811 - 37,142,401 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540336,989,509 - 37,141,188 (+)NCBIChiLan1.0ChiLan1.0
SH3RF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14173,392,485 - 173,569,072 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4173,394,739 - 173,567,096 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04161,319,093 - 161,495,917 (-)NCBIMhudiblu_PPA_v0panPan3
SH3RF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2520,015,915 - 20,205,946 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12520,025,920 - 20,208,470 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Sh3rf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365161,267,128 - 1,429,040 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SH3RF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1420,420,618 - 20,559,272 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11420,420,618 - 20,559,273 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21421,797,298 - 21,846,362 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SH3RF1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl7115,332,460 - 115,504,411 (-)Ensembl
ChlSab1.17115,330,171 - 115,504,443 (-)NCBI
Sh3rf1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624769668,175 - 834,863 (-)NCBI

Position Markers
R75531  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38861,395,908 - 61,395,999UniSTSGRCm38
MGSCv37863,874,705 - 63,874,796UniSTSGRCm37
Celera863,958,268 - 63,958,359UniSTS
Cytogenetic Map8B3.1UniSTS
Whitehead/MRC_RH8689.22UniSTS
D8Mit128  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38861,294,880 - 61,295,025UniSTSGRCm38
MGSCv37863,773,677 - 63,773,822UniSTSGRCm37
Celera863,861,158 - 63,861,289UniSTS
Cytogenetic Map8B3.1UniSTS
cM Map831.5UniSTS
cM Map8 UniSTS
Whitehead Genetic832.8UniSTS
Whitehead_YAC8 UniSTS
D8Mit160  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38861,308,418 - 61,308,564UniSTSGRCm38
MGSCv37863,787,215 - 63,787,361UniSTSGRCm37
Celera863,874,691 - 63,874,833UniSTS
Cytogenetic Map8B3.1UniSTS
cM Map831.0UniSTS
Whitehead Genetic832.8UniSTS
Whitehead_YAC8 UniSTS
RH125258  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38861,395,845 - 61,396,017UniSTSGRCm38
MGSCv37863,874,642 - 63,874,814UniSTSGRCm37
Celera863,958,205 - 63,958,377UniSTS
Cytogenetic Map8B3.1UniSTS
AF030131  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38861,393,935 - 61,394,023UniSTSGRCm38
MGSCv37863,872,732 - 63,872,820UniSTSGRCm37
Celera863,956,294 - 63,956,382UniSTS
Cytogenetic Map8B3.1UniSTS
Whitehead/MRC_RH8690.4UniSTS
UniSTS:224689  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38861,395,849 - 61,395,999UniSTSGRCm38
MGSCv37863,874,646 - 63,874,796UniSTSGRCm37
Celera863,958,209 - 63,958,359UniSTS
Cytogenetic Map8B3.1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83383736267837502Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:722
Count of miRNA genes:427
Interacting mature miRNAs:520
Transcripts:ENSMUST00000034060
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC134339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF030131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK035372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK173185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY741307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO040875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000034060   ⟹   ENSMUSP00000034060
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl861,223,872 - 61,396,071 (+)Ensembl
RefSeq Acc Id: ENSMUST00000209611   ⟹   ENSMUSP00000148118
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl861,224,244 - 61,386,641 (+)Ensembl
RefSeq Acc Id: ENSMUST00000210210
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl861,361,589 - 61,364,588 (+)Ensembl
RefSeq Acc Id: NM_021506   ⟹   NP_067481
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,677,205 - 61,849,106 (+)NCBI
GRCm38861,224,171 - 61,396,072 (+)NCBI
MGSCv37863,702,968 - 63,874,869 (+)RGD
Celera863,790,185 - 63,958,432 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011242231   ⟹   XP_011240533
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,677,117 - 61,918,327 (+)NCBI
GRCm38861,224,083 - 61,465,293 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036154204   ⟹   XP_036010097
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,677,774 - 61,849,107 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_067481   ⟸   NM_021506
- UniProtKB: Q69ZI1 (UniProtKB/Swiss-Prot),   E9QQ33 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011240533   ⟸   XM_011242231
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000034060   ⟸   ENSMUST00000034060
RefSeq Acc Id: ENSMUSP00000148118   ⟸   ENSMUST00000209611
RefSeq Acc Id: XP_036010097   ⟸   XM_036154204
- Peptide Label: isoform X1
Protein Domains
RING-type   SH3

Promoters
RGD ID:8667149
Promoter ID:EPDNEW_M11605
Type:initiation region
Name:Sh3rf1_1
Description:Mus musculus SH3 domain containing ring finger 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38861,224,268 - 61,224,328EPDNEW
RGD ID:6843710
Promoter ID:MM_KWN:54497
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000093488,   ENSMUST00000110291,   NM_021506,   UC009LTW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36863,702,526 - 63,703,057 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913066 AgrOrtholog
Ensembl Genes ENSMUSG00000031642 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034060 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000148118 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034060 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000209611 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3RF1/SH3RF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3RF1/SH3RF3_SH3_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3RF1_SH3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:59009 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1913066 ENTREZGENE
NCBI Gene 59009 ENTREZGENE
PANTHER PTHR14167:SF62 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sh3rf1 PhenoGen
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.27949 ENTREZGENE
UniProt A0A1B0GSY0_MOUSE UniProtKB/TrEMBL
  E9QQ33 ENTREZGENE, UniProtKB/TrEMBL
  Q69ZI1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O70254 UniProtKB/Swiss-Prot
  Q3UG42 UniProtKB/Swiss-Prot
  Q6P9M8 UniProtKB/Swiss-Prot
  Q8BR66 UniProtKB/Swiss-Prot
  Q8C2T5 UniProtKB/Swiss-Prot