Gene: Klhdc8b (kelch domain containing 8B) Mus musculus
Analyze
Symbol:
Klhdc8b
Name:
kelch domain containing 8B
Description:
INVOLVED IN mitotic cytokinetic process (ortholog); mitotic nuclear division (ortholog); nuclear chromosome segregation (ortholog); ASSOCIATED WITH Hodgkin's lymphoma (ortholog); FOUND IN cellularization cleavage furrow (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; carbon nanotube
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
4931406O17Rik; kelch domain-containing protein 8B
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
KLHDC8B (kelch domain containing 8B) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB
Rattus norvegicus (Norway rat):
Klhdc8b (kelch domain containing 8B) HGNC
EggNOG, NCBI, OMA, HomoloGene, Inparanoid, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Klhdc8b (kelch domain containing 8B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
KLHDC8B (kelch domain containing 8B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
KLHDC8B (kelch domain containing 8B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Klhdc8b (kelch domain containing 8B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
KLHDC8B (kelch domain containing 8B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Klhdc8b (kelch domain containing 8B)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):
KLHDC8B (kelch domain containing 8B)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Danio rerio (zebrafish):
klhdc8b (kelch domain containing 8B)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, ZFIN)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 108,447,635 - 108,461,581 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 108,349,970 - 108,363,912 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 108,305,742 - 108,319,684 (-) NCBI mm8 Celera 9 108,056,827 - 108,070,762 (-) NCBI Celera Cytogenetic Map 9 F2 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - CTD
Hodgkin's lymphoma ISO RGD:1602285 11554173 CTD Direct Evidence: marker/mechanism CTD
Imported Annotations - OMIM
Hodgkin's lymphoma susceptibility ISO RGD:1602285 7240710 OMIM
Gene-Chemical Interaction Annotations
(RS)-amphetamine decreases expression ISO RGD:1359445 6480464 Amphetamine results in decreased expression of KLHDC8B mRNA CTD PMID:30779732 17beta-estradiol multiple interactions ISO RGD:1602285 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of KLHDC8B mRNA CTD PMID:30165855 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of KLHDC8B mRNA CTD PMID:21570461 2-methylcholine affects expression ISO RGD:1602285 6480464 beta-methylcholine affects the expression of KLHDC8B mRNA CTD PMID:21179406 4-hydroxyphenyl retinamide decreases expression EXP 6480464 Fenretinide results in decreased expression of KLHDC8B mRNA CTD PMID:28973697 6-propyl-2-thiouracil increases expression ISO RGD:1359445 6480464 Propylthiouracil results in increased expression of KLHDC8B mRNA CTD PMID:24780913 aflatoxin B1 increases expression ISO RGD:1602285 6480464 Aflatoxin B1 results in increased expression of KLHDC8B mRNA CTD PMID:22100608 antirheumatic drug increases expression ISO RGD:1602285 6480464 Antirheumatic Agents results in increased expression of KLHDC8B mRNA CTD PMID:24449571 benzo[a]pyrene decreases expression ISO RGD:1602285 6480464 Benzo(a)pyrene results in decreased expression of KLHDC8B mRNA CTD PMID:20064835 benzo[a]pyrene increases expression ISO RGD:1602285 6480464 Benzo(a)pyrene results in increased expression of KLHDC8B mRNA CTD PMID:20106945 , PMID:21632981 bisphenol A decreases expression ISO RGD:1602285 6480464 bisphenol A results in decreased expression of KLHDC8B mRNA CTD PMID:22576693 bisphenol A increases expression ISO RGD:1359445 6480464 bisphenol A results in increased expression of KLHDC8B mRNA CTD PMID:25181051 bisphenol A increases methylation ISO RGD:1602285 6480464 bisphenol A results in increased methylation of KLHDC8B gene CTD PMID:22576693 C60 fullerene increases expression ISO RGD:1359445 6480464 fullerene C60 results in increased expression of KLHDC8B mRNA CTD PMID:19167457 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of KLHDC8B mRNA, Nanotubes, Carbon results in decreased expression of KLHDC8B mRNA CTD PMID:25554681 , PMID:25620056 cisplatin affects expression ISO RGD:1602285 6480464 Cisplatin affects the expression of KLHDC8B mRNA CTD PMID:23300844 copper atom decreases expression ISO RGD:1359445 6480464 Copper results in decreased expression of KLHDC8B mRNA CTD PMID:30556269 copper(0) decreases expression ISO RGD:1359445 6480464 Copper results in decreased expression of KLHDC8B mRNA CTD PMID:30556269 copper(2+) decreases expression ISO RGD:1359445 6480464 Copper results in decreased expression of KLHDC8B mRNA CTD PMID:30556269 cyclosporin A decreases expression ISO RGD:1602285 6480464 Cyclosporine results in decreased expression of KLHDC8B mRNA CTD PMID:20106945 , PMID:27989131 dorsomorphin multiple interactions ISO RGD:1602285 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLHDC8B mRNA CTD PMID:27188386 doxorubicin increases expression ISO RGD:1602285 6480464 Doxorubicin results in increased expression of KLHDC8B mRNA CTD PMID:29803840 methyl methanesulfonate increases expression ISO RGD:1602285 6480464 Methyl Methanesulfonate results in increased expression of KLHDC8B mRNA CTD PMID:23649840 methylmercury chloride decreases expression ISO RGD:1602285 6480464 methylmercuric chloride results in decreased expression of KLHDC8B mRNA CTD PMID:28001369 nickel atom decreases expression ISO RGD:1602285 6480464 Nickel results in decreased expression of KLHDC8B mRNA CTD PMID:24768652 , PMID:25583101 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of KLHDC8B mRNA CTD PMID:17562736 pirinixic acid multiple interactions EXP 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KLHDC8B mRNA CTD PMID:19710929 SB 431542 multiple interactions ISO RGD:1602285 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLHDC8B mRNA CTD PMID:27188386 tetraphene affects expression EXP 6480464 benz(a)anthracene affects the expression of KLHDC8B mRNA CTD PMID:26377693 titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of KLHDC8B mRNA CTD PMID:27760801 trichostatin A decreases expression ISO RGD:1602285 6480464 trichostatin A results in decreased expression of KLHDC8B mRNA CTD PMID:24935251 triclosan decreases expression ISO RGD:1602285 6480464 Triclosan results in decreased expression of KLHDC8B mRNA CTD PMID:30510588 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of KLHDC8B mRNA CTD PMID:21427059 valproic acid increases expression ISO RGD:1602285 6480464 Valproic Acid results in increased expression of KLHDC8B mRNA CTD PMID:29154799 valproic acid affects expression ISO RGD:1602285 6480464 Valproic Acid affects the expression of KLHDC8B mRNA CTD PMID:25979313 valproic acid decreases expression ISO RGD:1602285 6480464 Valproic Acid results in decreased expression of KLHDC8B mRNA CTD PMID:23527032 , PMID:26272509 valproic acid multiple interactions ISO RGD:1602285 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLHDC8B mRNA CTD PMID:27188386
Gene Ontology Annotations
13207569 Tcq13_m total cholesterol QTL 13 (mouse) 9 59990000 109260000 Mouse 4141833 W10q13_m weight 10 weeks QTL 13 (mouse) Not determined 63332429 120362868 Mouse 4141545 Tailaq2_m tail length adjusted QTL 2 (mouse) Not determined 63332429 120362868 Mouse 1357635 Splq4_m spleen weight QTL 4 (mouse) Not determined 9 63332429 120362868 Mouse 1302065 El1_m epilepsy 1 (mouse) Not determined 9 75775364 114474379 Mouse 10054492 El7_m epilepsy 7 (mouse) Not determined 9 75775364 114474379 Mouse 1301407 Rapop2_m radiation-induced apoptosis 2 (mouse) Not determined 9 76535936 110536130 Mouse 1301192 Skts6_m skin tumor susceptibility 6 (mouse) Not determined 9 78640645 112640755 Mouse 10401247 Bglu14_m blood glucose level 14 (mouse) Not determined 9 79397810 113397888 Mouse 1301732 Char1_m P. chabaudi malaria resistance QTL 1 (mouse) Not determined 9 81798268 115798392 Mouse 1300884 Sluc11_m susceptibility to lung cancer 11 (mouse) Not determined 9 82910333 116910428 Mouse 1357461 Idd2_m insulin dependent diabetes susceptibility 2 (mouse) Not determined 9 82910333 116910428 Mouse 10766454 Char10_m P. chabaudi malaria resistance QTL 10 (mouse) 9 82910333 116910428 Mouse 1301487 Nociq1_m nociceptive sensitivity inflammatory QTL 1 (mouse) Not determined 9 84528818 118528921 Mouse 10412180 Msam3_m muscle, skeletal, activity measure 3 (mouse) Not determined 9 85897510 108641186 Mouse 1300549 Bbaa17_m B. burgdorferi-associated arthritis 17 (mouse) Not determined 9 86230401 120230530 Mouse 1302103 Dob2_m dietary obesity 2 (mouse) Not determined 9 86239845 120289624 Mouse 11251716 Siim2_m stress induced immobility 2 (mouse) 9 86748483 120748483 Mouse 12880422 V25Dq6_m vitamin D inactive form serum level QTL 6 (mouse) 9 87800000 121800000 Mouse 10412242 Alpq8_m alcohol preference QTL 8 (mouse) Not determined 9 89284925 123284925 Mouse 1301649 Psl1_m promotion susceptibility QTL 1 (mouse) Not determined 9 89412277 123412396 Mouse 1357657 Pymr_m Plasmodium yoelli malaria resistance (mouse) Not determined 9 89977005 118938021 Mouse 12910770 Splic1_m spleen iron content 1 (mouse) 9 91413879 124595110 Mouse 12910772 Lvic6_m liver iron content 6 (mouse) 9 91413879 124595110 Mouse 12910773 Splic3_m spleen iron content 3 (mouse) 9 91413879 124595110 Mouse 1558767 Skmw11_m skeletal muscle weight 11 (mouse) Not determined 9 91641084 124595110 Mouse 13463474 Hbbcq5_m hemoglobin concentration QTL 5 (mouse) 9 91641084 124595110 Mouse 13463475 Hctq7_m hematocrit QTL 7 (mouse) 9 91641084 124595110 Mouse 13463477 Rbc9_m red blood cell count 9 (mouse) 9 91641084 124595110 Mouse 13463478 Mchq18_m mean corpuscular hemoglobin QTL 18 (mouse) 9 91641084 124595110 Mouse 13463480 Mchcq2_m mean corpuscular hemoglobin concentration QTL 2 (mouse) 9 91641084 124595110 Mouse 12904937 Edlmmq9_m extensor digitorum longus muscle mass QTL 9 (mouse) 9 91683173 124595110 Mouse 12904947 Tammq7_m tibialis anterior muscle mass QTL 7 (mouse) 9 91683173 124595110 Mouse 12904961 Gmmq7_m gastrocnemius muscle mass QTL 7 (mouse) 9 91683173 124595110 Mouse 1302001 Bdln5_m body length 5 (mouse) Not determined 9 93762590 124595110 Mouse 1301484 Bwq6_m body weight (mouse) Not determined 9 93762590 124595110 Mouse 14746992 Manh67_m mandible shape 67 (mouse) 9 94036768 124595110 Mouse 11081166 Psl5_m promotion susceptibility QTL 5 (mouse) 9 94981301 112872929 Mouse 11537364 Cnes5_m C. neoformans susceptibility locus 5 (mouse) 9 96917590 124595110 Mouse 1301297 Lcho1_m liver cholesterol 1 (mouse) Not determined 9 101060861 124595110 Mouse 1357627 Tgq2_m triglyceride QTL 2 (mouse) Not determined 9 102000187 124595110 Mouse 1357648 Obq18_m obesity QTL 18 (mouse) Not determined 9 102000187 124595110 Mouse 1301789 Pbwg4_m postnatal body weight growth 4 (mouse) Not determined 9 103289445 124595110 Mouse 10412290 Pvacm1l_m plasma vascular cell adhesion molecule 1 levels (mouse) Not determined 9 103289445 124595110 Mouse 12879896 Berr3_m berghei resistance locus 3 (mouse) 9 103289445 124595110 Mouse
Predicted Target Of
Count of predictions: 285 Count of miRNA genes: 223 Interacting mature miRNAs: 250 Transcripts: ENSMUST00000035232 Prediction methods: Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
