Plscr2 (phospholipid scramblase 2) - Rat Genome Database
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Gene: Plscr2 (phospholipid scramblase 2) Mus musculus
Analyze
Symbol: Plscr2
Name: phospholipid scramblase 2
RGD ID: 1551464
MGI Page MGI
Description: Predicted to have phospholipid scramblase activity. Involved in cellular response to lipopolysaccharide. Localizes to cytoplasm and nucleus. Is expressed in foregut; inner ear; mesothelium; and urogenital mesentery. Orthologous to human PLSCR1 (phospholipid scramblase 1) and PLSCR2 (phospholipid scramblase 2); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3-isobutyl-1-methyl-7H-xanthine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ca(2+)-dependent phospholipid scramblase 2; PL scramblase 2
RGD Orthologs
Human
Rat
Bonobo
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39992,157,655 - 92,179,805 (+)NCBIGRCm39mm39
GRCm38992,275,602 - 92,297,752 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl992,275,602 - 92,297,752 (+)EnsemblGRCm38mm10GRCm38
MGSCv37992,170,558 - 92,192,569 (+)NCBIGRCm37mm9NCBIm37
MGSCv36992,079,491 - 92,101,502 (+)NCBImm8
Celera991,863,214 - 91,885,598 (+)NCBICelera
Cytogenetic Map9E3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11591653   PMID:12477932   PMID:12509439   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16919269   PMID:17590392   PMID:21267068  
PMID:21677750   PMID:21873635   PMID:27626380  


Genomics

Comparative Map Data
Plscr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39992,157,655 - 92,179,805 (+)NCBIGRCm39mm39
GRCm38992,275,602 - 92,297,752 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl992,275,602 - 92,297,752 (+)EnsemblGRCm38mm10GRCm38
MGSCv37992,170,558 - 92,192,569 (+)NCBIGRCm37mm9NCBIm37
MGSCv36992,079,491 - 92,101,502 (+)NCBImm8
Celera991,863,214 - 91,885,598 (+)NCBICelera
Cytogenetic Map9E3.3NCBI
PLSCR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3146,391,421 - 146,495,991 (-)EnsemblGRCh38hg38GRCh38
GRCh383146,391,363 - 146,497,163 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373146,109,150 - 146,213,778 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363147,633,772 - 147,696,412 (-)NCBINCBI36hg18NCBI36
Build 343147,633,779 - 147,696,420NCBI
Celera3144,568,109 - 144,630,745 (-)NCBI
Cytogenetic Map3q24NCBI
HuRef3143,527,951 - 143,590,609 (-)NCBIHuRef
CHM1_13146,114,147 - 146,176,844 (-)NCBICHM1_1
Plscr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0899,650,351 - 99,725,514 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl899,625,545 - 99,725,217 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0899,199,390 - 99,210,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4897,231,930 - 97,274,354 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1897,251,384 - 97,293,808 (+)NCBI
Celera892,333,271 - 92,365,393 (+)NCBICelera
Cytogenetic Map8q31NCBI
PLSCR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13151,029,759 - 151,140,481 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3151,029,766 - 151,092,437 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03143,446,683 - 143,509,767 (-)NCBIMhudiblu_PPA_v0panPan3


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93739490198819654Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95212317899910428Mouse
1301172Fembrs6_mfemur breaking strength 6 (mouse)Not determined95911710593117252Mouse
1301803Stheal9_msoft tissue heal 9 (mouse)Not determined95911710593117252Mouse
5491195Mobq8_mmultigenic obesity QTL 8 (mouse)Not determined95946266493462846Mouse
1300848Skull13_mskull morphology 13 (mouse)Not determined95946266493462846Mouse
1301456Adip5_madiposity 5 (mouse)Not determined95946266493462846Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
1301611Lrnx3_mlearning contextual 3 (mouse)Not determined96224248596242599Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
11081165Psl6_mpromotion susceptibility QTL 6 (mouse)96513390995640755Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966207024100207122Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967124167101124167Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968897510102897652Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968897510102897652Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969239845103239920Mouse
10412174Habiir4_mhyperoxic acute lung injury imprinted region 4 (mouse)Not determined96936046598819654Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969546513103546645Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301869Tbbmd4_mtotal body bone mineral density 4 (mouse)Not determined976117105101528921Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:391
Count of miRNA genes:187
Interacting mature miRNAs:197
Transcripts:ENSMUST00000034932, ENSMUST00000113044, ENSMUST00000126911, ENSMUST00000156772, ENSMUST00000180154
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034932   ⟹   ENSMUSP00000034932
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl992,275,602 - 92,297,731 (+)Ensembl
RefSeq Acc Id: ENSMUST00000113044   ⟹   ENSMUSP00000108667
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl992,289,572 - 92,297,731 (+)Ensembl
RefSeq Acc Id: ENSMUST00000126911   ⟹   ENSMUSP00000119104
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl992,275,746 - 92,282,192 (+)Ensembl
RefSeq Acc Id: ENSMUST00000156772
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl992,290,819 - 92,291,784 (+)Ensembl
RefSeq Acc Id: ENSMUST00000180154   ⟹   ENSMUSP00000136481
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl992,275,602 - 92,297,752 (+)Ensembl
RefSeq Acc Id: NM_001195084   ⟹   NP_001182013
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39992,157,655 - 92,179,805 (+)NCBI
GRCm38992,275,602 - 92,297,752 (+)ENTREZGENE
Celera991,863,096 - 91,885,619 (+)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_008880   ⟹   NP_032906
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39992,157,655 - 92,179,805 (+)NCBI
GRCm38992,275,602 - 92,297,752 (+)ENTREZGENE
MGSCv37992,170,558 - 92,192,569 (+)RGD
Celera991,863,096 - 91,885,619 (+)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006510857   ⟹   XP_006510920
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39992,157,713 - 92,179,784 (+)NCBI
GRCm38992,275,660 - 92,297,731 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011242676   ⟹   XP_011240978
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39992,171,716 - 92,179,784 (+)NCBI
GRCm38992,289,663 - 92,297,731 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032906   ⟸   NM_008880
- UniProtKB: Q9DCW2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001182013   ⟸   NM_001195084
- UniProtKB: Q9DCW2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006510920   ⟸   XM_006510857
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011240978   ⟸   XM_011242676
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000108667   ⟸   ENSMUST00000113044
RefSeq Acc Id: ENSMUSP00000034932   ⟸   ENSMUST00000034932
RefSeq Acc Id: ENSMUSP00000119104   ⟸   ENSMUST00000126911
RefSeq Acc Id: ENSMUSP00000136481   ⟸   ENSMUST00000180154

Promoters
RGD ID:6844962
Promoter ID:MM_KWN:58370
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000055273,   OTTMUST00000055274
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36992,169,451 - 92,170,777 (+)MPROMDB
RGD ID:6844963
Promoter ID:MM_KWN:58372
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000055275
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36992,185,136 - 92,185,636 (+)MPROMDB
RGD ID:8670440
Promoter ID:EPDNEW_M13251
Type:initiation region
Name:Plscr2_2
Description:Mus musculus phospholipid scramblase 2 , transcript variant B,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13252  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38992,275,681 - 92,275,741EPDNEW
RGD ID:8670442
Promoter ID:EPDNEW_M13252
Type:initiation region
Name:Plscr2_1
Description:Mus musculus phospholipid scramblase 2 , transcript variant B,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13251  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38992,275,882 - 92,275,942EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1270860 AgrOrtholog
Ensembl Genes ENSMUSG00000032372 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034932 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000108667 UniProtKB/TrEMBL
  ENSMUSP00000119104 UniProtKB/TrEMBL
  ENSMUSP00000136481 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034932 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000113044 UniProtKB/TrEMBL
  ENSMUST00000126911 UniProtKB/TrEMBL
  ENSMUST00000180154 UniProtKB/Swiss-Prot
InterPro Scramblase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18828 UniProtKB/Swiss-Prot
MGD MGI:1270860 ENTREZGENE
NCBI Gene 18828 ENTREZGENE
PANTHER PTHR23248 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Scramblase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plscr2 PhenoGen
UniGene Mm.10306 ENTREZGENE
UniProt D3Z2S8_MOUSE UniProtKB/TrEMBL
  D3Z7J3_MOUSE UniProtKB/TrEMBL
  PLS2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O70233 UniProtKB/Swiss-Prot
  Q921P6 UniProtKB/Swiss-Prot