Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of STXBP5 mRNA | CTD | PMID:22079256 | 1,2-dimethylhydrazine | affects expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine affects the expression of STXBP5 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [Estradiol co-treated with Norethindrone Acetate] results in increased expression of STXBP5 mRNA | CTD | PMID:22217510 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of STXBP5 mRNA | CTD | PMID:21354282 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Stxbp5 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of STXBP5 mRNA | CTD | PMID:34747641 | 2,4-dinitrotoluene | affects expression | ISO | Stxbp5 (Rattus norvegicus) | 6480464 | 2 and 4-dinitrotoluene affects the expression of STXBP5 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | ISO | Stxbp5 (Rattus norvegicus) | 6480464 | 2 and 6-dinitrotoluene affects the expression of STXBP5 mRNA | CTD | PMID:21346803 | 2-hydroxypropanoic acid | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of STXBP5 mRNA | CTD | PMID:30851411 | 2-palmitoylglycerol | increases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of STXBP5 mRNA | CTD | PMID:37199045 | 4-amino-2,6-dinitrotoluene | affects expression | ISO | Stxbp5 (Rattus norvegicus) | 6480464 | 4-amino-2 and 6-dinitrotoluene affects the expression of STXBP5 mRNA | CTD | PMID:21346803 | acrylamide | increases expression | ISO | Stxbp5 (Rattus norvegicus) | 6480464 | Acrylamide results in increased expression of STXBP5 mRNA | CTD | PMID:28959563 | aflatoxin B1 | increases methylation | ISO | STXBP5 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of STXBP5 intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of STXBP5 mRNA | CTD | PMID:33167477 | ammonium chloride | affects expression | ISO | Stxbp5 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of STXBP5 mRNA | CTD | PMID:16483693 | antirheumatic drug | increases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of STXBP5 mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of STXBP5 mRNA | CTD | PMID:33212167 | benzo[a]pyrene | decreases methylation | EXP | | 6480464 | Benzo(a)pyrene results in decreased methylation of STXBP5 intron | CTD | PMID:27901495 | bisphenol A | affects expression | ISO | Stxbp5 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of STXBP5 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of STXBP5 mRNA | CTD | PMID:32156529 | bisphenol A | decreases methylation | ISO | STXBP5 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of STXBP5 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of STXBP5 protein | CTD | PMID:33376534 | bisphenol A | increases methylation | ISO | Stxbp5 (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of STXBP5 gene | CTD | PMID:28505145 | cadmium atom | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of STXBP5 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of STXBP5 mRNA | CTD | PMID:35301059 | caffeine | decreases phosphorylation | ISO | STXBP5 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of STXBP5 protein | CTD | PMID:35688186 | CGP 52608 | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to STXBP5 gene] | CTD | PMID:28238834 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of STXBP5 gene | CTD | PMID:20938992 | chromium(6+) | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | chromium hexavalent ion results in decreased expression of STXBP5 mRNA | CTD | PMID:30690063 | cyclosporin A | increases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of STXBP5 mRNA | CTD | PMID:20106945 and PMID:25562108 | diethylstilbestrol | decreases expression | ISO | Stxbp5 (Rattus norvegicus) | 6480464 | Diethylstilbestrol results in decreased expression of STXBP5 mRNA | CTD | PMID:37077353 | dorsomorphin | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of STXBP5 mRNA | CTD | PMID:29803840 | ethanol | affects splicing | EXP | | 6480464 | Ethanol affects the splicing of STXBP5 mRNA | CTD | PMID:30319688 | fenvalerate | increases expression | ISO | Stxbp5 (Rattus norvegicus) | 6480464 | fenvalerate results in increased expression of STXBP5 mRNA | CTD | PMID:30307764 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of STXBP5 gene | CTD | PMID:20938992 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of STXBP5 mRNA | CTD | PMID:25629700 | formaldehyde | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of STXBP5 mRNA | CTD | PMID:23649840 | FR900359 | increases phosphorylation | ISO | STXBP5 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of STXBP5 protein | CTD | PMID:37730182 | gentamycin | increases expression | ISO | Stxbp5 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of STXBP5 mRNA | CTD | PMID:33387578 | ivermectin | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of STXBP5 protein | CTD | PMID:32959892 | ketoconazole | decreases expression | ISO | Stxbp5 (Rattus norvegicus) | 6480464 | Ketoconazole results in decreased expression of STXBP5 mRNA | CTD | PMID:37077353 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of STXBP5 gene | CTD | PMID:20938992 | methylmercury chloride | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of STXBP5 mRNA | CTD | PMID:28001369 | oxaliplatin | multiple interactions | ISO | Stxbp5 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of STXBP5 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of STXBP5 mRNA | CTD | PMID:27106289 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of STXBP5 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | Stxbp5 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of STXBP5 mRNA | CTD | PMID:33387578 | phenylmercury acetate | increases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of STXBP5 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STXBP5 mRNA | CTD | PMID:27188386 | pirinixic acid | multiple interactions | EXP | | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of STXBP5 mRNA | CTD | PMID:19710929 | potassium chromate | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of STXBP5 mRNA | CTD | PMID:22079256 | potassium chromate | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of STXBP5 mRNA | CTD | PMID:22079256 and PMID:22714537 | potassium dichromate | increases expression | EXP | | 6480464 | Potassium Dichromate results in increased expression of STXBP5 mRNA | CTD | PMID:23608068 | quercetin | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of STXBP5 mRNA | CTD | PMID:21632981 | rac-lactic acid | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of STXBP5 mRNA | CTD | PMID:30851411 | SB 431542 | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sodium arsenate | increases expression | EXP | | 6480464 | sodium arsenate results in increased expression of STXBP5 mRNA | CTD | PMID:21795629 | succimer | multiple interactions | EXP | | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of STXBP5 mRNA | CTD | PMID:21641980 | tetrachloromethane | affects expression | EXP | | 6480464 | Carbon Tetrachloride affects the expression of STXBP5 mRNA | CTD | PMID:17484886 | topotecan | decreases expression | ISO | Stxbp5 (Rattus norvegicus) | 6480464 | Topotecan results in decreased expression of STXBP5 mRNA | CTD | PMID:25729387 | topotecan | multiple interactions | ISO | Stxbp5 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of STXBP5 mRNA | CTD | PMID:25729387 | trichostatin A | increases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of STXBP5 mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STXBP5 mRNA | CTD | PMID:27188386 | trovafloxacin | decreases expression | EXP | | 6480464 | trovafloxacin results in decreased expression of STXBP5 mRNA | CTD | PMID:35537566 | tungsten | decreases expression | EXP | | 6480464 | Tungsten results in decreased expression of STXBP5 mRNA | CTD | PMID:30912803 | urethane | increases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Urethane results in increased expression of STXBP5 mRNA | CTD | PMID:28818685 | valproic acid | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of STXBP5 mRNA | CTD | PMID:23179753 and PMID:28001369 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
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Molecular Function
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Phenotype Annotations
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Functional annotation of a full-length mouse cDNA collection. | Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90. |
| 2. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 3. | Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. | Okazaki N, etal., DNA Res 2003 Feb 28;10(1):35-48. |
| 4. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 5. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 6. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:8889548 | PMID:10349636 | PMID:11042159 | PMID:11076861 | PMID:12477932 | PMID:12832401 | PMID:15659226 | PMID:15690082 | PMID:15782199 | PMID:16141072 | PMID:16141073 | PMID:16505218 |
| PMID:16787939 | PMID:17114649 | PMID:18936251 | PMID:19928526 | PMID:21089602 | PMID:21267068 | PMID:21330375 | PMID:21873635 | PMID:24614299 | PMID:24744148 | PMID:25244094 | PMID:25244095 |
| PMID:27303031 | PMID:27732637 | PMID:28062498 | PMID:28746398 | PMID:32325033 | PMID:32554809 | PMID:32581705 | PMID:37432648 | PMID:37695731 |
Genomics
Comparative Map Data
| Stxbp5 (Mus musculus - house mouse) |
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| STXBP5 (Homo sapiens - human) |
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| Stxbp5 (Rattus norvegicus - Norway rat) |
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| Stxbp5 (Chinchilla lanigera - long-tailed chinchilla) |
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| STXBP5 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| STXBP5 (Canis lupus familiaris - dog) |
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| Stxbp5 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| STXBP5 (Sus scrofa - pig) |
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| STXBP5 (Chlorocebus sabaeus - green monkey) |
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| Stxbp5 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Stxbp5
5460 total Variants 
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