Cpn2 (carboxypeptidase N, polypeptide 2) - Rat Genome Database

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Gene: Cpn2 (carboxypeptidase N, polypeptide 2) Mus musculus
Analyze
Symbol: Cpn2
Name: carboxypeptidase N, polypeptide 2
RGD ID: 1551729
MGI Page MGI
Description: Located in collagen-containing extracellular matrix. Orthologous to human CPN2 (carboxypeptidase N subunit 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1300018K11Rik; carboxypeptidase N 83 kDa chain; carboxypeptidase N large subunit; carboxypeptidase N polypeptide 2; carboxypeptidase N regulatory subunit; carboxypeptidase N subunit 2; carboxypeptidase N, polypeptide 2 homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391630,075,196 - 30,086,350 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1630,075,196 - 30,086,317 (-)EnsemblGRCm39 Ensembl
GRCm381630,256,378 - 30,267,532 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1630,256,378 - 30,267,499 (-)EnsemblGRCm38mm10GRCm38
MGSCv371630,256,464 - 30,267,618 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361630,178,417 - 30,187,279 (-)NCBIMGSCv36mm8
Celera1630,763,276 - 30,774,455 (-)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1621.22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16944957   PMID:17330941   PMID:21677750   PMID:21873635   PMID:22159717  
PMID:32325033  


Genomics

Comparative Map Data
Cpn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391630,075,196 - 30,086,350 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1630,075,196 - 30,086,317 (-)EnsemblGRCm39 Ensembl
GRCm381630,256,378 - 30,267,532 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1630,256,378 - 30,267,499 (-)EnsemblGRCm38mm10GRCm38
MGSCv371630,256,464 - 30,267,618 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361630,178,417 - 30,187,279 (-)NCBIMGSCv36mm8
Celera1630,763,276 - 30,774,455 (-)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1621.22NCBI
CPN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383194,339,768 - 194,351,328 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3194,339,768 - 194,351,328 (-)EnsemblGRCh38hg38GRCh38
GRCh373194,060,497 - 194,072,057 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363195,542,189 - 195,553,350 (-)NCBINCBI36Build 36hg18NCBI36
Build 343195,542,203 - 195,545,138NCBI
Celera3192,475,891 - 192,487,060 (-)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3191,440,296 - 191,451,465 (-)NCBIHuRef
CHM1_13194,023,464 - 194,034,921 (-)NCBICHM1_1
T2T-CHM13v2.03197,038,329 - 197,049,487 (-)NCBIT2T-CHM13v2.0
Cpn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81183,990,943 - 84,000,821 (+)NCBIGRCr8
mRatBN7.21170,486,054 - 70,495,937 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1170,486,057 - 70,496,472 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1179,330,147 - 79,339,671 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,964,644 - 71,974,155 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01171,019,252 - 71,028,773 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01174,057,374 - 74,067,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1174,057,361 - 74,067,413 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,118,227 - 77,130,519 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41172,384,307 - 72,397,118 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11172,449,009 - 72,450,649 (+)NCBI
Celera1169,459,269 - 69,468,738 (+)NCBICelera
Cytogenetic Map11q22NCBI
Cpn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542014,423,974 - 14,425,602 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542014,416,308 - 14,425,945 (+)NCBIChiLan1.0ChiLan1.0
CPN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22192,262,625 - 192,274,017 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13192,267,347 - 192,278,739 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03191,637,388 - 191,648,283 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13201,951,777 - 201,962,455 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3201,952,336 - 201,953,973 (-)Ensemblpanpan1.1panPan2
CPN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13331,352,776 - 31,361,795 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3331,358,687 - 31,360,330 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3331,384,322 - 31,393,394 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03331,612,633 - 31,620,617 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13331,409,551 - 31,417,536 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03331,438,496 - 31,446,482 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03332,070,557 - 32,079,631 (+)NCBIUU_Cfam_GSD_1.0
Cpn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602123,789,200 - 123,799,858 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936711457,291 - 458,934 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13131,325,065 - 131,337,672 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113131,327,508 - 131,337,721 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213140,825,627 - 140,827,536 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CPN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11588,437,471 - 88,448,351 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1588,437,957 - 88,439,594 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604162,124,306 - 62,134,673 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cpn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473063,420,457 - 63,422,085 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473063,414,147 - 63,424,071 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cpn2
363 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1193
Count of miRNA genes:592
Interacting mature miRNAs:747
Transcripts:ENSMUST00000064856
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16647700935021216Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162001932985600826Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162193838355938574Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2277525257594076Mouse
15092062Egrme4_mearly growth rate, maternal effect 4 (mouse)162521866444220250Mouse
11059559Lmr12a_mleishmaniasis resistance 12a (mouse)162879281362792952Mouse
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162879281362792952Mouse
11049571Lmr12c_mleishmaniasis resistance 12c (mouse)162879281362792952Mouse
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162879281362792952Mouse

Markers in Region
D17971  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381630,256,385 - 30,256,536UniSTSGRCm38
MGSCv371630,256,471 - 30,256,622UniSTSGRCm37
Celera1630,763,283 - 30,763,434UniSTS
Cytogenetic Map16B2UniSTS
Whitehead_YAC16 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000064856   ⟹   ENSMUSP00000069318
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1630,075,196 - 30,086,317 (-)Ensembl
GRCm38.p6 Ensembl1630,256,378 - 30,267,499 (-)Ensembl
RefSeq Acc Id: NM_027904   ⟹   NP_082180
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391630,075,196 - 30,086,350 (-)NCBI
GRCm381630,256,378 - 30,267,532 (-)NCBI
MGSCv371630,256,464 - 30,267,618 (-)RGD
Celera1630,763,276 - 30,774,455 (-)RGD
cM Map16 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_082180   ⟸   NM_027904
- Peptide Label: precursor
- UniProtKB: B2RR89 (UniProtKB/Swiss-Prot),   Q8R113 (UniProtKB/Swiss-Prot),   Q9DBB9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000069318   ⟸   ENSMUST00000064856
Protein Domains
LRRCT   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9DBB9-F1-model_v2 AlphaFold Q9DBB9 1-547 view protein structure

Promoters
RGD ID:6826935
Promoter ID:MM_KWN:20678
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_027904
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361630,267,336 - 30,267,836 (-)MPROMDB
RGD ID:8685930
Promoter ID:EPDNEW_M20996
Type:initiation region
Name:Cpn2_1
Description:Mus musculus carboxypeptidase N, polypeptide 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381630,267,514 - 30,267,574EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919006 AgrOrtholog
Ensembl Genes ENSMUSG00000023176 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000064856 ENTREZGENE
  ENSMUST00000064856.9 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot
KEGG Report mmu:71756 UniProtKB/Swiss-Prot
MGD MGI:1919006 ENTREZGENE
NCBI Gene 71756 ENTREZGENE
PANTHER CHAOPTIN-LIKE PROTEIN UniProtKB/Swiss-Prot
  GH08155P UniProtKB/Swiss-Prot
  SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN UniProtKB/TrEMBL
  VASORIN UniProtKB/TrEMBL
Pfam LRR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cpn2 PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LRR_BAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RR89 ENTREZGENE
  CPN2_MOUSE UniProtKB/Swiss-Prot
  Q642I5_MOUSE UniProtKB/TrEMBL
  Q8R113 ENTREZGENE
  Q9DBB9 ENTREZGENE
UniProt Secondary B2RR89 UniProtKB/Swiss-Prot
  Q8R113 UniProtKB/Swiss-Prot