Adgrf3 (adhesion G protein-coupled receptor F3) - Rat Genome Database

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Gene: Adgrf3 (adhesion G protein-coupled receptor F3) Mus musculus
Analyze
Symbol: Adgrf3
Name: adhesion G protein-coupled receptor F3
RGD ID: 1550327
MGI Page MGI
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Is expressed in circumvallate papillae; testis; and tongue epithelium. Orthologous to human ADGRF3 (adhesion G protein-coupled receptor F3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adhesion G-protein coupled receptor F3; G protein coupled receptor Gpr113; G protein-coupled receptor 113; G-protein coupled receptor 113; G-protein coupled receptor PGR23; Gm1041; Gpr1; Gpr113; PGR; Pgr23; probable G-protein coupled receptor 113
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39530,398,429 - 30,410,752 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl530,398,429 - 30,410,720 (-)EnsemblGRCm39 Ensembl
GRCm38530,193,431 - 30,205,754 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,193,431 - 30,205,722 (-)EnsemblGRCm38mm10GRCm38
MGSCv37530,519,971 - 30,532,262 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36530,524,218 - 30,536,509 (-)NCBIMGSCv36mm8
Celera527,710,969 - 27,723,318 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map516.13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12679517   PMID:14610273   PMID:15203201   PMID:15780750   PMID:20562862   PMID:21267068   PMID:21873635   PMID:25713288  


Genomics

Comparative Map Data
Adgrf3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39530,398,429 - 30,410,752 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl530,398,429 - 30,410,720 (-)EnsemblGRCm39 Ensembl
GRCm38530,193,431 - 30,205,754 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,193,431 - 30,205,722 (-)EnsemblGRCm38mm10GRCm38
MGSCv37530,519,971 - 30,532,262 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36530,524,218 - 30,536,509 (-)NCBIMGSCv36mm8
Celera527,710,969 - 27,723,318 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map516.13NCBI
ADGRF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38226,308,173 - 26,346,789 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl226,308,173 - 26,346,817 (-)EnsemblGRCh38hg38GRCh38
GRCh37226,531,041 - 26,569,657 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36226,384,545 - 26,423,189 (-)NCBINCBI36Build 36hg18NCBI36
Build 34226,444,464 - 26,453,568NCBI
Celera226,371,279 - 26,413,239 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef226,266,987 - 26,308,935 (-)NCBIHuRef
CHM1_1226,461,016 - 26,499,646 (-)NCBICHM1_1
T2T-CHM13v2.0226,343,551 - 26,385,469 (-)NCBIT2T-CHM13v2.0
Adgrf3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,853,018 - 31,864,441 (+)NCBIGRCr8
mRatBN7.2626,133,176 - 26,144,601 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,133,192 - 26,144,601 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx626,426,970 - 26,437,232 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,742,857 - 26,753,122 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0626,222,239 - 26,232,522 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0627,534,525 - 27,546,804 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl627,535,020 - 27,546,454 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0637,345,539 - 37,357,475 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4626,120,168 - 26,130,428 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1626,124,259 - 26,133,274 (+)NCBI
Celera625,611,224 - 25,621,486 (+)NCBICelera
Cytogenetic Map6q14NCBI
Adgrf3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554698,280,131 - 8,291,512 (-)NCBIChiLan1.0ChiLan1.0
ADGRF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212100,168,846 - 100,210,205 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A100,172,814 - 100,214,173 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A26,303,414 - 26,345,041 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A26,397,211 - 26,437,715 (-)NCBIpanpan1.1PanPan1.1panPan2
ADGRF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11720,404,682 - 20,431,035 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1720,404,837 - 20,430,730 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1720,298,265 - 20,326,148 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01720,725,436 - 20,753,243 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1720,726,878 - 20,736,687 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11720,412,153 - 20,440,026 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01720,423,127 - 20,451,001 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01720,469,548 - 20,497,343 (-)NCBIUU_Cfam_GSD_1.0
Adgrf3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629264,706,279 - 64,715,957 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364936,123,635 - 6,133,999 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364936,125,610 - 6,132,797 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADGRF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3112,671,204 - 112,705,296 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13112,693,165 - 112,704,778 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23119,608,787 - 119,642,243 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADGRF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11481,303,452 - 81,344,638 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604530,813,283 - 30,853,642 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adgrf3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247388,429,651 - 8,439,581 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247388,428,834 - 8,439,869 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adgrf3
434 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:413
Count of miRNA genes:228
Interacting mature miRNAs:251
Transcripts:ENSMUST00000088117, ENSMUST00000114774, ENSMUST00000125367, ENSMUST00000135322
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401122Pgia41_mproteoglycan induced arthritis 41 (mouse)Not determined582314434823280Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5350482337504823Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5538452039384652Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5812411742124239Mouse
7394748Mom5_mmodifier of Min 5 (mouse)Not determined5884767233475637Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5891594940529869Mouse
14696730Kidlq1_mkidney weight, left QTL 1 (mouse)51356315247563152Mouse
1301685Estq2_mestradiol regulated response QTL 2 (mouse)Not determined51563408449634190Mouse
1300719Iba5_minduction of brown adipocytes 5 (mouse)Not determined52068699354687134Mouse
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52166729555667403Mouse
11537368Hmtb10_mhemostasis and thrombosis 10 (mouse)52210082354500318Mouse
11537367Hmtb11_mhemostasis and thrombosis 11 (mouse)52210082364806579Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
1300701Cd8ts1_mCD8 T cell subset 1 (mouse)Not determined52721534861215451Mouse

Markers in Region
D5Mit3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38530,194,084 - 30,194,245UniSTSGRCm38
MGSCv37530,520,624 - 30,520,785UniSTSGRCm37
Celera527,711,622 - 27,711,783UniSTS
Cytogenetic Map5B1UniSTS
cM Map518.0UniSTS
Whitehead Genetic514.2UniSTS
Whitehead_YAC5 UniSTS
Emv1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38530,201,764 - 30,201,868UniSTSGRCm38
MGSCv37530,528,304 - 30,528,408UniSTSGRCm37
Celera527,719,306 - 27,719,410UniSTS
Cytogenetic Map5B1UniSTS
cM Map520.0UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000088117   ⟹   ENSMUSP00000085440
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl530,398,429 - 30,410,720 (-)Ensembl
GRCm38.p6 Ensembl530,193,431 - 30,205,722 (-)Ensembl
RefSeq Acc Id: ENSMUST00000125367   ⟹   ENSMUSP00000120958
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl530,398,433 - 30,401,416 (-)Ensembl
GRCm38.p6 Ensembl530,193,435 - 30,196,418 (-)Ensembl
RefSeq Acc Id: ENSMUST00000135322
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl530,407,305 - 30,409,585 (-)Ensembl
GRCm38.p6 Ensembl530,202,307 - 30,204,587 (-)Ensembl
RefSeq Acc Id: NM_001014394   ⟹   NP_001014416
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39530,398,429 - 30,410,720 (-)NCBI
GRCm38530,193,431 - 30,205,722 (-)NCBI
MGSCv37530,519,971 - 30,532,262 (-)RGD
Celera527,710,969 - 27,723,318 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006535736   ⟹   XP_006535799
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39530,400,051 - 30,410,752 (-)NCBI
GRCm38530,195,060 - 30,205,754 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006535737   ⟹   XP_006535800
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39530,398,429 - 30,410,752 (-)NCBI
GRCm38530,193,431 - 30,205,754 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006535738   ⟹   XP_006535801
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39530,400,049 - 30,407,390 (-)NCBI
GRCm38530,195,058 - 30,202,392 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006535740   ⟹   XP_006535803
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39530,400,050 - 30,405,518 (-)NCBI
GRCm38530,195,058 - 30,200,519 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011249775   ⟹   XP_011248077
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39530,400,050 - 30,410,752 (-)NCBI
GRCm38530,195,059 - 30,205,754 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001014416   ⟸   NM_001014394
- Peptide Label: precursor
- UniProtKB: F8VPU1 (UniProtKB/Swiss-Prot),   Q80T50 (UniProtKB/Swiss-Prot),   Q58Y75 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006535800   ⟸   XM_006535737
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006535801   ⟸   XM_006535738
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006535803   ⟸   XM_006535740
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006535799   ⟸   XM_006535736
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011248077   ⟸   XM_011249775
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSMUSP00000120958   ⟸   ENSMUST00000125367
RefSeq Acc Id: ENSMUSP00000085440   ⟸   ENSMUST00000088117
Protein Domains
GPS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q58Y75-F1-model_v2 AlphaFold Q58Y75 1-991 view protein structure

Promoters
RGD ID:6837664
Promoter ID:MM_KWN:41750
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   Kidney
Transcripts:OTTMUST00000061045
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36530,523,011 - 30,523,662 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685887 AgrOrtholog
Ensembl Genes ENSMUSG00000067642 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000088117 ENTREZGENE
  ENSMUST00000088117.11 UniProtKB/Swiss-Prot
  ENSMUST00000125367.4 UniProtKB/TrEMBL
Gene3D-CATH 2.60.220.50 UniProtKB/Swiss-Prot
  4.10.1240.10 UniProtKB/Swiss-Prot
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GAIN_dom_sf UniProtKB/Swiss-Prot
  GPCR_2-like UniProtKB/Swiss-Prot
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot
  GPCR_2_secretin-like UniProtKB/Swiss-Prot
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot
  GPS UniProtKB/Swiss-Prot
KEGG Report mmu:381628 UniProtKB/Swiss-Prot
MGD MGI:2685887 ENTREZGENE
NCBI Gene 381628 ENTREZGENE
PANTHER ADHESION G-PROTEIN COUPLED RECEPTOR F3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45813 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/Swiss-Prot
  GPS UniProtKB/Swiss-Prot
PhenoGen Adgrf3 PhenoGen
PRINTS GPCRSECRETIN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot
  GPS UniProtKB/Swiss-Prot
SMART GPS UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
  SSF111418 UniProtKB/Swiss-Prot
UniProt AGRF3_MOUSE UniProtKB/Swiss-Prot
  F6UJY6_MOUSE UniProtKB/TrEMBL
  F8VPU1 ENTREZGENE
  Q58Y75 ENTREZGENE
  Q80T50 ENTREZGENE
UniProt Secondary F8VPU1 UniProtKB/Swiss-Prot
  Q80T50 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-19 Adgrf3  adhesion G protein-coupled receptor F3  Gpr113  G protein-coupled receptor 113  Symbol and/or name change 5135510 APPROVED