Car11 (carbonic anhydrase 11) - Rat Genome Database

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Gene: Car11 (carbonic anhydrase 11) Mus musculus
Analyze
Symbol: Car11
Name: carbonic anhydrase 11
RGD ID: 1550538
MGI Page MGI
Description: Predicted to have hydro-lyase activity. Predicted to be involved in one-carbon metabolic process. Localizes to basolateral plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human CA11 (carbonic anhydrase 11); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CA-RP II; CA-RP XI; CA-XI; Ca11; carbonic anhydrase-related protein 11; carbonic anhydrase-related protein 2; CARP XI; CARP-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,348,537 - 45,354,111 (+)NCBIGRCm39mm39
GRCm39 Ensembl745,349,267 - 45,354,106 (+)Ensembl
GRCm38745,699,171 - 45,704,687 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,699,843 - 45,704,682 (+)EnsemblGRCm38mm10GRCm38
MGSCv37752,955,337 - 52,960,041 (+)NCBIGRCm37mm9NCBIm37
MGSCv36745,568,009 - 45,572,713 (+)NCBImm8
Celera741,162,525 - 41,167,228 (+)NCBICelera
Cytogenetic Map7B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:9878252   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12388412   PMID:12477932   PMID:12531530   PMID:14610273   PMID:14681479   PMID:15489334   PMID:16141072  
PMID:16141073   PMID:17626619   PMID:21267068   PMID:21873635   PMID:23233153   PMID:24789143  


Genomics

Comparative Map Data
Car11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,348,537 - 45,354,111 (+)NCBIGRCm39mm39
GRCm39 Ensembl745,349,267 - 45,354,106 (+)Ensembl
GRCm38745,699,171 - 45,704,687 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,699,843 - 45,704,682 (+)EnsemblGRCm38mm10GRCm38
MGSCv37752,955,337 - 52,960,041 (+)NCBIGRCm37mm9NCBIm37
MGSCv36745,568,009 - 45,572,713 (+)NCBImm8
Celera741,162,525 - 41,167,228 (+)NCBICelera
Cytogenetic Map7B3NCBI
CA11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1948,637,946 - 48,646,187 (-)EnsemblGRCh38hg38GRCh38
GRCh381948,637,946 - 48,646,187 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371949,141,203 - 49,149,444 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,833,084 - 53,841,263 (-)NCBINCBI36hg18NCBI36
Build 341953,833,083 - 53,841,065NCBI
Celera1946,006,137 - 46,014,315 (-)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1945,520,726 - 45,528,907 (-)NCBIHuRef
CHM1_11949,143,073 - 49,151,416 (-)NCBICHM1_1
Ca11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2196,169,900 - 96,175,191 (+)NCBI
Rnor_6.0 Ensembl1101,682,172 - 101,687,293 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01101,682,009 - 101,687,358 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01102,760,809 - 102,766,190 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,167,823 - 96,172,934 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1196,245,933 - 96,251,046 (+)NCBI
Celera190,423,279 - 90,428,390 (+)NCBICelera
Cytogenetic Map1q22NCBI
Ca11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,910,421 - 1,916,156 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,910,421 - 1,914,988 (+)NCBIChiLan1.0ChiLan1.0
CA11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11954,231,798 - 54,240,248 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,231,798 - 54,240,247 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01945,639,401 - 45,647,555 (-)NCBIMhudiblu_PPA_v0panPan3
CA11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,669,184 - 107,674,825 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,669,419 - 107,674,792 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,190,692 - 107,196,318 (+)NCBI
ROS_Cfam_1.01108,193,244 - 108,198,874 (+)NCBI
UMICH_Zoey_3.11107,859,799 - 107,865,425 (+)NCBI
UNSW_CanFamBas_1.01107,507,095 - 107,512,719 (+)NCBI
UU_Cfam_GSD_1.01108,342,794 - 108,348,418 (+)NCBI
Ca11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,064,700 - 21,070,330 (-)NCBI
SpeTri2.0NW_0049366642,682,814 - 2,688,583 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,993,393 - 53,999,174 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1653,993,183 - 53,999,357 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,740,565 - 49,746,393 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CA11
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1641,889,786 - 41,905,358 (-)NCBI
ChlSab1.1 Ensembl641,889,504 - 41,905,561 (-)Ensembl
Ca11
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248325,234,331 - 5,240,038 (+)NCBI

Position Markers
Car11  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7B2UniSTS
cM Map7 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7346321287493512Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360000072900000Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71278145246781452Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71278145246781452Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1333306047333196Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71343577947435779Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71360000047700000Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71690336849509583Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718994869119886157Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71958059053580679Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined72014282554142942Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72302446357024609Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72323914857239292Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72341710757417107Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72719819161202351Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72789112561891125Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3033306081485905Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730500000109400000Mouse
1301175Ap7q_malcohol preference 7 QTL (mouse)Not determined73206509766065329Mouse
1300996Aorls2_maortic lesion size 2 (mouse)Not determined73274478466744933Mouse
4141909W10q18_mweight 10 weeks QTL 18 (mouse)Not determined3379830258499217Mouse
4142218W6q17_mweight 6 weeks QTL 17 (mouse)Not determined3379830258499217Mouse
4142102Tailq5_mtail length QTL 5 (mouse)Not determined3379830258499217Mouse
4142003W3q10_mweight 3 weeks QTL 10 (mouse)Not determined3379830258499217Mouse
1357469Kidq5_mkidney weight QTL 5 (mouse)Not determined73379830258499217Mouse
1357731Lvrq6_mliver weight QTL 6 (mouse)Not determined73379830258499217Mouse
1357634Splq7_mspleen weight QTL 7 (mouse)Not determined73379830258499217Mouse
1357883Epfq5_mepididymal fat pad weight QTL 5 (mouse)Not determined73379830258499217Mouse
39128210Lwq19_mliver weight QTL 19 (mouse)73379830258499217Mouse
1559000Ossc1_mosteosarcoma susceptibility 1 (mouse)Not determined73440327768403475Mouse
38501071Stsl6_mSalmonella typhimurium susceptibility locus 6 (mouse)73450000051500000Mouse
10045622Heal20_mwound healing/regeneration 20 (mouse)Not determined73466713968667295Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73479812168798270Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73658059092745138Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736580590116817642Mouse
25314301Vmm3_mvariable multisystem mineralization 3, lung (mouse)73760000072400000Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73760000087400000Mouse
1300878Skts1_mskin tumor susceptibility 1 (mouse)Not determined73824163872241834Mouse
10402488Dipa2_mdrug induced psychomotor activation 2 (mouse)Not determined73877180072771936Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined740024463103860803Mouse
4141929Chlq18_mcirculating hormone level QTL 18 (mouse)Not determined74149907275499217Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74149907275499217Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745512542119094307Mouse
12880417V125Dq5_mvitamin D active form serum level QTL 5 (mouse)74560000079600000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:736
Count of miRNA genes:348
Interacting mature miRNAs:373
Transcripts:ENSMUST00000003360, ENSMUST00000126106, ENSMUST00000137294
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000003360   ⟹   ENSMUSP00000003360
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl745,699,843 - 45,704,682 (+)Ensembl
RefSeq Acc Id: ENSMUST00000209796   ⟹   ENSMUSP00000147551
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl745,701,243 - 45,704,546 (+)Ensembl
RefSeq Acc Id: ENSMUST00000210027   ⟹   ENSMUSP00000148222
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl745,703,483 - 45,704,609 (+)Ensembl
RefSeq Acc Id: ENSMUST00000210872
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl745,701,016 - 45,703,477 (+)Ensembl
RefSeq Acc Id: ENSMUST00000211259
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl745,701,035 - 45,703,477 (+)Ensembl
RefSeq Acc Id: NM_001368349   ⟹   NP_001355278
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39745,349,228 - 45,354,111 (+)NCBI
GRCm38745,699,804 - 45,704,687 (+)NCBI
Sequence:
RefSeq Acc Id: NM_009800   ⟹   NP_033930
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39745,349,391 - 45,354,095 (+)NCBI
GRCm38745,699,967 - 45,704,671 (+)NCBI
MGSCv37752,955,337 - 52,960,041 (+)RGD
Celera741,162,525 - 41,167,228 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006540588   ⟹   XP_006540651
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39745,348,537 - 45,354,040 (+)NCBI
GRCm38745,699,171 - 45,704,616 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006540589   ⟹   XP_006540652
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39745,348,537 - 45,354,040 (+)NCBI
GRCm38745,699,848 - 45,704,616 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033930   ⟸   NM_009800
- Peptide Label: isoform 1 precursor
- UniProtKB: O70354 (UniProtKB/Swiss-Prot),   Q541E9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006540651   ⟸   XM_006540588
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006540652   ⟸   XM_006540589
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001355278   ⟸   NM_001368349
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000148222   ⟸   ENSMUST00000210027
RefSeq Acc Id: ENSMUSP00000003360   ⟸   ENSMUST00000003360
RefSeq Acc Id: ENSMUSP00000147551   ⟸   ENSMUST00000209796
Protein Domains
Alpha-carbonic anhydrase

Promoters
RGD ID:8664069
Promoter ID:EPDNEW_M10066
Type:initiation region
Name:Car11_1
Description:Mus musculus carbonic anhydrase 11 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38745,699,889 - 45,699,949EPDNEW
RGD ID:6840772
Promoter ID:MM_KWN:50447
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000077635
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36752,955,036 - 52,955,536 (+)MPROMDB
RGD ID:6840769
Promoter ID:MM_KWN:50448
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   MEF_B6
Transcripts:OTTMUST00000077636,   OTTMUST00000077637
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36752,956,056 - 52,956,556 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1336193 AgrOrtholog
Ensembl Genes ENSMUSG00000003273 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000003360 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000147551 UniProtKB/TrEMBL
  ENSMUSP00000148222 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000003360 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000209796 UniProtKB/TrEMBL
  ENSMUST00000210027 UniProtKB/TrEMBL
Gene3D-CATH 3.10.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro alpha_CARP_X/XI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12348 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1336193 ENTREZGENE
NCBI Gene 12348 ENTREZGENE
PANTHER PTHR18952 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Car11 PhenoGen
PROSITE ALPHA_CA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51069 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1B0GRJ7_MOUSE UniProtKB/TrEMBL
  A0A1B0GT65_MOUSE UniProtKB/TrEMBL
  CAH11_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3USV1_MOUSE UniProtKB/TrEMBL
  Q541E9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q8VEA9 UniProtKB/Swiss-Prot