Gene: Copb2 (coatomer protein complex, subunit beta 2 (beta prime)) Mus musculus
Analyze
Symbol:
Copb2
Name:
coatomer protein complex, subunit beta 2 (beta prime)
Description:
Predicted to have protein kinase C binding activity. Involved in toxin transport. Localizes to the Golgi apparatus. Used to study microcephaly. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 19. Is expressed in several structures, including alimentary system; liver lobe; nervous system; olfactory epithelium; and retina. Orthologous to human COPB2 (COPI coat complex subunit beta 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
AI256832; beta'-coat protein; beta'-COP; coatomer subunit beta'; p102
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
COPB2 (COPI coat complex subunit beta 2) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Copb2 (COPI coat complex subunit beta 2) HGNC
NCBI, HomoloGene, Panther
Chinchilla lanigera (long-tailed chinchilla):
Copb2 (COPI coat complex subunit beta 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
COPB2 (COPI coat complex subunit beta 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
COPB2 (COPI coat complex subunit beta 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Copb2 (COPI coat complex subunit beta 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
COPB2 (COPI coat complex subunit beta 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
COPB2 (COPI coat complex subunit beta 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Copb2 (COPI coat complex subunit beta 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
COPA (COPI coat complex subunit alpha) HGNC
Inparanoid
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Copb2 (COPI coat complex subunit beta 2)
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):
COPB2 (COPI coat complex subunit beta 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
copb2 (coatomer protein complex, subunit beta 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
E03H4.8
Alliance
DIOPT (Ensembl Compara, PhylomeDB, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
SEC27
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
beta'COP
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
copb-2
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 Ensembl 9 98,563,721 - 98,588,382 (+) Ensembl GRCm38 9 98,563,731 - 98,588,375 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 98,464,150 - 98,488,794 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 98,373,083 - 98,397,727 (+) NCBI mm8 Celera 9 98,109,355 - 98,134,004 (+) NCBI Celera Cytogenetic Map 9 E3.3 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - MGI
microcephaly IEA 13592920 OMIM:251200 more ... MouseDO
Imported Annotations - OMIM
primary autosomal recessive microcephaly 19 ISO RGD:732794 7240710 OMIM
17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of COPB2 mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COPB2 mRNA CTD PMID:17942748 17beta-estradiol increases expression ISO RGD:732794 6480464 Estradiol results in increased expression of COPB2 mRNA CTD PMID:16514628 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one multiple interactions ISO RGD:732794 6480464 Metribolone promotes the reaction [NDRG1 protein binds to COPB2 protein] CTD PMID:17220478 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of COPB2 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of COPB2 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COPB2 mRNA CTD PMID:17942748 2,4-dinitrotoluene affects expression ISO RGD:628746 6480464 2, 4-dinitrotoluene affects the expression of COPB2 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:628746 6480464 2, 6-dinitrotoluene affects the expression of COPB2 mRNA CTD PMID:21346803 2-hydroxypropanoic acid decreases expression ISO RGD:732794 6480464 Lactic Acid results in decreased expression of COPB2 mRNA CTD PMID:30851411 3,4-methylenedioxymethamphetamine decreases expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of COPB2 mRNA CTD PMID:26251327 3H-1,2-dithiole-3-thione decreases expression ISO RGD:628746 6480464 1, 2-dithiol-3-thione results in decreased expression of COPB2 mRNA CTD PMID:19162173 4-hydroxyphenyl retinamide decreases expression EXP 6480464 Fenretinide results in decreased expression of COPB2 mRNA CTD PMID:28973697 afimoxifene decreases expression ISO RGD:732794 6480464 afimoxifene results in decreased expression of COPB2 mRNA CTD PMID:16514628 Aroclor 1254 decreases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of COPB2 mRNA CTD PMID:23650126 arsenous acid increases expression ISO RGD:732794 6480464 Arsenic Trioxide results in increased expression of COPB2 protein CTD PMID:25419056 atrazine increases expression ISO RGD:732794 6480464 Atrazine results in increased expression of COPB2 mRNA CTD PMID:22378314 benzo[a]pyrene increases expression ISO RGD:628746 6480464 Benzo(a)pyrene results in increased expression of COPB2 mRNA CTD PMID:21839799 bicalutamide increases expression ISO RGD:732794 6480464 bicalutamide results in increased expression of COPB2 mRNA CTD PMID:16631469 bisphenol A increases expression ISO RGD:628746 6480464 bisphenol A results in increased expression of COPB2 mRNA CTD PMID:25181051 cisplatin decreases expression ISO RGD:732794 6480464 Cisplatin results in decreased expression of COPB2 mRNA CTD PMID:27594783 clofibrate multiple interactions EXP 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of COPB2 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of COPB2 mRNA] CTD PMID:17585979 clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of COPB2 mRNA CTD PMID:17585979 cyclosporin A increases expression ISO RGD:732794 6480464 Cyclosporine results in increased expression of COPB2 mRNA CTD PMID:20106945 dexamethasone multiple interactions ISO RGD:628746 6480464 Testosterone inhibits the reaction [Dexamethasone results in decreased expression of COPB2 mRNA] CTD PMID:20032058 dexamethasone decreases expression ISO RGD:628746 6480464 Dexamethasone results in decreased expression of COPB2 mRNA CTD PMID:20032058 diarsenic trioxide increases expression ISO RGD:732794 6480464 Arsenic Trioxide results in increased expression of COPB2 protein CTD PMID:25419056 diazinon increases methylation ISO RGD:732794 6480464 Diazinon results in increased methylation of COPB2 gene CTD PMID:22964155 dicrotophos decreases expression ISO RGD:732794 6480464 dicrotophos results in decreased expression of COPB2 mRNA CTD PMID:28302478 ethanol affects splicing EXP 6480464 Ethanol affects the splicing of COPB2 mRNA CTD PMID:30319688 flavonoids decreases expression ISO RGD:628746 6480464 Flavonoids results in decreased expression of COPB2 mRNA CTD PMID:18035473 flutamide increases expression ISO RGD:628746 6480464 Flutamide results in increased expression of COPB2 mRNA CTD PMID:24136188 fulvestrant decreases expression ISO RGD:732794 6480464 fulvestrant results in decreased expression of COPB2 mRNA CTD PMID:16514628 hydrogen peroxide affects expression ISO RGD:732794 6480464 Hydrogen Peroxide affects the expression of COPB2 mRNA CTD PMID:20044591 miconazole increases expression EXP 6480464 Miconazole results in increased expression of COPB2 mRNA CTD PMID:27462272 N-methyl-4-phenylpyridinium decreases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of COPB2 protein CTD PMID:26558463 nickel atom decreases expression ISO RGD:732794 6480464 Nickel results in decreased expression of COPB2 mRNA CTD PMID:23195993 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of COPB2 mRNA CTD PMID:17585979 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of COPB2 mRNA CTD PMID:17562736 paracetamol multiple interactions EXP 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of COPB2 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of COPB2 mRNA] CTD PMID:17585979 rac-lactic acid decreases expression ISO RGD:732794 6480464 Lactic Acid results in decreased expression of COPB2 mRNA CTD PMID:30851411 raloxifene decreases expression ISO RGD:732794 6480464 Raloxifene Hydrochloride results in decreased expression of COPB2 mRNA CTD PMID:16514628 Salinomycin decreases expression ISO RGD:732794 6480464 salinomycin results in decreased expression of COPB2 mRNA CTD PMID:19682730 sodium arsenate increases expression EXP 6480464 sodium arsenate results in increased expression of COPB2 mRNA CTD PMID:30953684 testosterone multiple interactions ISO RGD:628746 6480464 Testosterone inhibits the reaction [Dexamethasone results in decreased expression of COPB2 mRNA] CTD PMID:20032058 trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of COPB2 mRNA CTD PMID:19448997 tunicamycin increases expression ISO RGD:732794 6480464 Tunicamycin results in increased expression of COPB2 mRNA CTD PMID:22378314 valproic acid increases expression ISO RGD:732794 6480464 Valproic Acid results in increased expression of COPB2 mRNA CTD PMID:19101580 valproic acid affects expression ISO RGD:732794 6480464 Valproic Acid affects the expression of COPB2 mRNA CTD PMID:25979313
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport IBA PANTHER:PTN000458798 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 intra-Golgi vesicle-mediated transport ISO UniProtKB:P35606 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 intra-Golgi vesicle-mediated transport IBA PANTHER:PTN000458798 , UniProtKB:P35606 2290270 (PMID:21873635) GO_Central PMID:21873635 intracellular protein transport IBA PANTHER:PTN000458798 , WB:WBGene00009542 2290270 (PMID:21873635) GO_Central PMID:21873635 protein transport IEA UniProtKB-KW:KW-0653 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA PANTHER:PTN000458798 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 toxin transport IMP 2290270 (MGI:MGI:5492256, PMID:23716698) MGI MGI:MGI:5492256 , PMID:23716698 vesicle-mediated transport IEA InterPro:IPR006692 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 vesicle-mediated transport IEA UniProtKB-KW:KW-0931 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 Cellular Component COPI vesicle coat ISO UniProtKB:P35606 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 COPI vesicle coat IBA FB:FBgn0025724 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 cytoplasm IEA UniProtKB-KW:KW-0963 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 cytoplasmic vesicle IEA UniProtKB-KW:KW-0968 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 Golgi apparatus ISO UniProtKB:O35142 2290270 (MGI:MGI:3529210, PMID:15728249) MGI MGI:MGI:3529210 , PMID:15728249 Golgi apparatus IDA 2290270 (MGI:MGI:1095420 more ... MGI MGI:MGI:1095420 more ... Golgi membrane ISO RGD:628746 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 membrane IEA UniProtKB-KW:KW-0472 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 membrane coat IEA InterPro:IPR006692 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 Molecular Function protein kinase C binding ISO RGD:628746 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 structural molecule activity IEA InterPro:IPR006692 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098
Gene-Chemical Interaction Annotations
