Rln3 (relaxin 3) - Rat Genome Database
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Gene: Rln3 (relaxin 3) Mus musculus
Analyze
Symbol: Rln3
Name: relaxin 3
RGD ID: 1551268
MGI Page MGI
Description: Predicted to have G protein-coupled receptor binding activity. Predicted to localize to extracellular region. Is expressed in brain; ovary; and testis. Orthologous to human RLN3 (relaxin 3); INTERACTS WITH 1,2-dichloroethane; genistein; hydrogen sulfide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: insl7; insulin-like 7; insulin-like peptide 7; insulin-like peptide INSL7; M3; prorelaxin M3; relaxin-3
RGD Orthologs
Human
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,769,696 - 84,771,608 (-)NCBIGRCm39mm39
GRCm38884,043,067 - 84,044,979 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,042,929 - 84,045,000 (-)EnsemblGRCm38mm10GRCm38
MGSCv37886,566,966 - 86,568,878 (-)NCBIGRCm37mm9NCBIm37
MGSCv36886,933,172 - 86,935,084 (-)NCBImm8
Celera888,337,588 - 88,339,500 (-)NCBICelera
Cytogenetic Map8C2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:11689565   PMID:12686464   PMID:14610273   PMID:16411781   PMID:16602821   PMID:17170214   PMID:18831067   PMID:19416195   PMID:19416196   PMID:19416199   PMID:20138959   PMID:20737598  
PMID:21873635   PMID:21887138   PMID:21899720   PMID:24194600   PMID:24640569   PMID:24640570   PMID:24640571   PMID:24640572   PMID:24640573   PMID:24681162   PMID:24952961   PMID:26147879  
PMID:27626380   PMID:28100033  


Genomics

Comparative Map Data
Rln3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,769,696 - 84,771,608 (-)NCBIGRCm39mm39
GRCm38884,043,067 - 84,044,979 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,042,929 - 84,045,000 (-)EnsemblGRCm38mm10GRCm38
MGSCv37886,566,966 - 86,568,878 (-)NCBIGRCm37mm9NCBIm37
MGSCv36886,933,172 - 86,935,084 (-)NCBImm8
Celera888,337,588 - 88,339,500 (-)NCBICelera
Cytogenetic Map8C2NCBI
RLN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1914,028,148 - 14,031,551 (+)EnsemblGRCh38hg38GRCh38
GRCh381914,028,148 - 14,031,551 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371914,139,017 - 14,141,783 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,000,017 - 14,002,783 (+)NCBINCBI36hg18NCBI36
Build 341914,000,016 - 14,002,783NCBI
Celera1914,032,810 - 14,035,579 (+)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1913,711,000 - 13,713,769 (+)NCBIHuRef
CHM1_11914,139,507 - 14,142,914 (+)NCBICHM1_1
Rln3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01925,164,497 - 25,166,528 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,164,497 - 25,166,528 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,141,375 - 36,143,406 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,792,783 - 25,794,814 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11925,797,608 - 25,800,095 (+)NCBI
Celera1923,655,324 - 23,657,355 (+)NCBICelera
Cytogenetic Map19q11NCBI
Rln3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,747,362 - 32,749,338 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,747,362 - 32,749,338 (+)NCBIChiLan1.0ChiLan1.0
RLN3
(Canis lupus familiaris - dog)
No map positions available.
Rln3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366592,703,024 - 2,704,664 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RLN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl265,149,890 - 65,162,197 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1265,149,883 - 65,173,306 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,424,035 - 65,447,470 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RLN3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1612,645,677 - 12,679,190 (+)NCBI
ChlSab1.1 Ensembl612,675,383 - 12,678,601 (+)Ensembl
Rln3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249011,272,414 - 1,274,670 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:160
Interacting mature miRNAs:173
Transcripts:ENSMUST00000061923
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000061923   ⟹   ENSMUSP00000051392
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,042,929 - 84,045,000 (-)Ensembl
RefSeq Acc Id: NM_173184   ⟹   NP_775276
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,769,696 - 84,771,608 (-)NCBI
GRCm38884,043,067 - 84,044,979 (-)ENTREZGENE
MGSCv37886,566,966 - 86,568,878 (-)RGD
Celera888,337,588 - 88,339,500 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_775276 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC53760 (Get FASTA)   NCBI Sequence Viewer  
  EDL10929 (Get FASTA)   NCBI Sequence Viewer  
  Q8CHK2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_775276   ⟸   NM_173184
- Peptide Label: precursor
- UniProtKB: Q8CHK2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000051392   ⟸   ENSMUST00000061923

Promoters
RGD ID:8667639
Promoter ID:EPDNEW_M11851
Type:multiple initiation site
Name:Rln3_1
Description:Mus musculus relaxin 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38884,044,989 - 84,045,049EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2158015 AgrOrtholog
Ensembl Genes ENSMUSG00000045232 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000051392 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000061923 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Insulin-like UniProtKB/Swiss-Prot
  Insulin-like_sf UniProtKB/Swiss-Prot
  Insulin_CS UniProtKB/Swiss-Prot
  Insulin_family UniProtKB/Swiss-Prot
KEGG Report mmu:212108 UniProtKB/Swiss-Prot
MGD MGI:2158015 ENTREZGENE
NCBI Gene 212108 ENTREZGENE
Pfam Insulin UniProtKB/Swiss-Prot
PhenoGen Rln3 PhenoGen
PRINTS INSULINFAMLY UniProtKB/Swiss-Prot
PROSITE INSULIN UniProtKB/Swiss-Prot
SMART IlGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56994 UniProtKB/Swiss-Prot
UniGene Mm.261583 ENTREZGENE
UniProt Q8CHK2 ENTREZGENE, UniProtKB/Swiss-Prot