Add3<sup>em2Mcwi</sup> (adducin 3; ZFN induced mutant2, Mcwi) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Add3em2Mcwi (adducin 3; ZFN induced mutant2, Mcwi) Rattus norvegicus
Analyze
Symbol: Add3em2Mcwi
Name: adducin 3; ZFN induced mutant2, Mcwi
RGD ID: 150429619
Description: ZFN system was used to Knock out the rat Add3 gene of FHH-Chr 1BN/Mcwi rat embryos.The ZFN mRNA was injected into the pronucleus of fertilized FHH-Chr 1BN/Mcwi embryos and transferred to the oviduct of pseudopregnant females. PCR genotyping of tail biopsies confirmed a 68-bp deletion using forward primer 5'-GCCCCCATGAGTCACTACAC-3' and reverse primer 5'-GCTACAGGAAGCATCTCCTGTG-3'.
ASSOCIATED WITH decreased tubuloglomerular feedback response; decreased vasoconstriction
Type: allele  of Add3  
Is Marker For: Strains:   FHH-Chr 1BN-Add3em2Mcwi /Roman  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Fan F, etal., J Am Soc Nephrol. 2020 Apr;31(4):687-700. doi: 10.1681/ASN.2019080784. Epub 2020 Feb 6.

Genomics


Related Rat Strains
The following Strains have been annotated to Add3em2Mcwi


Expression


Sequence

Nucleotide Sequences


Additional Information