Ndufb4 (NADH:ubiquinone oxidoreductase subunit B4) - Rat Genome Database

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Gene: Ndufb4 (NADH:ubiquinone oxidoreductase subunit B4) Mus musculus
Analyze
Symbol: Ndufb4
Name: NADH:ubiquinone oxidoreductase subunit B4
RGD ID: 1550639
MGI Page MGI
Description: Predicted to be involved in mitochondrial respiratory chain complex I assembly and response to oxidative stress. Located in mitochondrial inner membrane. Is expressed in cranium and early conceptus. Orthologous to human NDUFB4 (NADH:ubiquinone oxidoreductase subunit B4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 0610006N12Rik; 1300010H20Rik; CI-B15; complex I-B15; NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4; NADH-ubiquinone oxidoreductase B15 subunit; NADH:ubiquinone oxidoreductase B15 subunit
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391637,467,962 - 37,474,779 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1637,467,532 - 37,474,815 (-)EnsemblGRCm39 Ensembl
GRCm381637,647,602 - 37,654,368 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1637,647,170 - 37,654,453 (-)EnsemblGRCm38mm10GRCm38
MGSCv371637,647,688 - 37,654,454 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361637,566,841 - 37,573,607 (-)NCBIMGSCv36mm8
Celera1638,055,526 - 38,062,293 (-)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1626.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12865426   PMID:14610273   PMID:14681479   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16930510  
PMID:17967808   PMID:18614015   PMID:18614564   PMID:18799693   PMID:21556144   PMID:21677750   PMID:21873635   PMID:29111324   PMID:30030361   PMID:30068389   PMID:30550785   PMID:30562941  
PMID:31097699   PMID:32325033   PMID:33601422   PMID:36808153  


Genomics

Comparative Map Data
Ndufb4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391637,467,962 - 37,474,779 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1637,467,532 - 37,474,815 (-)EnsemblGRCm39 Ensembl
GRCm381637,647,602 - 37,654,368 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1637,647,170 - 37,654,453 (-)EnsemblGRCm38mm10GRCm38
MGSCv371637,647,688 - 37,654,454 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361637,566,841 - 37,573,607 (-)NCBIMGSCv36mm8
Celera1638,055,526 - 38,062,293 (-)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1626.43NCBI
NDUFB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383120,596,336 - 120,602,507 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3120,596,328 - 120,602,507 (+)EnsemblGRCh38hg38GRCh38
GRCh373120,315,183 - 120,321,354 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363121,797,818 - 121,803,865 (+)NCBINCBI36Build 36hg18NCBI36
Celera3118,724,522 - 118,730,652 (+)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3117,688,335 - 117,694,465 (+)NCBIHuRef
CHM1_13120,278,792 - 120,284,922 (+)NCBICHM1_1
T2T-CHM13v2.03123,315,896 - 123,322,380 (+)NCBIT2T-CHM13v2.0
Ndufb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81176,569,178 - 76,575,879 (+)NCBIGRCr8
mRatBN7.21163,063,723 - 63,070,426 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1163,063,795 - 63,070,425 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,876,185 - 71,882,890 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01164,538,408 - 64,545,115 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,588,194 - 63,594,887 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,960,277 - 65,966,899 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,960,277 - 65,966,898 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01169,052,375 - 69,058,794 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,852,589 - 64,859,550 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11164,870,193 - 64,917,139 (+)NCBI
Celera1162,560,721 - 62,566,926 (+)NCBICelera
Cytogenetic Map11q21NCBI
Ndufb4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542720,117,426 - 20,124,292 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542720,117,550 - 20,124,114 (+)NCBIChiLan1.0ChiLan1.0
NDUFB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22118,556,895 - 118,564,845 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13118,563,600 - 118,569,623 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03117,704,061 - 117,710,071 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13124,614,838 - 124,620,850 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3124,614,838 - 124,620,850 (+)Ensemblpanpan1.1panPan2
NDUFB4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13324,044,498 - 24,051,545 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3324,044,508 - 24,051,548 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3324,073,847 - 24,080,895 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03324,284,157 - 24,291,293 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3324,283,860 - 24,291,298 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13324,085,179 - 24,092,226 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03324,125,256 - 24,132,517 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03324,689,703 - 24,696,753 (+)NCBIUU_Cfam_GSD_1.0
Ndufb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602130,223,516 - 130,230,114 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365367,291,906 - 7,298,490 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDUFB4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13139,724,148 - 139,730,493 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113139,724,145 - 139,730,492 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NDUFB4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12260,219,834 - 60,226,180 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041106,081,698 - 106,087,590 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndufb4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473127,625,758 - 27,641,646 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473127,634,669 - 27,641,144 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ndufb4
162 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:293
Count of miRNA genes:207
Interacting mature miRNAs:243
Transcripts:ENSMUST00000023514, ENSMUST00000135019
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162001932985600826Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162193838355938574Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2277525257594076Mouse
15092062Egrme4_mearly growth rate, maternal effect 4 (mouse)162521866444220250Mouse
11059559Lmr12a_mleishmaniasis resistance 12a (mouse)162879281362792952Mouse
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162879281362792952Mouse
11049571Lmr12c_mleishmaniasis resistance 12c (mouse)162879281362792952Mouse
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162879281362792952Mouse
1301070Cypr1_mcytokine production 1 (mouse)Not determined163231279566312933Mouse
4142187Arrd3_mage-related retinal degeneration 3 (mouse)Not determined3252290965466552Mouse
1302096Aod1a_mautoimmune ovarian dysgenesis 1a (mouse)Not determined163544664392573008Mouse
10412263Gvhd6_mgraft-versus host disease 6 (mouse)Not determined163606085745511148Mouse
26884416Bzwq5_mbi-zygomatic width QTL 5, 5 week (mouse)163732036284696888Mouse

Markers in Region
Ndufb4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381925,033,271 - 25,033,509UniSTSGRCm38
GRCm381573,809,529 - 73,809,767UniSTSGRCm38
MGSCv371925,107,761 - 25,107,999UniSTSGRCm37
MGSCv371573,639,959 - 73,640,197UniSTSGRCm37
Cytogenetic Map15D3UniSTS
Cytogenetic Map16B3UniSTS
Cytogenetic Map19BUniSTS
cM Map16 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_026610   ⟹   NP_080886
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391637,467,962 - 37,474,779 (-)NCBI
GRCm381637,647,602 - 37,654,368 (-)ENTREZGENE
MGSCv371637,647,688 - 37,654,454 (-)RGD
Celera1638,055,526 - 38,062,293 (-)RGD
cM Map16 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_080886   ⟸   NM_026610
- UniProtKB: Q9CQC7 (UniProtKB/Swiss-Prot),   Q4VAE8 (UniProtKB/TrEMBL)
- Sequence:

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CQC7-F1-model_v2 AlphaFold Q9CQC7 1-129 view protein structure

Promoters
RGD ID:6827295
Promoter ID:MM_KWN:20949
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000063324
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361637,654,111 - 37,654,737 (-)MPROMDB
RGD ID:8686166
Promoter ID:EPDNEW_M21114
Type:initiation region
Name:Ndufb4_1
Description:Mus musculus NADH dehydrogenase 1 beta subcomplex 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381637,654,367 - 37,654,427EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915444 AgrOrtholog
Ensembl Genes ENSMUSG00000022820 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000023514 ENTREZGENE
  ENSMUST00000023514.4 UniProtKB/Swiss-Prot
InterPro NADH_UbQ_OxRdtase_NDUFB4_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:100042503 UniProtKB/Swiss-Prot
  mmu:68194 UniProtKB/Swiss-Prot
MGD MGI:1915444 ENTREZGENE
NCBI Gene 68194 ENTREZGENE
PANTHER NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15469 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NDUF_B4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ndufb4 PhenoGen
UniProt NDUB4_MOUSE UniProtKB/Swiss-Prot
  Q4VAE8 ENTREZGENE, UniProtKB/TrEMBL
  Q9CQC7 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-22 Ndufb4  NADH:ubiquinone oxidoreductase subunit B4    NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4  Symbol and/or name change 5135510 APPROVED