Six3 (sine oculis-related homeobox 3) - Rat Genome Database

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Gene: Six3 (sine oculis-related homeobox 3) Mus musculus
Analyze
Symbol: Six3
Name: sine oculis-related homeobox 3
RGD ID: 1550672
MGI Page MGI
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and transcription corepressor binding activity. Involved in several processes, including camera-type eye development; forebrain development; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including forebrain development; lens induction in camera-type eye; and protein import into nucleus. Located in nucleus. Is expressed in several structures, including alimentary system; embryo ectoderm; limb; nervous system; and sensory organ. Used to study holoprosencephaly 2. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 2. Orthologous to human SIX3 (SIX homeobox 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E130112M24Rik; homeobox protein SIX3; RIKEN cDNA E130112M24 gene; sine oculis homeobox homolog 3; sine oculis-related homeobox 3 homolog; Six3a; Six3alpha; Six3b; Six3beta
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391785,921,036 - 85,933,619 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1785,921,036 - 85,936,730 (+)EnsemblGRCm39 Ensembl
GRCm381785,613,608 - 85,626,191 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1785,613,608 - 85,629,302 (+)EnsemblGRCm38mm10GRCm38
MGSCv371786,020,174 - 86,025,531 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361785,529,160 - 85,532,488 (+)NCBIMGSCv36mm8
Celera1789,974,811 - 89,987,580 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1755.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Functional characterization of SIX3 homeodomain mutations in holoprosencephaly: interaction with the nuclear receptor NR4A3/NOR1. Laflamme C, etal., Hum Mutat. 2004 Dec;24(6):502-8.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly. Wallis DE, etal., Nat Genet. 1999 Jun;22(2):196-8.
Additional References at PubMed
PMID:7720577   PMID:8575305   PMID:8814301   PMID:8889548   PMID:8934515   PMID:9096350   PMID:9449667   PMID:9551859   PMID:9620767   PMID:9620855   PMID:9671576   PMID:9811592  
PMID:9826681   PMID:9851982   PMID:9883582   PMID:9889003   PMID:9895322   PMID:10079223   PMID:10192390   PMID:10349636   PMID:10409502   PMID:10421635   PMID:10473118   PMID:10642791  
PMID:10686607   PMID:10688202   PMID:10704858   PMID:10804184   PMID:10882526   PMID:10887078   PMID:10903182   PMID:10985852   PMID:11003833   PMID:11042159   PMID:11050125   PMID:11069887  
PMID:11071765   PMID:11076861   PMID:11105055   PMID:11124115   PMID:11139622   PMID:11217851   PMID:11291863   PMID:11291866   PMID:11330864   PMID:11358868   PMID:11358869   PMID:11412024  
PMID:11456441   PMID:11458394   PMID:11468275   PMID:11493524   PMID:11493561   PMID:11532921   PMID:11641222   PMID:11702953   PMID:11731460   PMID:11748135   PMID:11820816   PMID:11846474  
PMID:11934155   PMID:11956759   PMID:12050133   PMID:12072567   PMID:12086465   PMID:12117810   PMID:12130660   PMID:12163408   PMID:12397111   PMID:12466851   PMID:12471260   PMID:12477932  
PMID:12490556   PMID:12569128   PMID:12588852   PMID:12642482   PMID:12645927   PMID:12676095   PMID:12724834   PMID:12915318   PMID:12925582   PMID:12952897   PMID:14651936   PMID:14668413  
PMID:14681194   PMID:14681479   PMID:15084457   PMID:15142971   PMID:15148409   PMID:15201223   PMID:15226823   PMID:15302604   PMID:15342729   PMID:15569927   PMID:15604100   PMID:15618518  
PMID:15703187   PMID:15857913   PMID:15973738   PMID:16024294   PMID:16141072   PMID:16141073   PMID:16256739   PMID:16284245   PMID:16284942   PMID:16291788   PMID:16303964   PMID:16368932  
PMID:16446698   PMID:16470613   PMID:16564040   PMID:16602821   PMID:16613831   PMID:16678814   PMID:16765103   PMID:16839541   PMID:16854970   PMID:16855091   PMID:16971467   PMID:17066077  
PMID:17084678   PMID:17107998   PMID:17127040   PMID:17140559   PMID:17241623   PMID:17389379   PMID:17481602   PMID:17576749   PMID:17666527   PMID:17699604   PMID:17980036   PMID:18094027  
PMID:18287559   PMID:18331719   PMID:18331887   PMID:18385072   PMID:18403408   PMID:18455718   PMID:18489003   PMID:18507827   PMID:18543315   PMID:18570229   PMID:18588871   PMID:18617531  
PMID:18653561   PMID:18694563   PMID:18697938   PMID:18775421   PMID:18794329   PMID:18836447   PMID:19030180   PMID:19102749   PMID:19103193   PMID:19146846   PMID:19334279   PMID:19386638  
PMID:19474320   PMID:19527706   PMID:19593386   PMID:19606496   PMID:19615442   PMID:19900183   PMID:19900438   PMID:19906857   PMID:20059953   PMID:20074369   PMID:20107170   PMID:20413611  
PMID:20653027   PMID:20682799   PMID:20702562   PMID:20708584   PMID:20730911   PMID:20816794   PMID:20869363   PMID:20890044   PMID:20932939   PMID:21118511   PMID:21219900   PMID:21228006  
PMID:21228153   PMID:21233129   PMID:21246658   PMID:21247964   PMID:21267068   PMID:21309073   PMID:21377456   PMID:21445260   PMID:21452241   PMID:21525287   PMID:21552538   PMID:21873635  
PMID:21886788   PMID:21936910   PMID:22007134   PMID:22071110   PMID:22075149   PMID:22186731   PMID:22264356   PMID:22340494   PMID:22353563   PMID:22383895   PMID:22479201   PMID:22698281  
PMID:22792072   PMID:22991444   PMID:23042297   PMID:23042737   PMID:23045697   PMID:23071453   PMID:23213481   PMID:23223288   PMID:23283339   PMID:23307637   PMID:23396189   PMID:23444355  
PMID:23592779   PMID:23595746   PMID:23674600   PMID:23720040   PMID:23792023   PMID:24027290   PMID:24038357   PMID:24073291   PMID:24131634   PMID:24148613   PMID:24167708   PMID:24324671  
PMID:24523460   PMID:24633704   PMID:24698271   PMID:24803591   PMID:24952961   PMID:25176648   PMID:25336744   PMID:25512300   PMID:25579066   PMID:25810521   PMID:25915183   PMID:25977363  
PMID:26034287   PMID:26071364   PMID:26226617   PMID:26288816   PMID:26297811   PMID:26534985   PMID:26718003   PMID:26956358   PMID:27003939   PMID:27302397   PMID:27631609   PMID:27657450  
PMID:27770010   PMID:27918583   PMID:28008752   PMID:28093895   PMID:28219675   PMID:28579317   PMID:28685891   PMID:28807898   PMID:28941984   PMID:29109536   PMID:29117559   PMID:29377931  
PMID:29423138   PMID:29589282   PMID:29679559   PMID:29967281   PMID:29972793   PMID:30261489   PMID:30352686   PMID:30485816   PMID:30581079   PMID:30635555   PMID:30692221   PMID:30905259  
PMID:30953627   PMID:31491374   PMID:31685615   PMID:31705443   PMID:31950080   PMID:31956913   PMID:32169553   PMID:32170006   PMID:32420617   PMID:32561725   PMID:32562661   PMID:32675279  
PMID:33053343   PMID:33184218   PMID:33230114   PMID:33492553   PMID:33712552   PMID:33723039   PMID:34014554   PMID:34212416   PMID:34321664   PMID:34769078   PMID:34974160   PMID:35008655  
PMID:35044299   PMID:35044906   PMID:35121076   PMID:35156680   PMID:35700169   PMID:35815619   PMID:35951005   PMID:36007540   PMID:36081908   PMID:36636025   PMID:36943865   PMID:37298722  
PMID:37452018   PMID:39025297   PMID:39446806   PMID:39569362  


Genomics

Comparative Map Data
Six3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391785,921,036 - 85,933,619 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1785,921,036 - 85,936,730 (+)EnsemblGRCm39 Ensembl
GRCm381785,613,608 - 85,626,191 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1785,613,608 - 85,629,302 (+)EnsemblGRCm38mm10GRCm38
MGSCv371786,020,174 - 86,025,531 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361785,529,160 - 85,532,488 (+)NCBIMGSCv36mm8
Celera1789,974,811 - 89,987,580 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1755.42NCBI
SIX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38244,941,702 - 44,946,071 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl244,941,702 - 44,946,071 (+)EnsemblGRCh38hg38GRCh38
GRCh37245,168,841 - 45,173,210 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36245,022,541 - 45,025,894 (+)NCBINCBI36Build 36hg18NCBI36
Build 34245,080,511 - 45,084,092NCBI
Celera245,007,709 - 45,011,888 (+)NCBICelera
Cytogenetic Map2p21NCBI
HuRef244,885,400 - 44,910,885 (+)NCBIHuRef
CHM1_1245,098,943 - 45,103,122 (+)NCBICHM1_1
T2T-CHM13v2.0244,946,967 - 44,951,332 (+)NCBIT2T-CHM13v2.0
Six3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8614,791,937 - 14,796,365 (-)NCBIGRCr8
mRatBN7.269,039,017 - 9,043,336 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl69,036,434 - 9,053,301 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx69,326,170 - 9,330,489 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.069,635,567 - 9,639,890 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.069,156,148 - 9,160,452 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.068,886,730 - 8,891,094 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl68,886,591 - 8,889,925 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.068,778,756 - 8,815,903 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.468,981,995 - 9,019,365 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.169,015,373 - 9,019,374 (+)NCBI
Celera68,770,011 - 8,793,533 (-)NCBICelera
Cytogenetic Map6q12NCBI
Six3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544111,966,389 - 11,979,466 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544111,966,389 - 11,978,545 (+)NCBIChiLan1.0ChiLan1.0
SIX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21281,436,292 - 81,469,922 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A81,440,269 - 81,466,464 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A45,038,634 - 45,072,867 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A45,978,828 - 45,988,078 (+)NCBIpanpan1.1PanPan1.1panPan2
SIX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11047,332,875 - 47,369,359 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1047,332,888 - 47,343,635 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1047,190,442 - 47,227,035 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01048,209,368 - 48,245,952 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1048,209,335 - 48,244,622 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11047,917,957 - 47,954,541 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01048,207,086 - 48,217,927 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01048,389,961 - 48,426,595 (+)NCBIUU_Cfam_GSD_1.0
Six3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629235,674,153 - 35,677,974 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365087,104,066 - 7,107,597 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365087,103,578 - 7,106,588 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl395,521,334 - 95,525,436 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1395,521,330 - 95,527,004 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SIX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11462,278,124 - 62,292,942 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1462,278,461 - 62,281,127 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604549,599,060 - 49,626,248 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Six3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473826,380,088 - 26,394,252 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473826,379,172 - 26,391,669 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Six3
479 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1038
Count of miRNA genes:521
Interacting mature miRNAs:615
Transcripts:ENSMUST00000162695, ENSMUST00000175898, ENSMUST00000176081
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141758Pstc5_mperiosteal circumference 5 (mouse)Not determined175710765191107803Mouse
11528551Sluc32_msusceptibility to lung cancer 32 (mouse)176230101095294699Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
12910536Nrq8a_mnoise-induced hearing loss resistant QTL 8a (mouse)175710765191107803Mouse
1357528Nhdlq3_mnon-HDL QTL 3 (mouse)Not determined177339513295294699Mouse
14697708Stsl5_mSalmonella typhimurium susceptibility locus 5 (mouse)178080742991407428Mouse
12910537Nrq8_mnoise-induced hearing loss resistant QTL 8 (mouse)175710765191107803Mouse
4141040Hmtb9_mhemostasis and thrombosis rebleeding time 9 (mouse)Not determined5758908991589197Mouse
4142256Nilac12_mnicotine induced locomotor activity 12 (mouse)Not determined176894131995294699Mouse
1302017Aliq3_macute lung injury QTL 3 (mouse)Not determined176388554895294699Mouse
1357447Heal13_mwound healing/regeneration 13 (mouse)Not determined175710765191107803Mouse
14928308Manh82_mmandible shape 82 (mouse)176631524395294699Mouse
1357646Axtq3_manxiety QTL 3 (mouse)Not determined177458908990395270Mouse
1301107Scc4_mcolon tumor susceptibility 4 (mouse)Not determined176230101095294699Mouse
11039498Ltpr7b_mLeishmania tropica response 7b (mouse)177070119895294699Mouse
11039499Ltpr7a_mLeishmania tropica response 7a (mouse)177070119895294699Mouse
11039500Ltpr7c_mLeishmania tropica response 7c (mouse)177070119895294699Mouse
1357552Aaj4_manxiety in A/J 4 (mouse)Not determined177458908990395270Mouse
4141011Bmd26_mbone mineral density 26 (mouse)Not determined175710765191107803Mouse
1300735Pgia20_mproteoglycan induced arthritis 20 (mouse)Not determined175710765191107803Mouse
4142414Pregq4_mpregnancy QTL 4 (mouse)Not determined175753444793507179Mouse
11039514Ltpr7_mLeishmania tropica response 7 (mouse)177070119895294699Mouse
1301728Ffal1_mfree fatty acid level 1 (mouse)Not determined176521493895294699Mouse
4141195Nilac11_mnicotine induced locomotor activity 11 (mouse)Not determined177339513295294699Mouse
4141697Hbnr3_mHeligmosomoides bakeri nematode resistance 3 (mouse)Not determined7410765193507179Mouse

Markers in Region
Six3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E4UniSTS
cM Map1745.5UniSTS
RH143896  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381785,621,874 - 85,621,999UniSTSGRCm38
MGSCv371786,021,214 - 86,021,339UniSTSGRCm37
Celera1789,983,220 - 89,983,345UniSTS
Cytogenetic Map17E4UniSTS
cM Map1745.5UniSTS
Six3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381785,624,057 - 85,624,312UniSTSGRCm38
Celera1789,985,450 - 89,985,705UniSTS
Cytogenetic Map17E4UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000162695   ⟹   ENSMUSP00000125169
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1785,928,459 - 85,936,730 (+)Ensembl
GRCm38.p6 Ensembl1785,621,031 - 85,629,302 (+)Ensembl
Ensembl Acc Id: ENSMUST00000175898   ⟹   ENSMUSP00000135677
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1785,921,036 - 85,932,650 (+)Ensembl
GRCm38.p6 Ensembl1785,613,608 - 85,625,222 (+)Ensembl
Ensembl Acc Id: ENSMUST00000176081   ⟹   ENSMUSP00000135312
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1785,928,262 - 85,933,619 (+)Ensembl
GRCm38.p6 Ensembl1785,620,834 - 85,626,191 (+)Ensembl
RefSeq Acc Id: NM_011381   ⟹   NP_035511
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391785,928,262 - 85,933,619 (+)NCBI
GRCm381785,620,834 - 85,626,191 (+)NCBI
MGSCv371786,020,174 - 86,025,531 (+)RGD
Celera1789,974,811 - 89,987,580 (+)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017317367   ⟹   XP_017172856
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391785,921,036 - 85,932,653 (+)NCBI
GRCm381785,613,608 - 85,625,225 (+)NCBI
Sequence:
RefSeq Acc Id: NP_035511   ⟸   NM_011381
- UniProtKB: P70177 (UniProtKB/Swiss-Prot),   P70176 (UniProtKB/Swiss-Prot),   Q4QQQ3 (UniProtKB/Swiss-Prot),   Q62233 (UniProtKB/Swiss-Prot),   Q52KB8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017172856   ⟸   XM_017317367
- Peptide Label: isoform X1
- UniProtKB: Q52KB8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000125169   ⟸   ENSMUST00000162695
Ensembl Acc Id: ENSMUSP00000135312   ⟸   ENSMUST00000176081
Ensembl Acc Id: ENSMUSP00000135677   ⟸   ENSMUST00000175898
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62233-F1-model_v2 AlphaFold Q62233 1-333 view protein structure

Promoters
RGD ID:13676918
Promoter ID:EPDNEW_M22608
Type:initiation region
Name:Six3_1
Description:Mus musculus sine oculis-related homeobox 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381785,620,782 - 85,620,842EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:102764 AgrOrtholog
Ensembl Genes ENSMUSG00000038805 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000162695.3 UniProtKB/TrEMBL
  ENSMUST00000175898.4 UniProtKB/Swiss-Prot
  ENSMUST00000176081 ENTREZGENE
  ENSMUST00000176081.3 UniProtKB/Swiss-Prot
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SIX1_SD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20473 UniProtKB/Swiss-Prot
MGD MGI:102764 ENTREZGENE
NCBI Gene 20473 ENTREZGENE
PANTHER HOMEOBOX PROTEIN SIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10390:SF31 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SIX1_SD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Six3 PhenoGen
PROSITE HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P70176 ENTREZGENE
  P70177 ENTREZGENE
  Q4QQQ3 ENTREZGENE
  Q52KB8 ENTREZGENE, UniProtKB/TrEMBL
  Q62233 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P70176 UniProtKB/Swiss-Prot
  P70177 UniProtKB/Swiss-Prot
  Q4QQQ3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Six3  sine oculis-related homeobox 3  E130112M24Rik  RIKEN cDNA E130112M24 gene  Data merged from RGD:1607294 737654 PROVISIONAL
2012-07-17 Six3  sine oculis-related homeobox 3  Six3  sine oculis-related homeobox 3 homolog (Drosophila)  Symbol and/or name change 5135510 APPROVED