Kcnk6 (potassium inwardly-rectifying channel, subfamily K, member 6) - Rat Genome Database

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Gene: Kcnk6 (potassium inwardly-rectifying channel, subfamily K, member 6) Mus musculus
Analyze
Symbol: Kcnk6
Name: potassium inwardly-rectifying channel, subfamily K, member 6
RGD ID: 1550095
MGI Page MGI
Description: Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Acts upstream of or within negative regulation of systemic arterial blood pressure and regulation of resting membrane potential. Predicted to be active in plasma membrane. Is expressed in heart; liver left lobe; and liver right lobe. Orthologous to human KCNK6 (potassium two pore domain channel subfamily K member 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: D7Ertd764; D7Ertd764e; potassium channel subfamily K member 6; T; Toss; Twik; TWIK-2 two-pore-domain K+ channel; Twik2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm7531  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,921,353 - 28,931,947 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,921,351 - 28,931,940 (-)EnsemblGRCm39 Ensembl
GRCm38729,221,928 - 29,232,522 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl729,221,926 - 29,232,515 (-)EnsemblGRCm38mm10GRCm38
MGSCv37730,006,947 - 30,017,541 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,930,688 - 28,941,253 (-)NCBIMGSCv36mm8
Celera723,793,186 - 23,803,782 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke. Buga AM, etal., PLoS One. 2012;7(12):e50985. doi: 10.1371/journal.pone.0050985. Epub 2012 Dec 12.
2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16354767   PMID:16985003   PMID:21267068   PMID:21873635   PMID:21876070  
PMID:23637138   PMID:25245387   PMID:29290552   PMID:29958799   PMID:30632293   PMID:37158595   PMID:37898389  


Genomics

Comparative Map Data
Kcnk6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,921,353 - 28,931,947 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,921,351 - 28,931,940 (-)EnsemblGRCm39 Ensembl
GRCm38729,221,928 - 29,232,522 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl729,221,926 - 29,232,515 (-)EnsemblGRCm38mm10GRCm38
MGSCv37730,006,947 - 30,017,541 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,930,688 - 28,941,253 (-)NCBIMGSCv36mm8
Celera723,793,186 - 23,803,782 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.94NCBI
KCNK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,319,845 - 38,332,076 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1938,319,845 - 38,332,076 (+)EnsemblGRCh38hg38GRCh38
GRCh371938,810,485 - 38,822,716 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361943,502,322 - 43,511,494 (+)NCBINCBI36Build 36hg18NCBI36
Build 341943,502,323 - 43,511,487NCBI
Celera1935,612,720 - 35,621,891 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1935,258,112 - 35,267,183 (+)NCBIHuRef
CHM1_11938,810,843 - 38,820,013 (+)NCBICHM1_1
T2T-CHM13v2.01941,122,020 - 41,134,251 (+)NCBIT2T-CHM13v2.0
Kcnk6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,652,888 - 93,661,419 (-)NCBIGRCr8
mRatBN7.2184,525,613 - 84,533,948 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,525,590 - 84,534,677 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,937,040 - 89,945,285 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0198,396,659 - 98,404,888 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,692,885 - 91,701,131 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0188,168,438 - 88,176,610 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,169,378 - 88,176,610 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,166,109 - 87,174,821 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0189,343,864 - 89,352,036 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4184,359,738 - 84,367,910 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1184,404,339 - 84,446,021 (-)NCBI
Celera178,912,886 - 78,921,054 (-)NCBICelera
Cytogenetic Map1q21NCBI
Kcnk6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554681,108,025 - 1,117,366 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554681,108,025 - 1,117,366 (-)NCBIChiLan1.0ChiLan1.0
KCNK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22044,604,902 - 44,623,635 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11946,475,224 - 46,495,898 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01935,409,752 - 35,422,490 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11943,984,592 - 43,995,374 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1943,985,074 - 43,995,374 (+)Ensemblpanpan1.1panPan2
KCNK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,665,958 - 114,677,845 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,666,476 - 114,677,639 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1114,070,430 - 114,081,304 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01115,268,446 - 115,279,326 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1115,267,617 - 115,279,326 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11114,841,288 - 114,852,160 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01114,458,924 - 114,469,776 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01115,497,600 - 115,508,474 (-)NCBIUU_Cfam_GSD_1.0
Kcnk6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934912,927,338 - 12,937,848 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368011,092,692 - 1,103,210 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368011,092,694 - 1,101,940 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,238,685 - 47,249,136 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,237,665 - 47,249,178 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2642,739,715 - 42,747,510 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNK6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1632,959,275 - 32,977,601 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl632,962,535 - 32,973,196 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607310,904,586 - 10,921,256 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnk6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046251476,580 - 14,674 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046251473,759 - 16,164 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnk6
295 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1038
Count of miRNA genes:604
Interacting mature miRNAs:712
Transcripts:ENSMUST00000085818
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
7394747asp3_maudiogenic seizure prone 3 (mouse)Not determined72730579836842367Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse

Markers in Region
RH136303  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38729,222,124 - 29,222,331UniSTSGRCm38
MGSCv37730,007,143 - 30,007,350UniSTSGRCm37
Celera723,793,382 - 23,793,589UniSTS
Cytogenetic Map7B1UniSTS
cM Map79.5UniSTS
UniSTS:235636  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38729,226,560 - 29,226,946UniSTSGRCm38
MGSCv37730,011,579 - 30,011,965UniSTSGRCm37
Celera723,797,820 - 23,798,206UniSTS
Cytogenetic Map7B1UniSTS
cM Map79.5UniSTS
UniSTS:235637  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38729,223,312 - 29,223,681UniSTSGRCm38
MGSCv37730,008,331 - 30,008,700UniSTSGRCm37
Celera723,794,570 - 23,794,939UniSTS
Cytogenetic Map7B1UniSTS
cM Map79.5UniSTS
UniSTS:235638  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38729,224,705 - 29,224,973UniSTSGRCm38
MGSCv37730,009,724 - 30,009,992UniSTSGRCm37
Celera723,795,965 - 23,796,233UniSTS
Cytogenetic Map7B1UniSTS
cM Map79.5UniSTS
D7Ertd764e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38729,221,949 - 29,222,168UniSTSGRCm38
MGSCv37730,006,968 - 30,007,187UniSTSGRCm37
Celera723,793,207 - 23,793,426UniSTS
Cytogenetic Map7B1UniSTS
cM Map79.5UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000085818   ⟹   ENSMUSP00000082975
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,921,351 - 28,931,940 (-)Ensembl
GRCm38.p6 Ensembl729,221,926 - 29,232,515 (-)Ensembl
RefSeq Acc Id: ENSMUST00000208807
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,924,343 - 28,930,732 (-)Ensembl
GRCm38.p6 Ensembl729,224,918 - 29,231,307 (-)Ensembl
RefSeq Acc Id: NM_001033525   ⟹   NP_001028697
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,921,353 - 28,931,947 (-)NCBI
GRCm38729,221,928 - 29,232,522 (-)ENTREZGENE
MGSCv37730,006,947 - 30,017,541 (-)RGD
Celera723,793,186 - 23,803,782 (-)RGD
cM Map7 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001028697   ⟸   NM_001033525
- UniProtKB: Q3TBV4 (UniProtKB/TrEMBL),   Q3V1G1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000082975   ⟸   ENSMUST00000085818
Protein Domains
Potassium channel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3TBV4-F1-model_v2 AlphaFold Q3TBV4 1-313 view protein structure

Promoters
RGD ID:6892524
Promoter ID:EPDNEW_M9713
Type:initiation region
Name:Kcnk6_1
Description:Mus musculus potassium inwardly-rectifying channel, subfamilyK, member 6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38729,232,513 - 29,232,573EPDNEW
RGD ID:6841381
Promoter ID:MM_KWN:49709
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:UC009GBF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36730,016,916 - 30,017,416 (-)MPROMDB
RGD ID:6841379
Promoter ID:MM_KWN:49710
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung
Transcripts:NM_001033525
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36730,017,196 - 30,017,696 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1891291 AgrOrtholog
Ensembl Genes ENSMUSG00000046410 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000085818 ENTREZGENE
  ENSMUST00000085818.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
InterPro 2pore_dom_K_chnl UniProtKB/TrEMBL
  2pore_dom_K_chnl_TASK UniProtKB/TrEMBL
  2pore_dom_K_chnl_TWIK UniProtKB/TrEMBL
  2pore_dom_K_chnl_TWIK2 UniProtKB/TrEMBL
  Ion_trans_2 UniProtKB/TrEMBL
KEGG Report mmu:52150 UniProtKB/TrEMBL
MGD MGI:1891291 ENTREZGENE
NCBI Gene 52150 ENTREZGENE
PANTHER PTHR11003 UniProtKB/TrEMBL
  PTHR11003:SF28 UniProtKB/TrEMBL
Pfam Ion_trans_2 UniProtKB/TrEMBL
PhenoGen Kcnk6 PhenoGen
PIRSF K_channel_subfamily_K_type UniProtKB/TrEMBL
PRINTS 2POREKCHANEL UniProtKB/TrEMBL
  TWIK2CHANNEL UniProtKB/TrEMBL
  TWIKCHANNEL UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt Q14BF9_MOUSE UniProtKB/TrEMBL
  Q3TBV4 ENTREZGENE, UniProtKB/TrEMBL
  Q3TQ68_MOUSE UniProtKB/TrEMBL
  Q3V1G1 ENTREZGENE, UniProtKB/TrEMBL
  Q8BZ22_MOUSE UniProtKB/TrEMBL