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Gene: Icmt (isoprenylcysteine carboxyl methyltransferase) Mus musculus
Symbol: Icmt
Name: isoprenylcysteine carboxyl methyltransferase
Description: Exhibits cAMP response element binding protein binding activity and protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity. Involved in several processes, including TOR signaling; determination of adult lifespan; and growth. Predicted to localize to the endoplasmic reticulum and membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ICMT (isoprenylcysteine carboxyl methyltransferase); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1700008E11Rik; C80758; Gm13095; HSTE14; MGC118506; pcCMT; PPMT; prenylated protein carboxyl methyltransferase; prenylcysteine carboxyl methyltransferase; protein-S isoprenylcysteine O-methyltransferase; protein-S-isoprenylcysteine O-methyltransferase; STE14
Homo sapiens (human) : ICMT (isoprenylcysteine carboxyl methyltransferase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Icmt (isoprenylcysteine carboxyl methyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Icmt (isoprenylcysteine carboxyl methyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : ICMT (isoprenylcysteine carboxyl methyltransferase)
Canis lupus familiaris (dog) : ICMT (isoprenylcysteine carboxyl methyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Icmt (isoprenylcysteine carboxyl methyltransferase)
Sus scrofa (pig) : ICMT (isoprenylcysteine carboxyl methyltransferase)
Chlorocebus sabaeus (green monkey) : ICMT (isoprenylcysteine carboxyl methyltransferase)
Heterocephalus glaber (naked mole-rat) : Icmt (isoprenylcysteine carboxyl methyltransferase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl4152,297,227 - 152,307,121 (+)Ensembl
GRCm384152,297,214 - 152,307,126 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374151,671,460 - 151,681,231 (+)NCBIGRCm37mm9NCBIm37
MGSCv364151,141,151 - 151,150,922 (+)NCBImm8
Celera4154,584,546 - 154,594,458 (+)NCBICelera
Cytogenetic Map4 E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Icmt
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1550037
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.