Ccdc39<sup>em1Jgn</sup> (coiled-coil domain containing 39; CRISPR/Cas9 induced mutant 1, Jgn)

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Community Projects Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: Ccdc39^em1Jgn (coiled-coil domain containing 39; CRISPR/Cas9 induced mutant 1, Jgn) Rattus norvegicus

Analyze

Symbol:	Ccdc39^em1Jgn
Name:	coiled-coil domain containing 39; CRISPR/Cas9 induced mutant 1, Jgn
RGD ID:	150521525
Description:	The CRISPR/Case9 system was desgined to create the progressive hydrocephalus (prh) mutation in Sprague Dawley rats. The homozygous rat carries chr2:g.120305679A>T change that creates a splice site (Ccdc39c.916+2T ) mutation in the rat Ccdc39 gene. ASSOCIATED WITH abnormal cerebrospinal fluid flow; abnormal glymphatic system physiology; dilated lateral ventricle; ASSOCIATED WITH hydrocephalus; Ventriculomegaly
Type:	allele of Ccdc39
Is Marker For:	Strains: SD-Ccdc39^em1Jgn
Latest Assembly:	mRatBN7.2 - mRatBN7.2 Assembly
Position:	No map positions available.

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hydrocephalus (IMP)

Ventriculomegaly (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal cerebrospinal fluid flow (IMP)

abnormal glymphatic system physiology (IMP)

dilated lateral ventricle (IMP)

dysmyelination (IMP)

hydrocephaly (IMP)

increased apoptosis (IMP)

increased macrophage cell number (IMP)

increased neutrophil cell number (IMP)

intracranial hemorrhage (IMP)

postnatal growth retardation (IMP)

premature death (IMP)

subarachnoid hemorrhage (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Impaired neural differentiation and glymphatic CSF flow in the Ccdc39 rat model of neonatal hydrocephalus: genetic interaction with L1cam.	Emmert AS, etal., Dis Model Mech. 2019 Nov 21;12(11). pii: 12/11/dmm040972. doi: 10.1242/dmm.040972.

Genomics

Related Rat Strains

The following Strains have been annotated to Ccdc39^em1Jgn

SD-Ccdc39^em1Jgn

Expression

Sequence

Nucleotide Sequences

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Mammalian Phenotype