Taar4 (trace amine-associated receptor 4)

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Gene: Taar4 (trace amine-associated receptor 4) Mus musculus

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Symbol:

Taar4

Name:

trace amine-associated receptor 4

RGD ID:

1550330

MGI Page

MGI

Description:

Enables 2-phenylethylamine receptor activity and trace-amine receptor activity. Involved in behavioral fear response; chemosensory behavior; and sensory perception of chemical stimulus. Predicted to be active in plasma membrane. Is expressed in Grueneberg ganglion; nasal septum; and olfactory epithelium. Orthologous to human TAAR4P (trace amine associated receptor 4, pseudogene).

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

2-phenylethylamine receptor; Gm226; mTaar4; Ta2; taR-4; trace amine associated receptor 4; trace amine receptor 2; trace amine receptor 4

RGD Orthologs

Human

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	23,836,392 - 23,837,435 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	23,836,392 - 23,837,435 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	23,960,494 - 23,961,537 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	23,960,494 - 23,961,537 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	23,680,300 - 23,681,343 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	23,649,910 - 23,650,953 (+)	NCBI		MGSCv36	mm8
Celera	10	24,893,868 - 24,894,911 (+)	NCBI		Celera
Cytogenetic Map	10	A4	NCBI
cM Map	10	11.4	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (EXP)

dextran sulfate (EXP)

potassium dichromate (EXP)

titanium dioxide (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

behavioral fear response (IBA,IMP)

chemosensory behavior (IBA,IMP)

G protein-coupled receptor signaling pathway (IBA,RCA)

sensory perception of chemical stimulus (IDA,IMP)

Cellular Component

plasma membrane (IBA,IEA)

Molecular Function

2-phenylethylamine receptor activity (IBA,IDA,IMP)

G protein-coupled amine receptor activity (ISO)

trace-amine receptor activity (IBA,IDA,IMP,ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal olfactory system physiology (IAGP)

impaired olfaction (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.	Lindemann L, etal., Genomics 2005 Mar;85(3):372-85.
2.	MGDs mouse GO annotations	MGD data from the GO Consortium
3.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:12679517	PMID:16602821	PMID:16878137	PMID:17556730	PMID:21267068	PMID:21690383	PMID:21873635	PMID:22545963	PMID:22840399	PMID:23624375	PMID:25616211
PMID:30038239	PMID:34145232	PMID:37225986

Genomics

Comparative Map Data

Taar4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	23,836,392 - 23,837,435 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	23,836,392 - 23,837,435 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	23,960,494 - 23,961,537 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	23,960,494 - 23,961,537 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	23,680,300 - 23,681,343 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	23,649,910 - 23,650,953 (+)	NCBI		MGSCv36	mm8
Celera	10	24,893,868 - 24,894,911 (+)	NCBI		Celera
Cytogenetic Map	10	A4	NCBI
cM Map	10	11.4	NCBI

TAAR4P
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	132,594,389 - 132,595,439 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	132,594,398 - 132,595,436 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	132,915,528 - 132,916,578 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	132,957,123 - 132,958,371 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	6	133,662,364 - 133,663,414 (-)	NCBI		Celera
Cytogenetic Map	6	q23.2	NCBI
HuRef	6	130,490,443 - 130,491,493 (-)	NCBI		HuRef
CHM1_1	6	133,179,199 - 133,180,249 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	133,789,357 - 133,790,407 (-)	NCBI		T2T-CHM13v2.0

Variants

Variants in Taar4
40 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	107
Count of miRNA genes:	105
Interacting mature miRNAs:	107
Transcripts:	ENSMUST00000092660
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
11532718	Sluc44f_m	susceptibility to lung cancer 44f (mouse)					10	1	26289265	Mouse
11532717	Sluc44g_m	susceptibility to lung cancer 44g (mouse)					10	1	26289265	Mouse
1300881	Sluc29_m	susceptibility to lung cancer 29 (mouse)			Not determined		10	1	26289265	Mouse
12879494	Facq1_m	fear acquisition QTL 1 (mouse)					10	1	31279130	Mouse
39128215	Lwq17_m	liver weight QTL 17 (mouse)					10	12704051	84079784	Mouse
1302160	Mbis2_m	Mycobacterium bovis-induced systemic lupus erythematosus 2 (mouse)			Not determined		10	20283185	56031223	Mouse
1300759	Geot_m	geotaxia (mouse)			Not determined		10	1	26289265	Mouse
1558865	Lith21_m	lithogenic gene 21 (mouse)			Not determined		10	8525003	42525126	Mouse
15039341	Nmrs28_m	NAFLD-associated magnetic resonance shift 28 (mouse)					10	351001	34351001	Mouse
4141943	W6q6_m	weight 6 weeks QTL 6 (mouse)			Not determined			12704051	84079784	Mouse
1301659	Arrd2_m	age-related retinal degeneration 2 (mouse)			Not determined		10	20283185	26890391	Mouse
27226772	Tibl13_m	tibia length 13, 10 week (mouse)					10	18875748	129635869	Mouse
1357656	Hrtq3_m	heart weight QTL 3 (mouse)			Not determined		10	12704051	84079784	Mouse
4142380	W3q11_m	weight 3 weeks QTL 11 (mouse)			Not determined			12704051	84079784	Mouse
1357825	Kidpq2_m	kidney weight percentage QTL 2 (mouse)			Not determined		10	12704051	84079784	Mouse
1300997	Eae15_m	susceptibility to experimental allergic encephalomyelitis 15 (mouse)			Not determined		10	4408154	38408276	Mouse
1301003	Lmblgq4_m	limb length QTL 4 (mouse)			Not determined		10	21591192	68091639	Mouse
1301386	Sysbp1_m	systolic blood pressure 1 (mouse)			Not determined		10	10108265	87401095	Mouse
11532725	Sluc44b_m	susceptibility to lung cancer 44b (mouse)					10	1	26289265	Mouse
1301129	Alcp15_m	alcohol preference locus 15 (mouse)			Not determined		10	9890264	43890391	Mouse
10755518	Chol16_m	cholesterol 16 (mouse)					10	18915043	52915043	Mouse
11532724	Sluc44c_m	susceptibility to lung cancer 44c (mouse)					10	1	26289265	Mouse
1301448	Pas11_m	pulmonary adenoma susceptibility 11 (mouse)			Not determined		10	9890264	43890391	Mouse
11532723	Sluc44d_m	susceptibility to lung cancer 44d (mouse)					10	1	26289265	Mouse
11532722	Sluc44e_m	susceptibility to lung cancer 44e (mouse)					10	1	26289265	Mouse
11532721	Sluc44_m	susceptibility to lung cancer 44 (mouse)					10	1	26289265	Mouse
1558857	Igan1_m	IgA nephropathy 1 (mouse)			Not determined		10	17718313	29704155	Mouse
11532720	Sluc44a_m	susceptibility to lung cancer 44a (mouse)					10	1	26289265	Mouse
1302092	Ath11_m	atherosclerosis 11 (mouse)			Not determined		10	6151945	58693521	Mouse
1302067	Scc9_m	colon tumor susceptibility 9 (mouse)			Not determined		10	18259333	125575232	Mouse
1357813	Ath20_m	atherosclerosis 20 (mouse)			Not determined		10	3283185	37283334	Mouse
1300790	Pgia6_m	proteoglycan induced arthritis 6 (mouse)			Not determined		10	3810171	37810295	Mouse
1302133	Alcp16_m	alcohol preference locus 16 (mouse)			Not determined		10	9890264	43890391	Mouse
26884403	Cvht8_m	cranial vault height 8, 16 week (mouse)					10	22875899	91035862	Mouse
26884394	Humsd3_m	humerus midshaft diameter 3, 10 week (mouse)					10	22375899	51076096	Mouse
11533917	Mts2_m	mammary tumor susceptibility 2 (mouse)					10	1	26289265	Mouse
1558757	Eae34_m	experimental allergic encephalomyelitis susceptibility 34 (mouse)			Not determined		10	21408154	114217230	Mouse
13208570	Bmiq9_m	body mass index QTL 9 (mouse)					10	12875744	24875898	Mouse
1301796	Mop2_m	morphine preference 2 (mouse)			Not determined		10	9289119	29028424	Mouse
13208561	Wght8_m	weight 8 (mouse)					10	4950000	43875996	Mouse
1357740	Obsty3_m	obesity 3 (mouse)			Not determined		10	8235478	116190980	Mouse
4141956	Egq7_m	early growth QTL 7 (mouse)			Not determined			12704051	84079784	Mouse
1357864	Scfpq1_m	subcutaneous fat pad percentage QTL 1 (mouse)			Not determined		10	12704051	84079784	Mouse
4142272	W10q5_m	weight 10 weeks QTL 5 (mouse)			Not determined			12704051	84079784	Mouse

Markers in Region

Taar4

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	10	23,960,670 - 23,961,482	UniSTS	GRCm38
MGSCv37	10	23,680,476 - 23,681,288	UniSTS	GRCm37
Celera	10	24,894,044 - 24,894,856	UniSTS
Cytogenetic Map	10	A4	UniSTS
cM Map	10		UniSTS

UniSTS:487466

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	10	23,960,494 - 23,961,537	UniSTS	GRCm38
MGSCv37	10	23,680,300 - 23,681,343	UniSTS	GRCm37
Celera	10	24,893,868 - 24,894,911	UniSTS
Cytogenetic Map	10	A4	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001008499	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC117837	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY255547	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY702328	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC117729	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC117730	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466540	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FJ372497	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000092660 ⟹ ENSMUSP00000090330

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	10	23,836,392 - 23,837,435 (+)	Ensembl
GRCm38.p6 Ensembl	10	23,960,494 - 23,961,537 (+)	Ensembl

RefSeq Acc Id:

NM_001008499 ⟹ NP_001008499

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	10	23,836,392 - 23,837,435 (+)	NCBI
GRCm38	10	23,960,494 - 23,961,537 (+)	ENTREZGENE
MGSCv37	10	23,680,300 - 23,681,343 (+)	RGD
Celera	10	24,893,868 - 24,894,911 (+)	RGD
cM Map	10		ENTREZGENE

Sequence:

show sequence

ATGAATACACCCGACCCCTGGAGCTCCCCAGAAGTACAGTTTTGCTTTGCTGCTGCAAACAGTT
CTTGCCCAAGGAAGGCGAGGCCTGCGCTCGTTGTCTGTGCCATGTACCTCATCATGATTGGAGC
GATAGTGATGACCATGCTGGGAAACATGGCTGTGATCATCTCTATTGCCCACTTCAAGCAGCTC
CACTCCCCAACCAACTTCCTTATTCTCTCCATGGCTACCACAGACTTCCTGTTGAGTTGCGTGG
TCATGCCCTTCAGTATGATCCGGTCCATCGAGTCATGCTGGTACTTCGGAGACCTCTTTTGCAA
AGTTCACAGCTGCTGTGACATCATGCTCTGTACCACATCCATTTTCCACCTCTGCTTCATCTCA
GTTGACCGCCACTATGCCGTCTGCGACCCTTTGCACTACGTCACCCAAATCACGACCCGGGTGG
TAGGGGTCTTTCTACTCATCAGTTGGTCTGTTCCCATCTTTTTTGCCTTTGGCTTGGTATTCTC
AGAATTAAATCTGATTGGTGCTGAGGATTTTGTCGCAGCCATTGACTGTACAGGTTTGTGTGTG
TTGATATTTAACAAGCTCTGGGGAGTTCTGGCTTCCTTCATAGCTTTCTTTCTGCCTGGGACAG
TCATGGTAGGGATTTACATACACATTTTCACAGTTGCCCAGAAACATGCCAGGCAGATTGGTAC
AGGTCCTAGGACAAAACAGGCCCTCTCAGAAAGCAAAATGAAGGCCACATCAAAAAAGGAAAGC
AAGGCCACCAAGACTTTAAGCATTGTCATGGGAGTGTTTGTGTTGTGTTGGCTACCCTTTTTTG
TCTTGACAATCACAGACCCTTTCATTGATTTTACAACCCCTGAAGATTTGTATAATGTTTTCCT
TTGGCTTGGTTATTTTAATTCCACTTTCAATCCCATCATATATGGCATGTTCTATCCCTGGTTT
CGAAAGGCCCTGAGGATGATAGTCACAGGAACGATCTTCCGCTCTGACTCTTCTACCTCAAGCC
TGCATCCTGCACATCCTTAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001008499	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI17730	(Get FASTA)	NCBI Sequence Viewer
	AAI17731	(Get FASTA)	NCBI Sequence Viewer
	AAO85059	(Get FASTA)	NCBI Sequence Viewer
	AAV70138	(Get FASTA)	NCBI Sequence Viewer
	ACP18736	(Get FASTA)	NCBI Sequence Viewer
	EDL04774	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000090330
	ENSMUSP00000090330.2
GenBank Protein	Q5QD15	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001008499 ⟸ NM_001008499

- UniProtKB:

Q5QD15 (UniProtKB/Swiss-Prot), A4FUU0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNTPDPWSSPEVQFCFAAANSSCPRKARPALVVCAMYLIMIGAIVMTMLGNMAVIISIAHFKQL
HSPTNFLILSMATTDFLLSCVVMPFSMIRSIESCWYFGDLFCKVHSCCDIMLCTTSIFHLCFIS
VDRHYAVCDPLHYVTQITTRVVGVFLLISWSVPIFFAFGLVFSELNLIGAEDFVAAIDCTGLCV
LIFNKLWGVLASFIAFFLPGTVMVGIYIHIFTVAQKHARQIGTGPRTKQALSESKMKATSKKES
KATKTLSIVMGVFVLCWLPFFVLTITDPFIDFTTPEDLYNVFLWLGYFNSTFNPIIYGMFYPWF
RKALRMIVTGTIFRSDSSTSSLHPAHP

hide sequence

Ensembl Acc Id:

ENSMUSP00000090330 ⟸ ENSMUST00000092660

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5QD15-F1-model_v2	AlphaFold	Q5QD15	1-347	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2685072	AgrOrtholog
Ensembl Genes	ENSMUSG00000069707	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000092660	ENTREZGENE
	ENSMUST00000092660.2	UniProtKB/Swiss-Prot
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TAAR	UniProtKB/TrEMBL
	TAAR_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:209513	UniProtKB/Swiss-Prot
MGD	MGI:2685072	ENTREZGENE
NCBI Gene	209513	ENTREZGENE
PANTHER	5-HYDROXYTRYPTAMINE RECEPTOR 4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR	UniProtKB/TrEMBL
	TRACE AMINE-ASSOCIATED RECEPTOR 4	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Taar4	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRACEAMINER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	7TM_GPCR_Srsx	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0AUN7_MOUSE	UniProtKB/TrEMBL
	A4FUU0	ENTREZGENE, UniProtKB/TrEMBL
	D8KZM7_MOUSE	UniProtKB/TrEMBL
	Q5QD15	ENTREZGENE
	Q80UC9_MOUSE	UniProtKB/TrEMBL
	TAAR4_MOUSE	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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