Keg1 (kidney expressed gene 1) - Rat Genome Database

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Gene: Keg1 (kidney expressed gene 1) Mus musculus
Analyze
No known orthologs.
Symbol: Keg1
Name: kidney expressed gene 1
RGD ID: 1551520
MGI Page MGI
Description: Predicted to enable N-acyltransferase activity. Located in mitochondrion. Is expressed in several structures, including genitourinary system and liver.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 0610008P16Rik; Acyl-CoA:glycine N-acyltransferase protein Keg1; AI316519; glycine N-acyltransferase-like protein Keg1; GS405; GS4059; kidney-expressed gene 1 protein
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391912,673,154 - 12,697,266 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1912,673,150 - 12,697,266 (+)EnsemblGRCm39 Ensembl
GRCm381912,695,790 - 12,719,902 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1912,695,786 - 12,719,902 (+)EnsemblGRCm38mm10GRCm38
MGSCv371912,770,280 - 12,794,392 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361912,762,812 - 12,786,913 (+)NCBIMGSCv36mm8
Celera1913,360,762 - 13,384,883 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map198.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (ISO)
cytoplasm  (IEA)
cytoskeleton  (IEA)
microtubule  (IEA)
mitochondrion  (HDA,IBA,IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9507200   PMID:10194414   PMID:10349636   PMID:10470852   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16916647   PMID:18614015  
PMID:21267068   PMID:21731673   PMID:21873635   PMID:24194600  


Genomics

Variants

.
Variants in Keg1
714 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:735
Count of miRNA genes:482
Interacting mature miRNAs:548
Transcripts:ENSMUST00000025598, ENSMUST00000123407, ENSMUST00000128987, ENSMUST00000138545, ENSMUST00000147335, ENSMUST00000152017, ENSMUST00000154822
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300776Lfp3_mlong free running period 3 (mouse)Not determined19120328703Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
38455997Cdtm2_mCD62L+ CD8 TM cells 2 (mouse)19997736419977364Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
12801464Rta2_mretinal aging 2 (mouse)141230287425302874Mouse

Markers in Region
AI316519  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381912,719,691 - 12,719,828UniSTSGRCm38
MGSCv371912,794,181 - 12,794,318UniSTSGRCm37
Celera1913,384,672 - 13,384,809UniSTS
Cytogenetic Map19AUniSTS
Whitehead/MRC_RH19191.81UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000025598   ⟹   ENSMUSP00000025598
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1912,673,150 - 12,697,266 (+)Ensembl
GRCm38.p6 Ensembl1912,695,786 - 12,719,902 (+)Ensembl
RefSeq Acc Id: ENSMUST00000123407
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1912,673,157 - 12,695,928 (+)Ensembl
GRCm38.p6 Ensembl1912,695,793 - 12,718,564 (+)Ensembl
RefSeq Acc Id: ENSMUST00000128987
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1912,673,168 - 12,692,195 (+)Ensembl
GRCm38.p6 Ensembl1912,695,804 - 12,714,831 (+)Ensembl
RefSeq Acc Id: ENSMUST00000138545   ⟹   ENSMUSP00000116555
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1912,673,157 - 12,696,371 (+)Ensembl
GRCm38.p6 Ensembl1912,695,793 - 12,719,007 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147335
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1912,673,178 - 12,692,117 (+)Ensembl
GRCm38.p6 Ensembl1912,695,814 - 12,714,753 (+)Ensembl
RefSeq Acc Id: ENSMUST00000152017
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1912,673,151 - 12,693,411 (+)Ensembl
GRCm38.p6 Ensembl1912,695,787 - 12,716,047 (+)Ensembl
RefSeq Acc Id: ENSMUST00000154822   ⟹   ENSMUSP00000119879
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1912,673,178 - 12,696,481 (+)Ensembl
GRCm38.p6 Ensembl1912,695,814 - 12,719,117 (+)Ensembl
RefSeq Acc Id: NM_029550   ⟹   NP_083826
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391912,673,154 - 12,697,266 (+)NCBI
GRCm381912,695,790 - 12,719,902 (+)ENTREZGENE
MGSCv371912,770,280 - 12,794,392 (+)RGD
Celera1913,360,762 - 13,384,883 (+)RGD
cM Map19 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_083826 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH10803 (Get FASTA)   NCBI Sequence Viewer  
  BAB22039 (Get FASTA)   NCBI Sequence Viewer  
  BAE38231 (Get FASTA)   NCBI Sequence Viewer  
  EDL41481 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000025598
  ENSMUSP00000025598.4
  ENSMUSP00000116555.2
  ENSMUSP00000119879.2
GenBank Protein Q9DCY0 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_083826   ⟸   NM_029550
- UniProtKB: Q9DCY0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000116555   ⟸   ENSMUST00000138545
RefSeq Acc Id: ENSMUSP00000119879   ⟸   ENSMUST00000154822
RefSeq Acc Id: ENSMUSP00000025598   ⟸   ENSMUST00000025598
Protein Domains
Glycine N-acyltransferase C-terminal   Glycine N-acyltransferase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9DCY0-F1-model_v2 AlphaFold Q9DCY0 1-295 view protein structure

Promoters
RGD ID:13679024
Promoter ID:EPDNEW_M23661
Type:multiple initiation site
Name:Keg1_1
Description:Mus musculus kidney expressed gene 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23662  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381912,695,790 - 12,695,850EPDNEW
RGD ID:13679026
Promoter ID:EPDNEW_M23662
Type:single initiation site
Name:Keg1_2
Description:Mus musculus kidney expressed gene 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23661  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381912,697,819 - 12,697,879EPDNEW
RGD ID:6830146
Promoter ID:MM_KWN:26499
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000070109,   OTTMUST00000070110,   OTTMUST00000070111,   OTTMUST00000070112,   OTTMUST00000070113,   OTTMUST00000070114,   OTTMUST00000070115
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361912,769,989 - 12,770,489 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1928492 AgrOrtholog
Ensembl Genes ENSMUSG00000024694 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025598 ENTREZGENE
  ENSMUST00000025598.10 UniProtKB/Swiss-Prot
  ENSMUST00000138545.8 UniProtKB/TrEMBL
  ENSMUST00000154822.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.630.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Acyl_CoA_acyltransferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycine_N-acyltransferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycine_N-acyltransferase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycine_N-acyltransferase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:64697 UniProtKB/Swiss-Prot
MGD MGI:1928492 ENTREZGENE
NCBI Gene 64697 ENTREZGENE
PANTHER GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN KEG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15298 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Gly_acyl_tr_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gly_acyl_tr_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Keg1 PhenoGen
Superfamily-SCOP SSF55729 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3Z1F5_MOUSE UniProtKB/TrEMBL
  D3Z4V9_MOUSE UniProtKB/TrEMBL
  KEG1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE