Wfdc5 (WAP four-disulfide core domain 5) - Rat Genome Database

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Gene: Wfdc5 (WAP four-disulfide core domain 5) Mus musculus
Analyze
Symbol: Wfdc5
Name: WAP four-disulfide core domain 5
RGD ID: 1550079
MGI Page MGI
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in antibacterial humoral response and innate immune response. Predicted to be active in extracellular space. Orthologous to human WFDC5 (WAP four-disulfide core domain 5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BC019734; PR; PRG5; WA; WAP four-disulfide core domain protein 5; WAP1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,018,245 - 164,024,662 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2164,018,247 - 164,024,662 (-)EnsemblGRCm39 Ensembl
GRCm382164,176,325 - 164,182,742 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,176,327 - 164,182,742 (-)EnsemblGRCm38mm10GRCm38
MGSCv372164,002,061 - 164,008,478 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362163,868,802 - 163,874,182 (-)NCBIMGSCv36mm8
Celera2170,107,877 - 170,114,294 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map284.6NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The evolution of a genetic locus encoding small serine proteinase inhibitors. Clauss A, etal., Biochem Biophys Res Commun 2005 Jul 29;333(2):383-9.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:20562862   PMID:21873635   PMID:33034631  


Genomics

Comparative Map Data
Wfdc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,018,245 - 164,024,662 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2164,018,247 - 164,024,662 (-)EnsemblGRCm39 Ensembl
GRCm382164,176,325 - 164,182,742 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,176,327 - 164,182,742 (-)EnsemblGRCm38mm10GRCm38
MGSCv372164,002,061 - 164,008,478 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362163,868,802 - 163,874,182 (-)NCBIMGSCv36mm8
Celera2170,107,877 - 170,114,294 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map284.6NCBI
WFDC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382045,109,463 - 45,116,319 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2045,109,452 - 45,115,174 (-)EnsemblGRCh38hg38GRCh38
GRCh372043,738,104 - 43,744,960 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362043,171,507 - 43,177,217 (-)NCBINCBI36Build 36hg18NCBI36
Build 342043,171,506 - 43,177,217NCBI
Celera2040,446,736 - 40,452,445 (-)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2040,479,993 - 40,485,712 (-)NCBIHuRef
CHM1_12043,640,836 - 43,646,556 (-)NCBICHM1_1
T2T-CHM13v2.02046,845,367 - 46,852,223 (-)NCBIT2T-CHM13v2.0
Wfdc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,268,410 - 173,274,253 (-)NCBIGRCr8
mRatBN7.23152,849,025 - 152,854,868 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3152,849,025 - 152,854,904 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3156,656,516 - 156,662,359 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,155,456 - 165,161,299 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03162,899,871 - 162,905,829 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03160,567,805 - 160,573,978 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,567,805 - 160,573,978 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03166,752,479 - 166,758,652 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,116,781 - 155,122,624 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13155,023,347 - 155,028,636 (-)NCBI
Celera3151,497,132 - 151,502,959 (-)NCBICelera
Cytogenetic Map3q42NCBI
Wfdc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544512,279,799 - 12,283,506 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544512,279,799 - 12,284,819 (+)NCBIChiLan1.0ChiLan1.0
WFDC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22150,842,463 - 50,850,292 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12050,835,570 - 50,843,399 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02041,440,007 - 41,446,864 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12042,532,556 - 42,538,105 (-)NCBIpanpan1.1PanPan1.1panPan2
WFDC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12432,487,339 - 32,492,660 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2432,487,348 - 32,510,990 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2432,132,739 - 32,137,748 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02433,198,174 - 33,231,042 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2433,198,183 - 33,203,385 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12432,459,480 - 32,492,329 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02432,574,535 - 32,607,555 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02433,116,370 - 33,149,476 (-)NCBIUU_Cfam_GSD_1.0
Wfdc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640192,205,744 - 192,211,283 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365147,659,499 - 7,664,318 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100739507
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1747,499,935 - 47,506,306 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11747,499,800 - 47,506,298 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21752,999,548 - 53,004,474 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WFDC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,702,404 - 18,708,119 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl218,702,644 - 18,707,188 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605067,351,679 - 67,365,660 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wfdc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247909,387,902 - 9,393,179 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247909,386,787 - 9,393,060 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wfdc5
268 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1078
Count of miRNA genes:464
Interacting mature miRNAs:547
Transcripts:ENSMUST00000045127, ENSMUST00000131974
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143773445165665019Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
10412080Hylaq2_mHyperlocomotor activity related QTL 2 (mouse)Not determined2151640941164119146Mouse
12910520Scgq3_mspontaneous crescentic glomerulonephritis QTL 3 (mouse)2151709273174389124Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151778297181755017Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152329820181755017Mouse
1558867Gnf3_mgrowth and fatness 3 (mouse)Not determined2152699221169117924Mouse
1300622Cfld1_mcystic fibrosis lung disease 1 (mouse)Not determined2155823920181755017Mouse
1357537Lith12_mlithogenic gene 12 (mouse)Not determined2156196464181755017Mouse
1300688Nidd2k_mNidd2 on KK-A (mouse)Not determined2158078337178442452Mouse
12910800Pwgrq3_mpre-weaning growth rate QTL 3 (mouse)2160611165169794802Mouse
12910810Pwbwq2_mpre-weaning body weight QTL 2 (mouse)2160611165169794802Mouse
1302003Sluc17_msusceptibility to lung cancer 17 (mouse)Not determined2162433493181755017Mouse
1558991Tailq4_mtail length QTL 4 (mouse)Not determined2162736926178442452Mouse
1357435Epfq2_mepididymal fat pad weight QTL 2 (mouse)Not determined2162736926178442452Mouse
1301677Alcp6_malcohol preference locus 6 (mouse)Not determined2163486407181755017Mouse
1301348Alcp5_malcohol preference locus 5 (mouse)Not determined2163486407181755017Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000045127   ⟹   ENSMUSP00000035824
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2164,018,247 - 164,024,662 (-)Ensembl
GRCm38.p6 Ensembl2164,176,327 - 164,182,742 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131974   ⟹   ENSMUSP00000115448
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2164,019,387 - 164,024,518 (-)Ensembl
GRCm38.p6 Ensembl2164,177,467 - 164,182,598 (-)Ensembl
RefSeq Acc Id: NM_145369   ⟹   NP_663344
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392164,018,245 - 164,024,662 (-)NCBI
GRCm382164,176,325 - 164,182,742 (-)ENTREZGENE
MGSCv372164,002,061 - 164,008,478 (-)RGD
Celera2170,107,877 - 170,114,294 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_001781780
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392164,019,392 - 164,024,657 (-)NCBI
GRCm382164,177,509 - 164,182,737 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_663344   ⟸   NM_145369
- Peptide Label: precursor
- UniProtKB: Q4KXB6 (UniProtKB/TrEMBL),   Q8VE57 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000035824   ⟸   ENSMUST00000045127
RefSeq Acc Id: ENSMUSP00000115448   ⟸   ENSMUST00000131974
Protein Domains
WAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4KXB6-F1-model_v2 AlphaFold Q4KXB6 1-126 view protein structure

Promoters
RGD ID:6879608
Promoter ID:EPDNEW_M3255
Type:initiation region
Name:Wfdc5_1
Description:Mus musculus WAP four-disulfide core domain 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382164,182,754 - 164,182,814EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2384800 AgrOrtholog
Ensembl Genes ENSMUSG00000040154 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000045127 ENTREZGENE
  ENSMUST00000045127.12 UniProtKB/TrEMBL
  ENSMUST00000131974.2 UniProtKB/TrEMBL
Gene3D-CATH 4.10.75.10 UniProtKB/TrEMBL
InterPro Elafin-like_sf UniProtKB/TrEMBL
  Whey_acidic_protein_4-diS_core UniProtKB/TrEMBL
KEGG Report mmu:209232 UniProtKB/TrEMBL
MGD MGI:2384800 ENTREZGENE
NCBI Gene 209232 ENTREZGENE
PANTHER WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 5 UniProtKB/TrEMBL
  WHEY ACDIC PROTEIN WAP UniProtKB/TrEMBL
Pfam WAP UniProtKB/TrEMBL
PhenoGen Wfdc5 PhenoGen
PRINTS 4DISULPHCORE UniProtKB/TrEMBL
PROSITE WAP UniProtKB/TrEMBL
SMART WAP UniProtKB/TrEMBL
Superfamily-SCOP WAP UniProtKB/TrEMBL
UniProt F6TTH9_MOUSE UniProtKB/TrEMBL
  Q4KXB6 ENTREZGENE, UniProtKB/TrEMBL
  Q8VE57 ENTREZGENE, UniProtKB/TrEMBL