Cmtm8 (CKLF-like MARVEL transmembrane domain containing 8) - Rat Genome Database
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Gene: Cmtm8 (CKLF-like MARVEL transmembrane domain containing 8) Mus musculus
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Symbol: Cmtm8
Name: CKLF-like MARVEL transmembrane domain containing 8
RGD ID: 1550493
MGI Page MGI
Description: Predicted to be a structural constituent of myelin sheath. Predicted to be involved in myelination. Predicted to localize to integral component of membrane and nucleoplasm. Is expressed in several structures, including adenohypophysis; alimentary system; nasal cavity epithelium; respiratory system; and ventricular layer. Orthologous to human CMTM8 (CKLF like MARVEL transmembrane domain containing 8); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 2700018N07Rik; AA408515; chemokine-like factor super family 8; chemokine-like factor superfamily member 8; CKLF-like MARVEL transmembrane domain-containing protein 8; Cklfs; Cklfsf8
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399114,618,411 - 114,673,220 (-)NCBIGRCm39mm39
GRCm389114,789,343 - 114,844,152 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9114,789,345 - 114,844,156 (-)EnsemblGRCm38mm10GRCm38
MGSCv379114,698,463 - 114,753,270 (-)NCBIGRCm37mm9NCBIm37
MGSCv369114,638,043 - 114,692,850 (-)NCBImm8
Celera9115,265,153 - 115,321,558 (-)NCBICelera
Cytogenetic Map9F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
chemotaxis  (IEA)
myelination  (IBA)

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:18973680   PMID:21267068   PMID:21873635   PMID:22696295  


Genomics

Comparative Map Data
Cmtm8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399114,618,411 - 114,673,220 (-)NCBIGRCm39mm39
GRCm389114,789,343 - 114,844,152 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9114,789,345 - 114,844,156 (-)EnsemblGRCm38mm10GRCm38
MGSCv379114,698,463 - 114,753,270 (-)NCBIGRCm37mm9NCBIm37
MGSCv369114,638,043 - 114,692,850 (-)NCBImm8
Celera9115,265,153 - 115,321,558 (-)NCBICelera
Cytogenetic Map9F3NCBI
CMTM8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl332,238,679 - 32,370,321 (+)EnsemblGRCh38hg38GRCh38
GRCh38332,238,680 - 32,370,321 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37332,280,171 - 32,411,817 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36332,255,175 - 32,386,817 (+)NCBINCBI36hg18NCBI36
Build 34332,255,174 - 32,386,815NCBI
Celera332,217,566 - 32,349,242 (+)NCBI
Cytogenetic Map3p22.3NCBI
HuRef332,215,225 - 32,347,344 (+)NCBIHuRef
CHM1_1332,230,141 - 32,361,788 (+)NCBICHM1_1
Cmtm8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08122,848,249 - 122,913,597 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8122,848,501 - 122,904,913 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08122,160,334 - 122,226,662 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48119,209,101 - 119,265,441 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18119,228,839 - 119,285,178 (-)NCBI
Celera8113,728,864 - 113,785,306 (-)NCBICelera
Cytogenetic Map8q32NCBI
Cmtm8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543023,638,734 - 23,728,365 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543023,638,734 - 23,728,365 (+)NCBIChiLan1.0ChiLan1.0
CMTM8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1332,472,720 - 32,602,124 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl332,472,794 - 32,601,767 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0332,153,673 - 32,287,746 (+)NCBIMhudiblu_PPA_v0panPan3
CMTM8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2312,399,022 - 12,508,177 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12312,398,693 - 12,508,158 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cmtm8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647322,775,503 - 22,874,665 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CMTM8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1318,243,471 - 18,420,778 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11318,243,379 - 18,350,386 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21320,414,847 - 20,549,120 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CMTM8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1576,748,220 - 76,874,262 (+)Ensembl
ChlSab1.11576,748,254 - 76,873,970 (+)NCBI
Cmtm8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478810,333,314 - 10,417,228 (+)NCBI

Position Markers
D9Mit55  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389114,820,285 - 114,820,396UniSTSGRCm38
MGSCv379114,729,403 - 114,729,514UniSTSGRCm37
Celera9115,297,677 - 115,297,780UniSTS
Cytogenetic Map9F3UniSTS
cM Map961.0UniSTS
Whitehead Genetic960.1UniSTS
RH124721  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389114,789,609 - 114,789,698UniSTSGRCm38
MGSCv379114,698,727 - 114,698,816UniSTSGRCm37
Celera9115,265,416 - 115,265,505UniSTS
Cytogenetic Map9F3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse
13515058Adip20d_madiposity 20d (mouse)9108915010118915010Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:91
Interacting mature miRNAs:95
Transcripts:ENSMUST00000047013
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000047013   ⟹   ENSMUSP00000043706
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9114,789,345 - 114,844,152 (-)Ensembl
RefSeq Acc Id: ENSMUST00000213264
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9114,795,879 - 114,844,101 (-)Ensembl
RefSeq Acc Id: ENSMUST00000213929
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9114,841,610 - 114,844,156 (-)Ensembl
RefSeq Acc Id: NM_027294   ⟹   NP_081570
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399114,618,413 - 114,673,220 (-)NCBI
GRCm389114,789,345 - 114,844,152 (-)NCBI
MGSCv379114,698,463 - 114,753,270 (-)RGD
Celera9115,265,153 - 115,321,558 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011242999   ⟹   XP_011241301
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399114,618,411 - 114,648,097 (-)NCBI
GRCm389114,789,343 - 114,819,022 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_081570   ⟸   NM_027294
- UniProtKB: Q9CZR4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011241301   ⟸   XM_011242999
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000043706   ⟸   ENSMUST00000047013
Protein Domains
MARVEL

Promoters
RGD ID:6844120
Promoter ID:MM_KWN:59034
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Lung
Transcripts:NM_027294,   UC009RYH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369114,751,696 - 114,753,597 (-)MPROMDB
RGD ID:8671126
Promoter ID:EPDNEW_M13593
Type:initiation region
Name:Cmtm8_1
Description:Mus musculus CKLF-like MARVEL transmembrane domain containing8 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389114,844,150 - 114,844,210EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2447167 AgrOrtholog
Ensembl Genes ENSMUSG00000041012 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000043706 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000047013 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro MAL UniProtKB/Swiss-Prot
  Marvel UniProtKB/Swiss-Prot
KEGG Report mmu:70031 UniProtKB/Swiss-Prot
MGD MGI:2447167 ENTREZGENE
NCBI Gene 70031 ENTREZGENE
Pfam MARVEL UniProtKB/Swiss-Prot
PhenoGen Cmtm8 PhenoGen
PRINTS MALPROTEIN UniProtKB/Swiss-Prot
PROSITE MARVEL UniProtKB/Swiss-Prot
UniGene Mm.150064 ENTREZGENE
UniProt CKLF8_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE