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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Xkr4 | Rat | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of XKR4 mRNA | CTD | PMID:29097150 | Xkr4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of XKR4 mRNA | CTD | PMID:32109520 | Xkr4 | Rat | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2,3,7,8-tetrachlorodibenzofuran results in decreased expression of XKR4 mRNA | CTD | PMID:32109520 | Xkr4 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Xkr4 (Mus musculus) | 6480464 | bisphenol S results in increased expression of XKR4 mRNA | CTD | PMID:39298647 | Xkr4 | Rat | 4,4'-sulfonyldiphenol | increases methylation | ISO | XKR4 (Homo sapiens) | 6480464 | bisphenol S results in increased methylation of XKR4 gene | CTD | PMID:31601247 | Xkr4 | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of XKR4 mRNA | CTD | PMID:24780913 | Xkr4 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of XKR4 mRNA | CTD | PMID:31881176 | Xkr4 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of XKR4 mRNA | CTD | PMID:28959563 | Xkr4 | Rat | all-trans-retinoic acid | increases expression | ISO | XKR4 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of XKR4 mRNA | CTD | PMID:23724009 | Xkr4 | Rat | aristolochic acid A | decreases expression | ISO | XKR4 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of XKR4 mRNA | CTD | PMID:33212167 | Xkr4 | Rat | arsane | affects methylation | ISO | XKR4 (Homo sapiens) | 6480464 | Arsenic affects the methylation of XKR4 gene | CTD | PMID:25304211 | Xkr4 | Rat | arsenic atom | affects methylation | ISO | XKR4 (Homo sapiens) | 6480464 | Arsenic affects the methylation of XKR4 gene | CTD | PMID:25304211 | Xkr4 | Rat | benzo[a]pyrene | increases methylation | ISO | XKR4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of XKR4 3' UTR; Benzo(a)pyrene results in increased methylation of more ... | CTD | PMID:27901495 | Xkr4 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of XKR4 mRNA | CTD | PMID:25181051 | Xkr4 | Rat | bisphenol A | decreases methylation | ISO | XKR4 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of XKR4 gene | CTD | PMID:31601247 | Xkr4 | Rat | bisphenol A | decreases expression | ISO | Xkr4 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of XKR4 mRNA | CTD | PMID:34585602 | Xkr4 | Rat | bisphenol A | multiple interactions | ISO | XKR4 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of XKR4 gene | CTD | PMID:31601247 | Xkr4 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of XKR4 mRNA | CTD | PMID:29097150|PMID:30816183 | Xkr4 | Rat | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of XKR4 mRNA | CTD | PMID:19167457 | Xkr4 | Rat | cadmium dichloride | increases methylation | EXP | | 6480464 | Cadmium Chloride results in increased methylation of XKR4 promoter | CTD | PMID:22457795 | Xkr4 | Rat | CGP 52608 | multiple interactions | ISO | XKR4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to XKR4 gene] | CTD | PMID:28238834 | Xkr4 | Rat | chlorpyrifos | increases expression | ISO | Xkr4 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of XKR4 mRNA | CTD | PMID:37019170 | Xkr4 | Rat | dorsomorphin | multiple interactions | ISO | XKR4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... | CTD | PMID:27188386 | Xkr4 | Rat | entinostat | decreases expression | ISO | XKR4 (Homo sapiens) | 6480464 | entinostat results in decreased expression of XKR4 mRNA | CTD | PMID:27188386 | Xkr4 | Rat | ethanol | increases expression | ISO | Xkr4 (Mus musculus) | 6480464 | Ethanol results in increased expression of XKR4 mRNA | CTD | PMID:30319688 | Xkr4 | Rat | ethanol | affects splicing | ISO | Xkr4 (Mus musculus) | 6480464 | Ethanol affects the splicing of XKR4 mRNA | CTD | PMID:30319688 | Xkr4 | Rat | fenamidone | decreases expression | ISO | Xkr4 (Mus musculus) | 6480464 | fenamidone results in decreased expression of XKR4 mRNA | CTD | PMID:27029645 | Xkr4 | Rat | fulvestrant | multiple interactions | ISO | XKR4 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of XKR4 gene | CTD | PMID:31601247 | Xkr4 | Rat | malathion | decreases expression | ISO | XKR4 (Homo sapiens) | 6480464 | Malathion results in decreased expression of XKR4 mRNA | CTD | PMID:37047231 | Xkr4 | Rat | nickel atom | decreases expression | ISO | XKR4 (Homo sapiens) | 6480464 | Nickel results in decreased expression of XKR4 mRNA | CTD | PMID:24768652|PMID:25583101 | Xkr4 | Rat | panobinostat | multiple interactions | ISO | XKR4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... | CTD | PMID:27188386 | Xkr4 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of XKR4 mRNA | CTD | PMID:33387578 | Xkr4 | Rat | permethrin | decreases expression | ISO | XKR4 (Homo sapiens) | 6480464 | Permethrin results in decreased expression of XKR4 mRNA | CTD | PMID:37047231 | Xkr4 | Rat | phenylmercury acetate | increases expression | ISO | XKR4 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of XKR4 mRNA | CTD | PMID:26272509 | Xkr4 | Rat | phenylmercury acetate | multiple interactions | ISO | XKR4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Xkr4 | Rat | SB 431542 | multiple interactions | ISO | XKR4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... | CTD | PMID:27188386 | Xkr4 | Rat | sodium arsenite | decreases expression | ISO | Xkr4 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of XKR4 mRNA | CTD | PMID:37682722 | Xkr4 | Rat | sunitinib | decreases expression | ISO | XKR4 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of XKR4 mRNA | CTD | PMID:31533062 | Xkr4 | Rat | titanium dioxide | increases expression | ISO | Xkr4 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of XKR4 mRNA | CTD | PMID:29264374 | Xkr4 | Rat | titanium dioxide | increases methylation | ISO | Xkr4 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of XKR4 promoter | CTD | PMID:35295148 | Xkr4 | Rat | titanium dioxide | decreases methylation | ISO | Xkr4 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of XKR4 gene | CTD | PMID:35295148 | Xkr4 | Rat | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of XKR4 mRNA | CTD | PMID:33387578 | Xkr4 | Rat | trichostatin A | increases expression | ISO | XKR4 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of XKR4 mRNA | CTD | PMID:24935251 | Xkr4 | Rat | valproic acid | increases methylation | ISO | XKR4 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of XKR4 gene | CTD | PMID:29154799 | Xkr4 | Rat | valproic acid | increases expression | ISO | XKR4 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of XKR4 mRNA | CTD | PMID:23179753|PMID:24383497|PMID:26272509|PMID:28001369 | Xkr4 | Rat | valproic acid | multiple interactions | ISO | XKR4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Xkr4 | Rat | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of XKR4 mRNA | CTD | PMID:29427782 | Xkr4 | Rat | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of XKR4 mRNA | CTD | PMID:29427782 | |