Fxn (frataxin) - Rat Genome Database

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Gene: Fxn (frataxin) Mus musculus
Analyze
Symbol: Fxn
Name: frataxin
RGD ID: 1551716
MGI Page MGI
Description: Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; ferroxidase activity; and iron ion binding activity. Involved in [4Fe-4S] cluster assembly. Acts upstream of or within several processes, including adult walking behavior; muscle cell cellular homeostasis; and negative regulation of organ growth. Located in mitochondrion. Part of mitochondrial iron-sulfur cluster assembly complex. Is expressed in several structures, including brain; cartilage condensation; heart; hemolymphoid system; and lower jaw incisor. Used to study Friedreich ataxia. Human ortholog(s) of this gene implicated in Friedreich ataxia; Friedreich ataxia 1; glioblastoma; and type 2 diabetes mellitus. Orthologous to human FXN (frataxin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FA; FARR; Fr; frataxin, mitochondrial; Frda; Friedreich ataxia; X25
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm4325   Gm5037  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391924,236,909 - 24,257,954 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1924,238,817 - 24,257,969 (-)EnsemblGRCm39 Ensembl
GRCm381924,259,545 - 24,280,590 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1924,261,453 - 24,280,605 (-)EnsemblGRCm38mm10GRCm38
MGSCv371924,335,943 - 24,355,076 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361924,328,550 - 24,347,683 (-)NCBIMGSCv36mm8
Celera1925,027,779 - 25,046,379 (-)NCBICelera
Cytogenetic Map19BNCBI
cM Map1919.39NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
7,8-dihydro-8-oxoguanine  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-phellandrene  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
betamethasone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
camptothecin  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deferiprone  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ferrostatin-1  (ISO)
finasteride  (ISO)
folic acid  (EXP)
gentamycin  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
ivermectin  (ISO)
lipopolysaccharide  (EXP,ISO)
methyl methanesulfonate  (ISO)
molsidomine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
nimesulide  (ISO)
nimustine  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (ISO)
pentachlorophenol  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
resveratrol  (ISO)
retinyl acetate  (EXP)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sulindac  (ISO)
thioacetamide  (ISO)
toluene  (ISO)
topotecan  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
tungsten  (EXP)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal action potential  (IAGP)
abnormal axon morphology  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal enzyme/coenzyme level  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal gait  (IAGP)
abnormal iron homeostasis  (IAGP)
abnormal lumbar dorsal root ganglion morphology  (IAGP)
abnormal mitochondrial biogenesis  (IAGP)
abnormal mitochondrial morphology  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal myocardial fiber mitochondrial morphology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal nerve conduction  (IAGP)
abnormal respiratory electron transport chain  (IAGP)
ataxia  (IAGP)
brain inflammation  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
cardiomyopathy  (IEA)
chromatolysis  (IAGP)
decreased body length  (IAGP)
decreased body weight  (IAGP)
decreased cardiac muscle contractility  (IEA)
decreased cardiac output  (IAGP)
decreased embryo size  (IAGP)
decreased grip strength  (IAGP)
decreased heart rate  (IEA)
decreased locomotor activity  (IAGP)
decreased nerve conduction velocity  (IAGP)
decreased ventricle muscle contractility  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated heart left ventricle  (IAGP)
dilated mitochondrion  (IAGP)
embryo tissue necrosis  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality prior to organogenesis  (IEA)
fatigue  (IAGP)
heart left ventricle hypertrophy  (IAGP)
hunched posture  (IAGP)
impaired coordination  (IAGP)
increased body weight  (IAGP)
increased embryonic tissue cell apoptosis  (IAGP)
increased heart iron level  (IAGP)
increased heart left ventricle posterior wall thickness  (IAGP)
increased heart left ventricle wall thickness  (IAGP)
increased heart left ventricle weight  (IAGP)
increased mitochondrial fission  (IAGP)
increased susceptibility to weight gain  (IAGP)
myocardium necrosis  (IAGP)
neurodegeneration  (IAGP)
neuron degeneration  (IAGP)
oxidative stress  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
prolonged PR interval  (IAGP)
spongiform encephalopathy  (IAGP)
thick interventricular septum  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Exonic deletions of FXN and early-onset Friedreich ataxia. Anheim M, etal., Arch Neurol. 2012 Jul;69(7):912-6. doi: 10.1001/archneurol.2011.834.
2. Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion. Campuzano V, etal., Science. 1996 Mar 8;271(5254):1423-7.
3. G130V, a common FRDA point mutation, appears to have arisen from a common founder. Delatycki MB, etal., Hum Genet. 1999 Oct;105(4):343-6.
4. Clinical and genetic abnormalities in patients with Friedreich's ataxia. Durr A, etal., N Engl J Med. 1996 Oct 17;335(16):1169-75.
5. Heterozygous expansion of the GAA tract of the X25/frataxin gene is associated with insulin resistance in humans. Hebinck J, etal., Diabetes. 2000 Sep;49(9):1604-7.
6. A polymorphic miR-155 binding site in AGTR1 is associated with cardiac hypertrophy in Friedreich ataxia. Kelly M, etal., J Mol Cell Cardiol. 2011 Nov;51(5):848-54. doi: 10.1016/j.yjmcc.2011.07.001. Epub 2011 Jul 12.
7. Dual role of the mitochondrial protein frataxin in astrocytic tumors. Kirches E, etal., Lab Invest. 2011 Dec;91(12):1766-76. doi: 10.1038/labinvest.2011.130. Epub 2011 Aug 22.
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
11. Identification of Safe and Effective Intravenous Dose of AAVrh.10hFXN to Treat the Cardiac Manifestations of Friedreich's Ataxia. Munoz-Zuluaga C, etal., Hum Gene Ther. 2023 Jul;34(13-14):605-615. doi: 10.1089/hum.2023.020. Epub 2023 Jul 4.
12. Cardioprotective HIF-1α-frataxin signaling against ischemia-reperfusion injury. Nanayakkara G, etal., Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H867-79. doi: 10.1152/ajpheart.00875.2014. Epub 2015 Jun 12.
13. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Prevention and reversal of severe mitochondrial cardiomyopathy by gene therapy in a mouse model of Friedreich's ataxia. Perdomini M, etal., Nat Med. 2014 May;20(5):542-7. doi: 10.1038/nm.3510. Epub 2014 Apr 6.
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced obesity. Pomplun D, etal., Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6377-81. Epub 2007 Apr 2.
18. Mouse MP Annotation Import Pipeline RGD automated import pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. An association between NIDDM and a GAA trinucleotide repeat polymorphism in the X25/frataxin (Friedreich's ataxia) gene. Ristow M, etal., Diabetes. 1998 May;47(5):851-4.
22. Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass. Ristow M, etal., J Clin Invest. 2003 Aug;112(4):527-34.
23. Stress-Induced Mouse Model of the Cardiac Manifestations of Friedreich's Ataxia Corrected by AAV-mediated Gene Therapy. Salami CO, etal., Hum Gene Ther. 2020 Aug;31(15-16):819-827. doi: 10.1089/hum.2019.363.
24. Rescue of the Friedreich ataxia knockout mutation in transgenic mice containing an FXN-EGFP genomic reporter. Sarsero JP, etal., PLoS One. 2014 Mar 25;9(3):e93307. doi: 10.1371/journal.pone.0093307. eCollection 2014.
25. Increased Frataxin Levels Protect Retinal Ganglion Cells After Acute Ischemia/Reperfusion in the Mouse Retina In Vivo. Schultz R, etal., Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4115-24. doi: 10.1167/iovs.16-19260.
26. Altered beta-cell characteristics in impaired glucose tolerant carriers of a GAA trinucleotide repeat polymorphism in the frataxin gene. t Hart LM, etal., Diabetes. 1999 Apr;48(4):924-6.
27. A TAT-frataxin fusion protein increases lifespan and cardiac function in a conditional Friedreich's ataxia mouse model. Vyas PM, etal., Hum Mol Genet. 2012 Mar 15;21(6):1230-47. doi: 10.1093/hmg/ddr554. Epub 2011 Nov 23.
Additional References at PubMed
PMID:9241270   PMID:9331900   PMID:9405681   PMID:10349636   PMID:10767347   PMID:10900192   PMID:11042159   PMID:11054533   PMID:11076861   PMID:11175786   PMID:11217851   PMID:11714098  
PMID:11852098   PMID:12140189   PMID:12477932   PMID:12880182   PMID:14610273   PMID:14985441   PMID:15028670   PMID:15170226   PMID:15233994   PMID:16141072   PMID:16141073   PMID:16278235  
PMID:16442805   PMID:16919418   PMID:17322295   PMID:17597094   PMID:18045775   PMID:18614015   PMID:18621680   PMID:19154341   PMID:19376812   PMID:19629184   PMID:19805308   PMID:20799613  
PMID:21267068   PMID:21298097   PMID:21397024   PMID:21873635   PMID:22052287   PMID:22394676   PMID:22447512   PMID:22736457   PMID:23039828   PMID:23169664   PMID:23350650   PMID:23671637  
PMID:23886890   PMID:24714088   PMID:25104852   PMID:25113747   PMID:25198290   PMID:25597503   PMID:25651183   PMID:25681319   PMID:25765157   PMID:26393353   PMID:26752519   PMID:26954031  
PMID:27079523   PMID:27106929   PMID:27516386   PMID:27519411   PMID:27575947   PMID:27901468   PMID:28286293   PMID:28444186   PMID:28504123   PMID:28542596   PMID:28724806   PMID:28935570  
PMID:29070698   PMID:29097656   PMID:29125827   PMID:29259026   PMID:29325032   PMID:29610276   PMID:29853274   PMID:30519163   PMID:30544254   PMID:30635474   PMID:31665133   PMID:31877117  
PMID:31974344   PMID:32032665   PMID:32251310   PMID:32269244   PMID:32325033   PMID:32586831   PMID:32636300   PMID:32978498   PMID:33017621   PMID:33171227   PMID:33905372   PMID:34387346  
PMID:34408077   PMID:35038030   PMID:35322126   PMID:35531957   PMID:35664670   PMID:35769335   PMID:36089099   PMID:36587874   PMID:36638893   PMID:36777637   PMID:37164245   PMID:37343689  
PMID:37691621   PMID:37701569   PMID:38352270  


Genomics

Comparative Map Data
Fxn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391924,236,909 - 24,257,954 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1924,238,817 - 24,257,969 (-)EnsemblGRCm39 Ensembl
GRCm381924,259,545 - 24,280,590 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1924,261,453 - 24,280,605 (-)EnsemblGRCm38mm10GRCm38
MGSCv371924,335,943 - 24,355,076 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361924,328,550 - 24,347,683 (-)NCBIMGSCv36mm8
Celera1925,027,779 - 25,046,379 (-)NCBICelera
Cytogenetic Map19BNCBI
cM Map1919.39NCBI
FXN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38969,035,752 - 69,079,076 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl969,035,751 - 69,079,076 (+)EnsemblGRCh38hg38GRCh38
GRCh37971,650,668 - 71,693,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36970,840,164 - 70,878,772 (+)NCBINCBI36Build 36hg18NCBI36
Celera942,245,805 - 42,311,090 (+)NCBICelera
Cytogenetic Map9q21.11NCBI
HuRef941,495,732 - 41,559,839 (+)NCBIHuRef
CHM1_1971,797,667 - 71,861,767 (+)NCBICHM1_1
T2T-CHM13v2.0981,209,298 - 81,252,406 (+)NCBIT2T-CHM13v2.0
Fxn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81231,300,457 - 231,323,989 (-)NCBIGRCr8
mRatBN7.21221,874,007 - 221,897,543 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,872,420 - 221,897,540 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1230,329,217 - 230,352,686 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01237,259,279 - 237,282,748 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01230,077,299 - 230,100,759 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01242,123,975 - 242,152,834 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1242,123,975 - 242,152,834 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01249,419,972 - 249,426,597 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01249,400,435 - 249,400,757 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41227,647,092 - 227,671,081 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1219,085,510 - 219,108,749 (-)NCBICelera
Cytogenetic Map1q51NCBI
Fxn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554343,980,653 - 4,008,761 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554343,983,225 - 4,008,324 (-)NCBIChiLan1.0ChiLan1.0
FXN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21168,247,362 - 68,295,327 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1968,253,293 - 68,290,295 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0955,690,483 - 55,754,755 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1967,800,579 - 67,865,945 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl967,800,579 - 67,866,031 (+)Ensemblpanpan1.1panPan2
FXN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1188,288,566 - 88,311,228 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl188,288,566 - 88,311,228 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha188,755,862 - 88,778,465 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0188,835,320 - 88,857,379 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl188,835,320 - 88,857,379 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1188,490,664 - 88,513,141 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0188,197,072 - 88,219,719 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0188,962,061 - 88,984,873 (-)NCBIUU_Cfam_GSD_1.0
Fxn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947135,829,799 - 135,849,798 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365035,323,206 - 5,343,228 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FXN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,412,509 - 222,454,776 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,412,485 - 222,433,224 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FXN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11280,133,899 - 80,173,950 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1280,134,422 - 80,173,168 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603868,540,612 - 68,580,635 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fxn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247364,027,354 - 4,047,854 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247364,027,054 - 4,047,881 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fxn
864 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:639
Count of miRNA genes:309
Interacting mature miRNAs:337
Transcripts:ENSMUST00000081333, ENSMUST00000123684, ENSMUST00000132688
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
12801464Rta2_mretinal aging 2 (mouse)141230287425302874Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
1301197Tlyr1_mthymic lymphoma resistance 1 (mouse)Not determined192053952825313796Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
1357596Tgct3_mtesticular germ cell tumor 3 (mouse)Not determined192198409132912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse

Markers in Region
D5Mit392.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS
Cytogenetic Map18A1UniSTS
Cytogenetic Map1G3UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map7F1UniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map4D2.2UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map16B2UniSTS
Cytogenetic Map6F1UniSTS
Cytogenetic Map4B1UniSTS
Cytogenetic Map17DUniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map18A2UniSTS
Cytogenetic MapXF5UniSTS
Cytogenetic Map2G3UniSTS
Cytogenetic Map7A2UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map1H6UniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map1G2UniSTS
Cytogenetic MapXF3UniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map2F3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map15A1UniSTS
Cytogenetic Map1A2UniSTS
Cytogenetic Map13A3.1UniSTS
Cytogenetic Map11B4UniSTS
Cytogenetic Map1D2.3UniSTS
Cytogenetic Map19C1UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map2E1UniSTS
cM Map528.0UniSTS
Whitehead Genetic518.6UniSTS
D4S2924  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381924,270,410 - 24,271,354UniSTSGRCm38
MGSCv371924,344,900 - 24,345,844UniSTSGRCm37
Celera1925,039,509 - 25,040,453UniSTS
Cytogenetic Map19C1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000081333   ⟹   ENSMUSP00000080081
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1924,238,817 - 24,257,969 (-)Ensembl
GRCm38.p6 Ensembl1924,261,453 - 24,280,605 (-)Ensembl
RefSeq Acc Id: ENSMUST00000123684   ⟹   ENSMUSP00000117047
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1924,238,865 - 24,257,932 (-)Ensembl
GRCm38.p6 Ensembl1924,261,501 - 24,280,568 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132688
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1924,239,226 - 24,255,535 (-)Ensembl
GRCm38.p6 Ensembl1924,261,862 - 24,278,171 (-)Ensembl
RefSeq Acc Id: NM_008044   ⟹   NP_032070
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391924,236,909 - 24,257,954 (-)NCBI
GRCm381924,259,545 - 24,280,590 (-)NCBI
MGSCv371924,335,943 - 24,355,076 (-)RGD
Celera1925,027,779 - 25,046,379 (-)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_157400
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391924,236,909 - 24,257,954 (-)NCBI
GRCm381924,259,545 - 24,280,590 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032070   ⟸   NM_008044
- Peptide Label: precursor
- UniProtKB: O35943 (UniProtKB/Swiss-Prot),   Q3TV21 (UniProtKB/TrEMBL),   Q3UG34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000080081   ⟸   ENSMUST00000081333
RefSeq Acc Id: ENSMUSP00000117047   ⟸   ENSMUST00000123684

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35943-F1-model_v2 AlphaFold O35943 1-207 view protein structure

Promoters
RGD ID:13679132
Promoter ID:EPDNEW_M23715
Type:initiation region
Name:Fxn_1
Description:Mus musculus frataxin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381924,280,571 - 24,280,631EPDNEW
RGD ID:6830046
Promoter ID:MM_KWN:26696
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   Spleen
Transcripts:OTTMUST00000079025,   OTTMUST00000079026
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361924,354,746 - 24,355,262 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1096879 AgrOrtholog
Ensembl Genes ENSMUSG00000059363 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000081333 ENTREZGENE
  ENSMUST00000081333.11 UniProtKB/Swiss-Prot
  ENSMUST00000123684.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.920.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Frataxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frataxin/CyaY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frataxin/CyaY_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frataxin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14297 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1096879 ENTREZGENE
NCBI Gene 14297 ENTREZGENE
PANTHER FRATAXIN, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR16821 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Frataxin_Cyay UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fxn PhenoGen
PRINTS FRATAXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FRATAXIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FRATAXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Frataxin_Cyay UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55387 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9Q2P9_MOUSE UniProtKB/TrEMBL
  FRDA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TV21 ENTREZGENE, UniProtKB/TrEMBL
  Q3UG34 ENTREZGENE, UniProtKB/TrEMBL
  Q6PDS4_MOUSE UniProtKB/TrEMBL