Ddah1<sup>em1Ywxu</sup> (dimethylarginine dimethylaminohydrolase 1; CRISPR/Cas9 induced mutant 1, Ywxu) - Rat Genome Database

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Gene: Ddah1em1Ywxu (dimethylarginine dimethylaminohydrolase 1; CRISPR/Cas9 induced mutant 1, Ywxu) Rattus norvegicus
Analyze
Symbol: Ddah1em1Ywxu
Name: dimethylarginine dimethylaminohydrolase 1; CRISPR/Cas9 induced mutant 1, Ywxu
RGD ID: 151347606
Description: CRISPR-Cas9 technique was used to generate DDAH1-/- rats on Sprague-Dawley background. Genome deletion in exon 1 was confirmed by PCR analysis with the primers:DDAH1-F (5'-GCGCTGCTCTCGGGAAGA-3') and DDAH1-R (5'-GGGTGATGAGGGCGGTCT-3').
ASSOCIATED WITH increased aorta wall thickness; increased heart right ventricle weight; increased right ventricle systolic pressure; ASSOCIATED WITH Pulmonary Arterial Hypertension
Type: allele  of Ddah1  
Previously known as: Ddah1^[em1Ywxu]
Is Marker For: Strains:   SD-Ddah1em1Ywxu  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Dimethylarginine dimethylaminohydrolase 1 deficiency aggravates monocrotaline-induced pulmonary oxidative stress, pulmonary arterial hypertension and right heart failure in rats. Wang D, etal., Int J Cardiol. 2019 Nov 15;295:14-20. doi: 10.1016/j.ijcard.2019.07.078. Epub 2019 Jul 27.

Genomics


Related Rat Strains
The following Strains have been annotated to Ddah1em1Ywxu
SD-Ddah1em1Ywxu    


Expression


Sequence

Nucleotide Sequences


Additional Information