Pcyt1b (phosphate cytidylyltransferase 1, choline, beta isoform) - Rat Genome Database

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Pathways
Gene: Pcyt1b (phosphate cytidylyltransferase 1, choline, beta isoform) Mus musculus
Analyze
Symbol: Pcyt1b
Name: phosphate cytidylyltransferase 1, choline, beta isoform
RGD ID: 1551569
MGI Page MGI
Description: Enables choline-phosphate cytidylyltransferase activity. Involved in CDP-choline pathway. Acts upstream of or within ovarian follicle development and spermatogenesis. Predicted to be located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; nervous system; and sensory organ. Orthologous to human PCYT1B (phosphate cytidylyltransferase 1B, choline).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CCT B; CCT-beta; choline-phosphate cytidylyltransferase B; CT B; CTP:phosphocholine cytidylyltransferase B; CTTbet; CTTbeta; phosphorylcholine transferase B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X92,698,469 - 92,793,557 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX92,698,469 - 92,793,557 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X93,654,863 - 93,749,951 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX93,654,863 - 93,749,951 (+)Ensemblmm10GRCm38
MGSCv37X90,900,202 - 90,995,287 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X89,907,582 - 90,002,667 (+)NCBIMGSCv36mm8
CeleraX80,576,672 - 80,673,771 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX41.28NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
endoplasmic reticulum  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Gene structure, expression and identification of a new CTP:phosphocholine cytidylyltransferase beta isoform. Karim M, etal., Biochim Biophys Acta 2003 Jul 4;1633(1):1-12.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:14681479   PMID:15143167   PMID:15345747   PMID:15489334  
PMID:15798219   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16919269   PMID:17560827   PMID:17967808   PMID:18423385   PMID:18799693   PMID:21267068   PMID:21736954   PMID:21873635  
PMID:32900992   PMID:34321999   PMID:34702858   PMID:37196079  


Genomics

Comparative Map Data
Pcyt1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X92,698,469 - 92,793,557 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX92,698,469 - 92,793,557 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X93,654,863 - 93,749,951 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX93,654,863 - 93,749,951 (+)Ensemblmm10GRCm38
MGSCv37X90,900,202 - 90,995,287 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X89,907,582 - 90,002,667 (+)NCBIMGSCv36mm8
CeleraX80,576,672 - 80,673,771 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX41.28NCBI
PCYT1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X24,558,087 - 24,672,887 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX24,558,087 - 24,672,677 (-)Ensemblhg38GRCh38
GRCh37X24,576,204 - 24,691,004 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X24,486,125 - 24,575,274 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34X24,339,615 - 24,424,883NCBI
CeleraX28,699,089 - 28,813,849 (-)NCBICelera
Cytogenetic MapXp22.11NCBI
HuRefX22,318,180 - 22,433,269 (-)NCBIHuRef
CHM1_1X24,607,786 - 24,722,565 (-)NCBICHM1_1
T2T-CHM13v2.0X24,142,375 - 24,257,164 (-)NCBIT2T-CHM13v2.0
Pcyt1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X62,371,934 - 62,465,460 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX62,356,009 - 62,465,459 (+)EnsemblGRCr8
mRatBN7.2X58,378,090 - 58,471,623 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX58,378,116 - 58,468,935 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX59,837,010 - 59,906,338 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X63,338,109 - 63,407,443 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X60,889,498 - 60,958,732 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X62,727,691 - 62,821,199 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX62,727,755 - 62,818,522 (+)Ensemblrn6Rnor6.0
Rnor_5.0X63,320,419 - 63,413,884 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X81,023,064 - 81,087,051 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX58,842,540 - 58,906,499 (+)NCBICelera
RGSC_v3.1X81,096,355 - 81,160,338 (+)NCBI
Cytogenetic MapXq22NCBI
Pcyt1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555094,896,190 - 4,990,149 (-)Ensembl
ChiLan1.0NW_0049555094,896,208 - 4,990,101 (-)NCBIChiLan1.0ChiLan1.0
PCYT1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X26,356,526 - 26,471,450 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X26,359,913 - 26,474,830 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X17,155,065 - 17,269,909 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X24,522,460 - 24,611,590 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX24,522,460 - 24,636,942 (-)EnsemblpanPan2panpan1.1
PCYT1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X20,076,298 - 20,207,837 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX20,079,772 - 20,207,722 (-)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.0X20,031,175 - 20,162,981 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX20,023,407 - 20,162,855 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X20,069,376 - 20,200,639 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X20,102,493 - 20,234,074 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X20,159,787 - 20,291,298 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pcyt1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X13,032,509 - 13,126,131 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493662458,792 - 125,338 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493662431,678 - 125,318 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCYT1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX20,605,945 - 20,743,134 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X20,605,769 - 20,743,081 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X22,084,358 - 22,221,168 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PCYT1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X23,052,554 - 23,164,196 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX23,049,091 - 23,138,210 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605624,913,700 - 25,029,287 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcyt1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624897842,455 - 942,880 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624897842,581 - 943,194 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pcyt1b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X51,682,597 - 51,745,562 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pcyt1b
1838 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:4892
Count of miRNA genes:862
Interacting mature miRNAs:1210
Transcripts:ENSMUST00000045898, ENSMUST00000113933, ENSMUST00000146263
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
4141803Lmr30_mleishmaniasis resistance 30 (mouse)Not determined85062606119062720Mouse
1302054Gct4_mgranulosa cell tumorigenesis 4 (mouse)Not determinedX76124336102062720Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
11075102Modc2_mmodifier of Odc2 (mouse)X80189914114190059Mouse
1357500Mdmsc6_mmodifier of muscularity 6 (mouse)Not determinedX75306671109306758Mouse
12879918Shm4_msperm head morphology 4 (mouse)X72072050102062720Mouse
25314318Sccor2_msynaptonemal complex length to mean MLH1 count ratio 2 (mouse)X7054360696543606Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse

Markers in Region
Pcyt1b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37X90,920,640 - 90,920,710UniSTSGRCm37
CeleraX80,597,110 - 80,597,180UniSTS
Cytogenetic MapXC3UniSTS
cM MapX UniSTS
AW045697  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X93,749,616 - 93,749,735UniSTSGRCm38
MGSCv37X90,994,955 - 90,995,074UniSTSGRCm37
CeleraX80,673,439 - 80,673,558UniSTS
Cytogenetic MapXC3UniSTS
Whitehead/MRC_RHX1044.43UniSTS
px-30g9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X93,679,145 - 93,679,256UniSTSGRCm38
MGSCv37X90,924,484 - 90,924,595UniSTSGRCm37
CeleraX80,600,954 - 80,601,065UniSTS
Cytogenetic MapXC3UniSTS
Pcyt1b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXC3UniSTS
Pcyt1b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X93,675,301 - 93,675,371UniSTSGRCm38
MGSCv37X90,920,640 - 90,920,710UniSTSGRCm37
CeleraX80,597,110 - 80,597,180UniSTS
Cytogenetic MapXC3UniSTS
Pcyt1b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXC3UniSTS
Pcyt1b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXC3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000045898   ⟹   ENSMUSP00000044280
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX92,718,708 - 92,793,557 (+)Ensembl
GRCm38.p6 EnsemblX93,675,102 - 93,749,951 (+)Ensembl
Ensembl Acc Id: ENSMUST00000113933   ⟹   ENSMUSP00000109566
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX92,698,469 - 92,793,557 (+)Ensembl
GRCm38.p6 EnsemblX93,654,863 - 93,749,951 (+)Ensembl
Ensembl Acc Id: ENSMUST00000146263
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX92,775,168 - 92,778,462 (+)Ensembl
GRCm38.p6 EnsemblX93,731,562 - 93,734,856 (+)Ensembl
RefSeq Acc Id: NM_177546   ⟹   NP_808214
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X92,698,469 - 92,793,554 (+)NCBI
GRCm38X93,654,863 - 93,749,948 (+)NCBI
MGSCv37X90,900,202 - 90,995,287 (+)RGD
CeleraX80,576,672 - 80,673,771 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_211138   ⟹   NP_997593
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X92,718,718 - 92,793,554 (+)NCBI
GRCm38X93,675,112 - 93,749,948 (+)NCBI
MGSCv37X90,900,202 - 90,995,287 (+)RGD
CeleraX80,576,672 - 80,673,771 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006527985   ⟹   XP_006528048
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X92,744,669 - 92,793,557 (+)NCBI
GRCm38X93,701,067 - 93,749,951 (+)NCBI
Sequence:
RefSeq Acc Id: NP_808214   ⟸   NM_177546
- Peptide Label: isoform 2
- UniProtKB: Q811Q9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_997593   ⟸   NM_211138
- Peptide Label: isoform 1
- UniProtKB: Q8C085 (UniProtKB/Swiss-Prot),   Q8BKD2 (UniProtKB/Swiss-Prot),   Q811Q9 (UniProtKB/Swiss-Prot),   Q811Q8 (UniProtKB/Swiss-Prot),   Q80Y63 (UniProtKB/Swiss-Prot),   Q3UEW0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006528048   ⟸   XM_006527985
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000044280   ⟸   ENSMUST00000045898
Ensembl Acc Id: ENSMUSP00000109566   ⟸   ENSMUST00000113933

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q811Q9-F1-model_v2 AlphaFold Q811Q9 1-369 view protein structure

Promoters
RGD ID:6846067
Promoter ID:MM_KWN:61145
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   MEF_B6
Transcripts:OTTMUST00000043399
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X90,920,279 - 90,920,779 (+)MPROMDB
RGD ID:6848533
Promoter ID:MM_ACW:53615
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:PCYT1B.DSEP07,   PCYT1B.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X90,946,216 - 90,946,716 (+)MPROMDB
RGD ID:13680930
Promoter ID:EPDNEW_M24614
Type:multiple initiation site
Name:Pcyt1b_2
Description:Mus musculus phosphate cytidylyltransferase 1, choline, betaisoform , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24615  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X93,654,856 - 93,654,916EPDNEW
RGD ID:13680932
Promoter ID:EPDNEW_M24615
Type:initiation region
Name:Pcyt1b_1
Description:Mus musculus phosphate cytidylyltransferase 1, choline, betaisoform , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24614  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X93,675,121 - 93,675,181EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2147987 AgrOrtholog
Ensembl Genes ENSMUSG00000035246 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000045898 ENTREZGENE
  ENSMUST00000045898.4 UniProtKB/Swiss-Prot
  ENSMUST00000113933 ENTREZGENE
  ENSMUST00000113933.9 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.620 UniProtKB/Swiss-Prot
InterPro CCT UniProtKB/Swiss-Prot
  Cyt_trans-like UniProtKB/Swiss-Prot
  Pcy1-like UniProtKB/Swiss-Prot
  Rossmann-like_a/b/a_fold UniProtKB/Swiss-Prot
KEGG Report mmu:236899 UniProtKB/Swiss-Prot
MGD MGI:2147987 ENTREZGENE
NCBI Gene Pcyt1b ENTREZGENE
PANTHER CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE B UniProtKB/Swiss-Prot
  PTHR10739 UniProtKB/Swiss-Prot
Pfam CTP_transf_like UniProtKB/Swiss-Prot
PhenoGen Pcyt1b PhenoGen
Superfamily-SCOP Nucleotidylyl transferase UniProtKB/Swiss-Prot
UniProt PCY1B_MOUSE UniProtKB/Swiss-Prot
  Q3UEW0 ENTREZGENE
  Q80Y63 ENTREZGENE
  Q811Q8 ENTREZGENE
  Q811Q9 ENTREZGENE
  Q8BKD2 ENTREZGENE
  Q8C085 ENTREZGENE
UniProt Secondary Q3UEW0 UniProtKB/Swiss-Prot
  Q80Y63 UniProtKB/Swiss-Prot
  Q811Q8 UniProtKB/Swiss-Prot
  Q8BKD2 UniProtKB/Swiss-Prot
  Q8C085 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Pcyt1b  phosphate cytidylyltransferase 1, choline, beta isoform  AW045697  phosphate cytidylyltransferase 1, choline, beta isoform  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 AW045697  phosphate cytidylyltransferase 1, choline, beta isoform  Pcyt1b  phosphate cytidylyltransferase 1, choline, beta isoform  Symbol and/or name change 5135510 APPROVED