Gjd4 (gap junction protein, delta 4) - Rat Genome Database

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Gene: Gjd4 (gap junction protein, delta 4) Mus musculus
Analyze
Symbol: Gjd4
Name: gap junction protein, delta 4
RGD ID: 1550043
MGI Page MGI
Description: Predicted to enable gap junction channel activity. Acts upstream of or within regulation of satellite cell activation involved in skeletal muscle regeneration. Located in plasma membrane. Is expressed in several structures, including diaphragm; limb segment; liver; lung; and skeletal musculature. Orthologous to human GJD4 (gap junction protein delta 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9430022F06Rik; connexin u; connexin-39; connexin39; Cx39; Cxnu; gap junction delta-4 protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39189,278,124 - 9,289,808 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl189,278,607 - 9,282,809 (-)EnsemblGRCm39 Ensembl
GRCm38189,278,124 - 9,289,808 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl189,278,607 - 9,282,809 (-)EnsemblGRCm38mm10GRCm38
MGSCv37189,278,605 - 9,282,807 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36189,278,605 - 9,282,807 (-)NCBIMGSCv36mm8
Celera189,314,430 - 9,318,631 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map184.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12108537   PMID:12477932   PMID:14681012   PMID:15081111   PMID:15466892   PMID:16141072   PMID:16141073   PMID:16613780  
PMID:16613781   PMID:21267068   PMID:21272575   PMID:21873635   PMID:24194600   PMID:27626380   PMID:32591430  


Genomics

Comparative Map Data
Gjd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39189,278,124 - 9,289,808 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl189,278,607 - 9,282,809 (-)EnsemblGRCm39 Ensembl
GRCm38189,278,124 - 9,289,808 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl189,278,607 - 9,282,809 (-)EnsemblGRCm38mm10GRCm38
MGSCv37189,278,605 - 9,282,807 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36189,278,605 - 9,282,807 (-)NCBIMGSCv36mm8
Celera189,314,430 - 9,318,631 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map184.91NCBI
GJD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381035,605,341 - 35,608,935 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1035,605,341 - 35,608,935 (+)EnsemblGRCh38hg38GRCh38
GRCh371035,894,269 - 35,897,863 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361035,934,344 - 35,937,869 (+)NCBINCBI36Build 36hg18NCBI36
Celera1035,659,067 - 35,662,598 (+)NCBICelera
Cytogenetic Map10p11.21NCBI
HuRef1035,611,976 - 35,615,507 (+)NCBIHuRef
CHM1_11035,894,286 - 35,897,810 (+)NCBICHM1_1
T2T-CHM13v2.01035,633,783 - 35,637,383 (+)NCBIT2T-CHM13v2.0
Gjd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81762,043,770 - 62,047,527 (-)NCBIGRCr8
mRatBN7.21757,348,844 - 57,352,601 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1757,349,877 - 57,352,446 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1760,513,557 - 60,516,116 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01764,516,574 - 64,519,133 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01758,670,719 - 58,673,284 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01762,297,086 - 62,299,655 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1762,297,086 - 62,299,655 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01764,070,841 - 64,073,410 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41766,004,119 - 66,006,688 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11766,015,269 - 66,015,903 (-)NCBI
Celera1758,630,370 - 58,632,939 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
Gjd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554625,892,482 - 5,897,482 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554625,893,296 - 5,901,976 (-)NCBIChiLan1.0ChiLan1.0
GJD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2848,250,864 - 48,257,148 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11048,256,194 - 48,262,476 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01035,698,294 - 35,735,764 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11036,305,964 - 36,322,448 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1036,306,919 - 36,322,448 (+)Ensemblpanpan1.1panPan2
GJD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.121,360,697 - 1,365,411 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha21,449,108 - 1,452,111 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.021,642,709 - 1,645,734 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl21,641,937 - 1,645,530 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.121,414,394 - 1,417,412 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.021,457,243 - 1,460,245 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.021,578,446 - 1,581,436 (-)NCBIUU_Cfam_GSD_1.0
Gjd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934414,378,618 - 14,382,226 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365743,878,383 - 3,881,718 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365743,878,436 - 3,881,704 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11058,069,679 - 58,076,738 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21063,675,003 - 63,681,354 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GJD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1934,856,892 - 34,886,231 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl934,883,069 - 34,886,136 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605644,048,057 - 44,053,996 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gjd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480510,006,616 - 10,009,618 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480510,006,548 - 10,009,592 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gjd4
467 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:783
Count of miRNA genes:437
Interacting mature miRNAs:514
Transcripts:ENSMUST00000041007
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142127Rafaril_mRafar interacting locus (mouse)Not determined18123108555Mouse
14928307Manh83_mmandible shape 83 (mouse)18126902168Mouse
11354953Mom21_mmodifier of Min 21 (mouse)18128893823Mouse
12801462Intim3_mintima modifier 3 (mouse)18131720756Mouse
12801458Intmrm3_mintima/media ratio modifier 3 (mouse)18131720756Mouse
13207585Mwmlpt3_mMorris water maze latency to platform, training, 3 (mouse)18133547739Mouse
13207589Mwmlpa3_mMorris water maze latency to platform, all, 3 (mouse)18133547739Mouse
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
4142250Idd21.3_minsulin dependent diabetes susceptibility 21.3 (mouse)Not determined18610840421646477Mouse
1558873Hrtfm7_mheart failure modifier 7 (mouse)Not determined18808696442087106Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000041007   ⟹   ENSMUSP00000035472
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl189,278,607 - 9,282,809 (-)Ensembl
GRCm38.p6 Ensembl189,278,607 - 9,282,809 (-)Ensembl
RefSeq Acc Id: NM_153086   ⟹   NP_694726
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39189,278,606 - 9,282,760 (-)NCBI
GRCm38189,278,607 - 9,282,809 (-)NCBI
MGSCv37189,278,605 - 9,282,807 (-)RGD
Celera189,314,430 - 9,318,631 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006525809   ⟹   XP_006525872
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39189,278,124 - 9,289,808 (-)NCBI
GRCm38189,278,124 - 9,289,808 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_694726   ⟸   NM_153086
- UniProtKB: Q8C6W6 (UniProtKB/Swiss-Prot),   B2RQL7 (UniProtKB/Swiss-Prot),   Q91YD0 (UniProtKB/Swiss-Prot),   Q8BSD4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006525872   ⟸   XM_006525809
- Peptide Label: isoform X1
- UniProtKB: A0A654ICD8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000035472   ⟸   ENSMUST00000041007
Protein Domains
Connexin N-terminal   Gap junction protein cysteine-rich

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BSD4-F1-model_v2 AlphaFold Q8BSD4 1-364 view protein structure

Promoters
RGD ID:13677070
Promoter ID:EPDNEW_M22684
Type:multiple initiation site
Name:Gjd4_1
Description:Mus musculus gap junction protein, delta 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38189,282,760 - 9,282,820EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2444990 AgrOrtholog
Ensembl Genes ENSMUSG00000036855 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000041007 ENTREZGENE
  ENSMUST00000041007.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1440.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Connexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:225152 UniProtKB/Swiss-Prot
MGD MGI:2444990 ENTREZGENE
NCBI Gene 225152 ENTREZGENE
PANTHER GAP JUNCTION DELTA-4 PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11984 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Connexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gjd4 PhenoGen
PRINTS CONNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CONNEXINS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CONNEXINS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CNX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A654ICD8 ENTREZGENE, UniProtKB/TrEMBL
  B2RQL7 ENTREZGENE
  CXD4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8C6W6 ENTREZGENE
  Q91YD0 ENTREZGENE
UniProt Secondary B2RQL7 UniProtKB/Swiss-Prot
  Q8C6W6 UniProtKB/Swiss-Prot
  Q91YD0 UniProtKB/Swiss-Prot