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Gene: Fxn (frataxin) Mus musculus
Symbol: Fxn
Name: frataxin
Description: Predicted to have several functions, including 2 iron, 2 sulfur cluster binding activity; ferroxidase activity; and iron ion binding activity. Involved in several processes, including adult walking behavior; negative regulation of developmental growth; and proprioception. Localizes to the mitochondrion. Used to study Friedreich ataxia. Human ortholog(s) of this gene implicated in Friedreich ataxia; Friedreich ataxia 1; and type 2 diabetes mellitus. Is expressed in several structures, including brain; cartilage condensation; heart; hemolymphoid system; and lower jaw incisor. Orthologous to human FXN (frataxin); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 7,8-dihydro-8-oxoguanine; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FA; FARR; frataxin, mitochondrial; Frda; Friedreich ataxia; X25
Homo sapiens (human) : FXN (frataxin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Fxn (frataxin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fxn (frataxin)
Pan paniscus (bonobo/pygmy chimpanzee) : FXN (frataxin)
Canis lupus familiaris (dog) : FXN (frataxin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fxn (frataxin)
Sus scrofa (pig) : FXN (frataxin)
more info ...
Related Pseudogenes: Gm4325   Gm5037  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1924,261,453 - 24,280,605 (-)Ensembl
GRCm381924,259,545 - 24,280,590 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371924,335,943 - 24,355,076 (-)NCBIGRCm37mm9NCBIm37
MGSCv361924,328,550 - 24,347,683 (-)NCBImm8
Celera1925,027,779 - 25,046,379 (-)NCBICelera
Cytogenetic Map19 BNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Fxn
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1551716
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.