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Gene: Lgr5 (leucine rich repeat containing G protein coupled receptor 5) Mus musculus
Symbol: Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
RGD ID: 1550798
Description: Exhibits transmembrane signaling receptor activity. Involved in several processes, including epithelial cell proliferation involved in renal tubule morphogenesis; hair follicle development; and positive regulation of canonical Wnt signaling pathway. Predicted to localize to integral component of plasma membrane and trans-Golgi network membrane. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; reproductive system; and sensory organ. Used to study ankyloglossia. Orthologous to human LGR5 (leucine rich repeat containing G protein-coupled receptor 5).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FEX; follicle expressed hormone; G protein-coupled receptor 49; G-protein coupled receptor 49; Gpr; Gpr49; leucine-rich repeat-containing G-protein coupled receptor 5; orphan G-protein coupled receptor FEX
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910115,286,219 - 115,423,685 (-)NCBI
GRCm3810115,450,314 - 115,587,780 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10115,450,311 - 115,587,780 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710114,887,370 - 115,024,836 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610114,855,736 - 114,991,603 (-)NCBImm8
Celera10117,380,191 - 117,518,061 (-)NCBICelera
Cytogenetic Map10D2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lgr5
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1550798
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-11-17
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.