Msl2 (MSL complex subunit 2) - Rat Genome Database
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Gene: Msl2 (MSL complex subunit 2) Mus musculus
Analyze
Symbol: Msl2
Name: MSL complex subunit 2
RGD ID: 1551343
MGI Page MGI
Description: Predicted to have ubiquitin protein ligase activity. Predicted to be involved in histone H4-K16 acetylation and protein ubiquitination. Predicted to localize to MSL complex. Is expressed in embryo. Orthologous to human MSL2 (MSL complex subunit 2); INTERACTS WITH aflatoxin B1; folic acid; pirinixic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E130103E02Rik; E3 ubiquitin-protein ligase MSL2; E3 ubiquitin-protein transferase MSL2; male-specific lethal 2 homolog; male-specific lethal 2 homolog (Drosophila); male-specific lethal 2-like 1; male-specific lethal-2 homolog 1; Msl; MSL-2; MSL2-like 1; Msl2l1; ring finger protein 184; Rnf1; Rnf184
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399100,956,107 - 100,981,999 (+)NCBIGRCm39mm39
GRCm389101,074,054 - 101,104,800 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9101,074,101 - 101,104,800 (+)EnsemblGRCm38mm10GRCm38
MGSCv379100,978,451 - 100,979,143 (+)NCBIGRCm37mm9NCBIm37
MGSCv379101,002,900 - 101,007,130 (+)NCBIGRCm37mm9NCBIm37
MGSCv369100,956,680 - 100,964,191 (+)NCBImm8
Celera9100,614,669 - 100,640,555 (+)NCBICelera
Cytogenetic Map9E4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
MSL complex  (IBA,ISO)

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12698291   PMID:14610273   PMID:15368895   PMID:16141072   PMID:16141073   PMID:18799693   PMID:19033443  
PMID:21267068   PMID:21873635   PMID:23210685   PMID:23874665   PMID:28609438   PMID:32325033  


Genomics

Comparative Map Data
Msl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399100,956,107 - 100,981,999 (+)NCBIGRCm39mm39
GRCm389101,074,054 - 101,104,800 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9101,074,101 - 101,104,800 (+)EnsemblGRCm38mm10GRCm38
MGSCv379100,978,451 - 100,979,143 (+)NCBIGRCm37mm9NCBIm37
MGSCv379101,002,900 - 101,007,130 (+)NCBIGRCm37mm9NCBIm37
MGSCv369100,956,680 - 100,964,191 (+)NCBImm8
Celera9100,614,669 - 100,640,555 (+)NCBICelera
Cytogenetic Map9E4NCBI
MSL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3136,148,917 - 136,197,241 (-)EnsemblGRCh38hg38GRCh38
GRCh383136,148,917 - 136,197,300 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373135,867,760 - 135,915,522 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363137,350,450 - 137,397,378 (-)NCBINCBI36hg18NCBI36
Build 343137,350,457 - 137,397,386NCBI
Celera3134,293,973 - 134,340,053 (-)NCBI
Cytogenetic Map3q22.3NCBI
HuRef3133,245,191 - 133,291,938 (-)NCBIHuRef
CHM1_13135,831,027 - 135,878,223 (-)NCBICHM1_1
Msl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08109,456,097 - 109,480,143 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8109,455,786 - 109,478,584 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08108,872,826 - 108,898,055 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48106,034,690 - 106,059,395 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18106,053,694 - 106,077,241 (+)NCBI
Celera8101,068,882 - 101,092,934 (+)NCBICelera
Cytogenetic Map8q31NCBI
Msl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555012,601,424 - 2,645,341 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555012,601,424 - 2,645,341 (+)NCBIChiLan1.0ChiLan1.0
MSL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13140,667,652 - 140,714,924 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3140,667,652 - 140,714,294 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03133,203,579 - 133,252,294 (-)NCBIMhudiblu_PPA_v0panPan3
MSL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2332,631,804 - 32,664,277 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12332,629,120 - 32,663,885 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Msl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365299,035,198 - 9,068,567 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1377,146,299 - 77,180,745 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11377,147,823 - 77,181,410 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21384,517,847 - 84,550,666 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MSL2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11554,246,090 - 54,290,809 (+)NCBI
ChlSab1.1 Ensembl1554,246,127 - 54,288,555 (+)Ensembl
Msl2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473012,569,562 - 12,618,933 (-)NCBI

Position Markers
Pccb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389101,077,220 - 101,077,396UniSTSGRCm38
MGSCv379100,980,944 - 100,981,120UniSTSGRCm37
Celera9100,617,137 - 100,617,313UniSTS
Cytogenetic Map9E4UniSTS
cM Map9 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967124167101124167Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968897510102897652Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969239845103239920Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969546513103546645Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1301869Tbbmd4_mtotal body bone mineral density 4 (mouse)Not determined976117105101528921Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968897510102897652Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:551
Count of miRNA genes:407
Interacting mature miRNAs:452
Transcripts:ENSMUST00000085177
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001100451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001379344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC120390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC242670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC242673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK021369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK035934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK173208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE986573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CAAA01196876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH423688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000085177   ⟹   ENSMUSP00000082270
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9101,074,762 - 101,104,800 (+)Ensembl
RefSeq Acc Id: ENSMUST00000189616   ⟹   ENSMUSP00000139396
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9101,074,101 - 101,101,785 (+)Ensembl
RefSeq Acc Id: NM_001100451   ⟹   NP_001093921
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399100,956,815 - 100,981,999 (+)NCBI
GRCm389101,074,762 - 101,104,800 (+)NCBI
MGSCv379101,002,900 - 101,007,130 (+)RGD
Celera9100,614,679 - 100,640,555 (+)NCBI
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001379344   ⟹   NP_001366273
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399100,956,107 - 100,981,999 (+)NCBI
GRCm389101,074,054 - 101,104,800 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001093921   ⟸   NM_001100451
- Peptide Label: isoform 1
- UniProtKB: Q69ZF8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001366273   ⟸   NM_001379344
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000082270   ⟸   ENSMUST00000085177
RefSeq Acc Id: ENSMUSP00000139396   ⟸   ENSMUST00000189616

Promoters
RGD ID:8670596
Promoter ID:EPDNEW_M13328
Type:initiation region
Name:Msl2_1
Description:Mus musculus MSL complex subunit 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389101,074,690 - 101,074,750EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1925103 AgrOrtholog
Ensembl Genes ENSMUSG00000066415 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000082270 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000139396 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000085177 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000189616 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MSL2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Msl2-CXC UniProtKB/Swiss-Prot
  Msl2_Znf-RING UniProtKB/Swiss-Prot
  Tesmin/TSO1-like_CXC UniProtKB/Swiss-Prot
  Znf_RING UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:77853 UniProtKB/Swiss-Prot
MGD MGI:1925103 ENTREZGENE
NCBI Gene 77853 ENTREZGENE
PANTHER PTHR16048 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MSL2-CXC UniProtKB/Swiss-Prot
  zf-RING_10 UniProtKB/Swiss-Prot
PhenoGen Msl2 PhenoGen
PROSITE ZF_RING_2 UniProtKB/Swiss-Prot
SMART CXC UniProtKB/Swiss-Prot
UniGene Mm.326206 ENTREZGENE
  Mm.436586 ENTREZGENE
  Mm.491280 ENTREZGENE
UniProt A0A087WNL5_MOUSE UniProtKB/TrEMBL
  MSL2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q497U7 UniProtKB/Swiss-Prot
  Q8CBI7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Msl2  MSL complex subunit 2    male-specific lethal 2 homolog (Drosophila)  Symbol and/or name change 5135510 APPROVED