Polr3k (polymerase (RNA) III (DNA directed) polypeptide K) - Rat Genome Database

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Gene: Polr3k (polymerase (RNA) III (DNA directed) polypeptide K) Mus musculus
Analyze
Symbol: Polr3k
Name: polymerase (RNA) III (DNA directed) polypeptide K
RGD ID: 1551431
MGI Page MGI
Description: Predicted to enable zinc ion binding activity. Predicted to contribute to RNA polymerase III activity. Predicted to be involved in termination of RNA polymerase III transcription. Predicted to act upstream of or within defense response to virus and innate immune response. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Is expressed in several structures, including 1st branchial arch; alimentary system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 21. Orthologous to human POLR3K (RNA polymerase III subunit K).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 12.3kD; 12.3kDa; 1500004O14Rik; AI196849; AU014893; C11; DNA-directed RNA polymerase III subunit K; DNA-directed RNA polymerase III subunit RPC10; RNA polymerase III subunit C10; RNA polymerase III subunit C11; RPC; RPC10; RPC11
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392181,506,153 - 181,512,623 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2181,506,130 - 181,512,623 (+)EnsemblGRCm39 Ensembl
GRCm382181,864,360 - 181,870,830 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2181,864,337 - 181,870,830 (+)EnsemblGRCm38mm10GRCm38
MGSCv372181,599,065 - 181,605,535 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362181,793,852 - 181,799,571 (+)NCBIMGSCv36mm8
Celera2185,940,194 - 185,946,662 (+)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Dumay-Odelot H, etal., Cell Cycle. 2010 Sep 15;9(18):3687-99. Epub 2010 Sep 1.
2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
3. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. Hu P, etal., Mol Cell Biol. 2002 Nov;22(22):8044-55.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:14681479   PMID:15226823   PMID:15489334   PMID:16141072   PMID:16141073  
PMID:18287559   PMID:19521500   PMID:20059953   PMID:20412781   PMID:21267068   PMID:21873635   PMID:32325033  


Genomics

Comparative Map Data
Polr3k
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392181,506,153 - 181,512,623 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2181,506,130 - 181,512,623 (+)EnsemblGRCm39 Ensembl
GRCm382181,864,360 - 181,870,830 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2181,864,337 - 181,870,830 (+)EnsemblGRCm38mm10GRCm38
MGSCv372181,599,065 - 181,605,535 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362181,793,852 - 181,799,571 (+)NCBIMGSCv36mm8
Celera2185,940,194 - 185,946,662 (+)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.82NCBI
POLR3K
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381646,407 - 53,608 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1646,407 - 53,608 (-)EnsemblGRCh38hg38GRCh38
GRCh371696,407 - 103,608 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361637,000 - 43,625 (-)NCBINCBI36Build 36hg18NCBI36
Build 341636,999 - 43,625NCBI
Celera16298,898 - 305,526 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef1615,438 - 22,023 (-)NCBIHuRef
CHM1_11696,967 - 103,568 (-)NCBICHM1_1
T2T-CHM13v2.01639,992 - 47,144 (-)NCBIT2T-CHM13v2.0
Polr3k
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83189,360,349 - 189,364,546 (+)NCBIGRCr8
mRatBN7.23168,982,846 - 168,987,043 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,982,812 - 168,987,040 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3173,359,765 - 173,363,952 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03182,318,868 - 182,323,055 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,983,764 - 178,987,961 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03177,374,812 - 177,379,009 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3177,374,812 - 177,379,008 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03181,083,123 - 181,087,320 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43171,017,930 - 171,022,127 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3163,603,612 - 163,607,809 (-)NCBICelera
Cytogenetic Map3q43NCBI
Polr3k
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544217,101,585 - 17,106,689 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544217,101,585 - 17,106,689 (+)NCBIChiLan1.0ChiLan1.0
POLR3K
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v218262,237 - 268,920 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,054,323 - 4,060,963 (-)NCBINHGRI_mPanPan1
PanPan1.11637,772 - 44,598 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1637,772 - 44,598 (-)Ensemblpanpan1.1panPan2
POLR3K
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1640,417,020 - 40,420,030 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl640,417,051 - 40,419,917 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha641,680,034 - 41,683,047 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0640,760,045 - 40,763,059 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl640,760,079 - 40,762,946 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1640,447,597 - 40,450,614 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0640,408,524 - 40,411,541 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,887,713 - 40,890,726 (+)NCBIUU_Cfam_GSD_1.0
Polr3k
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344112,715,594 - 112,722,052 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936501813,457 - 819,883 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936501813,452 - 819,912 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLR3K
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl341,571,475 - 41,574,987 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1341,571,709 - 41,575,044 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2340,861,850 - 40,865,114 (-)NCBISscrofa10.2Sscrofa10.2susScr3
POLR3K
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,568 - 10,259 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl550 - 10,259 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606831,214,941 - 31,222,745 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Polr3k
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624913929,627 - 935,346 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624913928,871 - 934,876 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Polr3k
156 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:673
Count of miRNA genes:459
Interacting mature miRNAs:533
Transcripts:ENSMUST00000039551, ENSMUST00000153214
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151778297181755017Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152329820181755017Mouse
1300622Cfld1_mcystic fibrosis lung disease 1 (mouse)Not determined2155823920181755017Mouse
1357537Lith12_mlithogenic gene 12 (mouse)Not determined2156196464181755017Mouse
1302003Sluc17_msusceptibility to lung cancer 17 (mouse)Not determined2162433493181755017Mouse
1301677Alcp6_malcohol preference locus 6 (mouse)Not determined2163486407181755017Mouse
1301348Alcp5_malcohol preference locus 5 (mouse)Not determined2163486407181755017Mouse
1300676Prdt2_mprion disease incubation time 2 (mouse)Not determined2164515154181755017Mouse
1558748Vacq1_mvoluntary alcohol consumption QTL 1 (mouse)Not determined2178442338181515280Mouse

Markers in Region
AU014893  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382181,868,371 - 181,868,575UniSTSGRCm38
MGSCv372181,603,076 - 181,603,280UniSTSGRCm37
Celera2185,944,203 - 185,944,407UniSTS
Cytogenetic Map2H4UniSTS
Whitehead/MRC_RH12530.2UniSTS
AI196849  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382181,869,712 - 181,869,821UniSTSGRCm38
MGSCv372181,604,417 - 181,604,526UniSTSGRCm37
Celera2185,945,544 - 185,945,653UniSTS
Cytogenetic Map2H4UniSTS
Whitehead/MRC_RH22027.03UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000039551   ⟹   ENSMUSP00000044582
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2181,506,130 - 181,512,623 (+)Ensembl
GRCm38.p6 Ensembl2181,864,337 - 181,870,830 (+)Ensembl
RefSeq Acc Id: ENSMUST00000153214
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2181,506,153 - 181,508,002 (+)Ensembl
GRCm38.p6 Ensembl2181,864,360 - 181,866,209 (+)Ensembl
RefSeq Acc Id: NM_025901   ⟹   NP_080177
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392181,506,153 - 181,512,623 (+)NCBI
GRCm382181,864,360 - 181,870,830 (+)ENTREZGENE
MGSCv372181,599,065 - 181,605,535 (+)RGD
Celera2185,940,194 - 185,946,662 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_080177   ⟸   NM_025901
- UniProtKB: Q9D1U1 (UniProtKB/Swiss-Prot),   Q9CQZ7 (UniProtKB/Swiss-Prot),   Q8BU05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000044582   ⟸   ENSMUST00000039551
Protein Domains
TFIIS-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CQZ7-F1-model_v2 AlphaFold Q9CQZ7 1-108 view protein structure

Promoters
RGD ID:6830590
Promoter ID:MM_KWN:33679
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK013066_2810410D24RIK,   OTTMUST00000040907,   OTTMUST00000040908
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362181,598,774 - 181,599,274 (-)MPROMDB
RGD ID:6880176
Promoter ID:EPDNEW_M3539
Type:initiation region
Name:Polr3k_1
Description:Mus musculus polymerase III polypeptide K , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382181,864,429 - 181,864,489EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914255 AgrOrtholog
Ensembl Genes ENSMUSG00000038628 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000039551 ENTREZGENE
  ENSMUST00000039551.9 UniProtKB/Swiss-Prot
Gene3D-CATH 2.20.25.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DNA-dir_RNA_pol-M_15_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA-dir_RNA_pol_M/15kDasu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rpa12/Rpb9/Rpc10/TFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zn_ribbon_RPC11_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_TFIIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:67005 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1914255 ENTREZGENE
NCBI Gene 67005 ENTREZGENE
PANTHER DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RNA_POL_M_15KD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TFIIS_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Polr3k PhenoGen
PIRSF RNApol_RpoM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RNA_POL_M_15KD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_TFIIS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_TFIIS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RPOL9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C2C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Zinc beta-ribbon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q3TSW1_MOUSE UniProtKB/TrEMBL
  Q8BU05 ENTREZGENE, UniProtKB/TrEMBL
  Q9CQZ7 ENTREZGENE
  Q9D1U1 ENTREZGENE
  RPC10_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q9D1U1 UniProtKB/Swiss-Prot