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Gene: Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6) Mus musculus
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Symbol: Arhgef6
Name: Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Description: Predicted to have Rho guanyl-nucleotide exchange factor activity. Involved in lamellipodium assembly. Localizes to the cell-cell junction and lamellipodium. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability. Orthologous to human ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6); PARTICIPATES IN ceramide signaling pathway; pancreatic cancer pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1600028C08Rik; 1700038J06Rik; 4930592P22Rik; alpha PIX Rho GTPase guanine nucleotide exchange factor; alpha-PIX; Rac/Cdc42 guanine exchange factor (GEF) 6; rac/Cdc42 guanine nucleotide exchange factor 6; rho guanine nucleotide exchange factor 6
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38X57,231,485 - 57,338,758 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X54,484,662 - 54,591,906 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X53,578,271 - 53,685,513 (-)NCBImm8
CeleraX43,709,095 - 43,814,976 (-)NCBICelera
Cytogenetic MapX A6NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Arhgef6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1550432
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.