Dync2i2 (dynein 2 intermediate chain 2) - Rat Genome Database

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Gene: Dync2i2 (dynein 2 intermediate chain 2) Mus musculus
Analyze
Symbol: Dync2i2
Name: dynein 2 intermediate chain 2
RGD ID: 1550264
MGI Page MGI
Description: Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in cilium assembly and intraciliary retrograde transport. Located in cytoskeleton and filopodium. Part of cytoplasmic dynein complex. Is expressed in cerebral cortex ventricular layer and cortical plate. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 11 with or without polydactyly. Orthologous to human DYNC2I2 (dynein 2 intermediate chain 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3200002I06Rik; cytoplasmic dynein 2 intermediate chain 2; MGC103259; WD repeat domain 34; WD repeat-containing protein 34; Wdr34
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39229,921,563 - 29,938,891 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl229,921,558 - 29,938,893 (-)EnsemblGRCm39 Ensembl
GRCm38230,031,551 - 30,048,879 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl230,031,546 - 30,048,881 (-)EnsemblGRCm38mm10GRCm38
MGSCv37229,887,071 - 29,904,399 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36229,853,560 - 29,870,834 (-)NCBIMGSCv36mm8
Celera229,735,303 - 29,752,631 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map221.04NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15489334   PMID:16096065   PMID:16141072   PMID:16141073   PMID:18799693   PMID:19521500  
PMID:21677750   PMID:21873635   PMID:24183451   PMID:25294941   PMID:26073538   PMID:28379358   PMID:29091030   PMID:32325033   PMID:32581705   PMID:37228654  


Genomics

Comparative Map Data
Dync2i2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39229,921,563 - 29,938,891 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl229,921,558 - 29,938,893 (-)EnsemblGRCm39 Ensembl
GRCm38230,031,551 - 30,048,879 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl230,031,546 - 30,048,881 (-)EnsemblGRCm38mm10GRCm38
MGSCv37229,887,071 - 29,904,399 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36229,853,560 - 29,870,834 (-)NCBIMGSCv36mm8
Celera229,735,303 - 29,752,631 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map221.04NCBI
DYNC2I2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389128,633,653 - 128,684,460 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9128,633,653 - 128,656,847 (-)EnsemblGRCh38hg38GRCh38
GRCh379131,395,932 - 131,419,126 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369130,435,761 - 130,458,950 (-)NCBINCBI36Build 36hg18NCBI36
Build 349128,475,493 - 128,498,620NCBI
Celera9102,046,739 - 102,069,942 (-)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9101,007,761 - 101,029,056 (-)NCBIHuRef
CHM1_19131,546,867 - 131,570,080 (-)NCBICHM1_1
T2T-CHM13v2.09140,840,521 - 140,889,219 (-)NCBIT2T-CHM13v2.0
Dync2i2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8333,703,882 - 33,719,960 (-)NCBIGRCr8
mRatBN7.2313,306,039 - 13,322,121 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl313,306,039 - 13,322,121 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx316,380,386 - 16,396,488 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0324,965,345 - 24,981,447 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0323,216,070 - 23,232,168 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.038,599,251 - 8,615,329 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,599,148 - 8,615,532 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0313,950,876 - 13,967,221 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.439,021,833 - 9,037,243 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.139,022,132 - 9,037,543 (-)NCBI
Celera38,083,074 - 8,099,111 (-)NCBICelera
Cytogenetic Map3p12NCBI
Dync2i2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555701,076,568 - 1,086,613 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555701,076,498 - 1,086,629 (-)NCBIChiLan1.0ChiLan1.0
DYNC2I2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21110,694,048 - 10,718,344 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1910,696,398 - 10,720,696 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0999,755,972 - 99,780,279 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19128,422,958 - 128,447,444 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9128,423,053 - 128,447,387 (-)Ensemblpanpan1.1panPan2
DYNC2I2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1954,930,039 - 54,953,752 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl954,930,054 - 54,953,751 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,125,830 - 54,149,446 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0955,852,295 - 55,876,078 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl955,852,310 - 55,876,077 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1954,612,075 - 54,635,564 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0954,925,485 - 54,949,367 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,018,287 - 55,041,986 (+)NCBIUU_Cfam_GSD_1.0
Dync2i2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947196,373,926 - 196,389,417 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648716,142,658 - 16,157,804 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648716,142,659 - 16,157,929 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYNC2I2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1269,002,261 - 269,030,719 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11269,002,252 - 269,030,978 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21303,025,984 - 303,054,250 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DYNC2I2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,470,588 - 9,503,754 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl129,479,403 - 9,503,671 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660796,746,587 - 6,771,280 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dync2i2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247606,321,172 - 6,331,532 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247606,321,195 - 6,331,784 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dync2i2
505 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:498
Count of miRNA genes:346
Interacting mature miRNAs:383
Transcripts:ENSMUST00000113711, ENSMUST00000139145, ENSMUST00000143892, ENSMUST00000146275
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22459001254890012Mouse
8552705Cia25_mcollagen induced arthritis 25 (mouse)Not determined22467911533523172Mouse
8552706Cia24_mcollagen induced arthritis QTL 24 (mouse)Not determined22467911533523172Mouse
12792980Fbmd1_mfemoral bone mineral density 1, females only (mouse)22503449245034492Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22530805156971811Mouse
12904005Cfq2_mconditioned fear QTL 2 (mouse)22702264256396228Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
14746979Manh51_mmandible shape 51 (mouse)22896112962961129Mouse
14746997Mancz2_mmandible centroid size 2 (mouse)22896112962961129Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse

Markers in Region
AI747678  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38230,031,115 - 30,031,259UniSTSGRCm38
MGSCv37229,886,635 - 29,886,779UniSTSGRCm37
Celera229,734,867 - 29,735,011UniSTS
Cytogenetic Map2BUniSTS
cM Map218.0UniSTS
Whitehead/MRC_RH2475.23UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000113711   ⟹   ENSMUSP00000109340
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl229,921,558 - 29,938,893 (-)Ensembl
GRCm38.p6 Ensembl230,031,546 - 30,048,881 (-)Ensembl
RefSeq Acc Id: ENSMUST00000139145
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl229,921,924 - 29,922,517 (-)Ensembl
GRCm38.p6 Ensembl230,031,912 - 30,032,505 (-)Ensembl
RefSeq Acc Id: ENSMUST00000143892
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl229,923,806 - 29,925,058 (-)Ensembl
GRCm38.p6 Ensembl230,033,794 - 30,035,046 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146275
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl229,937,183 - 29,938,873 (-)Ensembl
GRCm38.p6 Ensembl230,047,171 - 30,048,861 (-)Ensembl
RefSeq Acc Id: NM_001008498   ⟹   NP_001008498
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39229,921,563 - 29,938,891 (-)NCBI
GRCm38230,031,551 - 30,048,879 (-)ENTREZGENE
MGSCv37229,887,071 - 29,904,399 (-)RGD
Celera229,735,303 - 29,752,631 (-)RGD
cM Map2 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001008498 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85113 (Get FASTA)   NCBI Sequence Viewer  
  EDL08430 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000109340
  ENSMUSP00000109340.3
GenBank Protein Q5U4F6 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001008498   ⟸   NM_001008498
- UniProtKB: Q5U4F6 (UniProtKB/Swiss-Prot),   A2BE91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000109340   ⟸   ENSMUST00000113711

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U4F6-F1-model_v2 AlphaFold Q5U4F6 1-537 view protein structure

Promoters
RGD ID:6833074
Promoter ID:MM_KWN:28485
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000040528
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36229,887,616 - 29,888,857 (-)MPROMDB
RGD ID:6833106
Promoter ID:MM_KWN:28487
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK010838_2410198J08RIK,   OTTMUST00000040525,   OTTMUST00000040526
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36229,904,231 - 29,904,812 (-)MPROMDB
RGD ID:6876860
Promoter ID:EPDNEW_M1881
Type:initiation region
Name:Wdr34_1
Description:Mus musculus WD repeat domain 34 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38230,048,844 - 30,048,904EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919070 AgrOrtholog
Ensembl Genes ENSMUSG00000039715 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000113711 ENTREZGENE
  ENSMUST00000113711.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot
InterPro WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot
  WD40_repeat UniProtKB/Swiss-Prot
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:71820 UniProtKB/Swiss-Prot
MGD MGI:1919070 ENTREZGENE
NCBI Gene 71820 ENTREZGENE
PANTHER CYTOPLASMIC DYNEIN 2 INTERMEDIATE CHAIN 2 UniProtKB/Swiss-Prot
  DYNEIN INTERMEDIATE CHAIN UniProtKB/Swiss-Prot
Pfam WD40 UniProtKB/Swiss-Prot
PhenoGen Dync2i2 PhenoGen
PROSITE WD_REPEATS_REGION UniProtKB/Swiss-Prot
SMART WD40 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot
UniProt A2BE91 ENTREZGENE
  Q5U4F6 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A2BE91 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-10-12 Dync2i2  dynein 2 intermediate chain 2  Wdr34  WD repeat domain 34  Symbol and/or name updated 27372883 PROVISIONAL