Dnah6 (dynein, axonemal, heavy chain 6) - Rat Genome Database
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Gene: Dnah6 (dynein, axonemal, heavy chain 6) Mus musculus
Analyze
Symbol: Dnah6
Name: dynein, axonemal, heavy chain 6
RGD ID: 1551162
MGI Page MGI
Description: Predicted to have ATP-dependent microtubule motor activity, minus-end-directed; dynein intermediate chain binding activity; and dynein light intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to localize to inner dynein arm. Is expressed in choroid invagination; diencephalon roof plate; medulla oblongata part of 4th ventricle choroid plexus; metencephalon part of 4th ventricle choroid plexus; and node. Orthologous to human DNAH6 (dynein axonemal heavy chain 6); INTERACTS WITH 4,4'-sulfonyldiphenol; acrylamide; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9830168K20; A730004I20Rik; axonemal dynein heavy chain; Dnah; Dnahc6; dynein heavy chain 6, axonemal; dynein, axon, heavy chain 6; KIAA1697; mdhc6; mKIAA1697
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,994,586 - 73,199,327 (-)NCBIGRCm39mm39
GRCm38673,017,603 - 73,222,227 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl673,017,606 - 73,221,651 (-)EnsemblGRCm38mm10GRCm38
MGSCv37672,967,600 - 73,171,625 (-)NCBIGRCm37mm9NCBIm37
MGSCv36672,947,115 - 73,088,822 (-)NCBImm8
Celera675,088,656 - 75,275,780 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:9373155   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12040188   PMID:12466851   PMID:14610273   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635  
PMID:26918822  


Genomics

Comparative Map Data
Dnah6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,994,586 - 73,199,327 (-)NCBIGRCm39mm39
GRCm38673,017,603 - 73,222,227 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl673,017,606 - 73,221,651 (-)EnsemblGRCm38mm10GRCm38
MGSCv37672,967,600 - 73,171,625 (-)NCBIGRCm37mm9NCBIm37
MGSCv36672,947,115 - 73,088,822 (-)NCBImm8
Celera675,088,656 - 75,275,780 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.37NCBI
DNAH6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl284,516,455 - 84,819,589 (+)EnsemblGRCh38hg38GRCh38
GRCh38284,459,572 - 84,819,589 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37284,743,622 - 85,046,713 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37284,743,579 - 85,046,713 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36284,743,579 - 85,046,713 (+)NCBINCBI36hg18NCBI36
Build 34284,763,682 - 84,773,351NCBI
Celera284,572,707 - 84,875,501 (+)NCBI
Cytogenetic Map2p11.2NCBI
HuRef284,639,804 - 84,942,713 (+)NCBIHuRef
CHM1_1284,673,549 - 84,976,538 (+)NCBICHM1_1
Dnah6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24105,064,123 - 105,284,361 (-)NCBI
Rnor_6.0 Ensembl4100,936,978 - 101,156,576 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04100,936,834 - 101,157,511 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04165,697,703 - 165,914,236 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44106,349,760 - 106,547,100 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14106,703,955 - 106,715,999 (-)NCBI
Celera494,213,584 - 94,426,027 (-)NCBICelera
Cytogenetic Map4q31NCBI
Dnah6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554242,575,496 - 2,787,739 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554242,575,333 - 2,788,742 (-)NCBIChiLan1.0ChiLan1.0
DNAH6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A86,128,375 - 86,431,912 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A86,129,741 - 86,431,912 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A84,569,813 - 84,873,380 (+)NCBIMhudiblu_PPA_v0panPan3
DNAH6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1740,134,493 - 40,366,442 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11740,134,143 - 40,366,419 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dnah6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366503,342,351 - 3,604,929 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNAH6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl359,859,863 - 60,114,221 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1359,859,858 - 60,114,274 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2362,982,989 - 63,131,658 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNAH6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11422,357,139 - 22,712,614 (-)NCBI
ChlSab1.1 Ensembl1422,357,102 - 22,659,471 (-)Ensembl
Dnah6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474918,267,959 - 18,516,919 (-)NCBI

Position Markers
D6Mit71  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38673,097,137 - 73,097,278UniSTSGRCm38
MGSCv37673,047,131 - 73,047,272UniSTSGRCm37
Celera675,168,227 - 75,168,368UniSTS
Cytogenetic Map6C1UniSTS
cM Map631.0UniSTS
Whitehead Genetic620.8UniSTS
Whitehead/MRC_RH6728.21UniSTS
Whitehead_YAC6 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080600000Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414873387692Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62500000080000000Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3285065078238974Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
12880424V25Dq4_mvitamin D inactive form serum level QTL 4 (mouse)64160000075600000Mouse
1301266Lmr4_mleishmaniasis resistance 4 (mouse)Not determined64211637376116515Mouse
11040600Lmr4c_mleishmaniasis resistance 4c (mouse)64211637376116515Mouse
11040601Lmr4a_mleishmaniasis resistance 4a (mouse)64211637376116515Mouse
11533915Mts4_mmammary tumor susceptibility 4 (mouse)64211637376116515Mouse
12910785Pwgrq16_mpost-weaning growth rate QTL 16 (mouse)64382681377811523Mouse
12910798Pwgrq5_mpre-weaning growth rate QTL 5 (mouse)64382681377811523Mouse
12910802Pwbwq12_mpost-weaning body weight QTL 12 (mouse)64382681377811523Mouse
12910807Pwbwq11_mpost-weaning body weight QTL 11 (mouse)64382681377811523Mouse
12910809Pwbwq10_mpost-weaning body weight QTL 10 (mouse)64382681377811523Mouse
12910820Ogrq3_moverall growth rate QTL 3 (mouse)64382681377811523Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
4140983Srilp_msleep response to influenza, light phase (mouse)Not determined4872655675447710Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65117915085179300Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:912
Count of miRNA genes:408
Interacting mature miRNAs:480
Transcripts:ENSMUST00000064948, ENSMUST00000114038, ENSMUST00000114040
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000064948   ⟹   ENSMUSP00000068758
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl673,017,606 - 73,221,631 (-)Ensembl
RefSeq Acc Id: ENSMUST00000114038
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl673,084,178 - 73,139,005 (-)Ensembl
RefSeq Acc Id: ENSMUST00000114040   ⟹   ENSMUSP00000109674
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl673,017,609 - 73,221,651 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204053   ⟹   ENSMUSP00000144791
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl673,017,742 - 73,212,663 (-)Ensembl
RefSeq Acc Id: NM_001164669   ⟹   NP_001158141
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39672,994,589 - 73,198,614 (-)NCBI
GRCm38673,017,606 - 73,221,631 (-)NCBI
MGSCv37672,967,600 - 73,171,625 (-)RGD
Celera675,088,656 - 75,275,780 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006506302   ⟹   XP_006506365
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39673,034,041 - 73,199,314 (-)NCBI
GRCm38673,057,058 - 73,222,225 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003956215
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39672,994,586 - 73,199,238 (-)NCBI
GRCm38673,017,603 - 73,222,223 (-)NCBI
Sequence:
RefSeq Acc Id: XR_377473
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39673,034,041 - 73,199,327 (-)NCBI
GRCm38673,067,396 - 73,222,227 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001158141 (Get FASTA)   NCBI Sequence Viewer  
  XP_006506365 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC29556 (Get FASTA)   NCBI Sequence Viewer  
  BAD90460 (Get FASTA)   NCBI Sequence Viewer  
  CAB06068 (Get FASTA)   NCBI Sequence Viewer  
  EDK98999 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001158141   ⟸   NM_001164669
- UniProtKB: E9Q0B6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006506365   ⟸   XM_006506302
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000144791   ⟸   ENSMUST00000204053
RefSeq Acc Id: ENSMUSP00000109674   ⟸   ENSMUST00000114040
RefSeq Acc Id: ENSMUSP00000068758   ⟸   ENSMUST00000064948
Protein Domains
AAA   AAA_6   AAA_lid_11   Dynein_C   Dynein_heavy

Promoters
RGD ID:6839187
Promoter ID:MM_KWN:46492
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:UC009CJJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36673,094,571 - 73,095,071 (-)MPROMDB
RGD ID:6890048
Promoter ID:EPDNEW_M8475
Type:single initiation site
Name:Dnah6_2
Description:Mus musculus dynein, axonemal, heavy chain 6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8476  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38673,138,950 - 73,139,010EPDNEW
RGD ID:6839189
Promoter ID:MM_KWN:46493
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   Brain,   Kidney,   Lung
Transcripts:ENSMUST00000114040,   NM_001164669,   UC009CJK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36673,171,581 - 73,172,081 (-)MPROMDB
RGD ID:6890050
Promoter ID:EPDNEW_M8476
Type:initiation region
Name:Dnah6_1
Description:Mus musculus dynein, axonemal, heavy chain 6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8475  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38673,221,617 - 73,221,677EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107744 AgrOrtholog
Ensembl Genes ENSMUSG00000052861 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000068758 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000109674 UniProtKB/TrEMBL
  ENSMUSP00000144791 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000064948 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000114040 UniProtKB/TrEMBL
  ENSMUST00000204053 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.710 UniProtKB/TrEMBL
  1.10.8.720 UniProtKB/TrEMBL
  1.20.140.100 UniProtKB/TrEMBL
  3.20.180.20 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  AAA_6 UniProtKB/TrEMBL
  AAA_lid_11 UniProtKB/TrEMBL
  AAA_lid_11_sf UniProtKB/TrEMBL
  DHC_D5 UniProtKB/TrEMBL
  DNAH3_AAA_lid_1 UniProtKB/TrEMBL
  DNAH6/14 UniProtKB/TrEMBL
  Dynein_2_C UniProtKB/TrEMBL
  Dynein_2_N UniProtKB/TrEMBL
  Dynein_AAA1S UniProtKB/TrEMBL
  Dynein_AAA5_ext UniProtKB/TrEMBL
  Dynein_C UniProtKB/TrEMBL
  Dynein_HC_stalk UniProtKB/TrEMBL
  Dynein_heavy_chain_D4_dom UniProtKB/TrEMBL
  Dynein_heavy_dom UniProtKB/TrEMBL
  Dynein_heavy_dom-2 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report mmu:330355 UniProtKB/TrEMBL
MGD MGI:107744 ENTREZGENE
NCBI Gene 330355 ENTREZGENE
PANTHER PTHR46454:SF6 UniProtKB/TrEMBL
Pfam AAA_6 UniProtKB/TrEMBL
  AAA_8 UniProtKB/TrEMBL
  AAA_9 UniProtKB/TrEMBL
  AAA_lid_1 UniProtKB/TrEMBL
  AAA_lid_11 UniProtKB/TrEMBL
  DHC_N2 UniProtKB/TrEMBL
  Dynein_AAA_lid UniProtKB/TrEMBL
  Dynein_C UniProtKB/TrEMBL
  Dynein_heavy UniProtKB/TrEMBL
  PF12777 UniProtKB/TrEMBL
PhenoGen Dnah6 PhenoGen
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt E9Q0B6 ENTREZGENE, UniProtKB/TrEMBL
  E9Q3H7_MOUSE UniProtKB/TrEMBL
  O08827_MOUSE UniProtKB/TrEMBL
  Q5DTV6_MOUSE UniProtKB/TrEMBL
  Q8BZ42_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-06-04 Dnah6  dynein, axonemal, heavy chain 6  Dnahc6    Symbol and/or name change 5135510 APPROVED