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Gene: Fxn (frataxin) Mus musculus
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Symbol: Fxn
Name: frataxin
Description: Predicted to have several functions, including 2 iron, 2 sulfur cluster binding activity; ferroxidase activity; and iron ion binding activity. Involved in several processes, including adult walking behavior; negative regulation of developmental growth; and proprioception. Localizes to the mitochondrion. Used to study Friedreich ataxia. Human ortholog(s) of this gene implicated in Friedreich ataxia; Friedreich ataxia 1; and type 2 diabetes mellitus. Is expressed in several structures, including brain; cartilage condensation; heart; hemolymphoid system; and lower jaw incisor. Orthologous to human FXN (frataxin); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 7,8-dihydro-8-oxoguanine; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FA; FARR; frataxin, mitochondrial; Frda; Friedreich ataxia; X25
Orthologs:
Homo sapiens (human) : FXN (frataxin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Fxn (frataxin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fxn (frataxin)
Pan paniscus (bonobo/pygmy chimpanzee) : FXN (frataxin)
Canis lupus familiaris (dog) : FXN (frataxin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fxn (frataxin)
Sus scrofa (pig) : FXN (frataxin)
more info ...
Related Pseudogenes: Gm4325   Gm5037  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1924,261,453 - 24,280,605 (-)Ensembl
GRCm381924,259,545 - 24,280,590 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371924,335,943 - 24,355,076 (-)NCBIGRCm37mm9NCBIm37
MGSCv361924,328,550 - 24,347,683 (-)NCBImm8
Celera1925,027,779 - 25,046,379 (-)NCBICelera
Cytogenetic Map19 BNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Fxn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1551716
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.