Scn9a*<sup>tm1Amgn</sup> (sodium voltage-gated channel alpha subunit 9;ZFN induced target mutant1, Amgn) - Rat Genome Database

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Gene: Scn9a*tm1Amgn (sodium voltage-gated channel alpha subunit 9;ZFN induced target mutant1, Amgn) Rattus norvegicus
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Symbol: Scn9a*tm1Amgn
Name: sodium voltage-gated channel alpha subunit 9;ZFN induced target mutant1, Amgn
RGD ID: 150429827
Description: Exon 25 of the rat Scn9a gene was replaced with the human SCN9A exon counterpart (exon 26) using ZFN technology. The mRNAs of the active ZFN pair targets middle region of the exon (CACCATCATGGTTCTTATAtgcctcAACATGGTAA CCATGATG, ZFN binding sites in uppercase).
ASSOCIATED WITH abnormal afterhyperpolarization; abnormal pain threshold; decreased susceptibility to induced hypothermia
Type: allele  of Scn9a  
Previously known as: Scn9a*^[tm1Amgn]
Is Marker For: Strains:   SD-Scn9a*tm1Amgn/Crl  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. Rat NaV1.7 loss-of-function genetic model: Deficient nociceptive and neuropathic pain behavior with retained olfactory function and intra-epidermal nerve fibers. Grubinska B, etal., Mol Pain. 2019 Jan-Dec;15:1744806919881846. doi: 10.1177/1744806919881846.

Genomics


Related Rat Strains
The following Strains have been annotated to Scn9a*tm1Amgn
SD-Scn9a*tm1Amgn/Crl    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information