Vwa1 (von Willebrand factor A domain containing 1) - Rat Genome Database

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Gene: Vwa1 (von Willebrand factor A domain containing 1) Mus musculus
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Symbol: Vwa1
Name: von Willebrand factor A domain containing 1
RGD ID: 1550446
MGI Page MGI
Description: Enables identical protein binding activity. Acts upstream of or within behavioral response to pain and extracellular matrix organization. Located in basement membrane; extracellular region; and interstitial matrix. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and respiratory system. Orthologous to human VWA1 (von Willebrand factor A domain containing 1).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4932416A11Rik; RP23-242K15.5; von Willebrand factor A domain-containing protein 1; von Willebrand factor A domain-related protein; W; WARP
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,852,952 - 155,859,042 (-)NCBIGRCm39mm39
GRCm39 Ensembl4155,852,606 - 155,859,155 (-)Ensembl
GRCm384155,768,495 - 155,774,693 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4155,768,149 - 155,774,698 (-)EnsemblGRCm38mm10GRCm38
MGSCv374155,142,604 - 155,148,670 (-)NCBIGRCm37mm9NCBIm37
MGSCv364154,612,295 - 154,618,314 (-)NCBImm8
Celera4158,040,276 - 158,046,381 (-)NCBICelera
Cytogenetic Map4E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12062410   PMID:12477932   PMID:14527666   PMID:16141072   PMID:16141073   PMID:16407285   PMID:16537572  
PMID:18314316   PMID:18757743   PMID:19279005   PMID:21873635   PMID:22159717   PMID:23300779   PMID:24194600   PMID:28071719  


Genomics

Comparative Map Data
Vwa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,852,952 - 155,859,042 (-)NCBIGRCm39mm39
GRCm39 Ensembl4155,852,606 - 155,859,155 (-)Ensembl
GRCm384155,768,495 - 155,774,693 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4155,768,149 - 155,774,698 (-)EnsemblGRCm38mm10GRCm38
MGSCv374155,142,604 - 155,148,670 (-)NCBIGRCm37mm9NCBIm37
MGSCv364154,612,295 - 154,618,314 (-)NCBImm8
Celera4158,040,276 - 158,046,381 (-)NCBICelera
Cytogenetic Map4E2NCBI
VWA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11,434,861 - 1,442,882 (+)EnsemblGRCh38hg38GRCh38
GRCh3811,435,690 - 1,442,882 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711,371,070 - 1,378,262 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611,360,772 - 1,366,009 (+)NCBINCBI36hg18NCBI36
Celera11,201,090 - 1,208,450 (-)NCBI
Cytogenetic Map1p36.33NCBI
HuRef1644,711 - 652,000 (+)NCBIHuRef
CHM1_111,358,164 - 1,365,523 (+)NCBICHM1_1
Vwa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25166,377,451 - 166,382,784 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl5166,377,455 - 166,382,637 (-)Ensembl
Rnor_6.05173,216,737 - 173,221,923 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,216,741 - 173,222,440 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05176,692,349 - 176,697,535 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,626,372 - 172,631,591 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15172,636,870 - 172,642,086 (-)NCBI
Celera5164,578,200 - 164,583,386 (-)NCBICelera
Cytogenetic Map5q36NCBI
Vwa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554869,366,796 - 9,369,115 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554869,365,920 - 9,369,117 (-)NCBIChiLan1.0ChiLan1.0
VWA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111,394,396 - 1,397,938 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01192,970 - 198,099 (+)NCBIMhudiblu_PPA_v0panPan3
VWA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1556,578,256 - 56,583,552 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl556,578,297 - 56,582,502 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha556,654,365 - 56,659,659 (+)NCBI
ROS_Cfam_1.0556,780,792 - 56,786,086 (+)NCBI
ROS_Cfam_1.0 Ensembl556,780,831 - 56,787,858 (+)Ensembl
UMICH_Zoey_3.1556,771,007 - 56,776,301 (+)NCBI
UNSW_CanFamBas_1.0556,663,265 - 56,668,559 (+)NCBI
UU_Cfam_GSD_1.0557,053,616 - 57,058,911 (+)NCBI
Vwa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505827,727,704 - 27,732,113 (+)NCBI
SpeTri2.0NW_0049367371,733,837 - 1,738,861 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VWA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl663,695,170 - 63,700,287 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1663,695,195 - 63,700,296 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2658,299,039 - 58,304,134 (+)NCBISscrofa10.2Sscrofa10.2susScr3
VWA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120130,016,802 - 130,023,138 (-)NCBIChlSab1.1chlSab2
ChlSab1.120130,016,802 - 130,023,138 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605434,557,942 - 34,563,225 (-)NCBIVero_WHO_p1.0
Vwa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248188,204,223 - 8,208,398 (-)NCBIHetGla_female_1.0hetGla2


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125504302156508116Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124893970156508116Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138859268156508116Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124893970156508116Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4132926037156508116Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125504302156508116Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134569994156508116Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134569994156508116Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124893970156508116Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4128057656156508116Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125504302156508116Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4128057656156508116Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133592276156508116Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156183778Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124826172156508116Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125562755156508116Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1070
Count of miRNA genes:538
Interacting mature miRNAs:663
Transcripts:ENSMUST00000042196
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000042196   ⟹   ENSMUSP00000040405
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4155,852,606 - 155,859,155 (-)Ensembl
GRCm38.p6 Ensembl4155,768,149 - 155,774,698 (-)Ensembl
RefSeq Acc Id: NM_147776   ⟹   NP_680085
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394155,852,952 - 155,859,018 (-)NCBI
GRCm384155,768,495 - 155,774,561 (-)ENTREZGENE
MGSCv374155,142,604 - 155,148,670 (-)RGD
Celera4158,040,276 - 158,046,381 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030253579   ⟹   XP_030109439
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394155,857,207 - 155,858,982 (-)NCBI
GRCm384155,772,750 - 155,774,524 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036164134   ⟹   XP_036020027
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394155,853,757 - 155,858,976 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003954953
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394155,853,757 - 155,859,042 (-)NCBI
GRCm384155,769,300 - 155,774,693 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_680085   ⟸   NM_147776
- Peptide Label: precursor
- UniProtKB: Q8R2Z5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030109439   ⟸   XM_030253579
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000040405   ⟸   ENSMUST00000042196
RefSeq Acc Id: XP_036020027   ⟸   XM_036164134
- Peptide Label: isoform X1
Protein Domains
Fibronectin type-III   VWFA

Promoters
RGD ID:6834795
Promoter ID:MM_KWN:41180
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:UC008WER.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364155,143,111 - 155,144,477 (+)MPROMDB
RGD ID:6836658
Promoter ID:MM_KWN:41181
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung,   MEF_B4
Transcripts:OTTMUST00000025385
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364155,148,651 - 155,149,677 (-)MPROMDB
RGD ID:6885812
Promoter ID:EPDNEW_M6357
Type:initiation region
Name:AK035229_1
Description:n/a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384155,769,978 - 155,770,038EPDNEW
RGD ID:6885832
Promoter ID:EPDNEW_M6358
Type:initiation region
Name:Vwa1_1
Description:Mus musculus von Willebrand factor A domain containing 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384155,774,514 - 155,774,574EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2179729 AgrOrtholog
Ensembl Genes ENSMUSG00000042116 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000040405 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000042196 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  3.40.50.410 UniProtKB/Swiss-Prot
InterPro FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Vwa1 UniProtKB/Swiss-Prot
  VWF_A UniProtKB/Swiss-Prot
  vWFA_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:246228 UniProtKB/Swiss-Prot
MGD MGI:2179729 ENTREZGENE
NCBI Gene 246228 ENTREZGENE
PANTHER PTHR24020:SF51 UniProtKB/Swiss-Prot
Pfam fn3 UniProtKB/Swiss-Prot
  VWA UniProtKB/Swiss-Prot
PhenoGen Vwa1 PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot
  VWFA UniProtKB/Swiss-Prot
SMART FN3 UniProtKB/Swiss-Prot
  VWA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot
  SSF53300 UniProtKB/Swiss-Prot
UniProt Q8R2Z5 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8C0Q7 UniProtKB/Swiss-Prot
  Q8VDV9 UniProtKB/Swiss-Prot
  Q923K3 UniProtKB/Swiss-Prot