Ust (uronyl-2-sulfotransferase) - Rat Genome Database

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Gene: Ust (uronyl-2-sulfotransferase) Mus musculus
Analyze
Symbol: Ust
Name: uronyl-2-sulfotransferase
RGD ID: 1550016
MGI Page MGI
Description: Predicted to enable sulfotransferase activity. Acts upstream of or within establishment of cell polarity and regulation of axonogenesis. Predicted to be located in Golgi apparatus and membrane. Is expressed in brain and limb bud. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human UST (uronyl 2-sulfotransferase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: D930010O20Rik; UA2; UA2OST; uronyl 2-sulfotransferase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39108,068,499 - 8,394,701 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl108,080,520 - 8,394,589 (-)EnsemblGRCm39 Ensembl
GRCm38108,204,753 - 8,518,825 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl108,204,756 - 8,518,825 (-)EnsemblGRCm38mm10GRCm38
MGSCv37107,924,551 - 8,238,623 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36107,897,457 - 8,208,962 (-)NCBIMGSCv36mm8
Celera108,087,930 - 8,411,124 (-)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mutation burden analysis of six common mental disorders in African Americans by whole genome sequencing. Liu Y, etal., Hum Mol Genet. 2022 Nov 10;31(22):3769-3776. doi: 10.1093/hmg/ddac129.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14681479   PMID:16141072   PMID:16141073   PMID:18079434   PMID:18819920   PMID:20600662  
PMID:21267068   PMID:21677750   PMID:21873635   PMID:26238476   PMID:28107390   PMID:28942923   PMID:32201365   PMID:34169071   PMID:34321999  


Genomics

Comparative Map Data
Ust
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39108,068,499 - 8,394,701 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl108,080,520 - 8,394,589 (-)EnsemblGRCm39 Ensembl
GRCm38108,204,753 - 8,518,825 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl108,204,756 - 8,518,825 (-)EnsemblGRCm38mm10GRCm38
MGSCv37107,924,551 - 8,238,623 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36107,897,457 - 8,208,962 (-)NCBIMGSCv36mm8
Celera108,087,930 - 8,411,124 (-)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.65NCBI
UST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386148,747,030 - 149,076,990 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6148,747,030 - 149,076,990 (+)EnsemblGRCh38hg38GRCh38
GRCh376149,068,166 - 149,398,126 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366149,110,157 - 149,439,818 (+)NCBINCBI36Build 36hg18NCBI36
Build 346149,110,156 - 149,439,818NCBI
Celera6149,804,170 - 150,133,178 (+)NCBICelera
Cytogenetic Map6q25.1NCBI
HuRef6146,637,095 - 146,966,117 (+)NCBIHuRef
CHM1_16149,333,029 - 149,662,873 (+)NCBICHM1_1
T2T-CHM13v2.06149,946,826 - 150,276,839 (+)NCBIT2T-CHM13v2.0
Ust
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814,487,316 - 4,782,579 (-)NCBIGRCr8
mRatBN7.212,666,983 - 2,962,276 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl12,669,592 - 2,962,044 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx12,325,889 - 2,623,315 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.018,326,290 - 8,623,726 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.012,608,001 - 2,905,423 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.012,330,631 - 2,627,654 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl12,333,778 - 2,627,747 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014,022,062 - 4,313,796 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.412,868,196 - 3,158,231 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.112,868,195 - 3,158,231 (-)NCBI
Celera11,217,279 - 1,507,424 (-)NCBICelera
Cytogenetic Map1p13NCBI
Ust
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543912,125,591 - 12,406,271 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543912,122,935 - 12,406,368 (-)NCBIChiLan1.0ChiLan1.0
UST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25168,769,032 - 169,101,939 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16166,662,491 - 166,995,609 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06146,562,541 - 146,895,450 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16151,270,358 - 151,600,651 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6151,270,505 - 151,597,779 (+)Ensemblpanpan1.1panPan2
UST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1139,633,276 - 39,922,361 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl139,633,501 - 39,921,289 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha140,532,475 - 40,759,827 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0139,810,126 - 40,102,153 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl139,810,043 - 40,102,150 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1139,687,116 - 39,978,672 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0139,553,715 - 39,843,184 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0139,893,472 - 40,184,349 (+)NCBIUU_Cfam_GSD_1.0
Ust
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946134,614,740 - 134,881,624 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364891,867,249 - 2,134,874 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364891,866,792 - 2,133,558 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl116,840,533 - 17,138,392 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1116,840,422 - 17,138,088 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2119,294,997 - 19,463,194 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11322,595,088 - 22,934,184 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040198,605,207 - 198,921,153 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ust
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247859,064,270 - 9,388,407 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247859,061,753 - 9,388,794 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ust
12421 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:934
Count of miRNA genes:503
Interacting mature miRNAs:604
Transcripts:ENSMUST00000061601
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11532725Sluc44b_msusceptibility to lung cancer 44b (mouse)10126289265Mouse
11532724Sluc44c_msusceptibility to lung cancer 44c (mouse)10126289265Mouse
11532723Sluc44d_msusceptibility to lung cancer 44d (mouse)10126289265Mouse
11532722Sluc44e_msusceptibility to lung cancer 44e (mouse)10126289265Mouse
11532721Sluc44_msusceptibility to lung cancer 44 (mouse)10126289265Mouse
11532720Sluc44a_msusceptibility to lung cancer 44a (mouse)10126289265Mouse
11532718Sluc44f_msusceptibility to lung cancer 44f (mouse)10126289265Mouse
11532717Sluc44g_msusceptibility to lung cancer 44g (mouse)10126289265Mouse
11533917Mts2_mmammary tumor susceptibility 2 (mouse)10126289265Mouse
1300759Geot_mgeotaxia (mouse)Not determined10126289265Mouse
1300881Sluc29_msusceptibility to lung cancer 29 (mouse)Not determined10126289265Mouse
12879494Facq1_mfear acquisition QTL 1 (mouse)10131279130Mouse
15039341Nmrs28_mNAFLD-associated magnetic resonance shift 28 (mouse)1035100134351001Mouse
1357813Ath20_matherosclerosis 20 (mouse)Not determined10328318537283334Mouse
1300790Pgia6_mproteoglycan induced arthritis 6 (mouse)Not determined10381017137810295Mouse
1300997Eae15_msusceptibility to experimental allergic encephalomyelitis 15 (mouse)Not determined10440815438408276Mouse
13208561Wght8_mweight 8 (mouse)10495000043875996Mouse
1302092Ath11_matherosclerosis 11 (mouse)Not determined10615194558693521Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse

Markers in Region
38.MMHAP53FRE11.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38108,459,820 - 8,460,109UniSTSGRCm38
MGSCv37108,179,618 - 8,179,907UniSTSGRCm37
Celera108,348,356 - 8,348,645UniSTS
Cytogenetic Map10A1UniSTS
Whitehead_YAC10 UniSTS
D10Mit76  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38108,503,628 - 8,503,826UniSTSGRCm38
MGSCv37108,223,426 - 8,223,624UniSTSGRCm37
Celera108,395,879 - 8,396,075UniSTS
Cytogenetic Map10A1UniSTS
cM Map104.0UniSTS
Whitehead Genetic102.2UniSTS
Whitehead_YAC10 UniSTS
Ust  
Mouse AssemblyChrPosition (strand)SourceJBrowse
cM Map10 UniSTS
Ust  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10A1UniSTS
Ust  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10A1UniSTS
cM Map10 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000061601   ⟹   ENSMUSP00000052017
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl108,080,573 - 8,394,589 (-)Ensembl
GRCm38.p6 Ensembl108,204,809 - 8,518,825 (-)Ensembl
RefSeq Acc Id: ENSMUST00000219116
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl108,080,520 - 8,178,006 (-)Ensembl
GRCm38.p6 Ensembl108,204,756 - 8,302,242 (-)Ensembl
RefSeq Acc Id: NM_177387   ⟹   NP_796361
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39108,080,517 - 8,394,589 (-)NCBI
GRCm38108,204,753 - 8,518,825 (-)NCBI
MGSCv37107,924,551 - 8,238,623 (-)RGD
Celera108,087,930 - 8,411,124 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_004936207
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39108,068,499 - 8,394,701 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004936208
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39108,068,499 - 8,394,701 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004936209
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39108,068,499 - 8,394,701 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004936210
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39108,068,499 - 8,394,701 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_796361 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI38156 (Get FASTA)   NCBI Sequence Viewer  
  BAC39625 (Get FASTA)   NCBI Sequence Viewer  
  BAE37128 (Get FASTA)   NCBI Sequence Viewer  
  EDL03535 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000052017
  ENSMUSP00000052017.8
GenBank Protein Q8BUB6 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_796361   ⟸   NM_177387
- UniProtKB: B2RR02 (UniProtKB/Swiss-Prot),   Q8BUB6 (UniProtKB/Swiss-Prot),   Q3TRA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000052017   ⟸   ENSMUST00000061601

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BUB6-F1-model_v2 AlphaFold Q8BUB6 1-407 view protein structure

Promoters
RGD ID:6820081
Promoter ID:MM_KWN:3503
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung,   MEF_B6
Transcripts:NM_177387
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36108,238,361 - 8,238,861 (-)MPROMDB
RGD ID:8671470
Promoter ID:EPDNEW_M13766
Type:initiation region
Name:Ust_1
Description:Mus musculus uronyl-2-sulfotransferase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38108,518,820 - 8,518,880EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2442406 AgrOrtholog
Ensembl Genes ENSMUSG00000047712 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000061601 ENTREZGENE
  ENSMUST00000061601.9 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Heparan_SO4_2-O-STrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sulfotransferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:338362 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2442406 ENTREZGENE
NCBI Gene 338362 ENTREZGENE
PANTHER PTHR12129 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  URONYL 2-SULFOTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sulfotransfer_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ust PhenoGen
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RR02 ENTREZGENE
  Q3TRA2 ENTREZGENE, UniProtKB/TrEMBL
  Q8BUB6 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2RR02 UniProtKB/Swiss-Prot