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Gene: Xkr4 (XK related 4) Rattus norvegicus

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Symbol:

Xkr4

Name:

XK related 4

RGD ID:

1549780

Description:

Predicted to enable phospholipid scramblase activity and protein homodimerization activity. Predicted to be involved in apoptotic process involved in development; engulfment of apoptotic cell; and phosphatidylserine exposure on apoptotic cell surface. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human XKR4 (XK related 4); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

X Kell blood group precursor related family member 4; X-linked Kx blood group related 4; XK, Kell blood group complex subunit-related family, member 4; XK-related protein 4; XRG4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	XKR4 (XK related 4)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Xkr4 (X-linked Kx blood group related 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Xkr4 (XK related 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	XKR4 (XK related 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	XKR4 (XK related 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Xkr4 (XK related 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	XKR4 (XK related 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	XKR4 (XK related 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Xkr4 (XK related 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	FBXO17 (F-box protein 17)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	XKR4 (XK related 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Xkr4 (X-linked Kx blood group related 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG18635	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PANTHER)
Caenorhabditis elegans (roundworm):	ced-8	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG32579	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG32579	Alliance	DIOPT (Hieranoid\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	xkr4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	xkr4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	xkr4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	20,694,433 - 21,095,350 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	20,693,966 - 21,080,579 (+)	Ensembl				GRCr8
mRatBN7.2	5	15,896,818 - 16,297,733 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	15,895,863 - 16,282,962 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	18,139,059 - 18,531,124 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	19,741,102 - 20,129,597 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	19,489,010 - 19,881,087 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	15,746,012 - 16,141,059 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	15,747,614 - 16,140,896 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	20,529,390 - 20,786,961 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	5	20,922,729 - 20,924,038 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	16,150,482 - 16,552,907 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	15,271,437 - 15,653,341 (+)	NCBI		Celera
Cytogenetic Map	5	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

substance-related disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

C60 fullerene (EXP)

cadmium dichloride (EXP)

CGP 52608 (ISO)

chlorpyrifos (ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethanol (ISO)

fenamidone (ISO)

fulvestrant (ISO)

malathion (ISO)

nickel atom (ISO)

panobinostat (ISO)

paracetamol (EXP)

permethrin (ISO)

phenylmercury acetate (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (IEA)

apoptotic process involved in development (IBA)

engulfment of apoptotic cell (IBA)

phosphatidylserine exposure on apoptotic cell surface (IBA,ISO,ISS)

Cellular Component

membrane (IEA)

plasma membrane (IBA,IEA,ISO,ISS)

Molecular Function

phospholipid scramblase activity (ISO,ISS)

protein binding (ISO)

protein homodimerization activity (ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Xkr4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	20,694,433 - 21,095,350 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	20,693,966 - 21,080,579 (+)	Ensembl				GRCr8
mRatBN7.2	5	15,896,818 - 16,297,733 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	15,895,863 - 16,282,962 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	18,139,059 - 18,531,124 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	19,741,102 - 20,129,597 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	19,489,010 - 19,881,087 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	15,746,012 - 16,141,059 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	15,747,614 - 16,140,896 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	20,529,390 - 20,786,961 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	5	20,922,729 - 20,924,038 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	16,150,482 - 16,552,907 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	15,271,437 - 15,653,341 (+)	NCBI		Celera
Cytogenetic Map	5	q12	NCBI

XKR4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	55,102,028 - 55,542,054 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	55,102,028 - 55,542,054 (+)	Ensembl			hg38	GRCh38
GRCh37	8	56,014,588 - 56,454,613 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	56,177,571 - 56,601,268 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	8	52,005,765 - 52,428,770 (+)	NCBI		Celera
Cytogenetic Map	8	q12.1	NCBI
HuRef	8	51,483,309 - 51,906,398 (+)	NCBI		HuRef
CHM1_1	8	56,066,642 - 56,490,559 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	55,479,588 - 55,919,328 (+)	NCBI		T2T-CHM13v2.0

Xkr4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	3,269,956 - 3,741,733 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	3,276,124 - 3,741,721 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	3,199,733 - 3,671,948 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	3,205,901 - 3,671,498 (-)	Ensembl			mm10	GRCm38
MGSCv37	1	3,204,563 - 3,661,579 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	3,204,563 - 3,661,579 (-)	NCBI		MGSCv36	mm8
Celera	1	3,222,752 - 3,677,461 (-)	NCBI		Celera
Cytogenetic Map	1	A1	NCBI
cM Map	1	1.6	NCBI

Xkr4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955454	14,313,308 - 14,687,687 (+)	Ensembl
ChiLan1.0	NW_004955454	14,311,466 - 14,704,334 (+)	NCBI	ChiLan1.0	ChiLan1.0

XKR4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	70,752,499 - 71,193,752 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	46,477,114 - 46,918,128 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	51,541,410 - 51,982,587 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	48,883,194 - 49,338,840 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	48,914,778 - 49,336,906 (+)	Ensembl			panPan2	panpan1.1

XKR4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	6,640,108 - 7,081,182 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	6,640,108 - 7,064,029 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	6,955,719 - 7,396,555 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	6,718,168 - 7,155,918 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	6,718,237 - 7,140,881 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	6,694,846 - 7,136,803 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	6,860,019 - 7,304,621 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	7,138,740 - 7,581,032 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Xkr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	72,487,107 - 72,897,540 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936496	1,888,068 - 2,287,963 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936496	1,887,943 - 2,289,928 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

XKR4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	76,050,102 - 76,382,818 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	76,056,895 - 76,382,976 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

XKR4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	51,169,122 - 51,427,310 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666039	90,220,104 - 90,652,025 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Xkr4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624735	77,042 - 543,924 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Xkr4
3192 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	153
Count of miRNA genes:	122
Interacting mature miRNAs:	134
Transcripts:	ENSRNOT00000029503
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2293666	Bmd38	Bone mineral density QTL 38	4.4		femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	5	13731153	43590997	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	6922282	81330203	Rat
1300117	Hrtrt8	Heart rate QTL 8	3.49		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	8627230	52665523	Rat
7394712	Emca13	Estrogen-induced mammary cancer QTL 13			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	14606078	59606078	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	17576633	62576633	Rat
1578774	Tcas8	Tongue tumor susceptibility QTL 8	3.47		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	15707451	60707451	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	91770353	Rat
2312562	Pur18	Proteinuria QTL 18	2.6	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	5	6922282	37468560	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	7065535	74335773	Rat
1641903	Alcrsp3	Alcohol response QTL 3			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	17486080	62486080	Rat
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	87027358	Rat
631827	Alc4	Alcohol consumption QTL 4	3.5		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	5	12970480	25683802	Rat
2303577	Gluco47	Glucose level QTL 47	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	16520019	61520019	Rat
1641922	Alcrsp8	Alcohol response QTL 8			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	5	17486080	62486080	Rat
2313085	Bss59	Bone structure and strength QTL 59	2.9	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	5	8627230	53627230	Rat

Markers in Region

D5Got208

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	16,029,447 - 16,029,591 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	15,860,105 - 15,860,248	NCBI	Rnor6.0
Rnor_5.0	5	20,643,289 - 20,643,432	UniSTS	Rnor5.0
RGSC_v3.4	5	16,286,509 - 16,286,652	UniSTS	RGSC3.4
Celera	5	15,400,209 - 15,400,352	UniSTS
Cytogenetic Map	5	q12	UniSTS

AI196452

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	80,378,265 - 80,378,358 (+)	MAPPER	mRatBN7.2
mRatBN7.2	5	16,046,131 - 16,046,224 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	83,311,048 - 83,311,140	NCBI	Rnor6.0
Rnor_6.0	5	15,876,789 - 15,876,881	NCBI	Rnor6.0
Rnor_5.0	5	20,659,973 - 20,660,065	UniSTS	Rnor5.0
Rnor_5.0	3	90,010,665 - 90,010,757	UniSTS	Rnor5.0
RGSC_v3.4	5	16,303,193 - 16,303,285	UniSTS	RGSC3.4
RGSC_v3.4	3	78,819,798 - 78,819,890	UniSTS	RGSC3.4
Celera	5	15,416,892 - 15,416,984	UniSTS
Celera	3	79,572,623 - 79,572,715	UniSTS
Cytogenetic Map	3	q31	UniSTS
Cytogenetic Map	5	q12	UniSTS

RH131924

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	16,068,350 - 16,068,538 (-)	MAPPER	mRatBN7.2
mRatBN7.2	X	140,681,929 - 140,682,117 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	145,423,206 - 145,423,393	NCBI	Rnor6.0
Rnor_6.0	5	16,079,717 - 16,079,904	NCBI	Rnor6.0
Rnor_5.0	5	20,862,886 - 20,863,073	UniSTS	Rnor5.0
Rnor_5.0	X	145,445,518 - 145,445,705	UniSTS	Rnor5.0
RGSC_v3.4	X	147,969,780 - 147,969,967	UniSTS	RGSC3.4
RGSC_v3.4	5	16,326,660 - 16,326,847	UniSTS	RGSC3.4
Celera	5	15,438,743 - 15,438,930	UniSTS
Celera	X	136,680,775 - 136,680,962	UniSTS
Cytogenetic Map	5	q12	UniSTS

AU048033

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	16,050,328 - 16,050,619 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	15,881,217 - 15,881,507	NCBI	Rnor6.0
Rnor_5.0	5	20,664,401 - 20,664,691	UniSTS	Rnor5.0
RGSC_v3.4	5	16,308,025 - 16,308,315	UniSTS	RGSC3.4
Celera	5	15,421,019 - 15,421,309	UniSTS
Cytogenetic Map	5	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
15	12	65	158	83	82	51	28	51	6	277	126	11	137	77	88	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001011971	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066347	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY534258	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473984	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000029503 ⟹ ENSRNOP00000029598

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	20,693,966 - 21,080,579 (+)	Ensembl
mRatBN7.2 Ensembl	5	15,895,863 - 16,282,962 (+)	Ensembl
Rnor_6.0 Ensembl	5	15,747,614 - 16,140,896 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000147607 ⟹ ENSRNOP00000108539

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	20,694,680 - 21,080,579 (+)	Ensembl

RefSeq Acc Id:

NM_001011971 ⟹ NP_001011971

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	20,694,433 - 21,080,579 (+)	NCBI
mRatBN7.2	5	15,896,818 - 16,282,962 (+)	NCBI
Rnor_6.0	5	15,746,012 - 16,141,059 (-)	NCBI
Rnor_5.0	5	20,529,390 - 20,786,961 (-)	NCBI
Rnor_5.0	5	20,922,729 - 20,924,038 (-)	NCBI
RGSC_v3.4	5	16,150,482 - 16,552,907 (+)	RGD
Celera	5	15,271,437 - 15,653,341 (+)	RGD

Sequence:

show sequence

ATGGGTAGAGCCCCAGGGCCTTCGCATTTCTCCAGGCTGGGGTTTGCCAGTACAGCATCCCTGA
GGCTGCCCTCTCCTTATCCCGAGGGCCCGCCCTCTGCTGCCGGCTTTGCTTTAGGTGTTCCAGC
CCTACAGGTCCTCTGCCACCCAGGATCTCCAAAGCATGGCACGCCCACCACCGCTGCTAGTACA
GAAGCCCAGCTTCCTAGTTGAAGCGTGCTGTTCACCCTCGCCGGCAACACACCTAGCACCGTAC
CACACCCAACCAGGTGCCCGAACTCCCAGTACAATACAAAGAGACCTGCTCTTCCCCATCCCTC
GCCGCTGCCACGCCCGCTCGAGTCCACGGCCCCCTGCCCTCGGCGGTGGCCCAACACAGAGACT
CCAACACGCGGCGCGCTCTGCCCACCCCATCCCCCCCAGCGTCAAGGAAATCCACCCAACGTTT
TCCGAAATCCCACGAGCCCGGGCCTCCGACTGCTGTGCTGCTGCCCTCGGCGTCCAGCACTGGC
CAGCCCGGCACCCCCACCCGCCGCTCCCCTCGATCTCGCTCGCTGTGGACTACTACCTGCTCGG
CCAGCGCTGGTGGTTTGGGCTCACCCTGTTCTTCGTGGTTCTGGGCTCGCTCTCTGTGCAAGTG
TTCAGCTTCCGGTGGTTTGTGCACGATTTCAGCACCGAGGACAGCGCCACGACCACCGCCTCCA
CCTGCCAGCAGCCTGGAGCGGATTGCAAGACCGTGGTCAGCAGTGGGTCTGCAGCCGGGGAAGG
CGAGGCTCGTCCTTCCACGCCGCAGAGGCAAGCATCCAACGCCAGCAAGAGCAACATCGCCGCC
ACCAACAGCGGAAGCAACAGCAACGGGGCCACCAGGACCAGCGGCAAACACAGGTCTGCGTCCT
GCTCCTTCTGCATCTGGCTCCTGCAGTCACTCATCCACATCTTGCAGCTCGGGCAAGTCTGGAG
GTATTTGCACACAATATACTTAGGTATCCGGAGCCGGCAGAGCGGGGAGAGCAGTAGGTGGCGG
TTTTACTGGAAGATGGTGTACGAGTATGCAGATGTGAGCATGCTGCACCTGCTGGCCACCTTTC
TGGAAAGTGCGCCACAACTGGTCCTGCAGCTCTGCATAATTGTACAGACTCACAGCTTACAGGC
CCTCCAAGGTTTTACAGCAGCAGCCTCCCTTGTGTCCTTGGCTTGGGCCCTAGCCTCCTACCAG
AAGGCTCTTCGGGACTCCCGAGATGACAAAAAGCCTATCAGCTACATGGCTGTCATCATCCAGT
TCTGCTGGCATTTCTTCACCATTGCTGCCAGGGTCATCACATTCGCCCTCTTTGCCTCGGTTTT
CCAGCTGTATTTTGGGATATTCATTGTCCTCCACTGGTGCATCATGACCTTCTGGATTGTCCAC
TGTGAGACAGAATTCTGTATCACCAAATGGGAAGAGATTGTGTTTGACATGGTGGTGGGTATCA
TCTACATCTTCAGTTGGTTCAATGTCAAGGAAGGCAGGACACGCTGCAGGCTGTTCATTTACTA
TTTTGTAATCCTTTTGGAAAATACAGCCTTGAGTGCACTCTGGTACCTCTACAAAGCTCCCCAG
ATTGCGGATGCATTTGCCATCCCTGCATTGTGCGTGGTTTTCAGCAGCTTTTTAACAGGTGTCG
TTTTTATGCTGATGTACTATGCCTTCTTCCATCCCAATGGGCCCAGATTTGGGCAGTCACCAAG
TTGTGCTTGTGACGACCCTGCCACTGCCTTCTCTATGCCTCCAGAAGTAGCCACAAGCACACTA
CGGTCCATCTCTAACAACCGCAGTGTTGCCAGTGACCGTGATCAGAAATTTGCAGAGCGGGATG
GATGTGTACCTGTGTTTCAGGTGAGACCAACTGCACCACCTACTCCATCATCTCGACCACCGCG
GATTGAAGAATCAGTCATTAAAATTGACCTGTTCAGGAATAGATATCCAGCATGGGAGAGACAT
GTGTTGGACCGAAGCCTGAGAAAGGCCATTTTAGCCTTTGAATGTTCCCCATCTCCTCCAAGGC
TGCAGTACAAAGACGATGCCCTTATTCAGGAGAGGCTGGAATATGAAACCACTTTATAAAACAC
AAAGAACCGTAATGTCCATATAAAGGGGTAACAGCAGGGCTGAGGCAATAATGACACCTTATCC
AAGAGTAGGGCAATGAGCTATATGTTCTTAGTCCAAACATTGTCACGGTATGGTTTGATCTTCC
ATCAGCTGACTGCCTGCTGCCGGTGAGCATTCAAGCCAGTAGTGCTGAGAGTTTCTTACTCCGC
TGAAAGGGGCGATGTCAGCTTAGTATGACTGTTGCTACAAATTCCTCCAGCACAGGCTTGGGGC
ACATTCACTGGAGGATAACATTATTGTGAGGAAATGTTGCCTCTAATCATTAGGGTATTTTAAT
GGAGTTTACTAATCTTTGCATAAATATGTTCATACCACCACCACCACCACCCCTCTATCAAAGG
AGTTAAGGTGGAGCTGGAGAGATGACTCAGTAGTTAAGAGCACTGACTGCTCTTGCAAAGAACC
CAGGCTTGAGCCCCAGCATCCATTTGATAGTTCACTACAACTCTAATTCCAGAATATCCAATGC
CCATTTTTGGCCTCCTCAGGCACTGCACTCACATGGTGCACAGACATATATGCAGGCAAAATAC
CCATACACATAAAATAAAAATAAATCTCCAAAAACAAAACAAAACAAAAACAAAAAAAAGTTTA
GGTGATTTCCTTGATGCAAAGCTCACAACAGACTCCAAGAAGAAAGCAACATGCTTGGAATGAC
CCTAGAAACCATTCTCTCCTTTGCAAACCAGTAGCATCAATGACAAAACCTGTGCAGTGGACAG
CAAGACTCAAGTGTTTACACTGATACTAGCATCGATGGGATGATTCTTTTTCTACGCATTTCAG
GATTTGTTTTTTACTTTTAAGTTTTGCAGATGAGAACATTCTTTATGACAGAAATCCTATGCAG
CACATGTATGGCTTTTGAAGAGACCAAGGAGCTCAATATTCATCCGTGATGTAAATTAAATGCT
AATCATGATTCAGTATTCAATTGCAAAAATAAAATTTATATACAAAGAGCCATGGCGGGAGGGA
CAGAATGAGAATCAGATTCTCAGGTGTGTGCATCTCCTATTGAAATACACCCACAAAGCCACGG
TCGAGAAAAAGGGACTGTTTCCAGGTCTGTTTCTAGGTGCAGGATGAGCACGGGTCAGCAGGTG
TGATTCCGGAAACCACATGCCACACCTTTCTAGTGCCAAACTTCGTTCAATCACAGAACTGATA
CGGTATTCCCCCAGACTGAGAATAAGTGGTGTCCCAAAACAGACAAGGACAGAATAATCAGGTT
CTTGGCTGTATACAGACTTACCCTCTTCCCATCCAAGGTCAAAGCGATGTGTCTACTAGAGACT
TTGGGACACCTTTTAGCAAGCGAGTGCATACAGATGCAATGTGTATGCTATCAAAAATAAAAAC
TGCCTGGACTGCTTGAGGGCTTACCACTCCATCAGCTAAGATTTGTATGTGAATCATCTGTAAA
GTTGTGCTTTTACAAGCTTCTGAGTTTTAAATACCTCCATACAGCAAGTAAACATTCCCGCTTT
CTGTTCTTGGTGTCATTGGTCATGGTGCTTTTTGTTGCATTAAAAGTGCCGGTCAAACTTTAAA
AAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XR_010066347

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	20,694,875 - 21,095,350 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001011971	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAT07107	(Get FASTA)	NCBI Sequence Viewer
	EDM11599	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000108539
GenBank Protein	Q5GH59	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001011971 ⟸ NM_001011971

- UniProtKB:

Q5GH59 (UniProtKB/Swiss-Prot), A0A8L2QFT8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MARPPPLLVQKPSFLVEACCSPSPATHLAPYHTQPGARTPSTIQRDLLFPIPRRCHARSSPRPP
ALGGGPTQRLQHAARSAHPIPPSVKEIHPTFSEIPRARASDCCAAALGVQHWPARHPHPPLPSI
SLAVDYYLLGQRWWFGLTLFFVVLGSLSVQVFSFRWFVHDFSTEDSATTTASTCQQPGADCKTV
VSSGSAAGEGEARPSTPQRQASNASKSNIAATNSGSNSNGATRTSGKHRSASCSFCIWLLQSLI
HILQLGQVWRYLHTIYLGIRSRQSGESSRWRFYWKMVYEYADVSMLHLLATFLESAPQLVLQLC
IIVQTHSLQALQGFTAAASLVSLAWALASYQKALRDSRDDKKPISYMAVIIQFCWHFFTIAARV
ITFALFASVFQLYFGIFIVLHWCIMTFWIVHCETEFCITKWEEIVFDMVVGIIYIFSWFNVKEG
RTRCRLFIYYFVILLENTALSALWYLYKAPQIADAFAIPALCVVFSSFLTGVVFMLMYYAFFHP
NGPRFGQSPSCACDDPATAFSMPPEVATSTLRSISNNRSVASDRDQKFAERDGCVPVFQVRPTA
PPTPSSRPPRIEESVIKIDLFRNRYPAWERHVLDRSLRKAILAFECSPSPPRLQYKDDALIQER
LEYETTL

hide sequence

Ensembl Acc Id:

ENSRNOP00000029598 ⟸ ENSRNOT00000029503

Ensembl Acc Id:

ENSRNOP00000108539 ⟸ ENSRNOT00000147607

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5GH59-F1-model_v2	AlphaFold	Q5GH59	1-647	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1549780	AgrOrtholog
BioCyc Gene	G2FUF-42140	BioCyc
Ensembl Genes	ENSRNOG00000027276	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000147607	ENTREZGENE
InterPro	XK-rel	UniProtKB/Swiss-Prot
	XK-related_scramblase	UniProtKB/Swiss-Prot
KEGG Report	rno:297801	UniProtKB/Swiss-Prot
NCBI Gene	297801	ENTREZGENE
PANTHER	XK-RELATED PROTEIN	UniProtKB/Swiss-Prot
	XK-RELATED PROTEIN 4	UniProtKB/Swiss-Prot
Pfam	XK-related	UniProtKB/Swiss-Prot
PhenoGen	Xkr4	PhenoGen
RatGTEx	ENSRNOG00000027276	RatGTEx
UniProt	A0A8L2QFT8	ENTREZGENE, UniProtKB/TrEMBL
	Q5GH59	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-17	Xkr4	XK related 4	Xkr4	X-linked Kx blood group related 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-02-11	Xkr4	X-linked Kx blood group related 4	Xkr4	XK, Kell blood group complex subunit-related family, member 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-12-15	Xkr4	XK, Kell blood group complex subunit-related family, member 4	Xkr4	X Kell blood group precursor related family member 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Xkr4	X Kell blood group precursor related family member 4	XRG4	XK-related protein 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-09-15	XRG4	XK-related protein 4			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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